Mutagenetix > Incidental Mutation

Incidental Mutation 'R7827:Dnah8'

602288

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

P1-Loop, Dnahc8, Hst6.7b

MMRRC Submission

045881-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.477) question?

Stock #

R7827 (G1)

Quality Score

214.458

Status

Not validated

Chromosome

Chromosomal Location

30845909-31094736 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT to CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT at 30979841 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000170651

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm2	A	G	3: 59,651,112 (GRCm39)	N78S	probably damaging	Het
Abca12	G	A	1: 71,453,837 (GRCm39)		probably benign	Het
Abcb1b	T	C	5: 8,887,747 (GRCm39)	S878P	probably damaging	Het
Adamts20	T	C	15: 94,223,814 (GRCm39)	R1305G	probably damaging	Het
Adcy2	A	T	13: 68,837,400 (GRCm39)	C650S	probably damaging	Het
Ahnak	A	T	19: 8,982,708 (GRCm39)	K1331*	probably null	Het
Alpk1	A	T	3: 127,473,700 (GRCm39)	S768T	probably benign	Het
Ap4b1	T	G	3: 103,722,398 (GRCm39)	L124R	probably damaging	Het
Arrdc2	A	T	8: 71,292,038 (GRCm39)	F3Y	probably damaging	Het
Atp9a	A	G	2: 168,547,114 (GRCm39)	V155A	probably benign	Het
Bptf	A	G	11: 106,938,013 (GRCm39)	S87P	probably benign	Het
Carmil1	A	T	13: 24,220,421 (GRCm39)	M697K	probably benign	Het
Ccdc42	G	A	11: 68,485,022 (GRCm39)	V32M	probably benign	Het
Cert1	A	G	13: 96,753,563 (GRCm39)	H391R	probably damaging	Het
Ces1d	A	G	8: 93,924,294 (GRCm39)		probably null	Het
Dcpp2	T	G	17: 24,119,566 (GRCm39)	Y127D	probably damaging	Het
Def8	C	A	8: 124,174,060 (GRCm39)	T7K	probably benign	Het
En2	G	A	5: 28,371,594 (GRCm39)	G24S	probably benign	Het
Evi2a	T	C	11: 79,418,688 (GRCm39)		probably benign	Het
Fam117b	A	T	1: 59,952,837 (GRCm39)	H172L	possibly damaging	Het
Fam169b	A	G	7: 67,954,338 (GRCm39)	I67M	probably benign	Het
Fbxo40	T	A	16: 36,789,861 (GRCm39)	E416D	probably damaging	Het
Gja8	T	A	3: 96,827,635 (GRCm39)	N9I	possibly damaging	Het
Gsg1l2	T	A	11: 67,676,097 (GRCm39)	C154S	probably benign	Het
Hdhd3	C	A	4: 62,418,232 (GRCm39)		probably benign	Het
Hunk	C	T	16: 90,278,214 (GRCm39)	P341L	possibly damaging	Het
Ighv8-5	T	C	12: 115,031,258 (GRCm39)	T94A	possibly damaging	Het
Ints3	T	C	3: 90,331,319 (GRCm39)	N75D	probably benign	Het
Krt39	T	C	11: 99,409,901 (GRCm39)	E212G	probably damaging	Het
Ldlrad4	A	G	18: 68,387,495 (GRCm39)	H269R	probably damaging	Het
Lrrc2	T	A	9: 110,790,049 (GRCm39)	V102E	possibly damaging	Het
Ltbp2	T	A	12: 84,836,655 (GRCm39)	I1292L	probably benign	Het
Mad2l1bp	A	T	17: 46,458,993 (GRCm39)	V179E	possibly damaging	Het
Map3k1	A	G	13: 111,892,663 (GRCm39)	V864A	probably benign	Het
Mapk8ip2	T	G	15: 89,342,322 (GRCm39)	V511G	probably damaging	Het
Mknk2	A	C	10: 80,503,021 (GRCm39)	S434A	probably benign	Het
Mllt11	A	G	3: 95,127,548 (GRCm39)	F74S	probably damaging	Het
Muc16	G	T	9: 18,506,519 (GRCm39)	T6412K	possibly damaging	Het
Nek5	C	A	8: 22,573,403 (GRCm39)	A518S	possibly damaging	Het
Npy1r	T	C	8: 67,156,864 (GRCm39)	F95L	possibly damaging	Het
Nup98	G	A	7: 101,773,569 (GRCm39)	T1586I	probably benign	Het
Olig3	A	T	10: 19,232,518 (GRCm39)	M48L	probably benign	Het
Or13n4	A	G	7: 106,422,932 (GRCm39)	M267T	probably benign	Het
Or14j7	T	A	17: 38,234,568 (GRCm39)	L37*	probably null	Het
Or5b120	T	G	19: 13,480,587 (GRCm39)	N293K	probably damaging	Het
Or6aa1	T	A	7: 86,043,765 (GRCm39)	K314*	probably null	Het
Pcdhb16	A	G	18: 37,611,904 (GRCm39)	D288G	possibly damaging	Het
Peg10	GC	GCTCC	6: 4,756,452 (GRCm39)		probably benign	Het
Phip	T	C	9: 82,790,886 (GRCm39)	I687V	probably benign	Het
Piezo1	G	A	8: 123,209,659 (GRCm39)	T2348M	probably damaging	Het
Plod3	A	G	5: 137,018,835 (GRCm39)	T291A	probably benign	Het
Pmpca	G	A	2: 26,280,144 (GRCm39)	V89I	possibly damaging	Het
Polr1b	C	A	2: 128,967,464 (GRCm39)	F952L	probably damaging	Het
Pou6f2	C	A	13: 18,553,092 (GRCm39)	A81S		Het
Ppl	T	A	16: 4,905,828 (GRCm39)	E1489V	probably damaging	Het
Ptpdc1	A	G	13: 48,733,264 (GRCm39)	F792S	probably damaging	Het
Pus1	A	G	5: 110,927,582 (GRCm39)	Y58H	probably damaging	Het
Rex2	C	A	4: 147,142,547 (GRCm39)	T345N	possibly damaging	Het
Rnf144a	T	C	12: 26,389,439 (GRCm39)	M1V	probably null	Het
Siglec15	A	T	18: 78,100,445 (GRCm39)	C13*	probably null	Het
Skint10	G	A	4: 112,632,003 (GRCm39)	Q6*	probably null	Het
Slc5a1	T	C	5: 33,304,057 (GRCm39)	W291R	probably damaging	Het
Snx27	A	G	3: 94,426,366 (GRCm39)	F378L	probably benign	Het
Strip2	A	T	6: 29,923,928 (GRCm39)	T81S	probably benign	Het
Tas2r143	A	G	6: 42,377,656 (GRCm39)	N162S	probably damaging	Het
Tatdn1	T	C	15: 58,776,607 (GRCm39)	D256G	probably benign	Het
Tbc1d5	A	G	17: 51,089,291 (GRCm39)	S630P	probably damaging	Het
Tlr11	A	G	14: 50,598,611 (GRCm39)	D199G	probably benign	Het
Tmed8	C	A	12: 87,246,991 (GRCm39)		probably benign	Het
Ttll3	CAAAGTAA	CAAAGTAAAGTAA	6: 113,376,118 (GRCm39)		probably null	Het
Ttll3	TAA	TAAAGCAA	6: 113,376,123 (GRCm39)		probably null	Het
U2af2	T	C	7: 5,077,661 (GRCm39)		probably null	Het
Ywhag	C	T	5: 135,940,394 (GRCm39)	E67K	probably damaging	Het
Zfp105	A	G	9: 122,759,808 (GRCm39)	H493R	probably damaging	Het
Zfp426	A	T	9: 20,381,446 (GRCm39)	C514S	probably damaging	Het
Zfp536	T	A	7: 37,269,113 (GRCm39)	D101V	probably damaging	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,896,150 (GRCm39)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	31,074,904 (GRCm39)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	31,034,677 (GRCm39)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,882,452 (GRCm39)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,875,615 (GRCm39)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,986,880 (GRCm39)	nonsense	probably null
IGL00840:Dnah8	APN	17	31,009,915 (GRCm39)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	31,038,250 (GRCm39)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,925,431 (GRCm39)	nonsense	probably null
IGL00976:Dnah8	APN	17	31,070,684 (GRCm39)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,854,979 (GRCm39)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,902,688 (GRCm39)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,867,459 (GRCm39)	missense	probably benign
IGL01723:Dnah8	APN	17	30,927,445 (GRCm39)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,970,565 (GRCm39)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,955,115 (GRCm39)	missense	probably benign
IGL01958:Dnah8	APN	17	31,074,869 (GRCm39)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,875,572 (GRCm39)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,936,854 (GRCm39)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,867,391 (GRCm39)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,925,487 (GRCm39)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,868,747 (GRCm39)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,978,588 (GRCm39)	missense	probably benign
IGL02263:Dnah8	APN	17	30,948,139 (GRCm39)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,932,021 (GRCm39)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,966,231 (GRCm39)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	31,013,770 (GRCm39)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	31,049,819 (GRCm39)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	31,037,025 (GRCm39)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,919,387 (GRCm39)	missense	probably benign
IGL02455:Dnah8	APN	17	30,891,308 (GRCm39)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,887,269 (GRCm39)	missense	probably benign
IGL02831:Dnah8	APN	17	30,931,250 (GRCm39)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,988,671 (GRCm39)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,940,084 (GRCm39)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,923,809 (GRCm39)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,965,735 (GRCm39)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,937,980 (GRCm39)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,905,347 (GRCm39)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,961,754 (GRCm39)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	31,003,118 (GRCm39)	missense	probably benign
IGL03176:Dnah8	APN	17	30,913,011 (GRCm39)	missense	probably benign
IGL03191:Dnah8	APN	17	30,945,804 (GRCm39)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	31,034,639 (GRCm39)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,892,894 (GRCm39)	splice site	probably null
IGL03255:Dnah8	APN	17	30,960,355 (GRCm39)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,891,323 (GRCm39)	missense	probably benign
IGL03348:Dnah8	APN	17	30,965,960 (GRCm39)	missense	probably damaging	0.99
Alternator	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
armature	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
Brush	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
Dynos	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
joule	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
solenoid	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,854,437 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,451 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,439 (GRCm39)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,882,428 (GRCm39)	missense	probably benign
P0029:Dnah8	UTSW	17	30,984,694 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,927,419 (GRCm39)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,882,290 (GRCm39)	missense	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,974,093 (GRCm39)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	31,003,064 (GRCm39)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0184:Dnah8	UTSW	17	30,902,657 (GRCm39)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,909,245 (GRCm39)	missense	probably benign
R0268:Dnah8	UTSW	17	30,988,681 (GRCm39)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,955,130 (GRCm39)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	31,090,325 (GRCm39)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,920,955 (GRCm39)	missense	probably benign
R0470:Dnah8	UTSW	17	30,927,514 (GRCm39)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,974,054 (GRCm39)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R0499:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,937,935 (GRCm39)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,927,332 (GRCm39)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,903,147 (GRCm39)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,955,129 (GRCm39)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,923,636 (GRCm39)	missense	probably benign
R0843:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	31,022,217 (GRCm39)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,892,894 (GRCm39)	splice site	probably null
R1102:Dnah8	UTSW	17	31,073,738 (GRCm39)	splice site	probably null
R1137:Dnah8	UTSW	17	31,074,910 (GRCm39)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,939,974 (GRCm39)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,956,269 (GRCm39)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	31,059,596 (GRCm39)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,971,049 (GRCm39)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,892,862 (GRCm39)	missense	probably benign
R1541:Dnah8	UTSW	17	30,966,221 (GRCm39)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,854,638 (GRCm39)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,944,098 (GRCm39)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	31,073,914 (GRCm39)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,988,625 (GRCm39)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,941,911 (GRCm39)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,927,381 (GRCm39)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,903,160 (GRCm39)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,950,154 (GRCm39)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,854,479 (GRCm39)	missense	unknown
R1935:Dnah8	UTSW	17	30,945,870 (GRCm39)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,950,181 (GRCm39)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,931,359 (GRCm39)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,950,133 (GRCm39)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,977,255 (GRCm39)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,854,632 (GRCm39)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,956,232 (GRCm39)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,872,367 (GRCm39)	missense	probably benign
R2180:Dnah8	UTSW	17	31,059,621 (GRCm39)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	31,013,718 (GRCm39)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,990,846 (GRCm39)	missense	probably benign
R2357:Dnah8	UTSW	17	31,093,909 (GRCm39)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,896,178 (GRCm39)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	31,070,705 (GRCm39)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,960,339 (GRCm39)	nonsense	probably null
R2509:Dnah8	UTSW	17	30,994,019 (GRCm39)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	31,052,542 (GRCm39)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,958,631 (GRCm39)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,958,622 (GRCm39)	nonsense	probably null
R3747:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3748:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3749:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,974,015 (GRCm39)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,889,621 (GRCm39)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,882,396 (GRCm39)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	31,073,911 (GRCm39)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,913,039 (GRCm39)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,988,813 (GRCm39)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,967,533 (GRCm39)	missense	probably benign
R4326:Dnah8	UTSW	17	30,971,066 (GRCm39)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,944,072 (GRCm39)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,971,120 (GRCm39)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	31,032,125 (GRCm39)	missense	probably benign
R4475:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,919,380 (GRCm39)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,881,026 (GRCm39)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,970,541 (GRCm39)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,903,211 (GRCm39)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,902,608 (GRCm39)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,944,140 (GRCm39)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	31,070,721 (GRCm39)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,986,898 (GRCm39)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,965,949 (GRCm39)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	31,059,688 (GRCm39)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	31,038,113 (GRCm39)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,948,116 (GRCm39)	missense	probably benign
R4969:Dnah8	UTSW	17	30,941,988 (GRCm39)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,882,275 (GRCm39)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	31,006,159 (GRCm39)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,955,070 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	31,019,505 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,958,731 (GRCm39)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,950,012 (GRCm39)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	31,029,327 (GRCm39)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,984,571 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,931,269 (GRCm39)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,965,739 (GRCm39)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	31,009,891 (GRCm39)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R5358:Dnah8	UTSW	17	30,965,928 (GRCm39)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	31,019,521 (GRCm39)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	31,009,930 (GRCm39)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,971,890 (GRCm39)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,925,360 (GRCm39)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	31,022,082 (GRCm39)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	31,019,561 (GRCm39)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,956,307 (GRCm39)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	31,022,235 (GRCm39)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	31,029,298 (GRCm39)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,937,981 (GRCm39)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,909,235 (GRCm39)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	31,093,978 (GRCm39)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,947,165 (GRCm39)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,875,659 (GRCm39)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	31,034,638 (GRCm39)	nonsense	probably null
R5986:Dnah8	UTSW	17	31,070,604 (GRCm39)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,882,279 (GRCm39)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,966,239 (GRCm39)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,966,828 (GRCm39)	nonsense	probably null
R6239:Dnah8	UTSW	17	31,029,333 (GRCm39)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
R6443:Dnah8	UTSW	17	30,990,859 (GRCm39)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,882,266 (GRCm39)	splice site	probably null
R6765:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,854,640 (GRCm39)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,984,698 (GRCm39)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,867,439 (GRCm39)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,960,147 (GRCm39)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,929,525 (GRCm39)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,965,933 (GRCm39)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	31,013,633 (GRCm39)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,986,899 (GRCm39)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,958,712 (GRCm39)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,881,065 (GRCm39)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,862,249 (GRCm39)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,923,698 (GRCm39)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	31,090,366 (GRCm39)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,988,618 (GRCm39)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,863,591 (GRCm39)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	31,093,988 (GRCm39)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	31,003,099 (GRCm39)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,986,939 (GRCm39)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,923,743 (GRCm39)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,925,363 (GRCm39)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	31,006,165 (GRCm39)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,994,077 (GRCm39)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	31,004,081 (GRCm39)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,868,651 (GRCm39)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,876,947 (GRCm39)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	31,074,918 (GRCm39)	missense	probably benign	0.20
R7866:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,882,348 (GRCm39)	missense	probably benign
R7891:Dnah8	UTSW	17	30,931,263 (GRCm39)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,960,311 (GRCm39)	nonsense	probably null
R8076:Dnah8	UTSW	17	31,003,127 (GRCm39)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,892,797 (GRCm39)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	31,090,393 (GRCm39)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8270:Dnah8	UTSW	17	31,059,687 (GRCm39)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,984,701 (GRCm39)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,988,805 (GRCm39)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8348:Dnah8	UTSW	17	30,955,121 (GRCm39)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,862,234 (GRCm39)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,914,152 (GRCm39)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8459:Dnah8	UTSW	17	30,944,221 (GRCm39)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,875,603 (GRCm39)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,940,108 (GRCm39)	missense	probably benign
R8524:Dnah8	UTSW	17	30,934,472 (GRCm39)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,940,084 (GRCm39)	nonsense	probably null
R8698:Dnah8	UTSW	17	31,094,009 (GRCm39)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,960,289 (GRCm39)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,944,078 (GRCm39)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	31,013,712 (GRCm39)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,981,616 (GRCm39)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,927,286 (GRCm39)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	31,070,628 (GRCm39)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	31,009,807 (GRCm39)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,956,401 (GRCm39)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,975,729 (GRCm39)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,854,647 (GRCm39)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	31,004,071 (GRCm39)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,944,099 (GRCm39)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,990,857 (GRCm39)	missense	probably benign
R9347:Dnah8	UTSW	17	30,927,333 (GRCm39)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,872,361 (GRCm39)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	31,029,297 (GRCm39)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	31,049,777 (GRCm39)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,932,021 (GRCm39)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,932,029 (GRCm39)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,998,112 (GRCm39)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	31,037,115 (GRCm39)	missense	probably benign
R9789:Dnah8	UTSW	17	30,980,104 (GRCm39)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,854,450 (GRCm39)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,967,654 (GRCm39)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	31,038,160 (GRCm39)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,867,514 (GRCm39)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,932,069 (GRCm39)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,913,007 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CTGTAAACCACGGTAGGCAAG -3'
(R):5'- TTAACGAGGTGAGTCATGGCG -3'

Sequencing Primer
(F):5'- CAAGGCTTGCTTCAGAGTGAC -3'
(R):5'- ATTGCCTCTGGTAGAACTGAAGC -3'

Posted On

2019-12-03