Incidental Mutation 'R6970:Zmynd8'
| ID |
542161 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmynd8
|
| Ensembl Gene |
ENSMUSG00000039671 |
| Gene Name |
zinc finger, MYND-type containing 8 |
| Synonyms |
ZMYND8, RACK7, 1110013E22Rik, 2010005I16Rik, Prkcbp1, 3632413B07Rik |
| MMRRC Submission |
045080-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6970 (G1)
|
| Quality Score |
131.008 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
165626072-165740896 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 165717670 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 14
(E14K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085436
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018050]
[ENSMUST00000088113]
[ENSMUST00000099084]
[ENSMUST00000109262]
[ENSMUST00000109269]
[ENSMUST00000136842]
[ENSMUST00000144530]
[ENSMUST00000177633]
[ENSMUST00000153655]
[ENSMUST00000170272]
|
| AlphaFold |
A2A484 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018050
|
| SMART Domains |
Protein: ENSMUSP00000018050
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
90 |
131 |
2.23e-11 |
SMART |
|
BROMO
|
147 |
254 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
275 |
349 |
4e-12 |
PFAM |
|
Pfam:DUF3544
|
412 |
624 |
9.8e-112 |
PFAM |
|
internal_repeat_2
|
640 |
701 |
9.06e-5 |
PROSPERO |
|
low complexity region
|
770 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
887 |
N/A |
INTRINSIC |
|
coiled coil region
|
916 |
978 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
988 |
1022 |
2.2e-7 |
PFAM |
|
low complexity region
|
1055 |
1075 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1156 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000088113
AA Change: E14K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
AA Change: E14K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099084
|
| SMART Domains |
Protein: ENSMUSP00000096683
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
4.95e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
880 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
914 |
N/A |
INTRINSIC |
|
coiled coil region
|
943 |
1005 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1015 |
1049 |
2.3e-7 |
PFAM |
|
low complexity region
|
1082 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1183 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109262
|
| SMART Domains |
Protein: ENSMUSP00000104885
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.2e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
460 |
3.1e-29 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109269
|
| SMART Domains |
Protein: ENSMUSP00000104892
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
60 |
N/A |
INTRINSIC |
|
PHD
|
94 |
135 |
2.23e-11 |
SMART |
|
BROMO
|
151 |
258 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
280 |
355 |
6.6e-11 |
PFAM |
|
Pfam:DUF3544
|
417 |
626 |
2.6e-102 |
PFAM |
|
internal_repeat_2
|
644 |
705 |
6.15e-5 |
PROSPERO |
|
low complexity region
|
774 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
924 |
N/A |
INTRINSIC |
|
low complexity region
|
931 |
943 |
N/A |
INTRINSIC |
|
coiled coil region
|
972 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1198 |
1212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000136842
AA Change: E25K
PolyPhen 2
Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000120631
Gene: ENSMUSG00000039671
AA Change: E25K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
30 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
87 |
N/A |
INTRINSIC |
|
PHD
|
96 |
137 |
2.23e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144530
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177633
AA Change: E14K
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000136211
Gene: ENSMUSG00000039671
AA Change: E14K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
9.6e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
619 |
1.8e-111 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
