Incidental Mutation 'R8024:Prl6a1'
ID 643777
Institutional Source Beutler Lab
Gene Symbol Prl6a1
Ensembl Gene ENSMUSG00000069259
Gene Name prolactin family 6, subfamily a, member 1
Synonyms PLP-B, Prlpb
MMRRC Submission 067463-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R8024 (G1)
Quality Score 89.0077
Status Validated
Chromosome 13
Chromosomal Location 27496610-27503235 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 27502678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000089269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091679] [ENSMUST00000091680]
AlphaFold O35257
Predicted Effect probably benign
Transcript: ENSMUST00000091679
SMART Domains Protein: ENSMUSP00000089268
Gene: ENSMUSG00000069259

DomainStartEndE-ValueType
low complexity region 4 15 N/A INTRINSIC
Pfam:Hormone_1 21 235 8e-65 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091680
SMART Domains Protein: ENSMUSP00000089269
Gene: ENSMUSG00000069259

DomainStartEndE-ValueType
Pfam:Hormone_1 16 230 1.1e-61 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,760,713 (GRCm39) N1257Y probably benign Het
2310057J18Rik A T 10: 28,858,591 (GRCm39) Y133* probably null Het
2310057J18Rik A C 10: 28,862,213 (GRCm39) S26A possibly damaging Het
9930012K11Rik G T 14: 70,394,116 (GRCm39) P220T probably damaging Het
Adam1b A C 5: 121,638,986 (GRCm39) S686R probably benign Het
Adam8 T C 7: 139,567,489 (GRCm39) D418G probably damaging Het
Adcy8 A G 15: 64,792,095 (GRCm39) L287P probably damaging Het
Adhfe1 T A 1: 9,634,080 (GRCm39) M373K probably benign Het
Alpk2 T C 18: 65,438,106 (GRCm39) S1096G probably benign Het
Ankmy1 A G 1: 92,812,716 (GRCm39) V531A probably benign Het
Ano3 C T 2: 110,498,128 (GRCm39) E738K probably damaging Het
Ano4 T A 10: 88,807,194 (GRCm39) I796F probably damaging Het
Apeh T C 9: 107,969,790 (GRCm39) E190G probably benign Het
Atpsckmt T C 15: 31,608,317 (GRCm39) Y123H probably damaging Het
Cadm3 A G 1: 173,165,622 (GRCm39) L346P probably damaging Het
Ccdc9b A G 2: 118,591,005 (GRCm39) probably null Het
Clec2e G A 6: 129,071,388 (GRCm39) H150Y possibly damaging Het
Cnga4 A T 7: 105,056,042 (GRCm39) N318Y probably damaging Het
Cnr2 T A 4: 135,644,196 (GRCm39) F91L probably damaging Het
Diaph3 T A 14: 86,893,835 (GRCm39) E1147V probably damaging Het
Elmo2 T C 2: 165,133,775 (GRCm39) T738A unknown Het
Exoc4 T A 6: 33,324,866 (GRCm39) W387R probably damaging Het
Focad T C 4: 88,315,237 (GRCm39) V1379A unknown Het
Frmd4a T C 2: 4,608,513 (GRCm39) S794P probably damaging Het
Ftl1-ps1 A G 13: 74,555,170 (GRCm39) T150A probably benign Het
Gm43517 A T 12: 49,436,409 (GRCm39) probably benign Het
Gm5773 C T 3: 93,680,475 (GRCm39) A49V probably benign Het
Helz T A 11: 107,577,247 (GRCm39) L1867Q unknown Het
Il22ra1 A G 4: 135,461,589 (GRCm39) H118R probably benign Het
Inf2 C T 12: 112,575,336 (GRCm39) P856S unknown Het
Ints5 T A 19: 8,873,504 (GRCm39) L488I probably damaging Het
Iqca1l A G 5: 24,755,634 (GRCm39) M296T possibly damaging Het
Kifc1 G A 17: 34,102,177 (GRCm39) R479C probably damaging Het
Lrba T A 3: 86,202,708 (GRCm39) C289* probably null Het
Mael A G 1: 166,054,196 (GRCm39) L196S probably damaging Het
Med23 T A 10: 24,755,581 (GRCm39) S229R possibly damaging Het
Mroh9 T C 1: 162,866,802 (GRCm39) N645D probably benign Het
Myom3 G A 4: 135,529,059 (GRCm39) V1132I probably benign Het
Naalad2 T G 9: 18,308,769 (GRCm39) probably benign Het
Ndufa13 A T 8: 70,347,187 (GRCm39) L71H probably damaging Het
Nepro A T 16: 44,551,778 (GRCm39) H212L probably benign Het
Nmd3 T A 3: 69,637,298 (GRCm39) probably benign Het
Nox4 T A 7: 86,954,118 (GRCm39) L141Q probably damaging Het
Or4a81 T C 2: 89,619,390 (GRCm39) E102G probably benign Het
Or5p53 T C 7: 107,533,645 (GRCm39) V306A probably benign Het
Or5p58 T A 7: 107,694,496 (GRCm39) T94S probably benign Het
Or6c215 T G 10: 129,637,812 (GRCm39) E194A probably damaging Het
Or8s2 T A 15: 98,276,878 (GRCm39) M38L probably benign Het
Pfpl A G 19: 12,407,570 (GRCm39) D607G possibly damaging Het
Pkd1l2 A T 8: 117,802,921 (GRCm39) F233L possibly damaging Het
Ptprz1 A T 6: 23,042,750 (GRCm39) E2058V probably damaging Het
Rag1 A T 2: 101,472,852 (GRCm39) N763K probably damaging Het
Rhbg A C 3: 88,155,760 (GRCm39) D63E probably damaging Het
Rrm1 T A 7: 102,106,472 (GRCm39) F330L probably benign Het
Scaf8 A T 17: 3,209,568 (GRCm39) Q97L unknown Het
Sdr9c7 G A 10: 127,734,751 (GRCm39) V80I probably benign Het
Slc18a1 A G 8: 69,527,799 (GRCm39) V4A probably benign Het
Slco3a1 T A 7: 74,204,218 (GRCm39) I41F probably benign Het
Slirp T C 12: 87,494,370 (GRCm39) V45A probably damaging Het
Spata31 A T 13: 65,070,618 (GRCm39) Q922L probably benign Het
Spg11 A G 2: 121,927,802 (GRCm39) S661P possibly damaging Het
Stab2 G T 10: 86,681,916 (GRCm39) T2495K probably benign Het
Supt16 A G 14: 52,408,332 (GRCm39) I871T probably damaging Het
Sval2 A G 6: 41,837,298 (GRCm39) Q9R probably damaging Het
Syngap1 A T 17: 27,160,426 (GRCm39) M1L probably benign Het
Tfpi A T 2: 84,284,266 (GRCm39) M62K possibly damaging Het
Tm4sf1 A T 3: 57,195,186 (GRCm39) Y200* probably null Het
Tmc1 A T 19: 20,878,181 (GRCm39) W105R probably damaging Het
Tmtc2 T C 10: 105,025,987 (GRCm39) E827G probably benign Het
Tollip T C 7: 141,446,563 (GRCm39) I33V probably benign Het
Unc80 T A 1: 66,645,803 (GRCm39) V1493D possibly damaging Het
Vmn2r6 G A 3: 64,467,245 (GRCm39) R85W probably benign Het
Vwa5a C A 9: 38,647,316 (GRCm39) S565* probably null Het
Xbp1 T A 11: 5,471,910 (GRCm39) V12D probably benign Het
Other mutations in Prl6a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01124:Prl6a1 APN 13 27,500,347 (GRCm39) missense possibly damaging 0.72
IGL01688:Prl6a1 APN 13 27,501,969 (GRCm39) missense probably damaging 1.00
IGL01922:Prl6a1 APN 13 27,499,343 (GRCm39) missense possibly damaging 0.57
IGL02059:Prl6a1 APN 13 27,499,348 (GRCm39) missense probably benign 0.02
IGL03170:Prl6a1 APN 13 27,499,406 (GRCm39) missense possibly damaging 0.95
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0049:Prl6a1 UTSW 13 27,501,980 (GRCm39) missense probably damaging 0.99
R0606:Prl6a1 UTSW 13 27,498,177 (GRCm39) intron probably benign
R0944:Prl6a1 UTSW 13 27,502,149 (GRCm39) splice site probably benign
R1518:Prl6a1 UTSW 13 27,502,911 (GRCm39) missense probably null 0.19
R1518:Prl6a1 UTSW 13 27,502,910 (GRCm39) missense possibly damaging 0.72
R1566:Prl6a1 UTSW 13 27,499,410 (GRCm39) missense possibly damaging 0.84
R1621:Prl6a1 UTSW 13 27,501,993 (GRCm39) missense probably benign 0.01
R2011:Prl6a1 UTSW 13 27,499,352 (GRCm39) missense probably benign 0.00
R2058:Prl6a1 UTSW 13 27,503,081 (GRCm39) missense probably benign 0.05
R2937:Prl6a1 UTSW 13 27,499,303 (GRCm39) missense probably damaging 0.98
R3079:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense possibly damaging 0.71
R4685:Prl6a1 UTSW 13 27,500,307 (GRCm39) missense probably benign 0.00
R4856:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R4886:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R5495:Prl6a1 UTSW 13 27,496,654 (GRCm39) missense possibly damaging 0.95
R5923:Prl6a1 UTSW 13 27,500,346 (GRCm39) missense probably benign 0.08
R6772:Prl6a1 UTSW 13 27,503,031 (GRCm39) missense probably damaging 1.00
R7411:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R7501:Prl6a1 UTSW 13 27,500,282 (GRCm39) missense possibly damaging 0.69
R7549:Prl6a1 UTSW 13 27,502,954 (GRCm39) missense probably damaging 0.96
R7563:Prl6a1 UTSW 13 27,498,221 (GRCm39) critical splice donor site probably null
R7773:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R8994:Prl6a1 UTSW 13 27,499,417 (GRCm39) missense probably benign 0.01
R9129:Prl6a1 UTSW 13 27,502,064 (GRCm39) missense
R9395:Prl6a1 UTSW 13 27,499,400 (GRCm39) missense possibly damaging 0.71
Z1177:Prl6a1 UTSW 13 27,499,304 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCTGAGGATTCCTTTCCATG -3'
(R):5'- GGGGTCCAGGCTGAATCTAATC -3'

Sequencing Primer
(F):5'- TATGGACAATAGACTTGGTTGAAAAG -3'
(R):5'- TGTCTCTATGCCAAAGTAGT -3'
Posted On 2020-08-14