Incidental Mutation 'R8171:Alpk2'
| ID |
634166 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Alpk2
|
| Ensembl Gene |
ENSMUSG00000032845 |
| Gene Name |
alpha-kinase 2 |
| Synonyms |
Hak |
| MMRRC Submission |
067597-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8171 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
65398600-65526959 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 65439054 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 780
(S780P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114658
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035548]
[ENSMUST00000141250]
|
| AlphaFold |
Q91ZB0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035548
AA Change: S1247P
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000048752
Gene: ENSMUSG00000032845
AA Change: S1247P
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
24 |
94 |
9.34e-4 |
SMART |
|
low complexity region
|
196 |
209 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1353 |
N/A |
INTRINSIC |
|
IG
|
1766 |
1849 |
2.27e-2 |
SMART |
|
Alpha_kinase
|
1879 |
2098 |
3.72e-79 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141250
AA Change: S780P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000114658
Gene: ENSMUSG00000032845
AA Change: S780P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
255 |
267 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
570 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
886 |
N/A |
INTRINSIC |
|
IG
|
1299 |
1382 |
2.27e-2 |
SMART |
|
Alpha_kinase
|
1412 |
1603 |
2.45e-56 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(1) : Targeted, knock-out(1) |
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
G |
T |
14: 32,383,982 (GRCm39) |
A661E |
probably benign |
Het |
| Abhd14a |
T |
A |
9: 106,317,960 (GRCm39) |
T142S |
probably benign |
Het |
| Actn1 |
A |
G |
12: 80,243,167 (GRCm39) |
|
probably null |
Het |
| Adss2 |
T |
C |
1: 177,623,917 (GRCm39) |
N15S |
probably benign |
Het |
| Asap1 |
G |
T |
15: 63,982,815 (GRCm39) |
L830M |
probably damaging |
Het |
| Atic |
T |
C |
1: 71,609,032 (GRCm39) |
V319A |
possibly damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,283,493 (GRCm39) |
I87N |
probably damaging |
Het |
| Bace2 |
G |
T |
16: 97,225,786 (GRCm39) |
V407L |
possibly damaging |
Het |
| Bltp1 |
T |
C |
3: 37,029,862 (GRCm39) |
V2423A |
probably benign |
Het |
| Bmp3 |
A |
T |
5: 99,020,528 (GRCm39) |
Y317F |
probably damaging |
Het |
| Ccdc159 |
A |
G |
9: 21,845,007 (GRCm39) |
E291G |
possibly damaging |
Het |
| Cct8l1 |
T |
A |
5: 25,721,552 (GRCm39) |
L89Q |
probably damaging |
Het |
| Cep83 |
T |
A |
10: 94,604,797 (GRCm39) |
N503K |
possibly damaging |
Het |
| Ces4a |
A |
G |
8: 105,873,839 (GRCm39) |
Y436C |
probably damaging |
Het |
| Cftr |
T |
A |
6: 18,258,287 (GRCm39) |
D579E |
probably damaging |
Het |
| Chd9 |
T |
A |
8: 91,752,015 (GRCm39) |
V1751D |
possibly damaging |
Het |
| Clasp2 |
A |
T |
9: 113,732,974 (GRCm39) |
T937S |
possibly damaging |
Het |
| Clock |
T |
A |
5: 76,414,261 (GRCm39) |
D17V |
possibly damaging |
Het |
| Cpm |
T |
C |
10: 117,519,220 (GRCm39) |
L376P |
probably damaging |
Het |
| Crocc2 |
T |
C |
1: 93,116,723 (GRCm39) |
|
probably null |
Het |
| Csnk1g2 |
A |
G |
10: 80,475,636 (GRCm39) |
D401G |
probably damaging |
Het |
| Cyb5r4 |
C |
T |
9: 86,924,863 (GRCm39) |
L206F |
possibly damaging |
Het |
| Cyp1a1 |
T |
A |
9: 57,607,479 (GRCm39) |
W36R |
probably benign |
Het |
| Cyp3a59 |
A |
T |
5: 146,022,584 (GRCm39) |
H30L |
probably damaging |
Het |
| Dab2 |
G |
A |
15: 6,453,407 (GRCm39) |
V182I |
probably benign |
Het |
| Dnah1 |
G |
T |
14: 31,019,067 (GRCm39) |
F1342L |
probably damaging |
Het |
| Draxin |
A |
T |
4: 148,200,123 (GRCm39) |
L109Q |
possibly damaging |
Het |
| Elfn1 |
G |
A |
5: 139,957,112 (GRCm39) |
V39M |
probably damaging |
Het |
| Erlin1 |
A |
G |
