Mutagenetix > Incidental Mutation

Incidental Mutation 'R0667:Vmn2r107'

218560

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

038852-MU

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R0667 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20355654 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Serine at position 82 (Y82S)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000042090
AA Change: Y82S

PolyPhen 2 Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: Y82S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.4%
20x: 94.8%

Validation Efficiency

98% (64/65)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5830411N06Rik	C	G	7: 140,261,537	S251R	possibly damaging	Het
Abca5	G	T	11: 110,327,811	N76K	probably benign	Het
Adamts12	C	T	15: 11,215,624	R244C	probably damaging	Het
Atad2	A	G	15: 58,098,719	S1143P	probably benign	Het
Avl9	G	T	6: 56,736,483	R242L	probably benign	Het
Cand1	A	G	10: 119,216,520	S234P	probably benign	Het
Cd200	T	A	16: 45,394,857	I144L	probably benign	Het
Cep76	A	T	18: 67,634,778	L228Q	possibly damaging	Het
Col12a1	A	G	9: 79,628,462	L2584S	probably damaging	Het
Col6a3	A	C	1: 90,828,101	D155E	probably damaging	Het
Col6a4	G	A	9: 106,029,959		probably benign	Het
Dsg2	A	C	18: 20,573,499	D24A	possibly damaging	Het
Gm5901	G	A	7: 105,377,490	S155N	possibly damaging	Het
Hkdc1	T	C	10: 62,411,865		probably benign	Het
Kansl1	A	G	11: 104,343,538	V714A	probably benign	Het
Kcnh1	T	A	1: 192,506,038	S936T	probably benign	Het
Klhdc3	A	T	17: 46,677,225	F205I	probably benign	Het
Krt31	T	A	11: 100,048,125	H290L	probably benign	Het
Lama2	T	A	10: 27,344,410		probably null	Het
Mep1a	T	G	17: 43,478,190	D565A	probably benign	Het
Mgme1	T	A	2: 144,278,987		probably benign	Het
Mtf2	C	T	5: 108,104,503	T409I	probably damaging	Het
Mylk3	A	G	8: 85,355,165		probably null	Het
Myo1c	A	G	11: 75,668,512	E650G	probably damaging	Het
Nipbl	A	C	15: 8,361,004	D260E	possibly damaging	Het
Nufip2	T	A	11: 77,692,013	V251D	possibly damaging	Het
Olfr1239	T	C	2: 89,417,688	I242V	probably benign	Het
Olfr138	C	A	17: 38,275,157	P129T	probably damaging	Het
Olfr855	T	A	9: 19,585,447	N303K	probably benign	Het
Osm	G	T	11: 4,239,918	R234L	possibly damaging	Het
Pabpc1	G	A	15: 36,598,031	A515V	probably benign	Het
Piwil1	T	A	5: 128,741,478		probably null	Het
Pld1	A	G	3: 28,079,178		probably null	Het
Plekhg3	C	T	12: 76,576,598	R871C	probably damaging	Het
Ppfia2	A	T	10: 106,913,694	Y1147F	probably damaging	Het
Prmt3	A	G	7: 49,791,995	Y240C	probably damaging	Het
Prr36	G	T	8: 4,216,311		probably benign	Het
Ptprd	A	G	4: 75,957,346	I908T	probably damaging	Het
Sae1	A	T	7: 16,368,532	N172K	probably damaging	Het
Satb1	T	G	17: 51,782,861	Q319H	probably damaging	Het
Scn2a	A	T	2: 65,751,996	I1563F	possibly damaging	Het
Scn3a	C	A	2: 65,484,411	R1102L	probably null	Het
Serpinb9b	T	A	13: 33,032,926	L60*	probably null	Het
Setd1a	A	G	7: 127,786,593	D281G	probably damaging	Het
Slc8a1	C	A	17: 81,648,881	V243F	probably damaging	Het
Tgfbr3	A	T	5: 107,177,850	H115Q	probably benign	Het
Tiam1	C	A	16: 89,897,984	S195I	probably damaging	Het
Tjp2	A	G	19: 24,108,749	V803A	probably benign	Het
Ttc5	T	A	14: 50,765,958	Q423L	probably benign	Het
Tyk2	A	C	9: 21,108,871	V997G	probably damaging	Het
Uhrf1	T	C	17: 56,310,677	V133A	probably benign	Het
Vmn2r93	T	C	17: 18,326,241	F792L	probably damaging	Het
Vps13c	G	A	9: 67,951,573	W2768*	probably null	Het
Zfp456	A	T	13: 67,366,742	C282S	probably benign	Het
Zhx1	T	C	15: 58,053,165	N562D	possibly damaging	Het
Zmynd15	G	T	11: 70,465,118	G481C	probably damaging	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- ACTAGTAATTCCATGCTGCCACACTC -3'
(R):5'- GCACATGAGCTGTGAGCCAAATAAC -3'

Sequencing Primer
(F):5'- CTCCAGAAGGACAAAGATGTTGATTC -3'
(R):5'- GAGCTGTGAGCCAAATAACAGTATTC -3'

Posted On

2014-08-18