Incidental Mutation 'R9616:Vmn2r6'
ID 724566
Institutional Source Beutler Lab
Gene Symbol Vmn2r6
Ensembl Gene ENSMUSG00000090581
Gene Name vomeronasal 2, receptor 6
Synonyms EG667069, EG620718
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R9616 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 64444916-64472855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64445724 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 667 (L667P)
Ref Sequence ENSEMBL: ENSMUSP00000135148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165012] [ENSMUST00000176481]
AlphaFold H3BK29
Predicted Effect probably damaging
Transcript: ENSMUST00000165012
AA Change: L578P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: L578P

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 1.4e-72 PFAM
Pfam:Peripla_BP_6 58 244 1.2e-10 PFAM
Pfam:NCD3G 458 511 1.8e-17 PFAM
Pfam:7tm_3 542 779 3.9e-76 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176481
AA Change: L667P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: L667P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 9.8e-77 PFAM
Pfam:Peripla_BP_6 142 331 3.4e-10 PFAM
Pfam:NCD3G 547 600 5.4e-17 PFAM
Pfam:7tm_3 633 867 3.9e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110040M04Rik T A 1: 151,080,480 (GRCm39) D189E probably benign Het
Abca13 A T 11: 9,240,501 (GRCm39) H788L probably benign Het
Abcb1b A G 5: 8,862,779 (GRCm39) I154V probably benign Het
Acsm4 A G 7: 119,293,872 (GRCm39) N81S probably benign Het
Adamts5 G A 16: 85,659,674 (GRCm39) H873Y probably benign Het
Aox4 C T 1: 58,268,020 (GRCm39) T200I possibly damaging Het
Arhgap33 A G 7: 30,229,367 (GRCm39) V336A probably damaging Het
Brca1 C T 11: 101,416,683 (GRCm39) E484K probably damaging Het
Capn13 T A 17: 73,672,964 (GRCm39) D113V probably benign Het
Catsper2 TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT 2: 121,228,053 (GRCm39) probably benign Het
Ceacam3 G A 7: 16,892,078 (GRCm39) E274K Het
Cfh A T 1: 140,030,254 (GRCm39) I891K probably damaging Het
Cgn A G 3: 94,670,332 (GRCm39) S1041P probably damaging Het
Cldn18 T C 9: 99,580,915 (GRCm39) D111G probably benign Het
Cnp G A 11: 100,467,261 (GRCm39) R68Q probably benign Het
Cntn4 T A 6: 106,674,525 (GRCm39) C1008* probably null Het
Cntnap5a T C 1: 116,029,323 (GRCm39) I259T probably benign Het
Cubn A G 2: 13,319,529 (GRCm39) I2897T probably benign Het
Cyp2c39 T A 19: 39,501,648 (GRCm39) L67Q probably damaging Het
Dclk1 G A 3: 55,387,854 (GRCm39) C100Y probably damaging Het
Ddc C T 11: 11,772,288 (GRCm39) W349* probably null Het
Dennd3 A G 15: 73,440,563 (GRCm39) E1198G probably benign Het
Dnah1 T C 14: 31,026,400 (GRCm39) D826G probably null Het
Dpp4 T C 2: 62,217,429 (GRCm39) Y56C probably damaging Het
Etv6 A G 6: 134,243,295 (GRCm39) D350G possibly damaging Het
Fat1 C A 8: 45,406,075 (GRCm39) P942Q probably damaging Het
Fbxl5 A G 5: 43,916,159 (GRCm39) F418L probably benign Het
Fbxo11 T A 17: 88,316,098 (GRCm39) H368L Het
Fhl2 G T 1: 43,167,546 (GRCm39) H182Q probably damaging Het
Gabpa T A 16: 84,649,461 (GRCm39) C223S probably damaging Het
Gigyf2 T C 1: 87,356,326 (GRCm39) I803T unknown Het
Greb1 A T 12: 16,790,038 (GRCm39) N3K probably damaging Het
Hmcn1 T G 1: 150,684,473 (GRCm39) S366R probably benign Het
Il17b A G 18: 61,825,363 (GRCm39) Q133R probably benign Het
Inha T A 1: 75,486,211 (GRCm39) S169T probably benign Het
Itsn1 G A 16: 91,650,055 (GRCm39) R243H probably benign Het
Kcnu1 G GA 8: 26,403,675 (GRCm39) probably null Het
Kdm1b A G 13: 47,234,030 (GRCm39) E788G probably damaging Het
Kdm2a A T 19: 4,370,308 (GRCm39) I1059N probably damaging Het
Klk1b9 G T 7: 43,628,795 (GRCm39) G100C probably benign Het
Knl1 T C 2: 118,899,994 (GRCm39) V565A probably benign Het
Knl1 A T 2: 118,907,425 (GRCm39) N1650Y probably damaging Het
Lpp T C 16: 24,580,719 (GRCm39) V270A probably benign Het
Lrrc15 A G 16: 30,092,517 (GRCm39) L274P probably damaging Het
Mertk C T 2: 128,643,255 (GRCm39) L885F probably benign Het
Mpst T A 15: 78,294,361 (GRCm39) L31* probably null Het
Ms4a10 T C 19: 10,944,440 (GRCm39) T115A possibly damaging Het
Myof A G 19: 37,923,263 (GRCm39) I1330T possibly damaging Het
Ncam2 T C 16: 81,240,142 (GRCm39) I201T probably damaging Het
Nefh T A 11: 4,889,443 (GRCm39) K1059* probably null Het
Nek1 T C 8: 61,473,107 (GRCm39) Y168H probably damaging Het
Nek11 T A 9: 105,082,011 (GRCm39) T531S probably damaging Het
Nelfa G A 5: 34,059,127 (GRCm39) P243S possibly damaging Het
Niban1 T C 1: 151,512,193 (GRCm39) Y32H probably damaging Het
Notum G T 11: 120,550,974 (GRCm39) T64K Het
Or13c7d T A 4: 43,770,193 (GRCm39) K273* probably null Het
Or52b2 A C 7: 104,986,520 (GRCm39) Y134* probably null Het
Or9i16 A G 19: 13,864,861 (GRCm39) S238P probably damaging Het
Otof A G 5: 30,539,708 (GRCm39) I1035T possibly damaging Het
Otud3 A G 4: 138,624,925 (GRCm39) Y259H probably benign Het
Per1 G T 11: 68,993,554 (GRCm39) C368F probably damaging Het
Pitrm1 G T 13: 6,605,602 (GRCm39) R183L probably damaging Het
Prl3a1 C T 13: 27,459,118 (GRCm39) A119V Het
Pycard C T 7: 127,592,776 (GRCm39) G17E probably benign Het
Rnf13 A G 3: 57,740,430 (GRCm39) D249G possibly damaging Het
Sdhaf2 T C 19: 10,494,689 (GRCm39) Y33C probably damaging Het
Sdk2 A G 11: 113,691,061 (GRCm39) V1838A probably benign Het
Sgo2b C T 8: 64,380,274 (GRCm39) V853I probably benign Het
Slc1a4 T C 11: 20,282,403 (GRCm39) T24A probably benign Het
Slc8a1 T C 17: 81,955,407 (GRCm39) T544A probably benign Het
Sntg2 T C 12: 30,326,732 (GRCm39) N143S probably benign Het
Sphkap T C 1: 83,254,989 (GRCm39) E920G probably damaging Het
Srgap2 T A 1: 131,252,828 (GRCm39) H132L Het
Srgap3 A T 6: 112,748,524 (GRCm39) V376D probably damaging Het
Stxbp5l T C 16: 37,036,314 (GRCm39) K434E probably damaging Het
Tab2 A T 10: 7,795,005 (GRCm39) N492K possibly damaging Het
Tbc1d32 T C 10: 56,037,246 (GRCm39) Q666R possibly damaging Het
Tekt4 T C 17: 25,692,782 (GRCm39) probably null Het
Tnni3k G A 3: 154,667,724 (GRCm39) Q230* probably null Het
Trp53bp1 A C 2: 121,066,657 (GRCm39) S690A probably benign Het
Trpa1 C A 1: 14,989,077 (GRCm39) probably benign Het
Trpm1 T G 7: 63,858,132 (GRCm39) V324G probably damaging Het
Usp29 A G 7: 6,966,179 (GRCm39) E674G possibly damaging Het
Vmn2r59 T C 7: 41,661,299 (GRCm39) R839G probably damaging Het
Vmn2r91 T A 17: 18,356,305 (GRCm39) F657L possibly damaging Het
Vps13d A G 4: 144,824,701 (GRCm39) V2923A Het
Xylb T A 9: 119,201,022 (GRCm39) L220Q probably damaging Het
Zbtb10 C T 3: 9,316,473 (GRCm39) T95M probably benign Het
Zfp263 C T 16: 3,567,482 (GRCm39) P599L probably damaging Het
Zfp532 A G 18: 65,789,639 (GRCm39) E1026G probably benign Het
Zfp78 A G 7: 6,382,078 (GRCm39) N376S probably benign Het
Other mutations in Vmn2r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01547:Vmn2r6 APN 3 64,445,525 (GRCm39) missense probably damaging 1.00
IGL01968:Vmn2r6 APN 3 64,463,766 (GRCm39) missense possibly damaging 0.94
IGL02009:Vmn2r6 APN 3 64,445,323 (GRCm39) missense possibly damaging 0.61
IGL02039:Vmn2r6 APN 3 64,463,610 (GRCm39) missense probably damaging 1.00
IGL02652:Vmn2r6 APN 3 64,463,749 (GRCm39) missense probably benign 0.24
IGL02737:Vmn2r6 APN 3 64,463,911 (GRCm39) missense possibly damaging 0.55
IGL02808:Vmn2r6 APN 3 64,463,917 (GRCm39) missense probably damaging 1.00
IGL03066:Vmn2r6 APN 3 64,472,574 (GRCm39) missense probably damaging 0.99
IGL03331:Vmn2r6 APN 3 64,445,428 (GRCm39) missense probably damaging 1.00
BB010:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
BB020:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
R0010:Vmn2r6 UTSW 3 64,466,966 (GRCm39) nonsense probably null
R0206:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0206:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0208:Vmn2r6 UTSW 3 64,447,333 (GRCm39) missense probably benign
R0427:Vmn2r6 UTSW 3 64,467,008 (GRCm39) missense probably damaging 1.00
R0466:Vmn2r6 UTSW 3 64,463,723 (GRCm39) missense probably damaging 1.00
R1018:Vmn2r6 UTSW 3 64,464,261 (GRCm39) missense probably benign 0.00
R1104:Vmn2r6 UTSW 3 64,445,487 (GRCm39) missense possibly damaging 0.93
R1186:Vmn2r6 UTSW 3 64,472,488 (GRCm39) missense probably benign 0.01
R1245:Vmn2r6 UTSW 3 64,464,211 (GRCm39) missense possibly damaging 0.53
R1295:Vmn2r6 UTSW 3 64,445,694 (GRCm39) missense probably damaging 1.00
R1473:Vmn2r6 UTSW 3 64,445,579 (GRCm39) nonsense probably null
R1498:Vmn2r6 UTSW 3 64,463,890 (GRCm39) missense probably damaging 1.00
R1925:Vmn2r6 UTSW 3 64,463,698 (GRCm39) missense possibly damaging 0.87
R2044:Vmn2r6 UTSW 3 64,445,262 (GRCm39) missense probably damaging 0.96
R2069:Vmn2r6 UTSW 3 64,463,519 (GRCm39) missense possibly damaging 0.89
R2253:Vmn2r6 UTSW 3 64,467,139 (GRCm39) missense probably damaging 1.00
R2261:Vmn2r6 UTSW 3 64,464,090 (GRCm39) missense probably benign 0.24
R2262:Vmn2r6 UTSW 3 64,464,090 (GRCm39) missense probably benign 0.24
R2350:Vmn2r6 UTSW 3 64,463,773 (GRCm39) missense probably benign 0.01
R2680:Vmn2r6 UTSW 3 64,445,707 (GRCm39) missense possibly damaging 0.91
R2846:Vmn2r6 UTSW 3 64,464,211 (GRCm39) missense possibly damaging 0.53
R2860:Vmn2r6 UTSW 3 64,454,760 (GRCm39) missense probably benign 0.00
R2861:Vmn2r6 UTSW 3 64,454,760 (GRCm39) missense probably benign 0.00
R3766:Vmn2r6 UTSW 3 64,463,929 (GRCm39) missense probably benign 0.19
R3870:Vmn2r6 UTSW 3 64,464,042 (GRCm39) missense probably damaging 0.96
R4018:Vmn2r6 UTSW 3 64,463,893 (GRCm39) missense probably benign 0.05
R4024:Vmn2r6 UTSW 3 64,445,671 (GRCm39) missense possibly damaging 0.73
R4026:Vmn2r6 UTSW 3 64,445,671 (GRCm39) missense possibly damaging 0.73
R4227:Vmn2r6 UTSW 3 64,445,369 (GRCm39) missense probably damaging 0.99
R4526:Vmn2r6 UTSW 3 64,445,145 (GRCm39) missense probably benign 0.32
R4570:Vmn2r6 UTSW 3 64,467,068 (GRCm39) missense probably benign 0.31
R4894:Vmn2r6 UTSW 3 64,454,829 (GRCm39) missense probably benign
R4934:Vmn2r6 UTSW 3 64,463,766 (GRCm39) missense probably damaging 0.99
R5057:Vmn2r6 UTSW 3 64,445,207 (GRCm39) missense probably damaging 1.00
R5059:Vmn2r6 UTSW 3 64,445,044 (GRCm39) missense possibly damaging 0.89
R5148:Vmn2r6 UTSW 3 64,464,015 (GRCm39) missense probably damaging 0.99
R5155:Vmn2r6 UTSW 3 64,445,935 (GRCm39) missense probably benign 0.44
R5179:Vmn2r6 UTSW 3 64,445,411 (GRCm39) missense probably benign 0.00
R5256:Vmn2r6 UTSW 3 64,464,263 (GRCm39) missense probably benign 0.33
R5861:Vmn2r6 UTSW 3 64,463,454 (GRCm39) missense probably benign 0.00
R5950:Vmn2r6 UTSW 3 64,472,652 (GRCm39) missense probably benign 0.05
R6081:Vmn2r6 UTSW 3 64,463,953 (GRCm39) missense probably benign 0.25
R6173:Vmn2r6 UTSW 3 64,467,176 (GRCm39) missense probably damaging 1.00
R6190:Vmn2r6 UTSW 3 64,445,424 (GRCm39) missense probably benign 0.04
R6240:Vmn2r6 UTSW 3 64,464,226 (GRCm39) missense probably damaging 1.00
R6433:Vmn2r6 UTSW 3 64,454,801 (GRCm39) nonsense probably null
R6645:Vmn2r6 UTSW 3 64,464,297 (GRCm39) missense probably damaging 1.00
R6791:Vmn2r6 UTSW 3 64,445,580 (GRCm39) missense probably damaging 1.00
R7265:Vmn2r6 UTSW 3 64,464,195 (GRCm39) missense probably benign 0.00
R7503:Vmn2r6 UTSW 3 64,447,372 (GRCm39) nonsense probably null
R7562:Vmn2r6 UTSW 3 64,463,941 (GRCm39) missense probably benign 0.00
R7584:Vmn2r6 UTSW 3 64,472,683 (GRCm39) missense probably benign 0.07
R7611:Vmn2r6 UTSW 3 64,472,563 (GRCm39) missense probably damaging 0.98
R7759:Vmn2r6 UTSW 3 64,463,991 (GRCm39) missense probably damaging 1.00
R7834:Vmn2r6 UTSW 3 64,445,443 (GRCm39) missense probably damaging 1.00
R7933:Vmn2r6 UTSW 3 64,467,224 (GRCm39) missense probably benign 0.02
R7982:Vmn2r6 UTSW 3 64,467,241 (GRCm39) missense probably damaging 1.00
R8024:Vmn2r6 UTSW 3 64,467,245 (GRCm39) missense probably benign 0.40
R8074:Vmn2r6 UTSW 3 64,455,064 (GRCm39) intron probably benign
R8169:Vmn2r6 UTSW 3 64,447,310 (GRCm39) missense probably benign 0.01
R8337:Vmn2r6 UTSW 3 64,463,526 (GRCm39) nonsense probably null
R8736:Vmn2r6 UTSW 3 64,467,221 (GRCm39) missense probably damaging 1.00
R8962:Vmn2r6 UTSW 3 64,463,576 (GRCm39) missense probably damaging 1.00
R9139:Vmn2r6 UTSW 3 64,464,277 (GRCm39) missense probably benign 0.12
R9206:Vmn2r6 UTSW 3 64,467,032 (GRCm39) missense probably damaging 0.97
R9295:Vmn2r6 UTSW 3 64,463,484 (GRCm39) missense probably benign 0.00
R9332:Vmn2r6 UTSW 3 64,454,671 (GRCm39) missense probably benign 0.01
R9663:Vmn2r6 UTSW 3 64,463,549 (GRCm39) missense possibly damaging 0.90
R9685:Vmn2r6 UTSW 3 64,464,081 (GRCm39) missense probably benign 0.19
X0020:Vmn2r6 UTSW 3 64,445,871 (GRCm39) missense probably benign
X0066:Vmn2r6 UTSW 3 64,454,799 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r6 UTSW 3 64,463,746 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AATGGGGTGCATGGATATTAGC -3'
(R):5'- AAATGACTGGTCCAATGCGG -3'

Sequencing Primer
(F):5'- GCCGAGTTTTAGATATGGAAATCCTG -3'
(R):5'- AACAAGTGTGTGCCAAAGC -3'
Posted On 2022-09-12