Incidental Mutation 'R4765:Gps2'
| ID |
366077 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gps2
|
| Ensembl Gene |
ENSMUSG00000023170 |
| Gene Name |
G protein pathway suppressor 2 |
| Synonyms |
|
| MMRRC Submission |
042406-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.891)
|
| Stock # |
R4765 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
69804714-69807417 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 69807187 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135185
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043419]
[ENSMUST00000057884]
[ENSMUST00000061837]
[ENSMUST00000070996]
[ENSMUST00000071026]
[ENSMUST00000072581]
[ENSMUST00000108607]
[ENSMUST00000134581]
[ENSMUST00000133203]
[ENSMUST00000108612]
[ENSMUST00000108617]
[ENSMUST00000108609]
[ENSMUST00000108610]
[ENSMUST00000152589]
[ENSMUST00000116358]
[ENSMUST00000153652]
[ENSMUST00000108613]
[ENSMUST00000108608]
[ENSMUST00000108611]
[ENSMUST00000177476]
[ENSMUST00000177138]
[ENSMUST00000164359]
|
| AlphaFold |
Q921N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043419
|
| SMART Domains |
Protein: ENSMUSP00000047008
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
eIF-5a
|
83 |
150 |
2.43e-29 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057884
|
| SMART Domains |
Protein: ENSMUSP00000054072
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:G_path_suppress
|
5 |
294 |
6.1e-93 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061837
|
| SMART Domains |
Protein: ENSMUSP00000053235
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
913 |
1043 |
2.27e-17 |
SMART |
|
low complexity region
|
1108 |
1117 |
N/A |
INTRINSIC |
|
NEUZ
|
1130 |
1250 |
4.93e-6 |
SMART |
|
low complexity region
|
1453 |
1464 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1483 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070996
|
| SMART Domains |
Protein: ENSMUSP00000067077
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071026
|
| SMART Domains |
Protein: ENSMUSP00000068651
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072581
|
| SMART Domains |
Protein: ENSMUSP00000072389
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108607
|
| SMART Domains |
Protein: ENSMUSP00000104247
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000134581
AA Change: L79P
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124596
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133203
|
| SMART Domains |
Protein: ENSMUSP00000117917
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
60 |
185 |
7.22e-52 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
NEUZ
|
263 |
387 |
6.15e-46 |
SMART |
|
low complexity region
|
429 |
443 |
N/A |
INTRINSIC |
|
NEUZ
|
459 |
583 |
7.81e-39 |
SMART |
|
NEUZ
|
656 |
786 |
2.27e-17 |
SMART |
|
low complexity region
|
851 |
860 |
N/A |
INTRINSIC |
|
Pfam:Neuralized
|
875 |
942 |
6.5e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108612
|
| SMART Domains |
Protein: ENSMUSP00000104252
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108617
|
| SMART Domains |
Protein: ENSMUSP00000104257
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
3.5e-31 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
2.5e-54 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
2e-48 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
2.6e-41 |
SMART |
|
NEUZ
|
891 |
1021 |
7.6e-20 |
SMART |
|
low complexity region
|
1086 |
1095 |
N/A |
INTRINSIC |
|
NEUZ
|
1108 |
