Mutagenetix > Incidental Mutation

Incidental Mutation 'R0980:Vmn1r170'

96987

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r170

Ensembl Gene

ENSMUSG00000094187

Gene Name

vomeronasal 1 receptor 170

Synonyms

Gm5999

MMRRC Submission

039106-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R0980 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23305600-23306514 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23305759 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 54 (I54F)

Ref Sequence

ENSEMBL: ENSMUSP00000127655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170166]

AlphaFold

K7N6W9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170166
AA Change: I54F

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000127655
Gene: ENSMUSG00000094187
AA Change: I54F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	1.8e-13	PFAM
Pfam:7tm_1	30	287	3.6e-6	PFAM
Pfam:V1R	42	295	1.4e-20	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.1%
20x: 89.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankdd1a	T	C	9: 65,424,253 (GRCm39)	H20R	probably damaging	Het
Arfgef3	T	C	10: 18,467,866 (GRCm39)	E1778G	possibly damaging	Het
Arhgef18	C	T	8: 3,439,095 (GRCm39)		probably benign	Het
Blm	A	T	7: 80,149,706 (GRCm39)		probably null	Het
Ccr6	A	G	17: 8,474,846 (GRCm39)	E17G	probably benign	Het
Cep126	T	C	9: 8,100,720 (GRCm39)	T605A	probably damaging	Het
Cnga4	C	A	7: 105,057,213 (GRCm39)	P439T	probably damaging	Het
Col11a1	G	A	3: 113,932,414 (GRCm39)	R113H	unknown	Het
Cyp2a5	A	G	7: 26,538,431 (GRCm39)		probably null	Het
D430041D05Rik	A	G	2: 104,079,690 (GRCm39)	V1131A	probably damaging	Het
Elp3	T	C	14: 65,815,402 (GRCm39)	T197A	probably damaging	Het
Etl4	A	G	2: 20,806,378 (GRCm39)	D1200G	probably damaging	Het
Gapt	G	C	13: 110,490,273 (GRCm39)	T130R	probably damaging	Het
Gprin1	T	C	13: 54,888,214 (GRCm39)	D20G	possibly damaging	Het
Hltf	T	C	3: 20,145,665 (GRCm39)	S432P	probably benign	Het
Immt	T	C	6: 71,851,310 (GRCm39)	V54A	probably benign	Het
Jhy	T	G	9: 40,856,133 (GRCm39)	Y118S	possibly damaging	Het
Kif23	C	A	9: 61,844,046 (GRCm39)	K154N	possibly damaging	Het
Krt79	T	C	15: 101,846,442 (GRCm39)	T169A	probably damaging	Het
Llgl2	A	G	11: 115,740,827 (GRCm39)	E443G	probably damaging	Het
Ltbp4	A	T	7: 27,023,587 (GRCm39)	C786S	probably damaging	Het
Mme	A	T	3: 63,247,550 (GRCm39)	E278D	probably benign	Het
Nt5c2	G	T	19: 46,887,317 (GRCm39)	Q162K	probably benign	Het
Obscn	A	G	11: 58,888,887 (GRCm39)	V2109A	possibly damaging	Het
Or5p64	GGTAG	GG	7: 107,855,229 (GRCm39)		probably benign	Het
Or8k28	T	C	2: 86,285,704 (GRCm39)	T304A	probably benign	Het
Or8k38	T	A	2: 86,488,209 (GRCm39)	I198L	probably benign	Het
Osmr	G	T	15: 6,881,921 (GRCm39)	N74K	probably benign	Het
Pes1	AGAGGAGGAGGAGGAGGA	AGAGGAGGAGGAGGA	11: 3,927,636 (GRCm39)		probably benign	Het
Pgd	A	T	4: 149,238,768 (GRCm39)		probably null	Het
Pld1	T	A	3: 28,178,724 (GRCm39)	S873T	probably damaging	Het
Polk	A	T	13: 96,620,272 (GRCm39)	C664S	probably benign	Het
Proca1	A	C	11: 78,095,773 (GRCm39)	H135P	probably benign	Het
Ptgs2	A	C	1: 149,980,061 (GRCm39)	D333A	probably damaging	Het
Rexo5	T	C	7: 119,423,035 (GRCm39)	V289A	probably damaging	Het
Rnf125	T	A	18: 21,112,117 (GRCm39)	C49*	probably null	Het
Rprd2	C	A	3: 95,673,216 (GRCm39)	R729L	probably damaging	Het
Sipa1l1	A	G	12: 82,388,994 (GRCm39)	S407G	possibly damaging	Het
Slc35a4	C	A	18: 36,815,834 (GRCm39)	N221K	probably damaging	Het
Sorcs1	T	C	19: 50,220,761 (GRCm39)	D563G	probably benign	Het
Stk39	G	T	2: 68,222,515 (GRCm39)	T183K	probably damaging	Het
Tc2n	T	A	12: 101,644,835 (GRCm39)	K264*	probably null	Het
Trim23	C	T	13: 104,324,635 (GRCm39)	R238W	probably damaging	Het
Trim66	C	A	7: 109,054,877 (GRCm39)	V1240L	probably damaging	Het
Ttn	T	C	2: 76,584,389 (GRCm39)	T13913A	probably damaging	Het
Ubap1	T	G	4: 41,379,832 (GRCm39)	C349G	probably damaging	Het

