Incidental Mutation 'R9642:Wdr90'
ID 726106
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R9642 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 26063745-26080475 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 26072694 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000078426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably null
Transcript: ENSMUST00000079461
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176678
Predicted Effect probably benign
Transcript: ENSMUST00000176923
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,619,412 (GRCm39) probably null Het
Aadacl3 A G 4: 144,182,512 (GRCm39) S319P probably benign Het
Abcc6 C A 7: 45,639,765 (GRCm39) D907Y probably benign Het
Apol7b T C 15: 77,308,103 (GRCm39) S131G probably benign Het
Atg2a C T 19: 6,300,198 (GRCm39) R669* probably null Het
Atr T A 9: 95,821,294 (GRCm39) I2260N probably damaging Het
Bmper T A 9: 23,395,198 (GRCm39) V643E probably benign Het
Cacna2d2 A G 9: 107,392,627 (GRCm39) I524V possibly damaging Het
Ccdc171 C A 4: 83,599,525 (GRCm39) A780E probably benign Het
Cdcp3 C A 7: 130,848,257 (GRCm39) Q688K probably benign Het
Cfhr2 A G 1: 139,738,620 (GRCm39) S314P probably damaging Het
Cops2 A T 2: 125,682,410 (GRCm39) D190E probably benign Het
Dmxl1 G A 18: 50,013,825 (GRCm39) G1538R probably damaging Het
Dyrk4 A T 6: 126,893,253 (GRCm39) V43E probably benign Het
Eif4a3l2 A G 6: 116,528,350 (GRCm39) R76G probably damaging Het
Enoph1 T C 5: 100,188,115 (GRCm39) I13T possibly damaging Het
Eya3 A T 4: 132,426,374 (GRCm39) I268F probably damaging Het
Ezh2 A C 6: 47,521,453 (GRCm39) M439R probably benign Het
Fam83c T C 2: 155,672,980 (GRCm39) N259S probably damaging Het
Gbf1 A T 19: 46,258,707 (GRCm39) M963L probably benign Het
Ghr A T 15: 3,355,469 (GRCm39) D271E probably benign Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,450 (GRCm39) probably benign Het
Gtse1 T A 15: 85,751,697 (GRCm39) L297I probably damaging Het
Hecw1 T A 13: 14,515,394 (GRCm39) H246L probably damaging Het
Hmox1 G A 8: 75,823,881 (GRCm39) R183H possibly damaging Het
Ifi202b A T 1: 173,799,850 (GRCm39) Y210* probably null Het
Ighv1-76 A T 12: 115,811,918 (GRCm39) I6N possibly damaging Het
Ildr1 T A 16: 36,536,490 (GRCm39) I173N probably damaging Het
Jaml T C 9: 45,000,116 (GRCm39) V138A probably damaging Het
Kmt2b A T 7: 30,283,340 (GRCm39) probably null Het
Krt87 T C 15: 101,385,074 (GRCm39) N341D probably benign Het
Map3k20 T C 2: 72,272,181 (GRCm39) W770R probably damaging Het
Mast2 A G 4: 116,170,966 (GRCm39) I667T probably damaging Het
Mdp1 T C 14: 55,896,933 (GRCm39) T71A probably damaging Het
Muc5ac A T 7: 141,349,601 (GRCm39) T505S possibly damaging Het
Mx1 A G 16: 97,256,376 (GRCm39) V181A probably damaging Het
Myo15b A G 11: 115,772,335 (GRCm39) E83G possibly damaging Het
Ncam2 A T 16: 81,418,251 (GRCm39) I769L probably benign Het
Notum T C 11: 120,550,980 (GRCm39) D62G probably damaging Het
Or4c124 A T 2: 89,155,907 (GRCm39) C206S possibly damaging Het
Or5ac22 A T 16: 59,135,610 (GRCm39) H53Q possibly damaging Het
Or7a39 C T 10: 78,715,395 (GRCm39) P130S probably damaging Het
Or8g32 T C 9: 39,305,857 (GRCm39) S254P probably damaging Het
P2rx2 A G 5: 110,489,878 (GRCm39) S196P possibly damaging Het
Pcdh7 A T 5: 57,876,717 (GRCm39) I91F probably damaging Het
Peak1 A G 9: 56,167,205 (GRCm39) V241A probably benign Het
Ppl C A 16: 4,915,602 (GRCm39) R623S probably benign Het
Prkaca A G 8: 84,717,088 (GRCm39) I151V probably benign Het
Psmb11 A T 14: 54,863,295 (GRCm39) Q171L probably benign Het
Rab3gap2 T G 1: 184,967,692 (GRCm39) F166V probably benign Het
Rab7 G A 6: 87,981,187 (GRCm39) A165V probably damaging Het
Ranbp2 T C 10: 58,318,907 (GRCm39) Y2473H probably damaging Het
Runx3 A G 4: 134,848,341 (GRCm39) probably benign Het
Sh3bp5l T A 11: 58,237,085 (GRCm39) C347* probably null Het
Smc5 A G 19: 23,238,752 (GRCm39) M208T probably damaging Het
Stk11ip T C 1: 75,510,899 (GRCm39) probably null Het
Tas2r136 A T 6: 132,754,462 (GRCm39) C222S probably benign Het
Themis2 A G 4: 132,513,047 (GRCm39) V393A possibly damaging Het
Tln2 A C 9: 67,157,826 (GRCm39) V1171G probably benign Het
Tmem63a T C 1: 180,776,393 (GRCm39) F68L probably damaging Het
Tpst1 T A 5: 130,130,959 (GRCm39) L143Q probably damaging Het
Trp63 C A 16: 25,682,508 (GRCm39) Q284K probably benign Het
Ttc17 T C 2: 94,194,735 (GRCm39) E546G probably benign Het
Ttn A G 2: 76,804,570 (GRCm39) I234T unknown Het
Upp1 A G 11: 9,085,206 (GRCm39) K231R probably benign Het
Uso1 T A 5: 92,285,967 (GRCm39) L4H probably damaging Het
Vmn1r9 T A 6: 57,048,216 (GRCm39) L97Q probably damaging Het
Vmn2r107 T C 17: 20,580,661 (GRCm39) C533R probably damaging Het
Vps35l C A 7: 118,437,451 (GRCm39) D909E probably benign Het
Ydjc A G 16: 16,966,073 (GRCm39) H219R probably benign Het
Ykt6 T C 11: 5,905,917 (GRCm39) L6P probably damaging Het
Zfp236 A G 18: 82,622,384 (GRCm39) V1682A probably benign Het
Zfp35 C T 18: 24,137,155 (GRCm39) Q500* probably null Het
Zfp780b T A 7: 27,664,135 (GRCm39) D140V probably benign Het
Zyg11b T C 4: 108,117,185 (GRCm39) T352A probably damaging Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 26,068,338 (GRCm39) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 26,073,661 (GRCm39) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 26,067,383 (GRCm39) missense probably benign
IGL02116:Wdr90 APN 17 26,078,466 (GRCm39) missense probably benign 0.12
IGL02172:Wdr90 APN 17 26,069,408 (GRCm39) missense probably benign 0.22
IGL02716:Wdr90 APN 17 26,076,194 (GRCm39) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 26,067,649 (GRCm39) nonsense probably null
IGL03229:Wdr90 APN 17 26,064,437 (GRCm39) splice site probably benign
IGL03367:Wdr90 APN 17 26,066,765 (GRCm39) splice site probably benign
IGL03098:Wdr90 UTSW 17 26,078,961 (GRCm39) intron probably benign
R0111:Wdr90 UTSW 17 26,067,418 (GRCm39) splice site probably benign
R0454:Wdr90 UTSW 17 26,079,023 (GRCm39) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 26,079,459 (GRCm39) missense probably benign 0.00
R0488:Wdr90 UTSW 17 26,067,591 (GRCm39) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 26,074,632 (GRCm39) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 26,065,367 (GRCm39) missense probably benign 0.04
R0799:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R1177:Wdr90 UTSW 17 26,065,028 (GRCm39) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 26,079,422 (GRCm39) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 26,068,284 (GRCm39) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 26,074,173 (GRCm39) missense probably benign 0.05
R2087:Wdr90 UTSW 17 26,065,577 (GRCm39) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 26,070,715 (GRCm39) missense probably benign
R2208:Wdr90 UTSW 17 26,079,362 (GRCm39) missense probably damaging 1.00
R2345:Wdr90 UTSW 17 26,078,136 (GRCm39) missense probably benign 0.05
R2391:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 26,074,326 (GRCm39) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 26,069,472 (GRCm39) missense probably benign 0.01
R3979:Wdr90 UTSW 17 26,078,252 (GRCm39) missense probably benign 0.00
R4111:Wdr90 UTSW 17 26,068,342 (GRCm39) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 26,072,705 (GRCm39) missense probably benign 0.25
R4459:Wdr90 UTSW 17 26,079,976 (GRCm39) missense possibly damaging 0.95
R4697:Wdr90 UTSW 17 26,074,337 (GRCm39) missense probably benign 0.03
R4735:Wdr90 UTSW 17 26,078,424 (GRCm39) missense probably benign
R4907:Wdr90 UTSW 17 26,079,624 (GRCm39) intron probably benign
R5070:Wdr90 UTSW 17 26,065,307 (GRCm39) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 26,074,277 (GRCm39) missense probably benign 0.01
R5268:Wdr90 UTSW 17 26,069,819 (GRCm39) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 26,080,441 (GRCm39) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 26,064,572 (GRCm39) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 26,063,995 (GRCm39) unclassified probably benign
R5545:Wdr90 UTSW 17 26,064,830 (GRCm39) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 26,076,166 (GRCm39) missense probably benign 0.00
R5973:Wdr90 UTSW 17 26,065,381 (GRCm39) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 26,064,107 (GRCm39) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 26,067,504 (GRCm39) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 26,064,885 (GRCm39) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 26,068,623 (GRCm39) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 26,064,367 (GRCm39) missense probably benign 0.00
R7288:Wdr90 UTSW 17 26,065,286 (GRCm39) missense probably benign 0.03
R7304:Wdr90 UTSW 17 26,070,480 (GRCm39) missense probably benign 0.10
R7309:Wdr90 UTSW 17 26,079,676 (GRCm39) missense probably benign 0.02
R7391:Wdr90 UTSW 17 26,065,502 (GRCm39) missense probably benign 0.08
R7622:Wdr90 UTSW 17 26,073,083 (GRCm39) missense probably benign 0.00
R7646:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R7772:Wdr90 UTSW 17 26,080,465 (GRCm39) start gained probably benign
R7779:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 26,071,532 (GRCm39) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 26,079,513 (GRCm39) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 26,069,723 (GRCm39) missense probably benign 0.00
R8126:Wdr90 UTSW 17 26,067,951 (GRCm39) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 26,064,141 (GRCm39) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 26,064,399 (GRCm39) missense probably benign 0.21
R8919:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8938:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8940:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R9038:Wdr90 UTSW 17 26,076,200 (GRCm39) missense
R9079:Wdr90 UTSW 17 26,076,403 (GRCm39) missense
R9401:Wdr90 UTSW 17 26,064,750 (GRCm39) small insertion probably benign
R9471:Wdr90 UTSW 17 26,080,015 (GRCm39) missense possibly damaging 0.72
X0064:Wdr90 UTSW 17 26,067,537 (GRCm39) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 26,079,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGAGCATGGAGGTAATGGC -3'
(R):5'- TTTGCAGGAAAGCCAGTGCC -3'

Sequencing Primer
(F):5'- ACCTCTATCAGATTGGCCATGTGAG -3'
(R):5'- ATCTTGGCTCCCAGGACCAAG -3'
Posted On 2022-09-12