1228 |
1.7e-8 |
SMART |
|
low complexity region
|
1431 |
1442 |
N/A |
INTRINSIC |
|
low complexity region
|
1452 |
1461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108609
|
| SMART Domains |
Protein: ENSMUSP00000104249
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108610
|
| SMART Domains |
Protein: ENSMUSP00000104250
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152589
|
| SMART Domains |
Protein: ENSMUSP00000123402
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
2e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
149 |
6.9e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000116358
|
| SMART Domains |
Protein: ENSMUSP00000112062
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153652
|
| SMART Domains |
Protein: ENSMUSP00000137459
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:eIF-5a
|
5 |
72 |
1.7e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132183
|
| SMART Domains |
Protein: ENSMUSP00000118868
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
161 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108613
|
| SMART Domains |
Protein: ENSMUSP00000104253
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108608
|
| SMART Domains |
Protein: ENSMUSP00000104248
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108611
|
| SMART Domains |
Protein: ENSMUSP00000104251
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177476
|
| SMART Domains |
Protein: ENSMUSP00000135185
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
911 |
1041 |
2.27e-17 |
SMART |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
NEUZ
|
1128 |
1248 |
4.93e-6 |
SMART |
|
low complexity region
|
1451 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1481 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177138
|
| SMART Domains |
Protein: ENSMUSP00000135277
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
7.22e-52 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
6.15e-46 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
7.81e-39 |
SMART |
|
NEUZ
|
889 |
1019 |
2.27e-17 |
SMART |
|
low complexity region
|
1084 |
1093 |
N/A |
INTRINSIC |
|
NEUZ
|
1106 |
1226 |
4.93e-6 |
SMART |
|
low complexity region
|
1429 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1450 |
1459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164359
|
| SMART Domains |
Protein: ENSMUSP00000132717
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Gene trapped(1)
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
T |
11: 58,771,987 (GRCm39) |
R490C |
probably benign |
Het |
| Abcb11 |
A |
T |
2: 69,076,211 (GRCm39) |
F1166I |
probably damaging |
Het |
| Acta2 |
T |
C |
19: 34,223,552 (GRCm39) |
D181G |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,255,038 (GRCm39) |
I6195T |
probably damaging |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Ankfy1 |
T |
G |
11: 72,603,117 (GRCm39) |
S49A |
probably benign |
Het |
| Azi2 |
A |
T |
9: 117,890,539 (GRCm39) |
|
probably benign |
Het |
| Bend3 |
A |
T |
10: 43,386,746 (GRCm39) |
S380C |
probably damaging |
Het |
| Bicc1 |
T |
C |
10: 70,776,423 (GRCm39) |
T759A |
probably damaging |
Het |
| Cdh10 |
G |
T |
15: 19,013,364 (GRCm39) |
V655L |
probably damaging |
Het |
| Cdkn2aip |
C |
A |
8: 48,166,582 (GRCm39) |
W75L |
probably damaging |
Het |
| Cenpj |
G |
A |
14: 56,787,002 (GRCm39) |
R192* |
probably null |
Het |
| Cflar |
T |
C |
1: 58,771,480 (GRCm39) |
S203P |
probably damaging |
Het |
| Chd6 |
A |
T |
