Mutagenetix > Incidental Mutation

Incidental Mutation 'R6164:Olfr707'

490049

Institutional Source

Beutler Lab

Gene Symbol

Olfr707

Ensembl Gene

ENSMUSG00000069390

Gene Name

olfactory receptor 707

Synonyms

MOR260-8P, GA_x6K02T2PBJ9-9276470-9275547

MMRRC Submission

044310-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R6164 (G1)

Quality Score

95.0077

Status

Not validated

Chromosome

Chromosomal Location

106890446-106901241 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 106891928 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 60 (Y60*)

Ref Sequence

ENSEMBL: ENSMUSP00000150100 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088687] [ENSMUST00000208759] [ENSMUST00000210644] [ENSMUST00000213251] [ENSMUST00000213918] [ENSMUST00000214112]

AlphaFold

K7N662

Predicted Effect

probably null
Transcript: ENSMUST00000088687
AA Change: Y60*

SMART Domains

Protein: ENSMUSP00000086062
Gene: ENSMUSG00000069390
AA Change: Y60*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.2e-58	PFAM
Pfam:7TM_GPCR_Srsx	35	303	9.1e-9	PFAM
Pfam:7tm_1	41	290	1.4e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000208759
AA Change: Y60*

Predicted Effect

probably null
Transcript: ENSMUST00000210644
AA Change: Y60*

Predicted Effect

probably null
Transcript: ENSMUST00000213251
AA Change: Y60*

Predicted Effect

probably benign
Transcript: ENSMUST00000213918

Predicted Effect

probably null
Transcript: ENSMUST00000214112
AA Change: Y60*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214495

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216085

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216099

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.3%

Validation Efficiency

98% (61/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6030419C18Rik	C	A	9: 58,499,247	P147T	probably damaging	Het
Anpep	A	G	7: 79,842,205	I16T	possibly damaging	Het
Ap1s1	T	C	5: 137,037,386		probably benign	Het
Atp1a2	T	C	1: 172,278,892	S848G	probably damaging	Het
Bche	T	A	3: 73,701,056	I346F	possibly damaging	Het
Ccdc148	T	A	2: 58,823,633	Y502F	probably damaging	Het
Ccdc88c	T	C	12: 100,953,383	M416V	probably damaging	Het
Cdk17	T	C	10: 93,235,469	S351P	probably benign	Het
Cfap100	T	C	6: 90,415,786	E114G	probably benign	Het
Clec4a4	T	C	6: 122,991,874	I66T	possibly damaging	Het
Cpeb4	T	C	11: 31,920,584		probably null	Het
Cybrd1	T	C	2: 71,118,274	V52A	probably damaging	Het
Decr1	G	A	4: 15,924,347	A191V	probably benign	Het
Dnah5	A	T	15: 28,378,343	I2942L	probably benign	Het
Ehd4	C	T	2: 120,102,208	V246I	possibly damaging	Het
Ercc6l2	A	G	13: 63,872,344		probably benign	Het
Exoc4	T	A	6: 33,332,283	M280K	probably damaging	Het
Fam122a	T	A	19: 24,477,086	M91L	probably benign	Het
Fam71e2	T	C	7: 4,770,678	T73A	probably damaging	Het
Fmo1	T	G	1: 162,851,410	E89A	probably benign	Het
Foxm1	A	G	6: 128,373,935	D733G	probably benign	Het
Gm10093	T	C	17: 78,492,287	S236P	probably damaging	Het
Gulp1	A	C	1: 44,754,351	R57S	probably damaging	Het
Hdac4	G	T	1: 92,030,154	A46E	probably benign	Het
Hspg2	T	C	4: 137,514,655	S567P	possibly damaging	Het
Iqgap1	A	C	7: 80,809,106	C21W	unknown	Het
Isoc2a	T	C	7: 4,891,489	L57P	probably damaging	Het
Krt34	G	A	11: 100,038,446	Q313*	probably null	Het
Krt6a	C	T	15: 101,692,573	V263I	probably damaging	Het
Man2a1	A	G	17: 64,733,724	I106V	possibly damaging	Het
Muc16	T	C	9: 18,558,379	D7300G	probably damaging	Het
Muc5b	A	T	7: 141,863,345	S3343C	possibly damaging	Het
Mup11	C	T	4: 60,662,240	E21K	possibly damaging	Het
Myo3b	T	A	2: 70,245,410		probably null	Het
Nlrp4c	T	C	7: 6,092,508	L795P	probably damaging	Het
Nup160	T	A	2: 90,717,876	Y984*	probably null	Het
Nwd1	C	T	8: 72,662,186	R81W	probably damaging	Het
Olfr472	A	G	7: 107,903,388	T224A	probably benign	Het
Osmr	A	G	15: 6,860,352	V5A	probably benign	Het
Pcsk5	A	G	19: 17,836,953		probably null	Het
Pex11a	G	A	7: 79,737,379	T235M	probably damaging	Het
Pik3r6	A	G	11: 68,551,973	T730A	probably benign	Het
Ppp1r9a	C	T	6: 5,110,715		probably benign	Het
Ppp2r2d	T	C	7: 138,873,013	I41T	probably damaging	Het
Prdm1	C	T	10: 44,450,195	R126H	probably damaging	Het
Primpol	C	T	8: 46,586,442	R381H	probably benign	Het
Prl7a1	C	A	13: 27,637,643	Q102H	probably benign	Het
Rbpjl	T	C	2: 164,410,879	L284P	probably damaging	Het
Rgs21	A	T	1: 144,541,297	C6S	probably benign	Het
Rnasel	T	C	1: 153,754,392	V218A	probably benign	Het
Sag	G	T	1: 87,824,453	V223L	probably damaging	Het
Sdk1	C	T	5: 142,132,069	T1574M	probably damaging	Het
Secisbp2	G	A	13: 51,679,860	V679M	probably damaging	Het
Sele	T	A	1: 164,051,817		probably null	Het
Senp7	T	A	16: 56,169,754	L622M	probably damaging	Het
Sgo1	G	A	17: 53,676,953	R466C	probably damaging	Het
Sh3tc1	C	A	5: 35,706,246	V866L	probably benign	Het
Snrnp25	T	A	11: 32,207,647	V75D	probably benign	Het
Syne1	C	T	10: 5,061,429	C7899Y	probably damaging	Het
U2af1l4	T	C	7: 30,564,582	S55P	probably damaging	Het
Vmn1r23	A	G	6: 57,926,055	I246T	possibly damaging	Het
Vmn1r66	T	A	7: 10,274,402	R235*	probably null	Het
Wnk4	C	T	11: 101,275,068	A807V	possibly damaging	Het

Other mutations in Olfr707

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02718:Olfr707	APN	7	106891329	missense	probably damaging	1.00
R1539:Olfr707	UTSW	7	106891276	missense	probably damaging	1.00
R1768:Olfr707	UTSW	7	106891977	splice site	probably null
R1768:Olfr707	UTSW	7	106891978	missense	probably damaging	0.97
R4367:Olfr707	UTSW	7	106891360	small deletion	probably benign
R4542:Olfr707	UTSW	7	106891360	small deletion	probably benign
R4874:Olfr707	UTSW	7	106891435	missense	probably benign	0.28
R8124:Olfr707	UTSW	7	106891881	missense	possibly damaging	0.91
R8883:Olfr707	UTSW	7	106891329	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TAGTGCAGAGGCTTGCAGAC -3'
(R):5'- CATTCATGGGTGAAGACAACAG -3'

Sequencing Primer
(F):5'- TAGCGGTCATAGGACATCACTGC -3'
(R):5'- GAACCTCTGTGACAGAATTCATC -3'

Posted On

2017-10-10