Incidental Mutation 'R4692:Or8c17'
ID 354979
Institutional Source Beutler Lab
Gene Symbol Or8c17
Ensembl Gene ENSMUSG00000096427
Gene Name olfactory receptor family 8 subfamily C member 17
Synonyms GA_x6K02T2PVTD-31962461-31963411, MOR170-1, Olfr895
MMRRC Submission 041943-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R4692 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38179297-38181049 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 38179826 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 6 (Q6*)
Ref Sequence ENSEMBL: ENSMUSP00000091387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093864] [ENSMUST00000212156]
AlphaFold L7N210
Predicted Effect probably null
Transcript: ENSMUST00000093864
AA Change: Q6*
SMART Domains Protein: ENSMUSP00000091387
Gene: ENSMUSG00000096427
AA Change: Q6*

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 4.6e-47 PFAM
Pfam:7tm_1 47 246 3.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212156
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik A T 10: 28,849,882 (GRCm39) Y230* probably null Het
9230104M06Rik A T 12: 112,963,692 (GRCm39) probably benign Het
Arhgap20 A G 9: 51,697,088 (GRCm39) D53G probably damaging Het
Arl2 T C 19: 6,187,776 (GRCm39) T54A probably damaging Het
Baz2a G A 10: 127,960,762 (GRCm39) G1521S probably damaging Het
Begain A G 12: 108,999,818 (GRCm39) S523P probably damaging Het
Car10 T C 11: 93,075,984 (GRCm39) probably null Het
Cenpe A G 3: 134,922,140 (GRCm39) I66V probably benign Het
Col14a1 T A 15: 55,286,864 (GRCm39) V895E unknown Het
Coro1b T C 19: 4,199,418 (GRCm39) Y26H probably damaging Het
Crebbp T C 16: 3,932,727 (GRCm39) E1017G possibly damaging Het
Cwf19l2 T C 9: 3,428,709 (GRCm39) S232P probably damaging Het
Cyp7b1 T A 3: 18,126,728 (GRCm39) I473F probably damaging Het
Efcab5 A T 11: 77,004,507 (GRCm39) I937N probably damaging Het
Fam53c A C 18: 34,901,743 (GRCm39) E220A probably damaging Het
Gsn A G 2: 35,188,883 (GRCm39) Y434C probably damaging Het
Igkv2-137 T C 6: 67,532,971 (GRCm39) S45P possibly damaging Het
Katnip T C 7: 125,466,841 (GRCm39) probably null Het
Kif13b C A 14: 65,041,024 (GRCm39) T1704K probably benign Het
Mapk7 A G 11: 61,380,068 (GRCm39) S697P possibly damaging Het
Mrgpra1 T A 7: 46,985,446 (GRCm39) I78F probably damaging Het
N6amt1 T C 16: 87,153,854 (GRCm39) V97A possibly damaging Het
Oas3 T C 5: 120,907,420 (GRCm39) T406A probably benign Het
Or4f61 A G 2: 111,923,026 (GRCm39) S7P probably damaging Het
Paxip1 T C 5: 27,977,095 (GRCm39) probably benign Het
Pfn4 A T 12: 4,824,486 (GRCm39) Y71F probably damaging Het
Plin4 C A 17: 56,410,762 (GRCm39) G1090C probably damaging Het
Ptk2b C T 14: 66,394,518 (GRCm39) G859S probably benign Het
Rbl2 T A 8: 91,849,047 (GRCm39) D1084E probably damaging Het
Robo1 T G 16: 72,757,090 (GRCm39) S350R probably damaging Het
Sbno2 A G 10: 79,922,161 (GRCm39) V4A possibly damaging Het
Sh3rf1 T C 8: 61,806,888 (GRCm39) probably null Het
Smgc T C 15: 91,738,764 (GRCm39) V474A possibly damaging Het
Snx13 A G 12: 35,136,917 (GRCm39) D126G possibly damaging Het
Sox9 C A 11: 112,673,803 (GRCm39) H131Q probably benign Het
Spag6 T C 2: 18,704,054 (GRCm39) I34T probably benign Het
Speer2 T A 16: 69,654,860 (GRCm39) T202S possibly damaging Het
Sspo T A 6: 48,459,621 (GRCm39) C3327S probably damaging Het
Vcpip1 G T 1: 9,818,299 (GRCm39) A28E unknown Het
Vstm5 A T 9: 15,168,718 (GRCm39) D94V probably damaging Het
Zfp329 T C 7: 12,544,559 (GRCm39) K322E probably damaging Het
Zfp932 G A 5: 110,157,052 (GRCm39) G250D probably damaging Het
Zscan26 A G 13: 21,629,427 (GRCm39) C359R probably damaging Het
Other mutations in Or8c17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Or8c17 APN 9 38,179,801 (GRCm39) splice site probably benign
IGL01477:Or8c17 APN 9 38,180,615 (GRCm39) missense possibly damaging 0.74
IGL02150:Or8c17 APN 9 38,180,564 (GRCm39) missense possibly damaging 0.56
R0616:Or8c17 UTSW 9 38,180,630 (GRCm39) missense probably benign 0.08
R0738:Or8c17 UTSW 9 38,180,421 (GRCm39) missense possibly damaging 0.93
R3155:Or8c17 UTSW 9 38,179,836 (GRCm39) start codon destroyed probably null 0.98
R3824:Or8c17 UTSW 9 38,179,814 (GRCm39) missense probably benign
R3825:Or8c17 UTSW 9 38,179,814 (GRCm39) missense probably benign
R4023:Or8c17 UTSW 9 38,180,757 (GRCm39) missense possibly damaging 0.83
R4687:Or8c17 UTSW 9 38,180,710 (GRCm39) missense probably damaging 1.00
R6171:Or8c17 UTSW 9 38,179,898 (GRCm39) nonsense probably null
R6736:Or8c17 UTSW 9 38,179,866 (GRCm39) missense probably damaging 1.00
R6950:Or8c17 UTSW 9 38,179,842 (GRCm39) missense probably damaging 1.00
R7256:Or8c17 UTSW 9 38,180,004 (GRCm39) missense probably damaging 0.98
R7774:Or8c17 UTSW 9 38,180,655 (GRCm39) missense probably damaging 0.99
R7937:Or8c17 UTSW 9 38,180,344 (GRCm39) missense probably benign 0.16
R8354:Or8c17 UTSW 9 38,180,513 (GRCm39) missense probably benign 0.02
R8772:Or8c17 UTSW 9 38,180,231 (GRCm39) missense probably benign 0.00
R8863:Or8c17 UTSW 9 38,180,655 (GRCm39) missense probably damaging 0.99
R9371:Or8c17 UTSW 9 38,179,926 (GRCm39) missense possibly damaging 0.94
Z1088:Or8c17 UTSW 9 38,179,908 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCCAGCATCTTTCTGAAGTG -3'
(R):5'- AGCCCATCAGCATTTTGGG -3'

Sequencing Primer
(F):5'- CCAGCATCTTTCTGAAGTGTTATAC -3'
(R):5'- CCCATCAGCATTTTGGGGGTAAAG -3'
Posted On 2015-10-21