Incidental Mutation 'R7257:Wdr17'
| ID |
564341 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
045318-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7257 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 55085522 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Aspartic acid
at position 1200
(E1200D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117710
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000144711]
[ENSMUST00000150488]
[ENSMUST00000175915]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127511
AA Change: E1225D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: E1225D
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: E1200D
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: E1200D
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150488
AA Change: E1193D
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: E1193D
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175915
AA Change: E1186D
PolyPhen 2
Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: E1186D
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.0582 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (77/77) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abtb1 |
A |
T |
6: 88,816,434 (GRCm39) |
V120E |
probably benign |
Het |
| Acot11 |
G |
A |
4: 106,615,599 (GRCm39) |
T284M |
probably damaging |
Het |
| Adk |
G |
T |
14: 21,102,739 (GRCm39) |
K11N |
probably damaging |
Het |
| Akr1c14 |
T |
A |
13: 4,138,966 (GRCm39) |
N316K |
probably benign |
Het |
| AL732309.1 |
A |
T |
2: 25,135,851 (GRCm39) |
V121D |
probably benign |
Het |
| Amh |
C |
A |
10: 80,642,487 (GRCm39) |
Q257K |
probably benign |
Het |
| Antxrl |
T |
G |
14: 33,787,806 (GRCm39) |
H276Q |
probably benign |
Het |
| Atp5po |
G |
A |
16: 91,723,755 (GRCm39) |
T105M |
probably damaging |
Het |
| Atxn2 |
T |
G |
5: 121,923,880 (GRCm39) |
N734K |
possibly damaging |
Het |
| B3gat3 |
T |
A |
19: 8,903,102 (GRCm39) |
V153D |
probably benign |
Het |
| Brd2 |
A |
G |
17: 34,332,796 (GRCm39) |
V528A |
probably damaging |
Het |
| Camk2g |
T |
C |
14: 20,797,907 (GRCm39) |
S335G |
probably benign |
Het |
| Cbln2 |
T |
A |
18: 86,734,859 (GRCm39) |
W211R |
probably damaging |
Het |
| Cry2 |
A |
T |
2: 92,243,326 (GRCm39) |
I505N |
possibly damaging |
Het |
| Ddx55 |
T |
A |
5: 124,698,784 (GRCm39) |
C249S |
possibly damaging |
Het |
| Dglucy |
A |
G |
12: 100,808,997 (GRCm39) |
T232A |
probably damaging |
Het |
| Dhx32 |
A |
G |
7: 133,361,206 (GRCm39) |
Y76H |
probably benign |
Het |
| Dmac2l |
T |
C |
12: 69,788,443 (GRCm39) |
I114T |
probably damaging |
Het |
| Dock7 |
T |
A |
4: 98,861,649 (GRCm39) |
N1356I |
unknown |
Het |
| Dock8 |
T |
A |
19: 25,104,449 (GRCm39) |
N710K |
probably benign |
Het |
| Dync1i2 |
T |
A |
2: 71,079,700 (GRCm39) |
N391K |
possibly damaging |
Het |
| Ect2 |
A |
G |
3: 27,192,684 (GRCm39) |
S420P |
probably damaging |
Het |
| Efcab5 |
T |
A |
11: 77,028,605 (GRCm39) |
E242V |
probably damaging |
Het |
| Fam83g |
T |
A |
11: 61,575,579 (GRCm39) |
Y74N |
probably damaging |
Het |
| Fbxo34 |
T |
A |
14: 47,738,329 (GRCm39) |
|
probably null |
Het |
| Flt4 |
A |
G |
11: 49,516,836 (GRCm39) |
T208A |
probably benign |
Het |
| Fxyd5 |
T |
A |
7: 30,734,576 (GRCm39) |
H183L |
unknown |
Het |
| Gpr150 |
T |
G |
13: 76,204,585 (GRCm39) |
D120A |
probably benign |
Het |
| Grm7 |
A |
G |
6: 110,623,079 (GRCm39) |
Y84C |
probably damaging |
Het |
| Ighmbp2 |
A |
G |
19: 3,316,405 (GRCm39) |
S562P |
probably damaging |
Het |
| Itga7 |
A |
G |
10: 128,780,282 (GRCm39) |
Y530C |
possibly damaging |
Het |
| Itpr3 |
T |
A |
17: 27,337,535 (GRCm39) |
D2448E |
probably benign |
Het |
| Mmp17 |
C |
A |
5: 129,672,697 (GRCm39) |
H216Q |
probably benign |
Het |
| Mns1 |
C |
T |
9: 72,360,097 (GRCm39) |
R416W |
probably damaging |
Het |
| Mog |
A |
G |
17: 37,334,019 (GRCm39) |
S25P |
unknown |
Het |
| Myh2 |
A |
G |
11: 67,071,976 (GRCm39) |
K568R |
possibly damaging |
Het |
| Myh7 |
A |
T |
14: 55,209,947 (GRCm39) |
|
probably null |
Het |
| Mymk |
A |
T |
2: 26,957,380 (GRCm39) |
W79R |
probably damaging |
Het |
| Ncoa4 |
T |
G |
14: 31,899,326 (GRCm39) |
L623R |
probably damaging |
Het |
| Oca2 |
G |
A |
7: 55,929,286 (GRCm39) |
|
probably benign |
Het |
| Odam |
A |
C |
5: 88,035,404 (GRCm39) |
S123R |
probably benign |
Het |
| Or14c39 |
T |
A |
7: 86,344,012 (GRCm39) |
M116K |
probably damaging |
Het |
| Or2w1 |
A |
G |
13: 21,317,427 (GRCm39) |
T161A |
probably benign |
Het |
| Or51f1d |
T |
C |
7: 102,700,837 (GRCm39) |
F111L |
probably benign |
Het |
| Or5d16 |
A |
G |
2: 87,773,915 (GRCm39) |
F19S |
probably damaging |
Het |
| Or6c69 |
T |
A |
10: 129,748,156 (GRCm39) |
|
probably benign |
Het |
| Or6c8b |
C |
T |
10: 128,882,324 (GRCm39) |
V203M |
probably benign |
Het |
| Ovch2 |
C |
T |
7: 107,393,640 (GRCm39) |
C162Y |
probably damaging |
Het |
| Padi1 |
C |
A |
4: 140,556,782 (GRCm39) |
G142C |
probably damaging |
Het |
| Pcdhga4 |
A |
G |
18: 37,820,451 (GRCm39) |
I667V |
probably damaging |
Het |
| Pfas |
A |
T |
11: 68,883,785 (GRCm39) |
V624E |
probably damaging |
Het |
| Phb1 |
A |
T |
11: 95,568,917 (GRCm39) |
E184V |
probably damaging |
Het |
| Phlpp2 |
G |
T |
8: 110,666,820 (GRCm39) |
M1116I |
probably benign |
Het |
| Pip5kl1 |
T |
C |
2: 32,470,443 (GRCm39) |
|
probably null |
Het |
| Pitpnm2 |
T |
A |
5: 124,263,419 (GRCm39) |
I824F |
possibly damaging |
Het |
| Pla2g4c |
G |
A |
7: 13,059,669 (GRCm39) |
S2N |
possibly damaging |
Het |
| Pla2r1 |
A |
T |
2: 60,257,969 (GRCm39) |
|
probably null |
Het |
| Pole2 |
T |
C |
12: 69,249,684 (GRCm39) |
D521G |
probably damaging |
Het |
| Ptch1 |
T |
C |
13: 63,721,108 (GRCm39) |
K54E |
not run |
Het |
| Rapgef2 |
A |
T |
3: 78,989,934 (GRCm39) |
L931Q |
probably damaging |
Het |
| Rassf3 |
G |
A |
10: 121,248,924 (GRCm39) |
Q206* |
probably null |
Het |
| Rnf123 |
T |
A |
9: 107,946,228 (GRCm39) |
T316S |
probably damaging |
Het |
| Rnf138 |
T |
A |
18: 21,141,750 (GRCm39) |
|
probably null |
Het |
| Septin3 |
G |
A |
15: 82,173,414 (GRCm39) |
A249T |
probably damaging |
Het |
| Slc35a4 |
A |
T |
18: 36,812,669 (GRCm39) |
D3V |
unknown |
Het |
| Sltm |
T |
A |
9: 70,451,247 (GRCm39) |
|
probably null |
Het |
| Smarca2 |
C |
T |
19: 26,631,864 (GRCm39) |
Q560* |
probably null |
Het |
| Tcl1b1 |
A |
T |
12: 105,130,790 (GRCm39) |
D91V |
probably damaging |
Het |
| Tirap |
A |
T |
9: 35,100,330 (GRCm39) |
V118E |
probably damaging |
Het |
| Tlr5 |
T |
A |
1: 182,801,798 (GRCm39) |
Y367* |
probably null |
Het |
| Tmcc1 |
A |
G |
6: 116,084,299 (GRCm39) |
F5L |
probably benign |
Het |
| Tnxb |
A |
G |
17: 34,935,475 (GRCm39) |
M2592V |
probably benign |
Het |
| Trim66 |
T |
A |
7: 109,059,451 (GRCm39) |
E931V |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,571,438 (GRCm39) |
I26485T |
probably damaging |
Het |
| Veph1 |
C |
A |
3: 66,065,703 (GRCm39) |
V455L |
probably benign |
Het |
| Vmn1r125 |
A |
T |
7: 21,006,750 (GRCm39) |
H216L |
probably damaging |
Het |
| Zbtb37 |
T |
A |
1: 160,860,231 (GRCm39) |
N25Y |
probably damaging |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGTCTGATAGTAGATTGTACCTGG -3'
(R):5'- ATGAGCAACTCACCTCTGCAG -3'
Sequencing Primer
(F):5'- GGATTTTTAGTCCAGTAAGACAAGAG -3'
(R):5'- AACTCACCTCTGCAGGCTGTG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation