Incidental Mutation 'R2513:Kif21a'
| ID |
253698 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
040419-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2513 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 90878594 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 229
(I229V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000067205
AA Change: I229V
PolyPhen 2
Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: I229V
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000088614
AA Change: I229V
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: I229V
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000100304
AA Change: I229V
PolyPhen 2
Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: I229V
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109287
AA Change: I229V
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: I229V
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109288
AA Change: I229V
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: I229V
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
T |
C |
14: 32,383,809 (GRCm39) |
T719A |
possibly damaging |
Het |
| Abcc1 |
A |
G |
16: 14,290,873 (GRCm39) |
|
probably null |
Het |
| Aftph |
C |
T |
11: 20,658,676 (GRCm39) |
|
probably null |
Het |
| Als2 |
C |
A |
1: 59,254,276 (GRCm39) |
K360N |
probably benign |
Het |
| Atg2a |
T |
A |
19: 6,308,076 (GRCm39) |
|
probably null |
Het |
| Axl |
T |
C |
7: 25,486,941 (GRCm39) |
D22G |
probably benign |
Het |
| Baiap2 |
G |
A |
11: 119,890,052 (GRCm39) |
A438T |
probably benign |
Het |
| Bean1 |
G |
C |
8: 104,908,643 (GRCm39) |
A7P |
probably benign |
Het |
| Birc6 |
C |
G |
17: 74,954,724 (GRCm39) |
P3431R |
probably damaging |
Het |
| Camk1d |
A |
G |
2: 5,719,047 (GRCm39) |
M1T |
probably null |
Het |
| Carmil3 |
T |
C |
14: 55,741,295 (GRCm39) |
Y1027H |
probably damaging |
Het |
| Ccdc6 |
G |
A |
10: 70,023,658 (GRCm39) |
|
probably benign |
Het |
| Cemip |
C |
A |
7: 83,591,233 (GRCm39) |
V1280L |
probably benign |
Het |
| Cfap58 |
C |
A |
19: 47,950,981 (GRCm39) |
N447K |
probably benign |
Het |
| Chd3 |
A |
G |
11: 69,251,471 (GRCm39) |
L520P |
probably damaging |
Het |
| Col1a2 |
T |
A |
6: 4,531,223 (GRCm39) |
|
probably null |
Het |
| Cpne7 |
A |
C |
8: 123,844,406 (GRCm39) |
|
probably null |
Het |
| Ctla4 |
T |
C |
1: 60,951,723 (GRCm39) |
V84A |
probably damaging |
Het |
| Dap3 |
A |
G |
3: 88,835,565 (GRCm39) |
V263A |
probably benign |
Het |
| Dhx57 |
T |
A |
17: 80,549,378 (GRCm39) |
|
probably null |
Het |
| Dlg5 |
C |
A |
14: 24,214,593 (GRCm39) |
K663N |
probably damaging |
Het |
| Dsg3 |
C |
A |
18: 20,656,719 (GRCm39) |
F196L |
possibly damaging |
Het |
| Eif2ak4 |
C |
A |
2: 118,257,064 (GRCm39) |
D402E |
probably damaging |
Het |
| Fance |
T |
C |
17: 28,537,068 (GRCm39) |
V24A |
probably benign |
Het |
| Fasn |
A |
T |
11: 120,705,574 (GRCm39) |
L1149Q |
probably damaging |
Het |
| Fcgbpl1 |
C |
G |
7: 27,831,060 (GRCm39) |
S91C |
probably damaging |
Het |
| Flg |
T |
A |
3: 93,187,093 (GRCm39) |
S182T |
possibly damaging |
Het |
| Gm128 |
T |
A |
3: 95,147,293 (GRCm39) |
S334C |
possibly damaging |
Het |
| Gm3727 |
A |
C |
14: 7,264,561 (GRCm38) |
H31Q |
probably damaging |
Het |
| Gm4841 |
T |
G |
18: 60,403,977 (GRCm39) |
T39P |
probably damaging |
Het |
| Golgb1 |
G |
T |
16: 36,735,513 (GRCm39) |
V1587L |
possibly damaging |
Het |
| Golm1 |
G |
A |
13: 59,790,072 (GRCm39) |
P243S |
probably benign |
Het |
| Gstcd |
C |
A |
3: 132,788,081 (GRCm39) |
A206S |
possibly damaging |
Het |
| Gstcd |
C |
A |
3: 132,788,082 (GRCm39) |
K205N |
possibly damaging |
Het |
| Gtf3c1 |
A |
G |
7: 125,280,345 (GRCm39) |
V355A |
probably benign |
Het |
| Hhatl |
T |
C |
9: 121,618,236 (GRCm39) |
D173G |
probably benign |
Het |
| Kcnu1 |
T |
A |
8: 26,395,994 (GRCm39) |
C660S |
probably benign |
Het |
| Kctd8 |
T |
C |
5: 69,267,988 (GRCm39) |
D374G |
probably benign |
Het |
| L3mbtl1 |
A |
T |
2: 162,809,505 (GRCm39) |
I702F |
probably benign |
Het |
| Lce1d |
T |
C |
3: 92,593,066 (GRCm39) |
|
probably benign |
Het |
| Lrig1 |
C |
T |
6: 94,594,347 (GRCm39) |
|
probably null |
Het |
| Lrp12 |
A |
T |
15: 39,739,507 (GRCm39) |
D563E |
probably damaging |
Het |
| Lrp2 |
C |
T |
2: 69,336,718 (GRCm39) |
|
probably null |
Het |
| Map3k5 |
G |
A |
10: 19,970,201 (GRCm39) |
V703I |
possibly damaging |
Het |
| Mecr |
A |
G |
4: 131,581,076 (GRCm39) |
R110G |
probably benign |
Het |
| Mtrr |
T |
A |
13: 68,715,092 (GRCm39) |
K445* |
probably null |
Het |
| Nanos1 |
T |
A |
19: 60,744,990 (GRCm39) |
L96Q |
probably benign |
Het |
| Or13a24 |
T |
G |
7: 140,154,069 (GRCm39) |
M1R |
probably null |
Het |
| Or51t4 |
T |
A |
7: 102,598,700 (GRCm39) |
F333I |
probably benign |
Het |
| Or6c214 |
T |
A |
10: 129,591,021 (GRCm39) |
L99F |
probably damaging |
Het |
| Otog |
T |
C |
7: 45,955,014 (GRCm39) |
|
probably null |
Het |
| Pcdhb3 |
G |
T |
18: 37,434,294 (GRCm39) |
V87F |
probably benign |
Het |
| Pcdhb3 |
T |
A |
18: 37,434,292 (GRCm39) |
L86* |
probably null |
Het |
| Pcdhb3 |
A |
T |
18: 37,434,293 (GRCm39) |
L86F |
probably damaging |
Het |
| Pdgfd |
A |
G |
9: 6,359,894 (GRCm39) |
K322E |
probably damaging |
Het |
| Picalm |
T |
C |
7: 89,846,217 (GRCm39) |
S648P |
probably damaging |
Het |
| Pigr |
T |
C |
1: 130,774,357 (GRCm39) |
S446P |
possibly damaging |
Het |
| Pik3cb |
A |
C |
9: 98,943,895 (GRCm39) |
L636W |
probably damaging |
Het |
| Pla2g2f |
A |
T |
4: 138,481,473 (GRCm39) |
L92Q |
probably damaging |
Het |
| Plod3 |
G |
C |
5: 137,017,000 (GRCm39) |
A50P |
probably benign |
Het |
| Prkar2b |
C |
T |
12: 32,025,928 (GRCm39) |
V191I |
possibly damaging |
Het |
| Prune1 |
C |
A |
3: 95,165,430 (GRCm39) |
A281S |
probably benign |
Het |
| Ptges3l |
A |
T |
11: 101,314,868 (GRCm39) |
C42S |
possibly damaging |
Het |
| Reg3b |
A |
T |
6: 78,348,802 (GRCm39) |
I33L |
probably benign |
Het |
| Rel |
A |
G |
11: 23,695,823 (GRCm39) |
I188T |
probably damaging |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Ripor1 |
G |
T |
8: 106,344,254 (GRCm39) |
V463L |
probably benign |
Het |
| Rrm1 |
T |
A |
7: 102,109,896 (GRCm39) |
D510E |
probably damaging |
Het |
| Setd7 |
A |
G |
3: 51,440,436 (GRCm39) |
S202P |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,432,889 (GRCm39) |
D1211E |
probably benign |
Het |
| Slc30a1 |
A |
T |
1: 191,639,674 (GRCm39) |
T186S |
possibly damaging |
Het |
| Slc4a4 |
G |
A |
5: 89,304,257 (GRCm39) |
V523I |
probably benign |
Het |
| Slc9a2 |
T |
A |
1: 40,781,768 (GRCm39) |
|
probably null |
Het |
| Smg6 |
A |
G |
11: 74,820,502 (GRCm39) |
T258A |
probably damaging |
Het |
| Sptlc1 |
C |
T |
13: 53,491,676 (GRCm39) |
D408N |
possibly damaging |
Het |
| Tasor2 |
G |
T |
13: 3,632,150 (GRCm39) |
L784I |
possibly damaging |
Het |
| Tbl3 |
T |
C |
17: 24,923,524 (GRCm39) |
|
probably null |
Het |
| Tdo2 |
T |
C |
3: 81,876,812 (GRCm39) |
D139G |
possibly damaging |
Het |
| Ticam1 |
T |
A |
17: 56,578,612 (GRCm39) |
H161L |
possibly damaging |
Het |
| Tnfaip3 |
T |
A |
10: 18,881,407 (GRCm39) |
D293V |
probably benign |
Het |
| Trim72 |
G |
A |
7: 127,603,878 (GRCm39) |
V75M |
possibly damaging |
Het |
| Trip11 |
T |
A |
12: 101,803,986 (GRCm39) |
N1632I |
possibly damaging |
Het |
| Tspan18 |
A |
T |
2: 93,050,440 (GRCm39) |
M61K |
possibly damaging |
Het |
| Tuba8 |
A |
T |
6: 121,202,932 (GRCm39) |
E415V |
probably damaging |
Het |
| Ung |
A |
G |
5: 114,275,253 (GRCm39) |
H214R |
probably benign |
Het |
| Uqcrc1 |
T |
C |
9: 108,765,836 (GRCm39) |
L17P |
probably damaging |
Het |
| Usp24 |
A |
G |
4: 106,236,602 (GRCm39) |
|
probably null |
Het |
| Vps39 |
A |
C |
2: 120,169,268 (GRCm39) |
Y245D |
probably damaging |
Het |
| Whrn |
T |
A |
4: 63,353,649 (GRCm39) |
T373S |
probably benign |
Het |
| Zc2hc1a |
C |
T |
3: 7,581,596 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCTTACACAATTGGTCAGCTTCC -3'
(R):5'- AGCACAGTGGGTTTTAGCCG -3'
Sequencing Primer
(F):5'- ACAACAACAAAAGGAAACTAAGAGG -3'
(R):5'- GGGTTTTAGCCGGCAGC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation