|Institutional Source||Beutler Lab|
|Gene Name||macrophage stimulating 1 receptor (c-met-related tyrosine kinase)|
|Synonyms||Fv-2, Ron, CDw136, Fv2, friend virus susceptibility 2, PTK8, STK|
|Is this an essential gene?||Probably non essential (E-score: 0.198)|
|Stock #||R6873 (G1)|
|Chromosomal Location||107906873-107920383 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 107911644 bp|
|Amino Acid Change||Histidine to Leucine at position 454 (H454L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000035203 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000035203] [ENSMUST00000195617]|
|Predicted Effect||possibly damaging
AA Change: H454L
PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
AA Change: H454L
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||98% (48/49)|
FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mst1r||
(F):5'- ACAGTTTGGGATTGCTGATAGAC -3'
(R):5'- AGCAGGTAGTTGAGTGACCTG -3'
(F):5'- AAGAGTCAATGCCCAGGCCTG -3'
(R):5'- AGTTGAGTGACCTGGCTATCTCC -3'