Incidental Mutation 'R4192:Vmn1r27'
ID |
318351 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r27
|
Ensembl Gene |
ENSMUSG00000071428 |
Gene Name |
vomeronasal 1 receptor 27 |
Synonyms |
V1rc33 |
MMRRC Submission |
041023-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.120)
|
Stock # |
R4192 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
58192091-58193002 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 58192812 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Arginine
at position 14
(I14R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154455
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095862]
[ENSMUST00000226666]
[ENSMUST00000228530]
|
AlphaFold |
K7N688 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000095862
AA Change: I64R
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000093547 Gene: ENSMUSG00000071428 AA Change: I64R
Domain | Start | End | E-Value | Type |
Pfam:V1R
|
28 |
293 |
4.2e-51 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000226666
AA Change: I14R
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000228530
AA Change: I64R
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.6%
- 20x: 96.0%
|
Validation Efficiency |
100% (40/40) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 37 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930474N05Rik |
G |
T |
14: 35,818,536 (GRCm39) |
R178L |
possibly damaging |
Het |
Acot4 |
T |
C |
12: 84,089,948 (GRCm39) |
|
probably benign |
Het |
Add3 |
C |
A |
19: 53,230,955 (GRCm39) |
D543E |
probably benign |
Het |
Angpt4 |
A |
C |
2: 151,785,238 (GRCm39) |
D418A |
probably benign |
Het |
Ano8 |
A |
T |
8: 71,935,936 (GRCm39) |
V260D |
probably damaging |
Het |
Cfh |
C |
T |
1: 140,030,454 (GRCm39) |
R860H |
possibly damaging |
Het |
Csmd3 |
T |
C |
15: 47,710,667 (GRCm39) |
D1536G |
probably damaging |
Het |
Dnajb9 |
A |
T |
12: 44,253,860 (GRCm39) |
D182E |
probably benign |
Het |
Epb42 |
G |
T |
2: 120,860,570 (GRCm39) |
|
probably null |
Het |
Fam185a |
T |
A |
5: 21,630,122 (GRCm39) |
|
probably benign |
Het |
Fer1l6 |
A |
G |
15: 58,518,998 (GRCm39) |
D1710G |
probably damaging |
Het |
Gabra2 |
G |
A |
5: 71,165,341 (GRCm39) |
P210S |
probably benign |
Het |
Gm8369 |
C |
T |
19: 11,479,596 (GRCm39) |
P9S |
probably damaging |
Het |
Il17ra |
A |
G |
6: 120,458,472 (GRCm39) |
D541G |
probably damaging |
Het |
Ints4 |
T |
G |
7: 97,156,940 (GRCm39) |
H337Q |
probably damaging |
Het |
Itgam |
A |
G |
7: 127,663,904 (GRCm39) |
T44A |
probably benign |
Het |
Lyst |
C |
A |
13: 13,915,098 (GRCm39) |
T3264N |
probably damaging |
Het |
Macf1 |
A |
G |
4: 123,366,835 (GRCm39) |
F1077S |
possibly damaging |
Het |
Myo3a |
T |
A |
2: 22,412,188 (GRCm39) |
F728I |
probably damaging |
Het |
Nacad |
T |
C |
11: 6,555,534 (GRCm39) |
E72G |
probably benign |
Het |
Nkain3 |
G |
A |
4: 20,485,003 (GRCm39) |
Q25* |
probably null |
Het |
Oca2 |
T |
C |
7: 55,946,997 (GRCm39) |
F342S |
probably damaging |
Het |
Or10d1c |
T |
A |
9: 38,894,313 (GRCm39) |
Q9L |
probably benign |
Het |
Osbpl6 |
T |
A |
2: 76,415,573 (GRCm39) |
L499Q |
probably damaging |
Het |
Pcdhgb8 |
G |
C |
18: 37,896,594 (GRCm39) |
D555H |
probably damaging |
Het |
Peak1 |
A |
T |
9: 56,166,025 (GRCm39) |
N634K |
probably damaging |
Het |
Pitpnm3 |
T |
C |
11: 71,942,785 (GRCm39) |
K818R |
possibly damaging |
Het |
Rab3gap1 |
T |
A |
1: 127,853,207 (GRCm39) |
|
probably benign |
Het |
Rcc1l |
T |
C |
5: 134,184,648 (GRCm39) |
T385A |
probably benign |
Het |
Rrm2 |
T |
C |
12: 24,758,377 (GRCm39) |
I11T |
probably benign |
Het |
Scnn1b |
A |
G |
7: 121,501,962 (GRCm39) |
T207A |
possibly damaging |
Het |
Spata31f3 |
A |
T |
4: 42,874,185 (GRCm39) |
|
probably benign |
Het |
Syt12 |
T |
A |
19: 4,497,709 (GRCm39) |
|
probably benign |
Het |
Tmprss6 |
A |
T |
15: 78,330,857 (GRCm39) |
|
probably null |
Het |
Ttbk1 |
A |
T |
17: 46,790,173 (GRCm39) |
C91S |
probably damaging |
Het |
Ube2q2l |
T |
C |
6: 136,378,435 (GRCm39) |
T132A |
probably benign |
Het |
Vit |
A |
G |
17: 78,894,255 (GRCm39) |
H219R |
probably benign |
Het |
|
Other mutations in Vmn1r27 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00160:Vmn1r27
|
APN |
6 |
58,192,119 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01548:Vmn1r27
|
APN |
6 |
58,192,538 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02662:Vmn1r27
|
APN |
6 |
58,192,272 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02726:Vmn1r27
|
APN |
6 |
58,192,854 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02795:Vmn1r27
|
APN |
6 |
58,192,287 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL03241:Vmn1r27
|
APN |
6 |
58,192,126 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03373:Vmn1r27
|
APN |
6 |
58,192,689 (GRCm39) |
missense |
probably damaging |
1.00 |
R0119:Vmn1r27
|
UTSW |
6 |
58,192,704 (GRCm39) |
missense |
possibly damaging |
0.56 |
R0124:Vmn1r27
|
UTSW |
6 |
58,192,233 (GRCm39) |
missense |
probably damaging |
1.00 |
R0136:Vmn1r27
|
UTSW |
6 |
58,192,704 (GRCm39) |
missense |
possibly damaging |
0.56 |
R3613:Vmn1r27
|
UTSW |
6 |
58,192,787 (GRCm39) |
missense |
probably damaging |
1.00 |
R4556:Vmn1r27
|
UTSW |
6 |
58,192,804 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4831:Vmn1r27
|
UTSW |
6 |
58,192,827 (GRCm39) |
missense |
possibly damaging |
0.85 |
R5354:Vmn1r27
|
UTSW |
6 |
58,192,581 (GRCm39) |
missense |
probably benign |
0.00 |
R5813:Vmn1r27
|
UTSW |
6 |
58,192,985 (GRCm39) |
missense |
possibly damaging |
0.76 |
R6856:Vmn1r27
|
UTSW |
6 |
58,192,432 (GRCm39) |
missense |
possibly damaging |
0.65 |
R7653:Vmn1r27
|
UTSW |
6 |
58,192,879 (GRCm39) |
missense |
probably benign |
0.21 |
R7653:Vmn1r27
|
UTSW |
6 |
58,192,785 (GRCm39) |
missense |
possibly damaging |
0.88 |
R8089:Vmn1r27
|
UTSW |
6 |
58,192,194 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8177:Vmn1r27
|
UTSW |
6 |
58,192,759 (GRCm39) |
missense |
probably benign |
0.00 |
R9123:Vmn1r27
|
UTSW |
6 |
58,192,416 (GRCm39) |
missense |
probably benign |
0.00 |
R9125:Vmn1r27
|
UTSW |
6 |
58,192,416 (GRCm39) |
missense |
probably benign |
0.00 |
R9372:Vmn1r27
|
UTSW |
6 |
58,192,746 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9422:Vmn1r27
|
UTSW |
6 |
58,192,867 (GRCm39) |
missense |
probably benign |
0.23 |
|
Predicted Primers |
PCR Primer
(F):5'- GAACATAGAAGATCCGGCTACTAC -3'
(R):5'- GAATGTCCTTTATTTCCAAGCTGG -3'
Sequencing Primer
(F):5'- GAAGATCCGGCTACTACTGTATG -3'
(R):5'- GACTTGGAGTCCTAGCAAATATGTC -3'
|
Posted On |
2015-06-10 |