Incidental Mutation 'R7593:Kif21a'
| ID |
587577 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7593 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 90828064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 1233
(A1233T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
[ENSMUST00000229801]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067205
AA Change: A1288T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: A1288T
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088614
AA Change: A1332T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: A1332T
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100304
AA Change: A1332T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: A1332T
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109287
AA Change: A1227T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: A1227T
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109288
AA Change: A1233T
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: A1233T
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229801
AA Change: A202T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
C |
T |
5: 64,055,774 (GRCm39) |
A170V |
probably damaging |
Het |
| Acp6 |
A |
T |
3: 97,073,266 (GRCm39) |
E102D |
probably benign |
Het |
| Acss1 |
T |
A |
2: 150,461,688 (GRCm39) |
R632* |
probably null |
Het |
| Adamtsl1 |
G |
T |
4: 86,259,450 (GRCm39) |
C832F |
probably damaging |
Het |
| Adgrg6 |
T |
G |
10: 14,344,573 (GRCm39) |
M127L |
probably damaging |
Het |
| Alkbh1 |
A |
T |
12: 87,487,095 (GRCm39) |
Y91* |
probably null |
Het |
| Arhgap35 |
A |
T |
7: 16,298,786 (GRCm39) |
I93N |
probably damaging |
Het |
| Asic2 |
A |
T |
11: 81,858,657 (GRCm39) |
D118E |
probably benign |
Het |
| Asprv1 |
G |
T |
6: 86,605,762 (GRCm39) |
V203L |
probably damaging |
Het |
| Atad2b |
G |
A |
12: 5,081,726 (GRCm39) |
D1212N |
probably benign |
Het |
| Atp4a |
A |
G |
7: 30,424,105 (GRCm39) |
I960V |
probably benign |
Het |
| Bin1 |
G |
T |
18: 32,552,932 (GRCm39) |
E186* |
probably null |
Het |
| Bmp10 |
A |
G |
6: 87,410,651 (GRCm39) |
Y148C |
probably damaging |
Het |
| Ccdc152 |
T |
A |
15: 3,310,137 (GRCm39) |
D246V |
probably damaging |
Het |
| Cdc16 |
A |
G |
8: 13,827,605 (GRCm39) |
T504A |
probably benign |
Het |
| Cdh9 |
A |
T |
15: 16,823,261 (GRCm39) |
D81V |
probably damaging |
Het |
| Cep162 |
A |
T |
9: 87,086,250 (GRCm39) |
S1025T |
probably benign |
Het |
| Cidea |
A |
G |
18: 67,493,283 (GRCm39) |
I101V |
probably benign |
Het |
| Clock |
G |
A |
5: 76,384,145 (GRCm39) |
S478L |
possibly damaging |
Het |
| Cp |
T |
A |
3: 20,020,494 (GRCm39) |
N162K |
probably benign |
Het |
| Crb1 |
C |
T |
1: 139,164,978 (GRCm39) |
E1110K |
probably damaging |
Het |
| Cyp2b13 |
A |
T |
7: 25,780,416 (GRCm39) |
I146L |
possibly damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,172,429 (GRCm39) |
S580P |
possibly damaging |
Het |
| Dars2 |
T |
C |
1: 160,885,113 (GRCm39) |
E224G |
probably damaging |
Het |
| Dcbld2 |
A |
G |
16: 58,244,941 (GRCm39) |
T72A |
possibly damaging |
Het |
| Ddx11 |
A |
T |
17: 66,433,193 (GRCm39) |
I8F |
possibly damaging |
Het |
| Dennd2d |
T |
C |
