Incidental Mutation 'R3926:Corin'
| ID |
308275 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
040821-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.267)
|
| Stock # |
R3926 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 72529473 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Alanine
at position 294
(D294A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135889
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005352
AA Change: D362A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: D362A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167460
AA Change: D296A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: D296A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175766
AA Change: D294A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: D294A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176396
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176439
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176974
AA Change: D296A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: D296A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177290
AA Change: D229A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: D229A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Meta Mutation Damage Score |
0.9510 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.6%
|
| Validation Efficiency |
98% (55/56) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
G |
T |
11: 109,684,980 (GRCm39) |
C172* |
probably null |
Het |
| Ahnak |
G |
A |
19: 8,983,692 (GRCm39) |
D1659N |
probably benign |
Het |
| Arfgap2 |
C |
T |
2: 91,105,150 (GRCm39) |
R405W |
probably damaging |
Het |
| Asb14 |
T |
C |
14: 26,619,695 (GRCm39) |
I48T |
possibly damaging |
Het |
| Astn1 |
A |
T |
1: 158,407,227 (GRCm39) |
I559F |
possibly damaging |
Het |
| Atg7 |
C |
T |
6: 114,650,639 (GRCm39) |
T83M |
possibly damaging |
Het |
| Bco1 |
T |
C |
8: 117,854,211 (GRCm39) |
S379P |
probably benign |
Het |
| Becn2 |
T |
C |
1: 175,748,852 (GRCm39) |
V306A |
probably benign |
Het |
| Bst1 |
T |
C |
5: 43,997,796 (GRCm39) |
V265A |
possibly damaging |
Het |
| Car11 |
T |
C |
7: 45,349,915 (GRCm39) |
F45L |
probably benign |
Het |
| Cdkl2 |
T |
C |
5: 92,180,998 (GRCm39) |
I214V |
possibly damaging |
Het |
| Cluap1 |
T |
A |
16: 3,729,398 (GRCm39) |
S141T |
probably damaging |
Het |
| Col11a1 |
C |
T |
3: 113,883,773 (GRCm39) |
|
probably benign |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Crct1 |
C |
A |
3: 92,922,014 (GRCm39) |
|
probably benign |
Het |
| Ddx41 |
A |
G |
13: 55,679,083 (GRCm39) |
L559P |
probably damaging |
Het |
| Ddx59 |
T |
A |
1: 136,344,482 (GRCm39) |
V51D |
probably benign |
Het |
| Dennd1b |
A |
G |
1: 139,071,697 (GRCm39) |
N397D |
probably benign |
Het |
| Evc2 |
T |
A |
5: 37,540,574 (GRCm39) |
L590Q |
probably damaging |
Het |
| Fhl5 |
A |
T |
4: 25,214,790 (GRCm39) |
|
probably benign |
Het |
| Flg2 |
A |
G |
3: 93,110,522 (GRCm39) |
Y850C |
unknown |
Het |
| Gal3st2b |
G |
T |
1: 93,868,512 (GRCm39) |
V246L |
probably benign |
Het |
| Jam3 |
A |
T |
9: 27,017,701 (GRCm39) |
I29K |
possibly damaging |
Het |
| Klhl1 |
A |
T |
14: 96,584,316 (GRCm39) |
C305S |
possibly damaging |
Het |
| Lims2 |
A |
G |
18: 32,090,996 (GRCm39) |
S327G |
probably benign |
Het |
| Lynx1 |
A |
G |
15: 74,623,205 (GRCm39) |
Y76H |
probably damaging |
Het |
| Mycbp2 |
G |
A |
14: 103,441,936 (GRCm39) |
P1943L |
probably damaging |
Het |
| Myo3a |
A |
G |
2: 22,455,053 (GRCm39) |
D86G |
probably damaging |
Het |
| Nkx3-2 |
T |
A |
5: 41,919,223 (GRCm39) |
Q255L |
probably damaging |
Het |
| Notch3 |
C |
T |
17: 32,372,531 (GRCm39) |
R641H |
possibly damaging |
Het |
| Nr2c2 |
T |
A |
6: 92,137,382 (GRCm39) |
M431K |
probably damaging |
Het |
| Ogfod3 |
T |
C |
11: 121,074,255 (GRCm39) |
T265A |
probably damaging |
Het |
| Pcdh9 |
G |
T |
14: 94,124,246 (GRCm39) |
Y641* |
probably null |
Het |
| Pcdha9 |
T |
A |
18: 37,132,465 (GRCm39) |
D511E |
probably damaging |
Het |
| Pcdhgb8 |
A |
G |
18: 37,895,443 (GRCm39) |
Y171C |
probably damaging |
Het |
| Pcnx1 |
T |
C |
12: 82,005,505 (GRCm39) |
C1075R |
probably damaging |
Het |
| Pik3c3 |
C |
A |
18: 30,444,382 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
T |
C |
1: 20,621,097 (GRCm39) |
T854A |
probably benign |
Het |
| Pycr1 |
T |
C |
11: 120,532,961 (GRCm39) |
T100A |
probably benign |
Het |
| Rhof |
T |
C |
5: 123,242,593 (GRCm39) |
|
probably null |
Het |
| Scn9a |
T |
A |
2: 66,357,217 (GRCm39) |
D1028V |
possibly damaging |
Het |
| Serpina3f |
T |
C |
12: 104,185,740 (GRCm39) |
I315T |
possibly damaging |
Het |
| Slc1a6 |
T |
A |
10: 78,648,715 (GRCm39) |
S479T |
possibly damaging |
Het |
| Tmcc1 |
T |
C |
6: 116,019,874 (GRCm39) |
D166G |
probably damaging |
Het |
| Trav3-3 |
A |
G |
14: 53,903,828 (GRCm39) |
K49E |
probably benign |
Het |
| Usp28 |
T |
C |
9: 48,942,223 (GRCm39) |
|
probably null |
Het |
| Utrn |
C |
T |
10: 12,573,786 (GRCm39) |
V1095I |
probably benign |
Het |
| Zfp217 |
T |
C |
2: 169,954,438 (GRCm39) |
D1038G |
probably damaging |
Het |
| Zfp709 |
A |
G |
8: 72,644,397 (GRCm39) |
R609G |
probably damaging |
Het |
| Zfp729a |
T |
A |
13: 67,768,310 (GRCm39) |
K640* |
probably null |
Het |
| Zfp986 |
A |
T |
4: 145,619,090 (GRCm39) |
|
probably benign |
Het |
| Zkscan6 |
A |
T |
11: 65,719,051 (GRCm39) |
H357L |
probably benign |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCTATTGGCTTCACCCAG -3'
(R):5'- AATGACAGCGAGGGGTTCTG -3'
Sequencing Primer
(F):5'- ATTGGCTTCACCCAGAATGG -3'
(R):5'- GGTTCTGGAAGGAAATCTGTCAAATC -3'
|
| Posted On |
2015-04-17 |
Incidental Mutation