19: 44,057,768 (GRCm39) |
I19T |
probably benign |
Het |
| F830016B08Rik |
T |
A |
18: 60,433,150 (GRCm39) |
S78T |
possibly damaging |
Het |
| Fer1l4 |
A |
G |
2: 155,890,151 (GRCm39) |
V258A |
probably benign |
Het |
| Fgb |
T |
C |
3: 82,949,822 (GRCm39) |
D445G |
probably damaging |
Het |
| Fgd6 |
T |
C |
10: 93,910,194 (GRCm39) |
|
probably null |
Het |
| Frem3 |
T |
A |
8: 81,341,869 (GRCm39) |
D1387E |
probably damaging |
Het |
| Gdf3 |
T |
C |
6: 122,586,862 (GRCm39) |
T22A |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,593,167 (GRCm39) |
A511V |
probably benign |
Het |
| Gldc |
A |
T |
19: 30,111,161 (GRCm39) |
N538K |
probably benign |
Het |
| Glipr1l1 |
C |
T |
10: 111,914,289 (GRCm39) |
P217S |
probably benign |
Het |
| Gpr161 |
A |
G |
1: 165,134,005 (GRCm39) |
N89S |
probably damaging |
Het |
| Gypa |
T |
A |
8: 81,236,092 (GRCm39) |
S166T |
probably benign |
Het |
| Hcar1 |
A |
G |
5: 124,017,152 (GRCm39) |
S180P |
probably damaging |
Het |
| Hcn1 |
T |
C |
13: 117,739,270 (GRCm39) |
S11P |
unknown |
Het |
| Hectd4 |
A |
G |
5: 121,456,819 (GRCm39) |
E728G |
possibly damaging |
Het |
| Ints14 |
A |
T |
9: 64,880,532 (GRCm39) |
H213L |
possibly damaging |
Het |
| Itih1 |
A |
T |
14: 30,659,047 (GRCm39) |
M323K |
possibly damaging |
Het |
| Ivl |
A |
G |
3: 92,479,085 (GRCm39) |
S327P |
probably damaging |
Het |
| Kcnt2 |
T |
A |
1: 140,437,203 (GRCm39) |
N545K |
probably benign |
Het |
| Kdm4b |
A |
T |
17: 56,696,534 (GRCm39) |
R417W |
probably damaging |
Het |
| Kif13a |
T |
C |
13: 46,932,444 (GRCm39) |
E1083G |
probably damaging |
Het |
| Klhl40 |
A |
T |
9: 121,607,623 (GRCm39) |
H261L |
probably benign |
Het |
| Kpnb1 |
A |
G |
11: 97,066,573 (GRCm39) |
|
probably null |
Het |
| Lamc3 |
C |
A |
2: 31,804,983 (GRCm39) |
T621N |
probably benign |
Het |
| Lingo3 |
T |
C |
10: 80,670,595 (GRCm39) |
H445R |
probably benign |
Het |
| Ly75 |
G |
A |
2: 60,144,572 (GRCm39) |
T1297I |
possibly damaging |
Het |
| Lypd6 |
C |
T |
2: 50,080,759 (GRCm39) |
T149M |
possibly damaging |
Het |
| Mcrs1 |
A |
T |
15: 99,146,613 (GRCm39) |
D139E |
probably damaging |
Het |
| Muc5b |
G |
A |
7: 141,414,737 (GRCm39) |
S2561N |
unknown |
Het |
| Mybpc1 |
C |
T |
10: 88,358,865 (GRCm39) |
G1095R |
probably damaging |
Het |
| Myh1 |
A |
G |
11: 67,093,398 (GRCm39) |
Y163C |
probably damaging |
Het |
| Notch4 |
T |
A |
17: 34,801,483 (GRCm39) |
C1110* |
probably null |
Het |
| Nt5el |
T |
A |
13: 105,246,291 (GRCm39) |
V284E |
probably benign |
Het |
| Or12j2 |
A |
T |
7: 139,916,143 (GRCm39) |
I123F |
probably damaging |
Het |
| Or2ag1 |
C |
T |
7: 106,313,825 (GRCm39) |
S21N |
probably benign |
Het |
| Or2ag1 |
T |
A |
7: 106,313,826 (GRCm39) |
S21C |
|
Het |
| Or4c10b |
A |
G |
2: 89,711,409 (GRCm39) |
I80V |
probably benign |
Het |
| Pcsk1 |
T |
A |
13: 75,238,210 (GRCm39) |
C10* |
probably null |
Het |
| Pdlim5 |
A |
T |
3: 142,017,948 (GRCm39) |
S107T |
probably benign |
Het |
| Plac8l1 |
T |
A |
18: 42,313,445 (GRCm39) |
D99V |
probably damaging |
Het |
| Plin2 |
A |
T |
4: 86,575,349 (GRCm39) |
V400E |
probably damaging |
Het |
| Plxna1 |
G |
A |
6: 89,334,102 (GRCm39) |
P176S |
probably benign |
Het |
| Pnn |
A |
G |
12: 59,117,223 (GRCm39) |
K238R |
probably damaging |
Het |
| Pou5f1 |
A |
G |
17: 35,820,933 (GRCm39) |
E231G |
probably benign |
Het |
| Ppara |
A |
T |
15: 85,682,077 (GRCm39) |
M258L |
probably benign |
Het |
| Prune2 |
G |
A |
19: 17,097,882 (GRCm39) |
D1129N |
probably damaging |
Het |
| Rai14 |
G |
A |
15: 10,633,249 (GRCm39) |
T47M |
probably damaging |
Het |
| Rdh5 |
T |
C |
10: 128,753,969 (GRCm39) |
I117V |
probably benign |
Het |
| Rpain |
G |
A |
11: 70,864,724 (GRCm39) |
C137Y |
probably damaging |
Het |
| Scn3a |
A |
G |
2: 65,361,154 (GRCm39) |
V126A |
possibly damaging |
Het |
| Senp7 |
G |
T |
16: 55,932,089 (GRCm39) |
L129F |
probably damaging |
Het |
| Setd1a |
A |
G |
7: 127,390,399 (GRCm39) |
D1025G |
unknown |
Het |
| Sirt4 |
A |
T |
5: 115,621,082 (GRCm39) |
V30E |
probably damaging |
Het |
| Slit1 |
C |
A |
19: 41,715,512 (GRCm39) |
R113L |
probably damaging |
Het |
| Stxbp5l |
G |
A |
16: 37,028,416 (GRCm39) |
T549I |
noncoding transcript |
Het |
| Sytl2 |
A |
G |
7: 90,058,678 (GRCm39) |
M926V |
probably damaging |
Het |
| Tgfbr2 |
C |
T |
9: 115,959,074 (GRCm39) |
W113* |
probably null |
Het |
| Tmem86a |
A |
G |
7: 46,703,512 (GRCm39) |
Y213C |
probably damaging |
Het |
| Tpo |
T |
A |
12: 30,154,045 (GRCm39) |
Y220F |
probably damaging |
Het |
| Ttc6 |
C |
A |
12: 57,720,096 (GRCm39) |
A889E |
probably damaging |
Het |
| Tyw1 |
A |
G |
5: 130,328,855 (GRCm39) |
D547G |
probably benign |
Het |
| Ubtfl1 |
A |
G |
9: 18,320,523 (GRCm39) |
K17R |
probably benign |
Het |
| Usp46 |
T |
A |
5: 74,163,354 (GRCm39) |
I331F |
probably benign |
Het |
| Vmn2r111 |
T |
C |
17: 22,792,073 (GRCm39) |
H61R |
probably benign |
Het |
| Wdr75 |
T |
A |
1: 45,861,706 (GRCm39) |
N715K |
probably benign |
Het |
| Wdr97 |
C |
A |
15: 76,247,819 (GRCm39) |
F1614L |
|
Het |
| Zfp772 |
A |
T |
7: 7,207,096 (GRCm39) |
C198* |
probably null |
Het |
|
| Other mutations in Alpk2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Alpk2
|
APN |
18 |
65,438,894 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL00478:Alpk2
|
APN |
18 |
65,440,297 (GRCm39) |
nonsense |
probably null |
|
|
IGL00898:Alpk2
|
APN |
18 |
65,483,644 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL00978:Alpk2
|
APN |
18 |
65,424,605 (GRCm39) |
splice site |
probably benign |
|
|
IGL01093:Alpk2
|
APN |
18 |
65,482,400 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01094:Alpk2
|
APN |
18 |
65,439,673 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01109:Alpk2
|
APN |
18 |
65,440,211 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01370:Alpk2
|
APN |
18 |
65,483,662 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01393:Alpk2
|
APN |
18 |
65,440,779 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01629:Alpk2
|
APN |
18 |
65,433,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Alpk2
|
APN |
18 |
65,437,824 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01983:Alpk2
|
APN |
18 |
65,483,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Alpk2
|
APN |
18 |
65,439,146 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
IGL02333:Alpk2
|
APN |
18 |
65,482,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02493:Alpk2
|
APN |
18 |
65,483,402 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02551:Alpk2
|
APN |
18 |
65,505,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02864:Alpk2
|
APN |
18 |
65,440,670 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02901:Alpk2
|
APN |
18 |
65,439,482 (GRCm39) |
missense |
probably benign |
|
|
IGL02954:Alpk2
|
APN |
18 |
65,439,207 (GRCm39) |
missense |
probably benign |
|
|
IGL03257:Alpk2
|
APN |
18 |
65,482,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03389:Alpk2
|
APN |
18 |
65,437,937 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
3-1:Alpk2
|
UTSW |
18 |
65,437,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4131001:Alpk2
|
UTSW |
18 |
65,439,450 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0098:Alpk2
|
UTSW |
18 |
65,482,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Alpk2
|
UTSW |
18 |
65,482,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0414:Alpk2
|
UTSW |
18 |
65,439,230 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0546:Alpk2
|
UTSW |
18 |
65,439,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0628:Alpk2
|
UTSW |
18 |
65,440,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0658:Alpk2
|
UTSW |
18 |
65,482,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0731:Alpk2
|
UTSW |
18 |
65,438,461 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0919:Alpk2
|
UTSW |
18 |
65,440,544 (GRCm39) |
missense |
probably benign |
|
|
R1069:Alpk2
|
UTSW |
18 |
65,438,085 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1186:Alpk2
|
UTSW |
18 |
65,427,412 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1508:Alpk2
|
UTSW |
18 |
65,482,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1535:Alpk2
|
UTSW |
18 |
65,483,275 (GRCm39) |
missense |
probably benign |
|
|
R1558:Alpk2
|
UTSW |
18 |
65,483,301 (GRCm39) |
missense |
probably benign |
|
|
R1600:Alpk2
|
UTSW |
18 |
65,511,108 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1664:Alpk2
|
UTSW |
18 |
65,482,944 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1672:Alpk2
|
UTSW |
18 |
65,414,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Alpk2
|
UTSW |
18 |
65,427,165 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2110:Alpk2
|
UTSW |
18 |
65,440,151 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2111:Alpk2
|
UTSW |
18 |
65,482,845 (GRCm39) |
missense |
probably benign |
|
|
R2113:Alpk2
|
UTSW |
18 |
65,438,754 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2126:Alpk2
|
UTSW |
18 |
65,483,439 (GRCm39) |
nonsense |
probably null |
|
|
R2198:Alpk2
|
UTSW |
18 |
65,483,255 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2227:Alpk2
|
UTSW |
18 |
65,511,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2245:Alpk2
|
UTSW |
18 |
65,438,234 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2282:Alpk2
|
UTSW |
18 |
65,440,697 (GRCm39) |
missense |
probably benign |
|
|
R2421:Alpk2
|
UTSW |
18 |
65,439,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2512:Alpk2
|
UTSW |
18 |
65,483,591 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3105:Alpk2
|
UTSW |
18 |
65,483,281 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3700:Alpk2
|
UTSW |
18 |
65,438,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4205:Alpk2
|
UTSW |
18 |
65,438,282 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4239:Alpk2
|
UTSW |
18 |
65,433,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4353:Alpk2
|
UTSW |
18 |
65,424,523 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4572:Alpk2
|
UTSW |
18 |
65,414,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Alpk2
|
UTSW |
18 |
65,440,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4591:Alpk2
|
UTSW |
18 |
65,438,894 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4595:Alpk2
|
UTSW |
18 |
65,422,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4648:Alpk2
|
UTSW |
18 |
65,482,953 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4815:Alpk2
|
UTSW |
18 |
65,483,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4828:Alpk2
|
UTSW |
18 |
65,482,184 (GRCm39) |
missense |
probably benign |
|
|
R4910:Alpk2
|
UTSW |
18 |
65,399,357 (GRCm39) |
nonsense |
probably null |
|
|
R5042:Alpk2
|
UTSW |
18 |
65,483,579 (GRCm39) |
nonsense |
probably null |
|
|
R5295:Alpk2
|
UTSW |
18 |
65,438,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5375:Alpk2
|
UTSW |
18 |
65,505,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5475:Alpk2
|
UTSW |
18 |
65,440,083 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5480:Alpk2
|
UTSW |
18 |
65,482,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Alpk2
|
UTSW |
18 |
65,427,425 (GRCm39) |
splice site |
probably null |
|
|
R5503:Alpk2
|
UTSW |
18 |
65,439,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5595:Alpk2
|
UTSW |
18 |
65,399,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5648:Alpk2
|
UTSW |
18 |
65,482,988 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5714:Alpk2
|
UTSW |
18 |
65,438,532 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5862:Alpk2
|
UTSW |
18 |
65,440,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5894:Alpk2
|
UTSW |
18 |
65,414,143 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Alpk2
|
UTSW |
18 |
65,440,694 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5936:Alpk2
