Incidental Mutation 'R1795:Kif21a'
| ID |
202178 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
039825-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1795 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 90856930 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000067205
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000088614
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100304
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109287
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109288
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
G |
11: 109,941,792 (GRCm39) |
I1159T |
probably benign |
Het |
| Abcc1 |
T |
C |
16: 14,283,001 (GRCm39) |
V1159A |
possibly damaging |
Het |
| Abcg5 |
A |
G |
17: 84,981,007 (GRCm39) |
I194T |
probably damaging |
Het |
| Abtb2 |
A |
G |
2: 103,397,369 (GRCm39) |
T100A |
probably benign |
Het |
| Adam4 |
C |
T |
12: 81,468,068 (GRCm39) |
M184I |
probably benign |
Het |
| Afap1l2 |
T |
C |
19: 56,916,841 (GRCm39) |
D155G |
probably damaging |
Het |
| Ahnak |
T |
C |
19: 8,979,802 (GRCm39) |
V362A |
possibly damaging |
Het |
| Ak7 |
C |
T |
12: 105,692,482 (GRCm39) |
R179* |
probably null |
Het |
| Akap8 |
C |
A |
17: 32,534,451 (GRCm39) |
G332C |
probably damaging |
Het |
| Akr1e1 |
T |
A |
13: 4,645,071 (GRCm39) |
Q204L |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,293,222 (GRCm39) |
E737G |
possibly damaging |
Het |
| Atrn |
A |
G |
2: 130,814,208 (GRCm39) |
D718G |
probably benign |
Het |
| Bco2 |
A |
G |
9: 50,452,469 (GRCm39) |
S200P |
possibly damaging |
Het |
| C030005K15Rik |
A |
T |
10: 97,561,648 (GRCm39) |
S28T |
unknown |
Het |
| Cdc14a |
T |
A |
3: 116,092,122 (GRCm39) |
Q356L |
possibly damaging |
Het |
| Cdk5rap3 |
A |
G |
11: 96,799,654 (GRCm39) |
L387P |
probably damaging |
Het |
| Celsr1 |
A |
T |
15: 85,914,524 (GRCm39) |
S1150T |
probably damaging |
Het |
| Cntfr |
A |
G |
4: 41,670,841 (GRCm39) |
|
probably null |
Het |
| Cramp1 |
T |
C |
17: 25,183,884 (GRCm39) |
N1244D |
probably damaging |
Het |
| Csmd3 |
G |
T |
15: 47,721,316 (GRCm39) |
D1542E |
possibly damaging |
Het |
| Cyp4f17 |
A |
T |
17: 32,736,943 (GRCm39) |
I92F |
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,937,051 (GRCm39) |
|
probably null |
Het |
| Dlg1 |
T |
A |
16: 31,561,965 (GRCm39) |
H120Q |
probably benign |
Het |
| Dmgdh |
A |
T |
13: 93,843,207 (GRCm39) |
M348L |
probably benign |
Het |
| Dnmt3b |
G |
A |
2: 153,525,559 (GRCm39) |
E741K |
possibly damaging |
Het |
| Dock3 |
T |
G |
9: 106,902,534 (GRCm39) |
H292P |
probably damaging |
Het |
| Ercc6 |
T |
A |
14: 32,238,985 (GRCm39) |
N24K |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,064,726 (GRCm39) |
Q338R |
probably benign |
Het |
| Etl4 |
T |
C |
2: 20,812,837 (GRCm39) |
|
probably null |
Het |
| Exoc7 |
A |
T |
11: 116,183,347 (GRCm39) |
I498N |
probably damaging |
Het |
| Fap |
G |
A |
2: 62,378,933 (GRCm39) |
S123L |
probably damaging |
Het |
| Foxn1 |
T |
C |
11: 78,262,051 (GRCm39) |
E106G |
probably benign |
Het |
| Fscb |
T |
A |
12: 64,521,175 (GRCm39) |
D97V |
probably damaging |
Het |
| Gabrg1 |
T |
C |
5: 70,939,596 (GRCm39) |
T174A |
possibly damaging |
Het |
| Gan |
C |
T |
8: 117,923,199 (GRCm39) |
A461V |
possibly damaging |
Het |
| Gbp2 |
T |
A |
3: 142,336,284 (GRCm39) |
D211E |
possibly damaging |
Het |
| Gm10271 |
A |
T |
10: 116,792,746 (GRCm39) |
Y47N |
unknown |
Het |
| Gm17333 |
G |
T |
16: 77,649,711 (GRCm39) |
|
noncoding transcript |
Het |
| Gm1758 |
T |
A |
16: 14,320,142 (GRCm39) |
|
noncoding transcript |
Het |
| Golga3 |
A |
G |
5: 110,355,493 (GRCm39) |
K989R |
possibly damaging |
Het |
| Gucy2g |
C |
A |
19: 55,187,973 (GRCm39) |
V1041F |
probably damaging |
Het |
| Guk1 |
A |
T |
11: 59,077,639 (GRCm39) |
F25I |
probably benign |
Het |
| H2al1o |
C |
T |
X: 9,438,329 (GRCm39) |
E87K |
possibly damaging |
Het |
| Hemgn |
C |
A |
4: 46,395,958 (GRCm39) |
C426F |
probably damaging |
Het |
| Hps3 |
A |
G |
3: 20,066,859 (GRCm39) |
|
probably null |
Het |
| Il2rb |
A |
T |
15: 78,368,187 (GRCm39) |
D287E |
probably damaging |
Het |
| Ino80 |
A |
T |
2: 119,237,340 (GRCm39) |
V1123D |
probably damaging |
Het |
| Kdm2b |
A |
G |
5: 123,122,523 (GRCm39) |
|
probably null |
Het |
| Klhl33 |
A |
T |
14: 51,129,583 (GRCm39) |
N347K |
probably damaging |
Het |
| Krt1c |
A |
G |
15: 101,724,861 (GRCm39) |
F250L |
possibly damaging |
Het |
| Krt82 |
T |
A |
15: 101,451,819 (GRCm39) |
N332I |
possibly damaging |
Het |
| Lgi1 |
A |
G |
19: 38,294,631 (GRCm39) |
I444V |
probably benign |
Het |
| Lmod1 |
G |
A |
1: 135,252,862 (GRCm39) |
V39M |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Mex3d |
T |
C |
10: 80,217,376 (GRCm39) |
T149A |
probably benign |
Het |
| Mideas |
A |
G |
12: 84,205,748 (GRCm39) |
|
probably null |
Het |
| Mlxipl |
A |
C |
5: 135,136,024 (GRCm39) |
D83A |
probably damaging |
Het |
| Mroh8 |
T |
A |
2: 157,111,471 (GRCm39) |
E161V |
probably benign |
Het |
| Mroh9 |
G |
A |
1: 162,884,347 (GRCm39) |
T397I |
probably damaging |
Het |
| Mtss1 |
T |
C |
15: 58,930,249 (GRCm39) |
D32G |
possibly damaging |
Het |
| Mus81 |
T |
C |
19: 5,533,504 (GRCm39) |
D495G |
probably benign |
Het |
| Neurod1 |
A |
C |
2: 79,284,673 (GRCm39) |
S237A |
probably benign |
Het |
| Npas1 |
G |
A |
7: 16,208,725 (GRCm39) |
R51C |
probably damaging |
Het |
| Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
| P2ry14 |
T |
C |
3: 59,023,274 (GRCm39) |
N62S |
probably damaging |
Het |
| Pcdh15 |
A |
G |
10: 74,460,087 (GRCm39) |
Y1308C |
probably damaging |
Het |
| Pcdhb14 |
A |
T |
18: 37,582,588 (GRCm39) |
M565L |
probably benign |
Het |
| Pde6a |
A |
G |
18: 61,390,283 (GRCm39) |
E502G |
probably damaging |
Het |
| Pde8b |
A |
G |
13: 95,178,527 (GRCm39) |
V566A |
probably benign |
Het |
| Phf11b |
G |
T |
14: 59,565,554 (GRCm39) |
Q108K |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,291,716 (GRCm39) |
Y1312H |
probably damaging |
Het |
| Plcb3 |
T |
C |
19: 6,933,381 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
G |
A |
1: 194,488,611 (GRCm39) |
G1629D |
probably damaging |
Het |
| Plxnb1 |
T |
C |
9: 108,929,813 (GRCm39) |
V223A |
probably benign |
Het |
| Prkca |
A |
T |
11: 107,903,518 (GRCm39) |
Y285N |
possibly damaging |
Het |
| Prl2a1 |
A |
T |
13: 27,992,554 (GRCm39) |
N226I |
probably damaging |
Het |
| Pus7 |
A |
C |
5: 23,946,914 (GRCm39) |
M636R |
probably damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,264 (GRCm39) |
Q666* |
probably null |
Het |
| Sema3d |
A |
G |
5: 12,634,854 (GRCm39) |
D640G |
probably benign |
Het |
| Slc6a15 |
A |
G |
10: 103,236,121 (GRCm39) |
I279V |
probably benign |
Het |
| Slk |
T |
C |
19: 47,608,973 (GRCm39) |
V642A |
possibly damaging |
Het |
| Spata31e2 |
C |
A |
1: 26,722,070 (GRCm39) |
G1037* |
probably null |
Het |
| Spta1 |
T |
A |
1: 174,073,296 (GRCm39) |
M2305K |
probably damaging |
Het |
| Srrt |
T |
C |
5: 137,301,274 (GRCm39) |
|
probably benign |
Het |
| Stfa2l1 |
A |
T |
16: 35,977,228 (GRCm39) |
I8L |
probably benign |
Het |
| Tap1 |
T |
C |
17: 34,413,899 (GRCm39) |
L638P |
probably benign |
Het |
| Tbccd1 |
A |
T |
16: 22,640,995 (GRCm39) |
L461M |
probably benign |
Het |
| Tecta |
T |
C |
9: 42,289,345 (GRCm39) |
T407A |
probably benign |
Het |
| Tmbim7 |
T |
C |
5: 3,707,493 (GRCm39) |
|
probably null |
Het |
| Tnrc18 |
C |
A |
5: 142,800,869 (GRCm39) |
V30L |
probably benign |
Het |
| Tomm7 |
A |
G |
5: 24,049,025 (GRCm39) |
F16S |
probably damaging |
Het |
| Ugt2a2 |
A |
G |
5: 87,622,315 (GRCm39) |
S428P |
probably benign |
Het |
| Vmn1r189 |
T |
C |
13: 22,286,324 (GRCm39) |
E171G |
probably benign |
Het |
| Vmn1r61 |
T |
C |
7: 5,614,324 (GRCm39) |
|
probably benign |
Het |
| Vmn2r120 |
A |
T |
17: 57,832,038 (GRCm39) |
S250R |
probably benign |
Het |
| Vmn2r8 |
T |
C |
5: 108,950,972 (GRCm39) |
R158G |
probably benign |
Het |
| Vmn2r98 |
A |
T |
17: 19,286,702 (GRCm39) |
Y400F |
probably damaging |
Het |
| Vps13c |
C |
A |
9: 67,801,267 (GRCm39) |
Y582* |
probably null |
Het |
| Zfp518a |
T |
A |
19: 40,904,000 (GRCm39) |
F1310I |
probably benign |
Het |
| Zswim1 |
A |
G |
2: 164,667,320 (GRCm39) |
I191V |
probably benign |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGCTATGGTAACCACCTC -3'
(R):5'- CCTGTTGTCAGTATTTCTAGAAGC -3'
Sequencing Primer
(F):5'- ACCTCCCTTTTGTTCGCATAATTAAG -3'
(R):5'- AAACTTTTACATGGTTGGTCAAGTGG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation