Incidental Mutation 'R6235:Dab2ip'
| ID |
504846 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab2ip
|
| Ensembl Gene |
ENSMUSG00000026883 |
| Gene Name |
disabled 2 interacting protein |
| Synonyms |
2310011D08Rik, AIP1 |
| MMRRC Submission |
044433-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.321)
|
| Stock # |
R6235 (G1)
|
| Quality Score |
120.008 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
35448285-35621006 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 35613099 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 1003
(E1003G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122341
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065001]
[ENSMUST00000091010]
[ENSMUST00000112983]
[ENSMUST00000112986]
[ENSMUST00000112987]
[ENSMUST00000112992]
[ENSMUST00000135741]
[ENSMUST00000145698]
|
| AlphaFold |
Q3UHC7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000065001
AA Change: E995G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000068832
Gene: ENSMUSG00000026883
AA Change: E995G
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
10 |
139 |
3.63e-2 |
SMART |
|
C2
|
149 |
245 |
1.34e-7 |
SMART |
|
RasGAP
|
255 |
592 |
1.08e-126 |
SMART |
|
low complexity region
|
604 |
616 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
629 |
694 |
4e-29 |
BLAST |
|
low complexity region
|
733 |
745 |
N/A |
INTRINSIC |
|
low complexity region
|
780 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
873 |
N/A |
INTRINSIC |
|
coiled coil region
|
961 |
1095 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000091010
AA Change: E1060G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000088532
Gene: ENSMUSG00000026883
AA Change: E1060G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
coiled coil region
|
1026 |
1160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112981
|
| SMART Domains |
Protein: ENSMUSP00000108605
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
2 |
80 |
6e-35 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112983
AA Change: E936G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108607
Gene: ENSMUSG00000026883
AA Change: E936G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
18 |
N/A |
INTRINSIC |
|
C2
|
90 |
186 |
1.34e-7 |
SMART |
|
RasGAP
|
196 |
533 |
1.08e-126 |
SMART |
|
low complexity region
|
545 |
557 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
570 |
635 |
3e-29 |
BLAST |
|
low complexity region
|
674 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
746 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
814 |
N/A |
INTRINSIC |
|
coiled coil region
|
902 |
1036 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112986
AA Change: E1032G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108610
Gene: ENSMUSG00000026883
AA Change: E1032G
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
45 |
176 |
5.58e-3 |
SMART |
|
C2
|
186 |
282 |
1.34e-7 |
SMART |
|
RasGAP
|
292 |
629 |
1.08e-126 |
SMART |
|
low complexity region
|
641 |
653 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
666 |
731 |
4e-29 |
BLAST |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
842 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
910 |
N/A |
INTRINSIC |
|
coiled coil region
|
998 |
1129 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112987
AA Change: E1003G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108611
Gene: ENSMUSG00000026883
AA Change: E1003G
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112992
AA Change: E1009G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108616
Gene: ENSMUSG00000026883
AA Change: E1009G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
986 |
1108 |
3.3e-61 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135741
AA Change: E1003G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122341
Gene: ENSMUSG00000026883
AA Change: E1003G
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1100 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000156669
AA Change: E612G
|
| SMART Domains |
Protein: ENSMUSP00000121506
Gene: ENSMUSG00000026883
AA Change: E612G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGAP
|
1 |
283 |
1.97e-88 |
SMART |
|
low complexity region
|
295 |
307 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
317 |
594 |
2.9e-78 |
PFAM |
|
Pfam:DUF3498
|
591 |
712 |
4.2e-70 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000124098
AA Change: E953G
|
| SMART Domains |
Protein: ENSMUSP00000119058
Gene: ENSMUSG00000026883
AA Change: E953G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
36 |
N/A |
INTRINSIC |
|
C2
|
108 |
204 |
1.34e-7 |
SMART |
|
RasGAP
|
214 |
551 |
1.08e-126 |
SMART |
|
low complexity region
|
563 |
575 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
588 |
653 |
3e-29 |
BLAST |
|
low complexity region
|
692 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
814 |
832 |
N/A |
INTRINSIC |
|
coiled coil region
|
919 |
1053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145698
|
| SMART Domains |
Protein: ENSMUSP00000114915
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
1 |
79 |
3e-18 |
BLAST |
|
low complexity region
|
80 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
135 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1252 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.4%
|
| Validation Efficiency |
95% (73/77) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam34l |
T |
G |
8: 44,078,949 (GRCm39) |
N425T |
probably benign |
Het |
| Adam6b |
T |
C |
12: 113,455,330 (GRCm39) |
F716L |
probably benign |
Het |
| Akip1 |
A |
G |
7: 109,306,620 (GRCm39) |
M106V |
probably benign |
Het |
| Aldh1l1 |
A |
T |
6: 90,541,439 (GRCm39) |
I278F |
probably benign |
Het |
| Aplnr |
A |
G |
2: 84,967,970 (GRCm39) |
T332A |
probably benign |
Het |
| Aqp4 |
A |
G |
18: 15,531,170 (GRCm39) |
V197A |
probably damaging |
Het |
| Arid4a |
A |
T |
12: 71,116,546 (GRCm39) |
|
probably null |
Het |
| Baiap2 |
A |
T |
11: 119,872,234 (GRCm39) |
N99Y |
probably damaging |
Het |
| Ceacam1 |
A |
T |
7: 25,171,217 (GRCm39) |
|
probably null |
Het |
| Cep78 |
T |
C |
19: 15,953,850 (GRCm39) |
|
probably null |
Het |
| Cldn3 |
T |
C |
5: 135,015,573 (GRCm39) |
F92S |
possibly damaging |
Het |
| Clec16a |
C |
A |
16: 10,512,499 (GRCm39) |
P812Q |
probably damaging |
Het |
| Cnga4 |
T |
G |
7: 105,056,906 (GRCm39) |
Y336* |
probably null |
Het |
| Copg2 |
A |
G |
6: 30,793,006 (GRCm39) |
I443T |
probably damaging |
Het |
| Crhbp |
C |
A |
13: 95,580,358 (GRCm39) |
A81S |
probably damaging |
Het |
| Csad |
A |
T |
15: 102,087,041 (GRCm39) |
V410D |
probably damaging |
Het |
| Ctps1 |
G |
A |
4: 120,416,003 (GRCm39) |
L207F |
probably benign |
Het |
| Ddx31 |
C |
G |
2: 28,734,854 (GRCm39) |
A5G |
probably benign |
Het |
| Dnah12 |
A |
T |
14: 26,576,761 (GRCm39) |
I3004F |
probably damaging |
Het |
| Fbxo15 |
A |
G |
18: 84,999,029 (GRCm39) |
|
probably benign |
Het |
| Fbxw28 |
C |
A |
9: 109,155,258 (GRCm39) |
W356C |
probably damaging |
Het |
| Gimap6 |
G |
T |
6: 48,679,391 (GRCm39) |
T215K |
probably benign |
Het |
| Hspa4 |
C |
T |
11: 53,153,766 (GRCm39) |
E702K |
probably benign |
Het |
| Hunk |
A |
G |
16: 90,229,594 (GRCm39) |
I152V |
probably damaging |
Het |
| Itk |
T |
C |
11: 46,227,255 (GRCm39) |
E456G |
probably benign |
Het |
| Krt40 |
G |
A |
11: 99,433,920 (GRCm39) |
A22V |
possibly damaging |
Het |
| Lars2 |
T |
C |
9: 123,240,945 (GRCm39) |
V204A |
probably damaging |
Het |
| Lipo3 |
A |
G |
19: 33,760,963 (GRCm39) |
Y140H |
probably damaging |
Het |
| Lrp1 |
G |
A |
10: 127,424,046 (GRCm39) |
R809W |
probably damaging |
Het |
| Magi3 |
C |
T |
3: 103,923,384 (GRCm39) |
G1111D |
probably damaging |
Het |
| Mis18bp1 |
A |
T |
12: 65,205,182 (GRCm39) |
V47E |
probably damaging |
Het |
| Mpdz |
T |
C |
4: 81,303,518 (GRCm39) |
E140G |
probably damaging |
Het |
| Myo1d |
T |
C |
11: 80,583,770 (GRCm39) |
I81V |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,821,113 (GRCm38) |
Y26* |
probably null |
Het |
| Ntng2 |
C |
A |
2: 29,117,991 (GRCm39) |
E152D |
probably damaging |
Het |
| Or10w1 |
C |
A |
19: 13,632,145 (GRCm39) |
C117* |
probably null |
Het |
| Or5m9b |
T |
C |
2: 85,905,510 (GRCm39) |
L142P |
possibly damaging |
Het |
| Otud3 |
A |
T |
4: 138,629,212 (GRCm39) |
V185D |
probably damaging |
Het |
| Parp6 |
C |
T |
9: 59,538,098 (GRCm39) |
R248W |
probably benign |
Het |
| Pcdhga7 |
A |
G |
18: 37,849,483 (GRCm39) |
T497A |
probably benign |
Het |
| Ppp1r18 |
A |
G |
17: 36,184,769 (GRCm39) |
E140G |
probably damaging |
Het |
| Prl3b1 |
T |
C |
13: 27,431,928 (GRCm39) |
L151P |
probably damaging |
Het |
| Pth1r |
C |
T |
9: 110,551,384 (GRCm39) |
E572K |
possibly damaging |
Het |
| Ptprq |
T |
A |
10: 107,471,199 (GRCm39) |
T1401S |
possibly damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,507,517 (GRCm39) |
T480A |
possibly damaging |
Het |
| Rax |
T |
A |
18: 66,068,232 (GRCm39) |
Q291L |
unknown |
Het |
| Reck |
T |
C |
4: 43,937,450 (GRCm39) |
L734P |
probably damaging |
Het |
| Rgmb |
A |
G |
17: 16,041,081 (GRCm39) |
F169L |
probably damaging |
Het |
| Rhobtb3 |
T |
C |
13: 76,041,029 (GRCm39) |
I426M |
probably damaging |
Het |
| Ring1 |
C |
A |
17: 34,242,280 (GRCm39) |
A76S |
probably damaging |
Het |
| Robo3 |
T |
G |
9: 37,332,225 (GRCm39) |
Y891S |
probably damaging |
Het |
| Rpusd2 |
A |
G |
2: 118,865,338 (GRCm39) |
I12V |
probably benign |
Het |
| Rragd |
T |
C |
4: 32,995,985 (GRCm39) |
V165A |
possibly damaging |
Het |
| Rsf1 |
G |
GACGGCGGCT |
7: 97,229,116 (GRCm39) |
|
probably benign |
Homo |
| Ryr1 |
G |
T |
7: 28,815,606 (GRCm39) |
Q95K |
probably benign |
Het |
| S1pr4 |
T |
A |
10: 81,334,716 (GRCm39) |
N253Y |
possibly damaging |
Het |
| Scn3a |
A |
C |
2: 65,291,679 (GRCm39) |
V1689G |
probably damaging |
Het |
| Sdhb |
A |
G |
4: 140,700,984 (GRCm39) |
N147D |
probably damaging |
Het |
| Sdk1 |
A |
T |
5: 142,020,181 (GRCm39) |
H913L |
possibly damaging |
Het |
| Serpina3i |
T |
A |
12: 104,232,791 (GRCm39) |
M232K |
probably damaging |
Het |
| Sipa1l2 |
A |
T |
8: 126,201,610 (GRCm39) |
V646E |
probably damaging |
Het |
| Slc38a1 |
A |
T |
15: 96,476,673 (GRCm39) |
I396N |
probably benign |
Het |
| Slc6a13 |
A |
T |
6: 121,279,753 (GRCm39) |
E42D |
probably benign |
Het |
| Stard9 |
G |
A |
2: 120,544,027 (GRCm39) |
V4442M |
probably damaging |
Het |
| Sumo3 |
T |
A |
10: 77,452,071 (GRCm39) |
|
probably benign |
Het |
| Syngap1 |
A |
G |
17: 27,177,104 (GRCm39) |
I356V |
probably benign |
Het |
| Tcam1 |
C |
T |
11: 106,174,880 (GRCm39) |
Q112* |
probably null |
Het |
| Tdp2 |
T |
A |
13: 25,024,378 (GRCm39) |
L225* |
probably null |
Het |
| Tmprss7 |
A |
G |
16: 45,478,485 (GRCm39) |
V747A |
probably benign |
Het |
| Ugt2b34 |
T |
A |
5: 87,054,223 (GRCm39) |
Y186F |
probably benign |
Het |
| Usp37 |
G |
T |
1: 74,514,292 (GRCm39) |
S293* |
probably null |
Het |
| Vmn1r36 |
A |
G |
6: 66,693,230 (GRCm39) |
I109T |
probably benign |
Het |
| Vsig10l |
T |
A |
7: 43,118,396 (GRCm39) |
V798E |
probably benign |
Het |
| Zfp36l1 |
G |
T |
12: 80,159,596 (GRCm39) |
C18* |
probably null |
Het |
| Zfp959 |
T |
C |
17: 56,204,427 (GRCm39) |
Y152H |
probably damaging |
Het |
| Zfyve26 |
A |
T |
12: 79,296,373 (GRCm39) |
C1949S |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 12,995,529 (GRCm39) |
E209V |
probably damaging |
Het |
|
| Other mutations in Dab2ip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00509:Dab2ip
|
APN |
2 |
35,610,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00799:Dab2ip
|
APN |
2 |
35,597,787 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL00902:Dab2ip
|
APN |
2 |
35,607,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00929:Dab2ip
|
APN |
2 |
35,598,889 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03052:Dab2ip
|
UTSW |
2 |
35,533,909 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0097:Dab2ip
|
UTSW |
2 |
35,608,928 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0137:Dab2ip
|
UTSW |
2 |
35,582,388 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0184:Dab2ip
|
UTSW |
2 |
35,608,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Dab2ip
|
UTSW |
2 |
35,608,757 (GRCm39) |
splice site |
probably benign |
|
|
R1195:Dab2ip
|
UTSW |
2 |
35,608,757 (GRCm39) |
splice site |
probably benign |
|
|
R1388:Dab2ip
|
UTSW |
2 |
35,611,268 (GRCm39) |
intron |
probably benign |
|
|
R1442:Dab2ip
|
UTSW |
2 |
35,600,268 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1496:Dab2ip
|
UTSW |
2 |
35,608,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Dab2ip
|
UTSW |
2 |
35,610,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Dab2ip
|
UTSW |
2 |
35,608,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3625:Dab2ip
|
UTSW |
2 |
35,533,903 (GRCm39) |
nonsense |
probably null |
|
|
R3819:Dab2ip
|
UTSW |
2 |
35,603,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4333:Dab2ip
|
UTSW |
2 |
35,551,632 (GRCm39) |
makesense |
probably null |
|
|
R4869:Dab2ip
|
UTSW |
2 |
35,610,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4894:Dab2ip
|
UTSW |
2 |
35,620,539 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5035:Dab2ip
|
UTSW |
2 |
35,599,953 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5180:Dab2ip
|
UTSW |
2 |
35,610,503 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5425:Dab2ip
|
UTSW |
2 |
35,600,003 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5513:Dab2ip
|
UTSW |
2 |
35,600,266 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5579:Dab2ip
|
UTSW |
2 |
35,605,339 (GRCm39) |
nonsense |
probably null |
|
|
R5829:Dab2ip
|
UTSW |
2 |
35,597,787 (GRCm39) |
unclassified |
probably benign |
|
|
R5840:Dab2ip
|
UTSW |
2 |
35,617,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5890:Dab2ip
|
UTSW |
2 |
35,605,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Dab2ip
|
UTSW |
2 |
35,582,267 (GRCm39) |
nonsense |
probably null |
|
|
R6360:Dab2ip
|
UTSW |
2 |
35,600,278 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6571:Dab2ip
|
UTSW |
2 |
35,602,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Dab2ip
|
UTSW |
2 |
35,620,485 (GRCm39) |
nonsense |
probably null |
|
|
R7262:Dab2ip
|
UTSW |
2 |
35,512,298 (GRCm39) |
splice site |
probably null |
|
|
R7883:Dab2ip
|
UTSW |
2 |
35,610,218 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8127:Dab2ip
|
UTSW |
2 |
35,534,138 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8313:Dab2ip
|
UTSW |
2 |
35,617,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8387:Dab2ip
|
UTSW |
2 |
35,609,870 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8422:Dab2ip
|
UTSW |
2 |
35,597,767 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8560:Dab2ip
|
UTSW |
2 |
35,603,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Dab2ip
|
UTSW |
2 |
35,602,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9342:Dab2ip
|
UTSW |
2 |
35,613,105 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9353:Dab2ip
|
UTSW |
2 |
35,598,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9423:Dab2ip
|
UTSW |
2 |
35,599,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9551:Dab2ip
|
UTSW |
2 |
35,605,330 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9563:Dab2ip
|
UTSW |
2 |
35,609,915 (GRCm39) |
nonsense |
probably null |
|
|
X0011:Dab2ip
|
UTSW |
2 |
35,613,097 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Dab2ip
|
UTSW |
2 |
35,598,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTTGGGTTGAGTCTTCACCC -3'
(R):5'- AGAGGCCCTGTGGACAAATG -3'
Sequencing Primer
(F):5'- CTTTGGCAGCCACAGAGTTGAATC -3'
(R):5'- ACAAATGGGCAGCCTGC -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation