Incidental Mutation 'R7929:Vmn2r107'
ID |
643494 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r107
|
Ensembl Gene |
ENSMUSG00000056910 |
Gene Name |
vomeronasal 2, receptor 107 |
Synonyms |
V2r6 |
MMRRC Submission |
045976-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.117)
|
Stock # |
R7929 (G1)
|
Quality Score |
999 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20565687-20596034 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 20565706 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Serine
at position 7
(I7S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000048706
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042090]
|
AlphaFold |
E9PZJ7 |
Predicted Effect |
probably null
Transcript: ENSMUST00000042090
AA Change: I7S
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000048706 Gene: ENSMUSG00000056910 AA Change: I7S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
466 |
3.6e-40 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
5.1e-21 |
PFAM |
Pfam:7tm_3
|
593 |
830 |
8e-51 |
PFAM |
|
Meta Mutation Damage Score |
0.9756 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.9%
- 20x: 99.7%
|
Validation Efficiency |
95% (59/62) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 59 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2410137M14Rik |
T |
A |
17: 37,289,412 (GRCm39) |
I105F |
possibly damaging |
Het |
Adprhl1 |
C |
T |
8: 13,298,682 (GRCm39) |
V83I |
probably damaging |
Het |
Adra1d |
G |
T |
2: 131,403,600 (GRCm39) |
C163* |
probably null |
Het |
Ak9 |
A |
G |
10: 41,259,944 (GRCm39) |
D874G |
|
Het |
Akap8 |
A |
T |
17: 32,528,419 (GRCm39) |
S498T |
probably damaging |
Het |
Alyref2 |
C |
G |
1: 171,331,407 (GRCm39) |
F61L |
probably benign |
Het |
Ank1 |
A |
T |
8: 23,606,123 (GRCm39) |
I1172F |
probably damaging |
Het |
Ankrd50 |
A |
T |
3: 38,511,258 (GRCm39) |
F370I |
probably damaging |
Het |
Apip |
A |
C |
2: 102,913,366 (GRCm39) |
T41P |
probably benign |
Het |
Atg4d |
G |
A |
9: 21,178,260 (GRCm39) |
R126Q |
probably null |
Het |
Ccdc86 |
A |
G |
19: 10,926,183 (GRCm39) |
S139P |
unknown |
Het |
Ceacam16 |
A |
G |
7: 19,587,556 (GRCm39) |
L404P |
probably damaging |
Het |
Dennd3 |
G |
T |
15: 73,436,423 (GRCm39) |
V1010L |
probably damaging |
Het |
Disp1 |
A |
G |
1: 182,917,103 (GRCm39) |
S108P |
probably benign |
Het |
Ecpas |
A |
G |
4: 58,869,554 (GRCm39) |
C238R |
probably damaging |
Het |
Ephb2 |
A |
G |
4: 136,388,195 (GRCm39) |
V635A |
probably damaging |
Het |
Fkbp3 |
A |
G |
12: 65,116,812 (GRCm39) |
|
probably benign |
Het |
G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
Gars1 |
A |
G |
6: 55,040,102 (GRCm39) |
H343R |
probably damaging |
Het |
Gli2 |
A |
T |
1: 118,769,772 (GRCm39) |
N593K |
possibly damaging |
Het |
Il18rap |
T |
A |
1: 40,570,740 (GRCm39) |
N227K |
probably damaging |
Het |
Il4ra |
T |
C |
7: 125,174,348 (GRCm39) |
S297P |
probably benign |
Het |
Itprid1 |
G |
A |
6: 55,874,946 (GRCm39) |
V299M |
probably damaging |
Het |
Jak1 |
A |
T |
4: 101,011,842 (GRCm39) |
F1087I |
probably damaging |
Het |
Klf16 |
A |
G |
10: 80,412,698 (GRCm39) |
S113P |
probably benign |
Het |
Klhl30 |
A |
T |
1: 91,283,238 (GRCm39) |
E280V |
possibly damaging |
Het |
Kti12 |
A |
C |
4: 108,705,443 (GRCm39) |
E119A |
probably benign |
Het |
Kti12 |
G |
T |
4: 108,705,444 (GRCm39) |
E119D |
probably benign |
Het |
Lama4 |
A |
G |
10: 38,954,843 (GRCm39) |
H1132R |
probably damaging |
Het |
Lmtk3 |
A |
G |
7: 45,444,572 (GRCm39) |
D1085G |
unknown |
Het |
Lrrc9 |
C |
A |
12: 72,533,071 (GRCm39) |
T980K |
possibly damaging |
Het |
Nceh1 |
A |
G |
3: 27,333,396 (GRCm39) |
D164G |
probably benign |
Het |
Nlrp2 |
A |
G |
7: 5,330,498 (GRCm39) |
S633P |
probably damaging |
Het |
Nxn |
A |
G |
11: 76,164,863 (GRCm39) |
V216A |
possibly damaging |
Het |
Odf4 |
A |
T |
11: 68,813,759 (GRCm39) |
V143D |
possibly damaging |
Het |
Or4d6 |
G |
A |
19: 12,086,118 (GRCm39) |
T38I |
unknown |
Het |
Or4p4b-ps1 |
T |
C |
2: 88,454,219 (GRCm39) |
Y191H |
unknown |
Het |
Pex12 |
A |
G |
11: 83,188,809 (GRCm39) |
I62T |
probably damaging |
Het |
Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
Plekhg1 |
G |
A |
10: 3,869,170 (GRCm39) |
D237N |
probably damaging |
Het |
Rxrb |
T |
A |
17: 34,255,645 (GRCm39) |
D377E |
probably benign |
Het |
Ryr2 |
T |
A |
13: 11,609,680 (GRCm39) |
D4382V |
probably damaging |
Het |
Ryr2 |
T |
A |
13: 11,705,181 (GRCm39) |
K2862* |
probably null |
Het |
Ryr3 |
A |
G |
2: 112,664,533 (GRCm39) |
L1606P |
probably benign |
Het |
Samd3 |
A |
G |
10: 26,127,813 (GRCm39) |
K270R |
probably damaging |
Het |
Slc2a5 |
C |
A |
4: 150,223,942 (GRCm39) |
F211L |
probably benign |
Het |
Spata31 |
T |
A |
13: 65,069,532 (GRCm39) |
V560D |
probably benign |
Het |
Sri |
T |
G |
5: 8,107,652 (GRCm39) |
|
probably benign |
Het |
Tbk1 |
A |
G |
10: 121,393,138 (GRCm39) |
C471R |
probably benign |
Het |
Tbx20 |
A |
T |
9: 24,637,059 (GRCm39) |
S343T |
possibly damaging |
Het |
Tesk2 |
A |
G |
4: 116,659,452 (GRCm39) |
E304G |
probably benign |
Het |
Tle1 |
A |
G |
4: 72,118,239 (GRCm39) |
F2L |
possibly damaging |
Het |
Tle4 |
G |
T |
19: 14,495,244 (GRCm39) |
P162T |
probably benign |
Het |
Ttn |
G |
A |
2: 76,673,816 (GRCm39) |
P11172S |
unknown |
Het |
Tulp1 |
T |
C |
17: 28,572,746 (GRCm39) |
N470S |
possibly damaging |
Het |
Unc13b |
A |
G |
4: 43,174,399 (GRCm39) |
I1742M |
unknown |
Het |
Vmn2r91 |
T |
G |
17: 18,327,906 (GRCm39) |
I500R |
probably damaging |
Het |
Xpnpep3 |
A |
G |
15: 81,311,626 (GRCm39) |
I111V |
probably damaging |
Het |
Zp3r |
T |
A |
1: 130,519,217 (GRCm39) |
E308V |
probably benign |
Het |
|
Other mutations in Vmn2r107 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01402:Vmn2r107
|
APN |
17 |
20,596,009 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01768:Vmn2r107
|
APN |
17 |
20,565,868 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02086:Vmn2r107
|
APN |
17 |
20,578,062 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02136:Vmn2r107
|
APN |
17 |
20,595,168 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02266:Vmn2r107
|
APN |
17 |
20,577,039 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02285:Vmn2r107
|
APN |
17 |
20,595,823 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02724:Vmn2r107
|
APN |
17 |
20,577,006 (GRCm39) |
missense |
possibly damaging |
0.49 |
IGL02998:Vmn2r107
|
APN |
17 |
20,578,017 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03089:Vmn2r107
|
APN |
17 |
20,595,974 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03284:Vmn2r107
|
APN |
17 |
20,577,173 (GRCm39) |
missense |
probably benign |
0.07 |
IGL03307:Vmn2r107
|
APN |
17 |
20,577,038 (GRCm39) |
missense |
probably benign |
0.09 |
IGL03399:Vmn2r107
|
APN |
17 |
20,578,220 (GRCm39) |
splice site |
probably benign |
|
3-1:Vmn2r107
|
UTSW |
17 |
20,565,766 (GRCm39) |
missense |
probably benign |
|
BB006:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
BB016:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
R0285:Vmn2r107
|
UTSW |
17 |
20,565,873 (GRCm39) |
missense |
probably benign |
0.00 |
R0455:Vmn2r107
|
UTSW |
17 |
20,595,085 (GRCm39) |
splice site |
probably benign |
|
R0497:Vmn2r107
|
UTSW |
17 |
20,595,394 (GRCm39) |
missense |
probably damaging |
1.00 |
R0506:Vmn2r107
|
UTSW |
17 |
20,578,021 (GRCm39) |
missense |
probably benign |
|
R0621:Vmn2r107
|
UTSW |
17 |
20,595,252 (GRCm39) |
missense |
probably benign |
0.01 |
R0667:Vmn2r107
|
UTSW |
17 |
20,575,916 (GRCm39) |
missense |
possibly damaging |
0.91 |
R1118:Vmn2r107
|
UTSW |
17 |
20,576,860 (GRCm39) |
missense |
probably benign |
0.03 |
R1204:Vmn2r107
|
UTSW |
17 |
20,578,031 (GRCm39) |
missense |
probably benign |
|
R1237:Vmn2r107
|
UTSW |
17 |
20,576,947 (GRCm39) |
nonsense |
probably null |
|
R1485:Vmn2r107
|
UTSW |
17 |
20,595,109 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1783:Vmn2r107
|
UTSW |
17 |
20,576,775 (GRCm39) |
missense |
possibly damaging |
0.51 |
R1873:Vmn2r107
|
UTSW |
17 |
20,565,840 (GRCm39) |
missense |
probably benign |
0.10 |
R1974:Vmn2r107
|
UTSW |
17 |
20,575,879 (GRCm39) |
splice site |
probably null |
|
R2009:Vmn2r107
|
UTSW |
17 |
20,595,729 (GRCm39) |
missense |
probably benign |
0.01 |
R2029:Vmn2r107
|
UTSW |
17 |
20,595,549 (GRCm39) |
missense |
probably benign |
0.01 |
R2164:Vmn2r107
|
UTSW |
17 |
20,595,904 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Vmn2r107
|
UTSW |
17 |
20,595,817 (GRCm39) |
missense |
possibly damaging |
0.58 |
R3087:Vmn2r107
|
UTSW |
17 |
20,580,607 (GRCm39) |
missense |
probably benign |
0.03 |
R3740:Vmn2r107
|
UTSW |
17 |
20,595,151 (GRCm39) |
missense |
probably benign |
0.00 |
R3961:Vmn2r107
|
UTSW |
17 |
20,595,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R4031:Vmn2r107
|
UTSW |
17 |
20,595,483 (GRCm39) |
missense |
probably benign |
0.00 |
R4270:Vmn2r107
|
UTSW |
17 |
20,576,041 (GRCm39) |
missense |
probably benign |
|
R4963:Vmn2r107
|
UTSW |
17 |
20,595,403 (GRCm39) |
missense |
probably damaging |
1.00 |
R5121:Vmn2r107
|
UTSW |
17 |
20,576,015 (GRCm39) |
missense |
probably benign |
0.01 |
R5640:Vmn2r107
|
UTSW |
17 |
20,595,426 (GRCm39) |
missense |
probably damaging |
1.00 |
R6007:Vmn2r107
|
UTSW |
17 |
20,595,316 (GRCm39) |
missense |
probably benign |
0.19 |
R6238:Vmn2r107
|
UTSW |
17 |
20,565,849 (GRCm39) |
missense |
probably benign |
0.43 |
R6298:Vmn2r107
|
UTSW |
17 |
20,576,044 (GRCm39) |
missense |
probably benign |
0.00 |
R6467:Vmn2r107
|
UTSW |
17 |
20,595,939 (GRCm39) |
missense |
probably damaging |
0.99 |
R6726:Vmn2r107
|
UTSW |
17 |
20,595,637 (GRCm39) |
missense |
probably damaging |
0.96 |
R6782:Vmn2r107
|
UTSW |
17 |
20,577,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R7299:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
R7301:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
R7375:Vmn2r107
|
UTSW |
17 |
20,576,138 (GRCm39) |
missense |
probably benign |
|
R7448:Vmn2r107
|
UTSW |
17 |
20,595,994 (GRCm39) |
missense |
probably benign |
0.00 |
R7495:Vmn2r107
|
UTSW |
17 |
20,595,271 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7589:Vmn2r107
|
UTSW |
17 |
20,595,634 (GRCm39) |
missense |
probably benign |
0.05 |
R7594:Vmn2r107
|
UTSW |
17 |
20,580,635 (GRCm39) |
missense |
probably benign |
0.03 |
R7678:Vmn2r107
|
UTSW |
17 |
20,576,901 (GRCm39) |
missense |
probably benign |
0.01 |
R7974:Vmn2r107
|
UTSW |
17 |
20,577,270 (GRCm39) |
missense |
probably benign |
0.00 |
R8040:Vmn2r107
|
UTSW |
17 |
20,595,808 (GRCm39) |
missense |
probably damaging |
1.00 |
R8263:Vmn2r107
|
UTSW |
17 |
20,580,614 (GRCm39) |
missense |
probably damaging |
1.00 |
R8426:Vmn2r107
|
UTSW |
17 |
20,577,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
R9175:Vmn2r107
|
UTSW |
17 |
20,577,051 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9537:Vmn2r107
|
UTSW |
17 |
20,595,149 (GRCm39) |
missense |
probably benign |
0.00 |
R9642:Vmn2r107
|
UTSW |
17 |
20,580,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R9711:Vmn2r107
|
UTSW |
17 |
20,577,262 (GRCm39) |
missense |
probably damaging |
1.00 |
X0022:Vmn2r107
|
UTSW |
17 |
20,577,230 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Predicted Primers |
PCR Primer
(F):5'- TCCCAATGGCATTTCTGAACCC -3'
(R):5'- CACCCATTACGTCATAAGAATTCTG -3'
Sequencing Primer
(F):5'- CTGAACCCTTGGAATATTTGTGTC -3'
(R):5'- ATTGTACTCACTGTATATAACCGTCC -3'
|
Posted On |
2020-08-07 |