6.45e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
983 |
1017 |
6.7e-7 |
PFAM |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
low complexity region
|
1137 |
1151 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153655
AA Change: E10K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000120932
Gene: ENSMUSG00000039671
AA Change: E10K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
15 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
3.5e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
480 |
6.7e-29 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170272
|
| SMART Domains |
Protein: ENSMUSP00000128680
Gene: ENSMUSG00000039671
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.1e-11 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1.9e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
7.92e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
828 |
843 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
862 |
N/A |
INTRINSIC |
|
coiled coil region
|
891 |
953 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
963 |
997 |
1.1e-6 |
PFAM |
|
low complexity region
|
1030 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.2%
- 20x: 97.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acadsb |
T |
C |
7: 131,036,044 (GRCm39) |
Y285H |
possibly damaging |
Het |
| Adam17 |
A |
G |
12: 21,395,669 (GRCm39) |
S285P |
probably benign |
Het |
| Adcy10 |
A |
G |
1: 165,384,485 (GRCm39) |
N1082S |
probably benign |
Het |
| Ahdc1 |
T |
A |
4: 132,789,656 (GRCm39) |
L299Q |
possibly damaging |
Het |
| Ambra1 |
T |
A |
2: 91,602,945 (GRCm39) |
|
probably benign |
Het |
| Arfgef1 |
T |
C |
1: 10,223,903 (GRCm39) |
Q1465R |
probably damaging |
Het |
| Arfgef1 |
G |
T |
1: 10,223,904 (GRCm39) |
Q1465K |
probably damaging |
Het |
| Atp8a1 |
A |
G |
5: 67,895,805 (GRCm39) |
V543A |
probably damaging |
Het |
| BC034090 |
T |
A |
1: 155,117,185 (GRCm39) |
D311V |
probably damaging |
Het |
| Blnk |
G |
T |
19: 40,950,821 (GRCm39) |
P110Q |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,875,927 (GRCm39) |
E968G |
probably damaging |
Het |
| Ccdc14 |
A |
T |
16: 34,529,903 (GRCm39) |
E394V |
probably damaging |
Het |
| Ccdc162 |
A |
T |
10: 41,491,954 (GRCm39) |
H1086Q |
probably benign |
Het |
| Ccdc85b |
T |
A |
19: 5,507,248 (GRCm39) |
I60F |
probably damaging |
Het |
| Ceacam20 |
T |
A |
7: 19,723,902 (GRCm39) |
L562Q |
probably damaging |
Het |
| Cntrl |
T |
C |
2: 35,008,149 (GRCm39) |
F188L |
probably benign |
Het |
| Cplane1 |
T |
C |
15: 8,217,032 (GRCm39) |
V750A |
probably benign |
Het |
| Dclk1 |
A |
T |
3: 55,374,022 (GRCm39) |
|
probably benign |
Het |
| Ddx20 |
A |
T |
3: 105,587,674 (GRCm39) |
L434H |
probably damaging |
Het |
| Ddx51 |
G |
A |
5: 110,804,728 (GRCm39) |
V547M |
probably damaging |
Het |
| Dnah11 |
T |
A |
12: 118,072,679 (GRCm39) |
Q1472L |
probably benign |
Het |
| Dnajb13 |
T |
C |
7: 100,156,629 (GRCm39) |
E149G |
probably damaging |
Het |
| Efcab3 |
A |
G |
11: 104,667,182 (GRCm39) |
E1422G |
probably benign |
Het |
| Eif1ad8 |
G |
T |
12: 87,563,388 (GRCm39) |
|
probably benign |
Het |
| Fat4 |
A |
G |
3: 39,035,924 (GRCm39) |
N3192S |
probably damaging |
Het |
| Fat4 |
A |
T |
3: 39,050,120 (GRCm39) |
D3994V |
probably damaging |
Het |
| Fcgr1 |
C |
A |
3: 96,191,936 (GRCm39) |
|
probably null |
Het |
| Gm12185 |
G |
A |
11: 48,798,739 (GRCm39) |
R585* |
probably null |
Het |
| Gm32687 |
A |
G |
10: 81,715,304 (GRCm39) |
H232R |
probably benign |
Het |
| Gm5431 |
G |
T |
11: 48,779,317 (GRCm39) |
A535D |
probably damaging |
Het |
| Jarid2 |
C |
T |
13: 45,056,461 (GRCm39) |
P556S |
probably damaging |
Het |
| Map3k4 |
C |
A |
17: 12,467,803 (GRCm39) |
G1077V |
probably damaging |
Het |
| Mast4 |
C |
T |
13: 102,941,155 (GRCm39) |
V301I |
probably damaging |
Het |
| Mlxip |
A |
G |
5: 123,583,735 (GRCm39) |
T433A |
possibly damaging |
Het |
| Ms4a20 |
A |
G |
19: 11,089,678 (GRCm39) |
|
probably null |
Het |
| Mus81 |
G |
T |
19: 5,535,554 (GRCm39) |
H199Q |
probably benign |
Het |
| Mylk3 |
G |
A |
8: 86,085,892 (GRCm39) |
T54M |
probably damaging |
Het |
| Nalcn |
A |
G |
14: 123,551,506 (GRCm39) |
F1034L |
possibly damaging |
Het |
| Nfatc1 |
A |
C |
18: 80,710,228 (GRCm39) |
S513A |
probably benign |
Het |
| Ninj2 |
A |
G |
6: 120,175,092 (GRCm39) |
I88V |
possibly damaging |
Het |
| Nomo1 |
C |
T |
7: 45,695,391 (GRCm39) |
P277L |
probably damaging |
Het |
| Nup214 |
C |
T |
2: 31,941,810 (GRCm39) |
S571L |
probably damaging |
Het |
| Or10g9b |
T |
A |
9: 39,918,009 (GRCm39) |
M79L |
probably benign |
Het |
| Or5b3 |
T |
A |
19: 13,388,792 (GRCm39) |
N286K |
probably damaging |
Het |
| Or9a7 |
T |
C |
6: 40,521,590 (GRCm39) |
S108G |
probably benign |
Het |
| Pcdh15 |
C |
T |
10: 74,338,519 (GRCm39) |
P1005S |
probably damaging |
Het |
| Pkhd1l1 |
G |
A |
15: 44,375,070 (GRCm39) |
A942T |
possibly damaging |
Het |
| Plagl1 |
T |
C |
10: 13,000,860 (GRCm39) |
C34R |
probably damaging |
Het |
| Plekha2 |
T |
C |
8: 25,549,280 (GRCm39) |
Q168R |
probably benign |
Het |
| Plekha6 |
G |
A |
1: 133,191,556 (GRCm39) |
A146T |
probably benign |
Het |
| Plekhm3 |
T |
G |
1: 64,931,912 (GRCm39) |
K564T |
possibly damaging |
Het |
| Plpp2 |
A |
G |
10: 79,366,380 (GRCm39) |
V26A |
possibly damaging |
Het |
| Prdm10 |
T |
G |
9: 31,241,119 (GRCm39) |
Y302* |
probably null |
Het |
| Prdm8 |
A |
G |
5: 98,332,471 (GRCm39) |
E124G |
probably damaging |
Het |
| Prg4 |
T |
G |
1: 150,331,657 (GRCm39) |
|
probably benign |
Het |
| Qser1 |
A |
G |
2: 104,618,475 (GRCm39) |
V779A |
probably benign |
Het |
| Rbm39 |
G |
A |
2: 156,009,504 (GRCm39) |
R123C |
probably damaging |
Het |
| Ric1 |
C |
T |
19: 29,565,172 (GRCm39) |
P640S |
probably damaging |
Het |
| Rpl14 |
G |
A |
9: 120,403,293 (GRCm39) |
|
probably benign |
Het |
| Rsl1d1 |
T |
A |
16: 11,011,558 (GRCm39) |
D382V |
probably benign |
Het |
| Rubcn |
G |
T |
16: 32,688,514 (GRCm39) |
|
probably benign |
Het |
| Sec16a |
G |
A |
2: 26,320,498 (GRCm39) |
R1361C |
probably damaging |
Het |
| Slc26a11 |
T |
G |
11: 119,247,798 (GRCm39) |
V41G |
probably damaging |
Het |
| Slc41a2 |
A |
G |
10: 83,151,960 (GRCm39) |
F172L |
possibly damaging |
Het |
| Slc4a4 |
A |
C |
5: 89,327,690 (GRCm39) |
Y674S |
probably damaging |
Het |
| Spata31e3 |
A |
T |
13: 50,401,007 (GRCm39) |
Y440N |
possibly damaging |
Het |
| Strc |
A |
C |
2: 121,208,495 (GRCm39) |
M292R |
probably benign |
Het |
| Syde2 |
A |
G |
3: 145,694,381 (GRCm39) |
T210A |
probably benign |
Het |
| Tcf7l2 |
C |
A |
19: 55,743,480 (GRCm39) |
A97E |
probably benign |
Het |
| Tenm3 |
C |
T |
8: 48,689,474 (GRCm39) |
D2038N |
probably damaging |
Het |
| Tepsin |
G |
A |
11: 119,986,190 (GRCm39) |
T168M |
probably damaging |
Het |
| Tex15 |
A |
T |
8: 34,047,456 (GRCm39) |
M178L |
probably benign |
Het |
| Tgfbr2 |
T |
C |
9: 115,939,119 (GRCm39) |
N236S |
probably damaging |
Het |
| Tnrc18 |
A |
G |
5: 142,713,744 (GRCm39) |
V2531A |
probably damaging |
Het |
| Ttn |
T |
G |
2: 76,725,767 (GRCm39) |
|
probably benign |
Het |
| Tubgcp3 |
G |
T |
8: 12,687,000 (GRCm39) |
D630E |
probably damaging |
Het |
| Ubr4 |
G |
A |
4: 139,133,839 (GRCm39) |
W745* |
probably null |
Het |
| Vmn2r115 |
G |
A |
17: 23,564,989 (GRCm39) |
G292D |
probably benign |
Het |
| Vmn2r38 |
T |
A |
7: 9,078,340 (GRCm39) |
K681* |
probably null |
Het |
| Xrcc6 |
A |
G |
15: 81,915,375 (GRCm39) |
K98E |
probably benign |
Het |
| Zfp423 |
A |
G |
8: 88,530,407 (GRCm39) |
V13A |
probably benign |
Het |
| Zfp512b |
A |
G |
2: 181,228,141 (GRCm39) |
I5T |
possibly damaging |
Het |
|
| Other mutations in Zmynd8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01288:Zmynd8
|
APN |
2 |
165,654,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01311:Zmynd8
|
APN |
2 |
165,647,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02317:Zmynd8
|
APN |
2 |
165,662,492 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02548:Zmynd8
|
APN |
2 |
165,675,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Zmynd8
|
APN |
2 |
165,694,070 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02933:Zmynd8
|
APN |
2 |
165,670,238 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
cain
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
I1329:Zmynd8
|
UTSW |
2 |
165,670,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0031:Zmynd8
|
UTSW |
2 |
165,662,618 (GRCm39) |
splice site |
probably benign |
|
|
R0267:Zmynd8
|
UTSW |
2 |
165,670,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zmynd8
|
UTSW |
2 |
165,629,078 (GRCm39) |
splice site |
probably null |
|
|
R1663:Zmynd8
|
UTSW |
2 |
165,649,805 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2212:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3413:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Zmynd8
|
UTSW |
2 |
165,647,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3820:Zmynd8
|
UTSW |
2 |
165,657,381 (GRCm39) |
nonsense |
probably null |
|
|
R3836:Zmynd8
|
UTSW |
2 |
165,700,019 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3957:Zmynd8
|
UTSW |
2 |
165,654,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4379:Zmynd8
|
UTSW |
2 |
165,649,858 (GRCm39) |
splice site |
probably null |
|
|
R4526:Zmynd8
|
UTSW |
2 |
165,649,527 (GRCm39) |
intron |
probably benign |
|
|
R4739:Zmynd8
|
UTSW |
2 |
165,647,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4838:Zmynd8
|
UTSW |
2 |
165,681,954 (GRCm39) |
nonsense |
probably null |
|
|
R4932:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4933:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4997:Zmynd8
|
UTSW |
2 |
165,634,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5652:Zmynd8
|
UTSW |
2 |
165,649,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5741:Zmynd8
|
UTSW |
2 |
165,681,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6008:Zmynd8
|
UTSW |
2 |
165,684,707 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6242:Zmynd8
|
UTSW |
2 |
165,740,867 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6332:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6394:Zmynd8
|
UTSW |
2 |
165,687,943 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Zmynd8
|
UTSW |
2 |
165,649,521 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6986:Zmynd8
|
UTSW |
2 |
165,675,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7229:Zmynd8
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7266:Zmynd8
|
UTSW |
2 |
165,649,492 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7296:Zmynd8
|
UTSW |
2 |
165,681,929 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7642:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Zmynd8
|
UTSW |
2 |
165,684,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7821:Zmynd8
|
UTSW |
2 |
165,723,000 (GRCm39) |
intron |
probably benign |
|
|
R8135:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8828:Zmynd8
|
UTSW |
2 |
165,654,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9128:Zmynd8
|
UTSW |
2 |
165,700,058 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9200:Zmynd8
|
UTSW |
2 |
165,682,005 (GRCm39) |
missense |
probably benign |
|
|
R9345:Zmynd8
|
UTSW |
2 |
165,654,668 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9478:Zmynd8
|
UTSW |
2 |
165,649,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Zmynd8
|
UTSW |
2 |
165,654,268 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9649:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9759:Zmynd8
|
UTSW |
2 |
165,680,746 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
V7580:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7581:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7583:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Zmynd8
|
UTSW |
2 |
165,670,091 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zmynd8
|
UTSW |
2 |
165,670,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGACTGAACCATGTCTCCAG -3'
(R):5'- TGCACTTGGTTGAAGTCAGG -3'
Sequencing Primer
(F):5'- ATGTCTCCAGAAATTAGGTCCATCC -3'
(R):5'- TGAAGTCAGGTGTGTCCCCTC -3'
|
| Posted On |
2018-11-28 |
Incidental Mutation