2: 160,808,164 (GRCm39) |
C1683* |
probably null |
Het |
| Cpsf2 |
A |
G |
12: 101,963,699 (GRCm39) |
Y476C |
probably damaging |
Het |
| Cyp4a12a |
A |
G |
4: 115,183,388 (GRCm39) |
D169G |
possibly damaging |
Het |
| D430041D05Rik |
T |
A |
2: 104,044,441 (GRCm39) |
R1536S |
probably damaging |
Het |
| Depdc5 |
A |
C |
5: 33,094,979 (GRCm39) |
D752A |
probably damaging |
Het |
| Dnah9 |
C |
T |
11: 65,818,552 (GRCm39) |
G78D |
probably damaging |
Het |
| Drc1 |
G |
T |
5: 30,506,075 (GRCm39) |
Q249H |
probably benign |
Het |
| Drg1 |
T |
C |
11: 3,200,280 (GRCm39) |
I364V |
probably benign |
Het |
| Dtymk |
T |
C |
1: 93,720,631 (GRCm39) |
H130R |
probably damaging |
Het |
| Elac2 |
T |
G |
11: 64,883,048 (GRCm39) |
F140V |
probably damaging |
Het |
| Enpp2 |
A |
G |
15: 54,739,068 (GRCm39) |
V353A |
possibly damaging |
Het |
| Fat2 |
T |
C |
11: 55,172,013 (GRCm39) |
D2900G |
probably damaging |
Het |
| Fermt2 |
G |
T |
14: 45,699,693 (GRCm39) |
T536K |
probably benign |
Het |
| Foxj2 |
G |
T |
6: 122,810,230 (GRCm39) |
Q196H |
probably benign |
Het |
| Gadl1 |
A |
G |
9: 115,795,381 (GRCm39) |
K328R |
probably null |
Het |
| Gata6 |
A |
G |
18: 11,054,394 (GRCm39) |
T108A |
probably benign |
Het |
| Gm16503 |
G |
T |
4: 147,625,554 (GRCm39) |
G16V |
unknown |
Het |
| Gpr37 |
T |
G |
6: 25,669,107 (GRCm39) |
E579A |
probably damaging |
Het |
| Hcn4 |
A |
T |
9: 58,765,260 (GRCm39) |
I581F |
unknown |
Het |
| Hfm1 |
T |
A |
5: 106,990,405 (GRCm39) |
Y1335F |
probably benign |
Het |
| Igsf10 |
A |
T |
3: 59,237,126 (GRCm39) |
S1018R |
probably benign |
Het |
| Katnal2 |
C |
T |
18: 77,065,239 (GRCm39) |
|
probably null |
Het |
| Kctd8 |
T |
C |
5: 69,498,191 (GRCm39) |
K152E |
possibly damaging |
Het |
| Lrp8 |
T |
C |
4: 107,711,592 (GRCm39) |
C459R |
probably damaging |
Het |
| Ly6l |
A |
T |
15: 75,321,543 (GRCm39) |
I48L |
probably benign |
Het |
| Megf10 |
A |
T |
18: 57,420,866 (GRCm39) |
I835F |
possibly damaging |
Het |
| Mei1 |
A |
T |
15: 81,996,686 (GRCm39) |
I946F |
possibly damaging |
Het |
| Mrtfb |
C |
A |
16: 13,230,458 (GRCm39) |
P1048T |
probably damaging |
Het |
| Myo7b |
G |
C |
18: 32,094,953 (GRCm39) |
L1881V |
probably benign |
Het |
| Nfkbiz |
T |
C |
16: 55,639,387 (GRCm39) |
|
probably null |
Het |
| Or4b13 |
T |
A |
2: 90,082,807 (GRCm39) |
Y175F |
probably damaging |
Het |
| Or5b24 |
T |
C |
19: 12,912,440 (GRCm39) |
C113R |
possibly damaging |
Het |
| Pcdhgc5 |
T |
C |
18: 37,955,122 (GRCm39) |
S799P |
probably benign |
Het |
| Plk4 |
A |
G |
3: 40,756,457 (GRCm39) |
E97G |
probably damaging |
Het |
| Pole2 |
A |
T |
12: 69,268,826 (GRCm39) |
H114Q |
possibly damaging |
Het |
| Rad9a |
C |
A |
19: 4,250,488 (GRCm39) |
V109L |
probably benign |
Het |
| Scn8a |
A |
G |
15: 100,938,352 (GRCm39) |
H1917R |
probably benign |
Het |
| Scyl2 |
C |
T |
10: 89,495,160 (GRCm39) |
V304I |
probably damaging |
Het |
| Serpina3f |
G |
C |
12: 104,185,690 (GRCm39) |
E298D |
probably benign |
Het |
| Shoc2 |
A |
G |
19: 53,976,734 (GRCm39) |
E208G |
probably benign |
Het |
| Sin3a |
G |
A |
9: 57,004,087 (GRCm39) |
V280I |
probably benign |
Het |
| Slc26a2 |
A |
T |
18: 61,332,558 (GRCm39) |
I291N |
probably damaging |
Het |
| Slc4a7 |
T |
G |
14: 14,762,414 (GRCm38) |
D600E |
probably damaging |
Het |
| Slc5a6 |
A |
T |
5: 31,195,427 (GRCm39) |
F430L |
possibly damaging |
Het |
| Snx19 |
A |
C |
9: 30,351,453 (GRCm39) |
Q840H |
probably damaging |
Het |
| Spast |
C |
A |
17: 74,676,211 (GRCm39) |