3: 106,407,244 (GRCm39) |
F432L |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,823,608 (GRCm39) |
V543A |
probably benign |
Het |
| Eef2k |
G |
A |
7: 120,488,491 (GRCm39) |
|
probably null |
Het |
| Elmo1 |
A |
G |
13: 20,474,610 (GRCm39) |
M345V |
probably benign |
Het |
| Ephb4 |
A |
G |
5: 137,359,560 (GRCm39) |
M377V |
probably benign |
Het |
| Erbb4 |
C |
A |
1: 68,293,758 (GRCm39) |
R711L |
probably damaging |
Het |
| Fads1 |
A |
G |
19: 10,162,361 (GRCm39) |
E95G |
probably damaging |
Het |
| Farsa |
G |
A |
8: 85,594,278 (GRCm39) |
|
probably null |
Het |
| Galntl6 |
A |
G |
8: 58,230,293 (GRCm39) |
S42P |
probably damaging |
Het |
| Gga2 |
G |
A |
7: 121,589,672 (GRCm39) |
T559M |
probably benign |
Het |
| Glipr1l2 |
G |
A |
10: 111,928,465 (GRCm39) |
G120D |
probably damaging |
Het |
| Gm14226 |
A |
T |
2: 154,866,114 (GRCm39) |
I24L |
unknown |
Het |
| Gprc5b |
G |
T |
7: 118,583,492 (GRCm39) |
R126S |
probably damaging |
Het |
| Gys1 |
A |
G |
7: 45,092,360 (GRCm39) |
D321G |
probably damaging |
Het |
| Hdlbp |
C |
T |
1: 93,358,005 (GRCm39) |
A299T |
probably benign |
Het |
| Hic2 |
A |
G |
16: 17,076,979 (GRCm39) |
T603A |
probably damaging |
Het |
| Hoxa11 |
A |
T |
6: 52,220,524 (GRCm39) |
I253N |
probably damaging |
Het |
| Iglon5 |
A |
T |
7: 43,126,064 (GRCm39) |
D222E |
probably benign |
Het |
| Inpp5d |
T |
A |
1: 87,645,500 (GRCm39) |
S1023T |
possibly damaging |
Het |
| Kif9 |
A |
T |
9: 110,350,421 (GRCm39) |
T771S |
possibly damaging |
Het |
| Klre1 |
T |
A |
6: 129,560,150 (GRCm39) |
C141S |
probably damaging |
Het |
| Lats1 |
A |
G |
10: 7,577,476 (GRCm39) |
Y200C |
probably damaging |
Het |
| Lgr4 |
T |
A |
2: 109,829,801 (GRCm39) |
L247H |
probably damaging |
Het |
| Lrrc37a |
T |
C |
11: 103,391,778 (GRCm39) |
K1216E |
probably benign |
Het |
| Lrrc41 |
G |
A |
4: 115,950,141 (GRCm39) |
R518H |
possibly damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,958,439 (GRCm39) |
V320A |
probably benign |
Het |
| Mcm9 |
C |
T |
10: 53,506,088 (GRCm39) |
R62H |
probably benign |
Het |
| Mmp10 |
T |
G |
9: 7,503,154 (GRCm39) |
L38R |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,071,867 (GRCm39) |
L546P |
probably damaging |
Het |
| Mtcl2 |
A |
T |
2: 156,882,776 (GRCm39) |
D425E |
probably benign |
Het |
| Myt1 |
T |
A |
2: 181,439,532 (GRCm39) |
D393E |
possibly damaging |
Het |
| Mzb1 |
A |
T |
18: 35,780,901 (GRCm39) |
I129N |
probably damaging |
Het |
| Nek10 |
A |
G |
14: 14,826,955 (GRCm38) |
D51G |
probably benign |
Het |
| Nme5 |
A |
G |
18: 34,700,201 (GRCm39) |
I148T |
probably benign |
Het |
| Nr2e1 |
G |
A |
10: 42,439,475 (GRCm39) |
P348L |
probably damaging |
Het |
| Nrp2 |
A |
G |
1: 62,758,203 (GRCm39) |
E63G |
probably damaging |
Het |
| Or2d2 |
A |
T |
7: 106,727,782 (GRCm39) |
S273T |
probably damaging |
Het |
| Or51ab3 |
A |
T |
7: 103,200,956 (GRCm39) |
|
probably benign |
Het |
| Or52e3 |
A |
G |
7: 102,869,471 (GRCm39) |
E182G |
probably damaging |
Het |
| Or52e5 |
A |
G |
7: 104,718,704 (GRCm39) |
H10R |
probably benign |
Het |
| Or56a3 |
A |
G |
7: 104,735,372 (GRCm39) |
T150A |
probably benign |
Het |
| Pak5 |
A |
G |
2: 135,942,884 (GRCm39) |