|
UTSW |
18 |
65,483,591 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6142:Alpk2
|
UTSW |
18 |
65,438,456 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6291:Alpk2
|
UTSW |
18 |
65,438,972 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6339:Alpk2
|
UTSW |
18 |
65,482,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6407:Alpk2
|
UTSW |
18 |
65,422,809 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6487:Alpk2
|
UTSW |
18 |
65,399,254 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6667:Alpk2
|
UTSW |
18 |
65,440,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6786:Alpk2
|
UTSW |
18 |
65,439,705 (GRCm39) |
missense |
probably benign |
|
|
R6833:Alpk2
|
UTSW |
18 |
65,439,480 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6984:Alpk2
|
UTSW |
18 |
65,438,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6999:Alpk2
|
UTSW |
18 |
65,437,584 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7157:Alpk2
|
UTSW |
18 |
65,399,348 (GRCm39) |
nonsense |
probably null |
|
|
R7167:Alpk2
|
UTSW |
18 |
65,440,049 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7225:Alpk2
|
UTSW |
18 |
65,438,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7409:Alpk2
|
UTSW |
18 |
65,440,023 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7533:Alpk2
|
UTSW |
18 |
65,437,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7576:Alpk2
|
UTSW |
18 |
65,439,887 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7589:Alpk2
|
UTSW |
18 |
65,433,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7598:Alpk2
|
UTSW |
18 |
65,437,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Alpk2
|
UTSW |
18 |
65,440,073 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7711:Alpk2
|
UTSW |
18 |
65,439,555 (GRCm39) |
missense |
probably benign |
|
|
R7722:Alpk2
|
UTSW |
18 |
65,483,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7783:Alpk2
|
UTSW |
18 |
65,439,325 (GRCm39) |
nonsense |
probably null |
|
|
R7806:Alpk2
|
UTSW |
18 |
65,482,487 (GRCm39) |
missense |
probably benign |
|
|
R7953:Alpk2
|
UTSW |
18 |
65,482,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Alpk2
|
UTSW |
18 |
65,438,106 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8043:Alpk2
|
UTSW |
18 |
65,482,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Alpk2
|
UTSW |
18 |
65,483,417 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8280:Alpk2
|
UTSW |
18 |
65,440,274 (GRCm39) |
missense |
probably benign |
|
|
R8383:Alpk2
|
UTSW |
18 |
65,438,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8414:Alpk2
|
UTSW |
18 |
65,440,542 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8791:Alpk2
|
UTSW |
18 |
65,438,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8872:Alpk2
|
UTSW |
18 |
65,413,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9352:Alpk2
|
UTSW |
18 |
65,439,783 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9449:Alpk2
|
UTSW |
18 |
65,424,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Alpk2
|
UTSW |
18 |
65,399,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Alpk2
|
UTSW |
18 |
65,439,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9710:Alpk2
|
UTSW |
18 |
65,482,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Alpk2
|
UTSW |
18 |
65,424,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Alpk2
|
UTSW |
18 |
65,440,542 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
X0063:Alpk2
|
UTSW |
18 |
65,440,434 (GRCm39) |
missense |
probably benign |
|
|
X0064:Alpk2
|
UTSW |
18 |
65,482,755 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1176:Alpk2
|
UTSW |
18 |
65,438,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTGGGAAGACAGACAATTGC -3'
(R):5'- CTGTGGGAGAAGACAGTCATTTG -3'
Sequencing Primer
(F):5'- GACAGACAATTGCAGTTTGCTTG -3'
(R):5'- ACAGTCATTTGGTAGTCAGTGTCCC -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation