Mutagenetix > Incidental Mutation

Incidental Mutation 'R0164:Dnah8'

24075

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

Dnahc8, P1-Loop, Hst6.7b

MMRRC Submission

038440-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.423) question?

Stock #

R0164 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

30624354-30875264 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 30748665 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 2617 (G2617D)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000170651
AA Change: G2617D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: G2617D

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 94.0%

Validation Efficiency

98% (85/87)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 89 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010315B03Rik	T	C	9: 124,295,159 (GRCm38)		probably benign	Het
4732465J04Rik	GATCTATCTATCTATCTATCTATCTATCTATCTATCTATC	GATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATC	10: 95,794,578 (GRCm38)		probably null	Het
4930522L14Rik	T	C	5: 109,736,847 (GRCm38)	K382E	probably damaging	Het
Adck1	A	G	12: 88,455,510 (GRCm38)	E297G	probably damaging	Het
Ahrr	G	A	13: 74,283,024 (GRCm38)		probably benign	Het
Aldh3a2	C	T	11: 61,248,888 (GRCm38)	V473I	probably benign	Het
Arfgef3	A	T	10: 18,647,915 (GRCm38)	I369K	possibly damaging	Het
Atl2	A	G	17: 79,853,831 (GRCm38)		probably benign	Het
Atp1b3	T	C	9: 96,338,709 (GRCm38)	I178V	possibly damaging	Het
Axdnd1	T	C	1: 156,378,386 (GRCm38)	E520G	possibly damaging	Het
Bahcc1	A	T	11: 120,285,074 (GRCm38)		probably benign	Het
BB019430	A	T	10: 58,704,271 (GRCm38)		noncoding transcript	Het
BC028528	A	T	3: 95,887,334 (GRCm38)		probably benign	Het
Btbd1	T	A	7: 81,801,003 (GRCm38)	Q343L	probably benign	Het
Catsper1	A	G	19: 5,339,475 (GRCm38)	T473A	possibly damaging	Het
Chmp6	G	A	11: 119,915,523 (GRCm38)		probably null	Het
D130040H23Rik	T	C	8: 69,302,543 (GRCm38)	V200A	possibly damaging	Het
D830013O20Rik	C	T	12: 73,364,331 (GRCm38)		noncoding transcript	Het
Dcaf1	T	A	9: 106,844,145 (GRCm38)	S379T	possibly damaging	Het
Dcaf4	G	A	12: 83,535,988 (GRCm38)		probably benign	Het
Dhx58	T	C	11: 100,695,324 (GRCm38)	I624V	probably benign	Het
Disp3	T	C	4: 148,254,251 (GRCm38)	E821G	probably damaging	Het
Dlc1	T	A	8: 36,599,440 (GRCm38)	E464V	probably damaging	Het
Dnah10	G	A	5: 124,783,834 (GRCm38)	V2151I	probably damaging	Het
Dnah6	C	T	6: 73,188,535 (GRCm38)		probably benign	Het
Dnah9	C	A	11: 65,918,804 (GRCm38)	E872*	probably null	Het
Dock9	T	C	14: 121,597,665 (GRCm38)	Y99C	probably damaging	Het
Dpy19l3	T	A	7: 35,716,646 (GRCm38)	I310F	probably damaging	Het
Fggy	A	T	4: 95,837,654 (GRCm38)	I137F	probably damaging	Het
Gli2	A	G	1: 118,890,283 (GRCm38)		probably benign	Het
Gm14421	A	T	2: 177,056,722 (GRCm38)		noncoding transcript	Het
Gm5689	T	A	18: 42,173,543 (GRCm38)	D58E	probably damaging	Het
Grin2a	A	G	16: 9,994,821 (GRCm38)		probably null	Het
Grin2b	A	G	6: 135,778,648 (GRCm38)		probably benign	Het
Incenp	A	G	19: 9,894,879 (GRCm38)	S72P	probably benign	Het
Ipo11	A	G	13: 106,910,194 (GRCm38)		probably benign	Het
Klc3	T	A	7: 19,394,926 (GRCm38)	N469Y	possibly damaging	Het
Lrrc42	A	G	4: 107,247,505 (GRCm38)	S88P	probably benign	Het
Lrrc49	G	A	9: 60,680,600 (GRCm38)	T93I	probably benign	Het
Ltn1	G	A	16: 87,405,519 (GRCm38)		probably benign	Het
Mlycd	A	T	8: 119,407,641 (GRCm38)	Q294L	probably damaging	Het
Mmrn1	T	A	6: 60,975,815 (GRCm38)		probably benign	Het
Mrpl22	T	A	11: 58,171,821 (GRCm38)	I19N	probably benign	Het
Msh3	T	A	13: 92,349,209 (GRCm38)	K202N	probably damaging	Het
N4bp2	T	C	5: 65,803,573 (GRCm38)		probably benign	Het
Ncam1	C	T	9: 49,568,409 (GRCm38)	D90N	probably damaging	Het
Nckap5	A	T	1: 126,024,407 (GRCm38)	D1405E	possibly damaging	Het
Ncoa2	A	G	1: 13,186,731 (GRCm38)		probably null	Het
Ncoa6	TGC	TGCGC	2: 155,408,291 (GRCm38)		probably null	Het
Nlrp1b	A	T	11: 71,164,099 (GRCm38)	W844R	probably damaging	Het
Nmnat1	G	T	4: 149,469,150 (GRCm38)	N168K	possibly damaging	Het
Olfr1446	A	G	19: 12,890,445 (GRCm38)	L44P	probably damaging	Het
Ost4	T	C	5: 30,907,459 (GRCm38)	H26R	probably damaging	Het
Otog	G	A	7: 46,304,231 (GRCm38)	V2638M	probably damaging	Het
Otogl	A	T	10: 107,874,530 (GRCm38)	I566N	probably damaging	Het
Pcyt1a	T	C	16: 32,470,186 (GRCm38)	S282P	probably damaging	Het
Prkcg	G	A	7: 3,329,119 (GRCm38)	E581K	probably damaging	Het
Ralgps2	A	G	1: 156,887,089 (GRCm38)		probably null	Het
Rnf157	A	G	11: 116,354,810 (GRCm38)		probably benign	Het
Scmh1	T	C	4: 120,529,865 (GRCm38)		probably benign	Het
Sgo2b	T	C	8: 63,938,383 (GRCm38)	H150R	possibly damaging	Het
Sh2b3	T	G	5: 121,829,037 (GRCm38)	T5P	probably damaging	Het
Skint6	A	T	4: 112,991,236 (GRCm38)		probably benign	Het
Slfn10-ps	T	C	11: 83,035,302 (GRCm38)		noncoding transcript	Het
Sspo	T	A	6: 48,494,194 (GRCm38)		probably benign	Het
Tcp1	T	A	17: 12,922,747 (GRCm38)		probably benign	Het
Tdp2	A	G	13: 24,838,239 (GRCm38)	M214V	probably damaging	Het
Tenm4	T	G	7: 96,729,340 (GRCm38)		probably benign	Het
Tmem144	G	A	3: 79,839,273 (GRCm38)		probably benign	Het
Tmem204	A	G	17: 25,058,350 (GRCm38)	I187T	probably damaging	Het
Tmem208	T	G	8: 105,334,694 (GRCm38)	D117E	probably benign	Het
Tnks1bp1	C	T	2: 85,059,221 (GRCm38)	P631S	possibly damaging	Het
Tomm70a	T	C	16: 57,147,821 (GRCm38)	V517A	probably damaging	Het
Ttc7	T	C	17: 87,379,895 (GRCm38)	V801A	probably damaging	Het
Txndc5	A	T	13: 38,507,953 (GRCm38)	C146S	probably damaging	Het
Ubac2	A	G	14: 122,008,917 (GRCm38)		probably benign	Het
Ube4b	G	T	4: 149,360,324 (GRCm38)	T493K	probably damaging	Het
Ufl1	A	T	4: 25,256,008 (GRCm38)	Y504N	probably benign	Het
Ugt1a6a	T	C	1: 88,139,270 (GRCm38)	V266A	possibly damaging	Het
Ugt1a6b	T	A	1: 88,107,467 (GRCm38)	C176S	probably damaging	Het
Ulk3	T	A	9: 57,590,686 (GRCm38)	I90N	probably damaging	Het
Unc13c	T	C	9: 73,694,892 (GRCm38)	I1357M	probably benign	Het
Vmn1r28	G	A	6: 58,265,717 (GRCm38)	A182T	probably benign	Het
Vmn2r114	A	G	17: 23,309,826 (GRCm38)		probably null	Het
Vmn2r91	A	C	17: 18,106,137 (GRCm38)	N228T	probably benign	Het
Wdr43	T	G	17: 71,631,997 (GRCm38)		probably benign	Het
Wisp1	T	C	15: 66,919,210 (GRCm38)	L287P	probably damaging	Het
Zbtb6	G	T	2: 37,429,588 (GRCm38)	Y109*	probably null	Het
Zfp980	A	G	4: 145,701,997 (GRCm38)	D432G	probably benign	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,677,176 (GRCm38)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	30,855,930 (GRCm38)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	30,815,703 (GRCm38)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,663,478 (GRCm38)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,656,641 (GRCm38)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,767,906 (GRCm38)	nonsense	probably null
IGL00840:Dnah8	APN	17	30,790,941 (GRCm38)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	30,819,276 (GRCm38)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,706,457 (GRCm38)	nonsense	probably null
IGL00976:Dnah8	APN	17	30,851,710 (GRCm38)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,636,005 (GRCm38)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,683,714 (GRCm38)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,648,485 (GRCm38)	missense	probably benign
IGL01723:Dnah8	APN	17	30,708,471 (GRCm38)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,751,591 (GRCm38)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,736,141 (GRCm38)	missense	probably benign
IGL01958:Dnah8	APN	17	30,855,895 (GRCm38)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,656,598 (GRCm38)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,717,880 (GRCm38)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,648,417 (GRCm38)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,706,513 (GRCm38)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,649,773 (GRCm38)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,759,614 (GRCm38)	missense	probably benign
IGL02263:Dnah8	APN	17	30,729,165 (GRCm38)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,713,047 (GRCm38)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,747,257 (GRCm38)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	30,794,796 (GRCm38)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	30,830,845 (GRCm38)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	30,818,051 (GRCm38)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,700,413 (GRCm38)	missense	probably benign
IGL02455:Dnah8	APN	17	30,672,334 (GRCm38)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,668,295 (GRCm38)	missense	probably benign
IGL02831:Dnah8	APN	17	30,712,276 (GRCm38)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,769,697 (GRCm38)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,721,110 (GRCm38)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,704,835 (GRCm38)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,746,761 (GRCm38)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,719,006 (GRCm38)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,686,373 (GRCm38)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,742,780 (GRCm38)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	30,784,144 (GRCm38)	missense	probably benign
IGL03176:Dnah8	APN	17	30,694,037 (GRCm38)	missense	probably benign
IGL03191:Dnah8	APN	17	30,726,830 (GRCm38)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	30,815,665 (GRCm38)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,673,920 (GRCm38)	splice site	probably null
IGL03255:Dnah8	APN	17	30,741,381 (GRCm38)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,672,349 (GRCm38)	missense	probably benign
IGL03348:Dnah8	APN	17	30,746,986 (GRCm38)	missense	probably damaging	0.99
Alternator	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
armature	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
Brush	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
Dynos	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
joule	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
solenoid	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,635,463 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,477 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,465 (GRCm38)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,663,454 (GRCm38)	missense	probably benign
P0029:Dnah8	UTSW	17	30,765,720 (GRCm38)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,708,445 (GRCm38)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,663,316 (GRCm38)	missense	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,755,119 (GRCm38)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	30,784,090 (GRCm38)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,748,665 (GRCm38)	missense	probably benign
R0184:Dnah8	UTSW	17	30,683,683 (GRCm38)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,690,271 (GRCm38)	missense	probably benign
R0268:Dnah8	UTSW	17	30,769,707 (GRCm38)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,736,156 (GRCm38)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	30,871,351 (GRCm38)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,701,981 (GRCm38)	missense	probably benign
R0470:Dnah8	UTSW	17	30,708,540 (GRCm38)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,755,080 (GRCm38)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R0499:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,718,961 (GRCm38)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,708,358 (GRCm38)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,684,173 (GRCm38)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,736,155 (GRCm38)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,704,662 (GRCm38)	missense	probably benign
R0843:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	30,803,243 (GRCm38)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,673,920 (GRCm38)	splice site	probably null
R1102:Dnah8	UTSW	17	30,854,764 (GRCm38)	splice site	probably null
R1137:Dnah8	UTSW	17	30,855,936 (GRCm38)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,721,000 (GRCm38)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,737,295 (GRCm38)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	30,840,622 (GRCm38)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,752,075 (GRCm38)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,673,888 (GRCm38)	missense	probably benign
R1541:Dnah8	UTSW	17	30,747,247 (GRCm38)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,635,664 (GRCm38)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,725,124 (GRCm38)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	30,854,940 (GRCm38)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,769,651 (GRCm38)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,722,937 (GRCm38)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,708,407 (GRCm38)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,684,186 (GRCm38)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,731,180 (GRCm38)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,635,505 (GRCm38)	missense	unknown
R1935:Dnah8	UTSW	17	30,726,896 (GRCm38)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,731,207 (GRCm38)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,712,385 (GRCm38)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,731,159 (GRCm38)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,758,281 (GRCm38)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,635,658 (GRCm38)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,737,258 (GRCm38)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,653,393 (GRCm38)	missense	probably benign
R2180:Dnah8	UTSW	17	30,840,647 (GRCm38)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	30,794,744 (GRCm38)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,874,935 (GRCm38)	missense	probably benign	0.00
R2357:Dnah8	UTSW	17	30,771,872 (GRCm38)	missense	probably benign
R2360:Dnah8	UTSW	17	30,677,204 (GRCm38)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	30,851,731 (GRCm38)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,741,365 (GRCm38)	nonsense	probably null
R2509:Dnah8	UTSW	17	30,775,045 (GRCm38)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	30,833,568 (GRCm38)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,739,657 (GRCm38)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,739,648 (GRCm38)	nonsense	probably null
R3747:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3748:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3749:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,755,041 (GRCm38)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,670,647 (GRCm38)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,663,422 (GRCm38)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	30,854,937 (GRCm38)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,694,065 (GRCm38)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,769,839 (GRCm38)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,748,559 (GRCm38)	missense	probably benign
R4326:Dnah8	UTSW	17	30,752,092 (GRCm38)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,725,098 (GRCm38)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,752,146 (GRCm38)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	30,813,151 (GRCm38)	missense	probably benign
R4475:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,700,406 (GRCm38)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,662,052 (GRCm38)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,751,567 (GRCm38)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,684,237 (GRCm38)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,683,634 (GRCm38)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,725,166 (GRCm38)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	30,851,747 (GRCm38)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,767,924 (GRCm38)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,746,975 (GRCm38)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	30,840,714 (GRCm38)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	30,819,139 (GRCm38)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,729,142 (GRCm38)	missense	probably benign
R4969:Dnah8	UTSW	17	30,723,014 (GRCm38)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,663,301 (GRCm38)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	30,787,185 (GRCm38)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,736,096 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	30,800,531 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,739,757 (GRCm38)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,731,038 (GRCm38)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	30,810,353 (GRCm38)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,765,597 (GRCm38)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,712,295 (GRCm38)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,746,765 (GRCm38)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	30,790,917 (GRCm38)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R5358:Dnah8	UTSW	17	30,746,954 (GRCm38)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	30,800,547 (GRCm38)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	30,790,956 (GRCm38)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,752,916 (GRCm38)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,706,386 (GRCm38)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	30,803,108 (GRCm38)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	30,800,587 (GRCm38)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,737,333 (GRCm38)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	30,803,261 (GRCm38)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	30,810,324 (GRCm38)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,719,007 (GRCm38)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,690,261 (GRCm38)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	30,875,004 (GRCm38)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,728,191 (GRCm38)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,656,685 (GRCm38)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	30,815,664 (GRCm38)	nonsense	probably null
R5986:Dnah8	UTSW	17	30,851,630 (GRCm38)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,663,305 (GRCm38)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,747,265 (GRCm38)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,747,854 (GRCm38)	nonsense	probably null
R6239:Dnah8	UTSW	17	30,810,359 (GRCm38)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
R6443:Dnah8	UTSW	17	30,771,885 (GRCm38)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,663,292 (GRCm38)	splice site	probably null
R6765:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,635,666 (GRCm38)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,765,724 (GRCm38)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,648,465 (GRCm38)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,741,173 (GRCm38)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,710,551 (GRCm38)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,746,959 (GRCm38)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	30,794,659 (GRCm38)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,767,925 (GRCm38)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,739,738 (GRCm38)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,662,091 (GRCm38)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,643,275 (GRCm38)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,704,724 (GRCm38)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	30,871,392 (GRCm38)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,769,644 (GRCm38)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,644,617 (GRCm38)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	30,875,014 (GRCm38)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	30,784,125 (GRCm38)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,767,965 (GRCm38)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,704,769 (GRCm38)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,706,389 (GRCm38)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	30,787,191 (GRCm38)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,775,103 (GRCm38)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	30,785,107 (GRCm38)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,649,677 (GRCm38)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,657,973 (GRCm38)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	30,855,944 (GRCm38)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R7866:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,663,374 (GRCm38)	missense	probably benign
R7891:Dnah8	UTSW	17	30,712,289 (GRCm38)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,741,337 (GRCm38)	nonsense	probably null
R8076:Dnah8	UTSW	17	30,784,153 (GRCm38)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,673,823 (GRCm38)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	30,871,419 (GRCm38)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8270:Dnah8	UTSW	17	30,840,713 (GRCm38)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,765,727 (GRCm38)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,769,831 (GRCm38)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8348:Dnah8	UTSW	17	30,736,147 (GRCm38)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,643,260 (GRCm38)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,695,178 (GRCm38)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8459:Dnah8	UTSW	17	30,725,247 (GRCm38)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,656,629 (GRCm38)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,721,134 (GRCm38)	missense	probably benign
R8524:Dnah8	UTSW	17	30,715,498 (GRCm38)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,721,110 (GRCm38)	nonsense	probably null
R8698:Dnah8	UTSW	17	30,875,035 (GRCm38)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,741,315 (GRCm38)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,725,104 (GRCm38)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	30,794,738 (GRCm38)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,762,642 (GRCm38)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,708,312 (GRCm38)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	30,851,654 (GRCm38)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	30,790,833 (GRCm38)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,737,427 (GRCm38)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,756,755 (GRCm38)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,635,673 (GRCm38)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	30,785,097 (GRCm38)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,725,125 (GRCm38)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,771,883 (GRCm38)	missense	probably benign
R9347:Dnah8	UTSW	17	30,708,359 (GRCm38)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,653,387 (GRCm38)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	30,810,323 (GRCm38)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	30,830,803 (GRCm38)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,713,047 (GRCm38)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,713,055 (GRCm38)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,779,138 (GRCm38)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	30,818,141 (GRCm38)	missense	probably benign
R9789:Dnah8	UTSW	17	30,761,130 (GRCm38)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,635,476 (GRCm38)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,748,680 (GRCm38)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	30,819,186 (GRCm38)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,648,540 (GRCm38)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,713,095 (GRCm38)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,694,033 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CGCAAGGACACTCATCAGGCTATG -3'
(R):5'- AGACCACTCCAAGTGGAGAAGTCAG -3'

Sequencing Primer
(F):5'- CTTTCAAAAATGTCAGCCTGCG -3'
(R):5'- GAAAAATCCCACCTCTGGCTTATTG -3'

Posted On

2013-04-16