Other mutations in Vmn1r170

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02005:Vmn1r170	APN	7	23,306,338 (GRCm39)	missense	probably damaging	1.00
IGL02150:Vmn1r170	APN	7	23,306,465 (GRCm39)	nonsense	probably null
IGL02216:Vmn1r170	APN	7	23,305,915 (GRCm39)	missense	probably damaging	1.00
IGL02749:Vmn1r170	APN	7	23,305,716 (GRCm39)	missense	probably benign	0.00
IGL02807:Vmn1r170	APN	7	23,305,760 (GRCm39)	missense	probably damaging	1.00
IGL02828:Vmn1r170	APN	7	23,305,943 (GRCm39)	missense	probably damaging	0.99
IGL02971:Vmn1r170	APN	7	23,305,759 (GRCm39)	missense	possibly damaging	0.81
IGL03073:Vmn1r170	APN	7	23,306,273 (GRCm39)	missense	probably damaging	1.00
IGL03151:Vmn1r170	APN	7	23,306,002 (GRCm39)	missense	probably benign	0.35
R0079:Vmn1r170	UTSW	7	23,305,735 (GRCm39)	missense	possibly damaging	0.95
R0266:Vmn1r170	UTSW	7	23,305,906 (GRCm39)	missense	probably benign	0.00
R1345:Vmn1r170	UTSW	7	23,305,787 (GRCm39)	missense	probably benign	0.00
R1620:Vmn1r170	UTSW	7	23,305,754 (GRCm39)	missense	probably benign	0.30
R1713:Vmn1r170	UTSW	7	23,306,288 (GRCm39)	missense	probably benign	0.30
R1745:Vmn1r170	UTSW	7	23,305,759 (GRCm39)	missense	probably damaging	0.98
R1974:Vmn1r170	UTSW	7	23,305,906 (GRCm39)	missense	probably benign	0.00
R2163:Vmn1r170	UTSW	7	23,306,462 (GRCm39)	missense	probably damaging	1.00
R3812:Vmn1r170	UTSW	7	23,305,717 (GRCm39)	missense	probably damaging	1.00
R4583:Vmn1r170	UTSW	7	23,306,087 (GRCm39)	missense	probably benign	0.25
R5309:Vmn1r170	UTSW	7	23,305,880 (GRCm39)	missense	probably damaging	0.97
R5378:Vmn1r170	UTSW	7	23,305,963 (GRCm39)	missense	probably benign	0.00
R5379:Vmn1r170	UTSW	7	23,306,054 (GRCm39)	missense	possibly damaging	0.81
R5661:Vmn1r170	UTSW	7	23,306,231 (GRCm39)	missense	possibly damaging	0.82
R5673:Vmn1r170	UTSW	7	23,305,630 (GRCm39)	missense	possibly damaging	0.58
R6181:Vmn1r170	UTSW	7	23,305,692 (GRCm39)	missense	probably damaging	0.98
R6192:Vmn1r170	UTSW	7	23,305,934 (GRCm39)	missense	probably damaging	1.00
R7467:Vmn1r170	UTSW	7	23,306,320 (GRCm39)	missense	not run
R7667:Vmn1r170	UTSW	7	23,306,473 (GRCm39)	missense	probably damaging	1.00
R8458:Vmn1r170	UTSW	7	23,306,321 (GRCm39)	missense	possibly damaging	0.90
R8699:Vmn1r170	UTSW	7	23,306,080 (GRCm39)	nonsense	probably null
R8927:Vmn1r170	UTSW	7	23,305,814 (GRCm39)	missense	possibly damaging	0.82
R8928:Vmn1r170	UTSW	7	23,305,814 (GRCm39)	missense	possibly damaging	0.82
R9269:Vmn1r170	UTSW	7	23,306,263 (GRCm39)	missense	probably benign	0.02
R9569:Vmn1r170	UTSW	7	23,306,294 (GRCm39)	missense	probably benign	0.19
X0060:Vmn1r170	UTSW	7	23,306,368 (GRCm39)	missense	possibly damaging	0.50
Z1176:Vmn1r170	UTSW	7	23,305,835 (GRCm39)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- CCATGCAGATAAAGTAGAGCTGCCC -3'
(R):5'- TGTTTGTACTTCGAGCCACCAGCC -3'

Sequencing Primer
(F):5'- ATAAAGTAGAGCTGCCCTTCGTG -3'
(R):5'- GCCAAATGAAGTACCCAAGTTTAC -3'

Posted On

2014-01-05