S419P |
probably benign |
Het |
| Pfas |
C |
A |
11: 68,881,921 (GRCm39) |
M25I |
|
Het |
| Prdm9 |
A |
G |
17: 15,764,867 (GRCm39) |
S638P |
possibly damaging |
Het |
| Psd |
G |
A |
19: 46,301,352 (GRCm39) |
T954I |
possibly damaging |
Het |
| Psph |
T |
C |
5: 129,864,337 (GRCm39) |
|
probably benign |
Het |
| Ptprf |
A |
G |
4: 118,069,593 (GRCm39) |
I1517T |
probably benign |
Het |
| Rassf8 |
A |
G |
6: 145,761,129 (GRCm39) |
R152G |
probably benign |
Het |
| Rfx3 |
G |
A |
19: 27,827,139 (GRCm39) |
T149I |
probably benign |
Het |
| Rfx8 |
A |
T |
1: 39,722,838 (GRCm39) |
F260I |
probably damaging |
Het |
| Rnft1 |
C |
T |
11: 86,384,023 (GRCm39) |
Q308* |
probably null |
Het |
| Rock2 |
A |
G |
12: 17,008,241 (GRCm39) |
N528S |
probably benign |
Het |
| Rpp25l |
T |
C |
4: 41,712,305 (GRCm39) |
R157G |
unknown |
Het |
| Ryr1 |
A |
T |
7: 28,735,528 (GRCm39) |
N4083K |
probably damaging |
Het |
| Scd1 |
G |
T |
19: 44,388,739 (GRCm39) |
T237N |
probably benign |
Het |
| Sema3d |
T |
C |
5: 12,558,112 (GRCm39) |
F215L |
probably benign |
Het |
| Sema7a |
C |
T |
9: 57,867,858 (GRCm39) |
T478I |
probably benign |
Het |
| Sftpc |
T |
C |
14: 70,759,623 (GRCm39) |
T99A |
possibly damaging |
Het |
| Slc25a4 |
G |
A |
8: 46,662,241 (GRCm39) |
T139I |
probably damaging |
Het |
| Snx27 |
T |
C |
3: 94,410,272 (GRCm39) |
E468G |
possibly damaging |
Het |
| Snx33 |
T |
C |
9: 56,834,058 (GRCm39) |
K4E |
possibly damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,148 (GRCm39) |
L253* |
probably null |
Het |
| Sycp2l |
A |
T |
13: 41,326,192 (GRCm39) |
N749I |
probably damaging |
Het |
| Synj2bp |
A |
T |
12: 81,557,664 (GRCm39) |
I47N |
probably damaging |
Het |
| Tmem82 |
T |
A |
4: 141,343,605 (GRCm39) |
I222F |
probably damaging |
Het |
| Ube2o |
A |
T |
11: 116,471,905 (GRCm39) |
L112Q |
possibly damaging |
Het |
| Vmn1r204 |
G |
A |
13: 22,740,754 (GRCm39) |
W128* |
probably null |
Het |
| Vmn2r114 |
A |
T |
17: 23,510,817 (GRCm39) |
Y554* |
probably null |
Het |
| Vmn2r62 |
A |
T |
7: 42,437,213 (GRCm39) |
Y424N |
possibly damaging |
Het |
| Vmn2r70 |
A |
T |
7: 85,215,312 (GRCm39) |
L74* |
probably null |
Het |
| Vmp1 |
T |
A |
11: 86,477,377 (GRCm39) |
Y341F |
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,703,027 (GRCm39) |
V642D |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,674,619 (GRCm39) |
M383V |
probably benign |
Het |
| Vwf |
G |
A |
6: 125,624,731 (GRCm39) |
V1827I |
|
Het |
| Zc3hav1 |
A |
G |
6: 38,306,121 (GRCm39) |
Y644H |
probably benign |
Het |
| Zfp429 |
A |
C |
13: 67,538,410 (GRCm39) |
C345G |
probably damaging |
Het |
| Zfp595 |
T |
C |
13: 67,464,823 (GRCm39) |
H483R |
probably benign |
Het |
| Zfp748 |
G |
T |
13: 67,690,638 (GRCm39) |
H207Q |
probably benign |
Het |
| Zfp758 |
T |
C |
17: 22,593,939 (GRCm39) |
S142P |
probably damaging |
Het |
| Znfx1 |
A |
C |
2: 166,898,145 (GRCm39) |
S260A |
probably benign |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAAATCATGTATGCGCGCG -3'
(R):5'- TTGACTACAAGAATCAAGGGAATAGT -3'
Sequencing Primer
(F):5'- GAGAGCACCAGATTCCCTG -3'
(R):5'- GTGGGGAAAACTAAACCTAG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation