Incidental Mutation 'R7307:St7l'
ID 567297
Institutional Source Beutler Lab
Gene Symbol St7l
Ensembl Gene ENSMUSG00000045576
Gene Name suppression of tumorigenicity 7-like
Synonyms St7r
MMRRC Submission 045366-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R7307 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 104864005-104930064 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 104889353 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 261 (F261L)
Ref Sequence ENSEMBL: ENSMUSP00000058455 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059271] [ENSMUST00000106769] [ENSMUST00000123876] [ENSMUST00000183914] [ENSMUST00000200132]
AlphaFold Q8K4P7
Predicted Effect probably benign
Transcript: ENSMUST00000059271
AA Change: F261L

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000058455
Gene: ENSMUSG00000045576
AA Change: F261L

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 559 1.6e-292 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000106769
AA Change: F261L

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000102380
Gene: ENSMUSG00000045576
AA Change: F261L

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 420 8.2e-209 PFAM
Pfam:ST7 419 527 1.4e-57 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000123876
AA Change: F254L

PolyPhen 2 Score 0.715 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000138577
Gene: ENSMUSG00000045576
AA Change: F254L

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 282 6.7e-96 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000183914
SMART Domains Protein: ENSMUSP00000139266
Gene: ENSMUSG00000045576

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
low complexity region 107 120 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000197098
AA Change: F129L

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000199335
Predicted Effect probably benign
Transcript: ENSMUST00000200132
SMART Domains Protein: ENSMUSP00000143759
Gene: ENSMUSG00000045576

DomainStartEndE-ValueType
low complexity region 22 31 N/A INTRINSIC
Pfam:ST7 41 212 2.7e-81 PFAM
Pfam:ST7 209 481 1.3e-167 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik G A 16: 17,118,395 (GRCm38) P155L probably benign Het
Adamts12 G T 15: 11,217,813 (GRCm38) L285F probably damaging Het
Ankrd6 A T 4: 32,816,949 (GRCm38) Y393N possibly damaging Het
Arhgap45 A G 10: 80,029,182 (GRCm38) Q993R probably benign Het
Arhgef33 G C 17: 80,347,120 (GRCm38) probably null Het
B4galnt3 T C 6: 120,215,431 (GRCm38) D448G probably benign Het
Capn1 C G 19: 5,993,908 (GRCm38) E564D possibly damaging Het
Ccdc85a A G 11: 28,399,384 (GRCm38) S474P probably benign Het
Cdk12 T A 11: 98,249,800 (GRCm38) L1289* probably null Het
Cramp1l A T 17: 24,974,745 (GRCm38) N920K possibly damaging Het
Cubn C T 2: 13,340,332 (GRCm38) S2091N probably damaging Het
Ddx1 A T 12: 13,223,959 (GRCm38) I581N probably damaging Het
Dnm2 A T 9: 21,485,687 (GRCm38) N487Y probably damaging Het
Enc1 A C 13: 97,245,093 (GRCm38) N37T probably damaging Het
Ephb3 T G 16: 21,222,226 (GRCm38) I932S probably benign Het
Frk T A 10: 34,591,938 (GRCm38) M316K probably damaging Het
Gdap2 C T 3: 100,202,033 (GRCm38) R25C unknown Het
Gm10436 A C 12: 88,181,749 (GRCm38) C32W probably damaging Het
Gpat2 T A 2: 127,434,890 (GRCm38) D671E probably damaging Het
Gpr179 C T 11: 97,338,846 (GRCm38) E828K probably benign Het
Greb1l T C 18: 10,538,142 (GRCm38) Y1052H probably damaging Het
Gtf2f1 C T 17: 57,007,833 (GRCm38) S69N probably damaging Het
Hid1 A C 11: 115,348,482 (GRCm38) I785S probably damaging Het
Hmcn2 T C 2: 31,343,081 (GRCm38) I214T probably damaging Het
Hsd3b5 G T 3: 98,619,769 (GRCm38) F120L probably damaging Het
Kif16b C T 2: 142,712,931 (GRCm38) R649Q probably benign Het
Kif17 A T 4: 138,262,643 (GRCm38) E47D probably benign Het
Kmt2b T C 7: 30,580,471 (GRCm38) H1368R probably damaging Het
Kmt2d A T 15: 98,849,418 (GRCm38) S3342T unknown Het
Krt82 A G 15: 101,542,907 (GRCm38) C356R probably damaging Het
Lrit2 A G 14: 37,072,199 (GRCm38) K407E probably benign Het
Malt1 T A 18: 65,451,569 (GRCm38) H325Q possibly damaging Het
Mccc2 T G 13: 99,988,600 (GRCm38) D187A possibly damaging Het
Mgll T A 6: 88,814,121 (GRCm38) probably null Het
Mindy2 T G 9: 70,610,959 (GRCm38) E449A possibly damaging Het
Muc5b G A 7: 141,842,294 (GRCm38) V96M unknown Het
Nlrp4e A G 7: 23,321,528 (GRCm38) E480G probably benign Het
Nup98 A G 7: 102,134,795 (GRCm38) I1093T probably benign Het
Olfr1288 A T 2: 111,478,760 (GRCm38) probably benign Het
Olfr243 G T 7: 103,716,966 (GRCm38) R124L probably damaging Het
Olfr350 G A 2: 36,850,125 (GRCm38) M26I probably benign Het
Olfr541 G A 7: 140,705,147 (GRCm38) V299I probably benign Het
Pcdhb6 A T 18: 37,335,478 (GRCm38) H484L probably benign Het
Phldb1 T C 9: 44,694,047 (GRCm38) T604A possibly damaging Het
Pitpnm3 G T 11: 72,070,964 (GRCm38) A275D probably damaging Het
Polr2a A T 11: 69,747,292 (GRCm38) probably null Het
Polr3a A G 14: 24,459,987 (GRCm38) C960R probably benign Het
Pou6f2 G A 13: 18,239,713 (GRCm38) A159V Het
Pramef6 A C 4: 143,896,775 (GRCm38) Y276* probably null Het
Psmc4 A G 7: 28,042,660 (GRCm38) V303A probably benign Het
Ptdss2 A G 7: 141,151,732 (GRCm38) N151S possibly damaging Het
Ptprk T A 10: 28,589,008 (GRCm38) Y1295* probably null Het
Rbm19 A G 5: 120,186,218 (GRCm38) K881E possibly damaging Het
Rcan2 T A 17: 44,021,102 (GRCm38) Y183* probably null Het
Rnd1 T C 15: 98,670,799 (GRCm38) E166G probably damaging Het
Rnf113a2 T A 12: 84,418,179 (GRCm38) C282S probably damaging Het
S100b G A 10: 76,257,092 (GRCm38) G20R probably benign Het
Sae1 G T 7: 16,368,544 (GRCm38) Y168* probably null Het
Samd9l C A 6: 3,372,600 (GRCm38) G1554* probably null Het
Samhd1 T C 2: 157,135,020 (GRCm38) S55G probably benign Het
Sgsm1 T C 5: 113,273,646 (GRCm38) D525G probably benign Het
Slc28a3 A T 13: 58,563,172 (GRCm38) M512K probably damaging Het
Slc9b2 T A 3: 135,318,390 (GRCm38) N67K probably benign Het
Smarca4 T A 9: 21,638,800 (GRCm38) I402N probably damaging Het
Syde2 T A 3: 146,015,798 (GRCm38) V1140D probably damaging Het
Syt6 T A 3: 103,587,472 (GRCm38) I251N probably damaging Het
Taok2 T C 7: 126,866,818 (GRCm38) E916G probably damaging Het
Tecta A G 9: 42,377,992 (GRCm38) S426P probably damaging Het
Thra T C 11: 98,764,308 (GRCm38) I338T probably damaging Het
Trub1 A T 19: 57,472,703 (GRCm38) Y137F probably damaging Het
Vps13b T C 15: 35,841,545 (GRCm38) F2574L probably benign Het
Ythdf3 T C 3: 16,183,500 (GRCm38) S2P possibly damaging Het
Zc3h13 T A 14: 75,330,541 (GRCm38) D1091E probably damaging Het
Zdhhc6 A G 19: 55,313,250 (GRCm38) Y100H probably damaging Het
Other mutations in St7l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00785:St7l APN 3 104,873,579 (GRCm38) splice site probably benign
IGL00919:St7l APN 3 104,926,466 (GRCm38) missense probably damaging 1.00
IGL00945:St7l APN 3 104,926,482 (GRCm38) missense probably damaging 0.96
IGL01644:St7l APN 3 104,919,456 (GRCm38) nonsense probably null
IGL02158:St7l APN 3 104,874,832 (GRCm38) missense possibly damaging 0.48
IGL02164:St7l APN 3 104,922,281 (GRCm38) critical splice donor site probably null
IGL02331:St7l APN 3 104,926,588 (GRCm38) missense probably damaging 0.98
IGL03220:St7l APN 3 104,874,823 (GRCm38) splice site probably benign
R0118:St7l UTSW 3 104,889,303 (GRCm38) missense probably damaging 0.97
R0320:St7l UTSW 3 104,870,913 (GRCm38) nonsense probably null
R0345:St7l UTSW 3 104,895,809 (GRCm38) splice site probably benign
R0714:St7l UTSW 3 104,874,928 (GRCm38) missense probably benign 0.06
R0784:St7l UTSW 3 104,870,924 (GRCm38) missense probably benign 0.13
R1664:St7l UTSW 3 104,870,898 (GRCm38) missense probably damaging 1.00
R1719:St7l UTSW 3 104,870,987 (GRCm38) missense probably benign 0.00
R1800:St7l UTSW 3 104,919,496 (GRCm38) missense probably damaging 1.00
R1882:St7l UTSW 3 104,868,047 (GRCm38) missense probably damaging 1.00
R3692:St7l UTSW 3 104,891,554 (GRCm38) missense probably benign 0.27
R3879:St7l UTSW 3 104,926,447 (GRCm38) missense probably damaging 1.00
R5130:St7l UTSW 3 104,895,764 (GRCm38) missense probably damaging 1.00
R5271:St7l UTSW 3 104,868,060 (GRCm38) missense probably damaging 1.00
R5887:St7l UTSW 3 104,874,928 (GRCm38) missense probably benign 0.06
R6191:St7l UTSW 3 104,868,033 (GRCm38) missense probably damaging 1.00
R6252:St7l UTSW 3 104,919,503 (GRCm38) critical splice donor site probably null
R7442:St7l UTSW 3 104,889,329 (GRCm38) missense possibly damaging 0.93
R7860:St7l UTSW 3 104,926,577 (GRCm38) missense probably benign 0.05
R8523:St7l UTSW 3 104,868,057 (GRCm38) missense probably damaging 1.00
R8934:St7l UTSW 3 104,889,318 (GRCm38) missense probably damaging 1.00
R8935:St7l UTSW 3 104,870,888 (GRCm38) missense probably damaging 1.00
Z1177:St7l UTSW 3 104,865,309 (GRCm38) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ACTGGTGAGTTGACATACTGAGTG -3'
(R):5'- GGACCATCCTCACCTACATG -3'

Sequencing Primer
(F):5'- TCTCAAAGATGGAAAGTATAGGTAGG -3'
(R):5'- CCTACATGGCAAATCGGAGGTTAAC -3'
Posted On 2019-06-26