D340E |
probably damaging |
Het |
| Sprr4 |
G |
A |
3: 92,407,716 (GRCm39) |
P29S |
unknown |
Het |
| Stk11ip |
T |
G |
1: 75,503,799 (GRCm39) |
L239R |
probably damaging |
Het |
| Thoc6 |
A |
G |
17: 23,889,862 (GRCm39) |
L20P |
probably damaging |
Het |
| Tnfrsf8 |
A |
T |
4: 145,023,447 (GRCm39) |
S129T |
probably benign |
Het |
| Tnrc6c |
A |
G |
11: 117,633,753 (GRCm39) |
I1284V |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,602,851 (GRCm39) |
Y16711C |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,541,331 (GRCm39) |
L33885P |
probably damaging |
Het |
| Ubn2 |
T |
A |
6: 38,456,075 (GRCm39) |
C501S |
probably damaging |
Het |
| Ubr1 |
A |
T |
2: 120,793,923 (GRCm39) |
L87* |
probably null |
Het |
| Uhmk1 |
T |
C |
1: 170,027,470 (GRCm39) |
Y320C |
probably damaging |
Het |
| Vldlr |
T |
C |
19: 27,217,947 (GRCm39) |
V465A |
probably damaging |
Het |
| Vmn1r1 |
C |
T |
1: 181,985,471 (GRCm39) |
A65T |
probably benign |
Het |
| Vmn2r25 |
C |
T |
6: 123,800,182 (GRCm39) |
C720Y |
probably damaging |
Het |
| Xrra1 |
T |
C |
7: 99,555,775 (GRCm39) |
Y381H |
probably benign |
Het |
| Zfhx4 |
T |
C |
3: 5,465,212 (GRCm39) |
L1790P |
probably benign |
Het |
| Zscan4d |
T |
A |
7: 10,896,594 (GRCm39) |
M259L |
probably benign |
Het |
|
| Other mutations in Gps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0067:Gps2
|
UTSW |
11 |
69,805,607 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Gps2
|
UTSW |
11 |
69,805,607 (GRCm39) |
nonsense |
probably null |
|
|
R1086:Gps2
|
UTSW |
11 |
69,806,050 (GRCm39) |
unclassified |
probably benign |
|
|
R1109:Gps2
|
UTSW |
11 |
69,806,507 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1938:Gps2
|
UTSW |
11 |
69,806,195 (GRCm39) |
missense |
probably benign |
|
|
R1964:Gps2
|
UTSW |
11 |
69,807,246 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2355:Gps2
|
UTSW |
11 |
69,806,207 (GRCm39) |
frame shift |
probably null |
|
|
R3773:Gps2
|
UTSW |
11 |
69,806,927 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4811:Gps2
|
UTSW |
11 |
69,806,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5119:Gps2
|
UTSW |
11 |
69,805,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5183:Gps2
|
UTSW |
11 |
69,806,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5218:Gps2
|
UTSW |
11 |
69,807,121 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5965:Gps2
|
UTSW |
11 |
69,805,620 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7172:Gps2
|
UTSW |
11 |
69,807,262 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7562:Gps2
|
UTSW |
11 |
69,807,308 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7854:Gps2
|
UTSW |
11 |
69,806,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8524:Gps2
|
UTSW |
11 |
69,805,832 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8713:Gps2
|
UTSW |
11 |
69,806,180 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1186:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1187:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1188:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1189:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1190:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1191:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1192:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCTCCCTTTAAGGTCAGC -3'
(R):5'- TTGGTTTGGGGCACATAAGACC -3'
Sequencing Primer
(F):5'- AAGGTCAGCTTTGTCTCCTAG -3'
(R):5'- ATAAGACCCCAGCCTGAGGG -3'
|
| Posted On |
2015-12-21 |
Incidental Mutation