Incidental Mutation 'R1521:Trpm3'
| ID |
167063 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm3
|
| Ensembl Gene |
ENSMUSG00000052387 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 3 |
| Synonyms |
6330504P12Rik, LTRPC3, melastatin 2, B930001P07Rik, MLSN2 |
| MMRRC Submission |
040870-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
R1521 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
22116410-22972774 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 22878585 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 504
(E504G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097160
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037901]
[ENSMUST00000074770]
[ENSMUST00000087576]
[ENSMUST00000099564]
[ENSMUST00000099569]
|
| AlphaFold |
J9S314 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000037901
AA Change: E672G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000042184
Gene: ENSMUSG00000052387
AA Change: E672G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:ANK
|
485 |
514 |
1e-6 |
BLAST |
|
low complexity region
|
619 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
689 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
821 |
840 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
883 |
1136 |
1.7e-19 |
PFAM |
|
Pfam:TRPM_tetra
|
1227 |
1282 |
1.5e-26 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000074770
AA Change: E664G
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000074328
Gene: ENSMUSG00000052387
AA Change: E664G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
Blast:ANK
|
487 |
516 |
5e-7 |
BLAST |
|
low complexity region
|
611 |
623 |
N/A |
INTRINSIC |
|
low complexity region
|
666 |
681 |
N/A |
INTRINSIC |
|
low complexity region
|
780 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
813 |
832 |
N/A |
INTRINSIC |
|
transmembrane domain
|
874 |
896 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
908 |
1116 |
5.1e-14 |
PFAM |
|
low complexity region
|
1378 |
1388 |
N/A |
INTRINSIC |
|
low complexity region
|
1433 |
1455 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087576
AA Change: E674G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000084857
Gene: ENSMUSG00000052387
AA Change: E674G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
Blast:ANK
|
487 |
516 |
5e-7 |
BLAST |
|
low complexity region
|
621 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
676 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
790 |
802 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
842 |
N/A |
INTRINSIC |
|
transmembrane domain
|
884 |
906 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
918 |
1126 |
5.1e-14 |
PFAM |
|
low complexity region
|
1388 |
1398 |
N/A |
INTRINSIC |
|
low complexity region
|
1443 |
1465 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099564
AA Change: E504G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000097160
Gene: ENSMUSG00000052387
AA Change: E504G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
451 |
463 |
N/A |
INTRINSIC |
|
low complexity region
|
506 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
653 |
672 |
N/A |
INTRINSIC |
|
transmembrane domain
|
714 |
736 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
748 |
919 |
1.5e-13 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099569
AA Change: E662G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000097164
Gene: ENSMUSG00000052387
AA Change: E662G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
Blast:ANK
|
487 |
516 |
6e-7 |
BLAST |
|
low complexity region
|
609 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
679 |
N/A |
INTRINSIC |
|
low complexity region
|
778 |
790 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
830 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
873 |
1138 |
3.2e-19 |
PFAM |
|
Pfam:TRPM_tetra
|
1229 |
1284 |
4.4e-26 |
PFAM |
|
low complexity region
|
1388 |
1398 |
N/A |
INTRINSIC |
|
low complexity region
|
1443 |
1465 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display impaired thermal and chemical nociception. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adat1 |
A |
G |
8: 112,713,867 (GRCm39) |
L104P |
possibly damaging |
Het |
| Adgrf5 |
T |
C |
17: 43,741,443 (GRCm39) |
V360A |
probably benign |
Het |
| Ahnak |
G |
A |
19: 8,982,092 (GRCm39) |
M1125I |
probably benign |
Het |
| Akap12 |
T |
C |
10: 4,304,804 (GRCm39) |
V538A |
probably benign |
Het |
| Arhgef10l |
T |
C |
4: 140,242,749 (GRCm39) |
D1088G |
possibly damaging |
Het |
| Atp7b |
A |
T |
8: 22,517,689 (GRCm39) |
L268Q |
probably damaging |
Het |
| Atxn2 |
A |
C |
5: 121,917,654 (GRCm39) |
N516T |
probably damaging |
Het |
| Cacna1h |
T |
C |
17: 25,616,328 (GRCm39) |
M184V |
possibly damaging |
Het |
| Cacnb2 |
G |
T |
2: 14,619,163 (GRCm39) |
R66L |
probably benign |
Het |
| Casp8ap2 |
A |
G |
4: 32,631,867 (GRCm39) |
E96G |
probably damaging |
Het |
| Ccdc78 |
G |
T |
17: 26,007,755 (GRCm39) |
R264L |
probably damaging |
Het |
| Cdh4 |
G |
A |
2: 179,439,351 (GRCm39) |
R166H |
probably damaging |
Het |
| Cog7 |
C |
T |
7: 121,529,797 (GRCm39) |
D615N |
possibly damaging |
Het |
| Crtc2 |
T |
C |
3: 90,164,690 (GRCm39) |
V115A |
probably benign |
Het |
| Crybg1 |
A |
G |
10: 43,874,412 (GRCm39) |
S899P |
probably damaging |
Het |
| Ctdnep1 |
T |
A |
11: 69,879,461 (GRCm39) |
V128E |
probably damaging |
Het |
| Ctnna3 |
A |
G |
10: 64,795,621 (GRCm39) |
K780E |
probably benign |
Het |
| Cul7 |
T |
A |
17: 46,974,116 (GRCm39) |
L1467H |
probably damaging |
Het |
| Dazap2 |
T |
A |
15: 100,515,946 (GRCm39) |
Y91* |
probably null |
Het |
| Dcdc5 |
T |
C |
2: 106,182,014 (GRCm39) |
|
noncoding transcript |
Het |
| Dppa1 |
T |
A |
11: 46,501,300 (GRCm39) |
R74S |
possibly damaging |
Het |
| Elovl1 |
A |
T |
4: 118,289,197 (GRCm39) |
T241S |
probably benign |
Het |
| Eya1 |
G |
T |
1: 14,344,774 (GRCm39) |
Q86K |
probably damaging |
Het |
| Fam110d |
T |
C |
4: 133,978,661 (GRCm39) |
*272W |
probably null |
Het |
| Fancm |
A |
T |
12: 65,168,478 (GRCm39) |
M1614L |
probably benign |
Het |
| Fcgbp |
C |
T |
7: 27,774,585 (GRCm39) |
T53I |
probably benign |
Het |
| Fpr3 |
T |
A |
17: 18,191,277 (GRCm39) |
W183R |
probably damaging |
Het |
| Galnt13 |
G |
A |
2: 54,744,657 (GRCm39) |
V119I |
probably benign |
Het |
| Garin4 |
T |
A |
1: 190,896,219 (GRCm39) |
R141S |
probably benign |
Het |
| Gcfc2 |
T |
C |
6: 81,900,793 (GRCm39) |
S36P |
probably benign |
Het |
| Gdap2 |
T |
A |
3: 100,101,931 (GRCm39) |
D412E |
possibly damaging |
Het |
| Gm12258 |
T |
C |
11: 58,750,381 (GRCm39) |
C41R |
probably damaging |
Het |
| Hipk1 |
T |
G |
3: 103,685,098 (GRCm39) |
E172D |
probably benign |
Het |
| Hmgcs1 |
T |
G |
13: 120,165,127 (GRCm39) |
L326R |
probably benign |
Het |
| Hs6st1 |
C |
A |
1: 36,107,967 (GRCm39) |
R77S |
probably damaging |
Het |
| Ifit3 |
A |
T |
19: 34,564,573 (GRCm39) |
N40Y |
probably damaging |
Het |
| Il1a |
T |
A |
2: 129,146,661 (GRCm39) |
Q144L |
possibly damaging |
Het |
| Itga7 |
A |
G |
10: 128,793,680 (GRCm39) |
E1128G |
possibly damaging |
Het |
| Itih2 |
T |
C |
2: 10,111,558 (GRCm39) |
D460G |
probably damaging |
Het |
| Ivns1abp |
G |
A |
1: 151,227,309 (GRCm39) |
C39Y |
probably damaging |
Het |
| Kif22 |
G |
T |
7: 126,627,011 (GRCm39) |
A646E |
probably damaging |
Het |
| Klhl29 |
T |
C |
12: 5,141,307 (GRCm39) |
Y559C |
probably damaging |
Het |
| Klhl7 |
T |
A |
5: 24,354,108 (GRCm39) |
|
probably null |
Het |
| Klhl9 |
A |
G |
4: 88,640,230 (GRCm39) |
S4P |
probably benign |
Het |
| Klk10 |
A |
G |
7: 43,432,304 (GRCm39) |
Q79R |
probably benign |
Het |
| Klk6 |
T |
C |
7: 43,478,699 (GRCm39) |
|
probably null |
Het |
| Kpna2rt |
T |
A |
17: 90,217,734 (GRCm39) |
N4I |
possibly damaging |
Het |
| Lamc2 |
C |
T |
1: 153,042,009 (GRCm39) |
E42K |
probably benign |
Het |
| Lingo3 |
T |
C |
10: 80,671,555 (GRCm39) |
D125G |
probably benign |
Het |
| Map1b |
T |
C |
13: 99,569,247 (GRCm39) |
N1158S |
unknown |
Het |
| Masp1 |
T |
A |
16: 23,313,387 (GRCm39) |
N183Y |
probably damaging |
Het |
| Mdga2 |
A |
G |
12: 66,615,700 (GRCm39) |
Y636H |
probably benign |
Het |
| Mical2 |
T |
A |
7: 111,980,817 (GRCm39) |
S264T |
probably damaging |
Het |
| Mif |
A |
G |
10: 75,695,375 (GRCm39) |
V95A |
possibly damaging |
Het |
| Mmp17 |
G |
A |
5: 129,672,152 (GRCm39) |
|
probably null |
Het |
| Mmp23 |
T |
C |
4: 155,735,174 (GRCm39) |
R390G |
possibly damaging |
Het |
| Ncoa6 |
A |
C |
2: 155,257,142 (GRCm39) |
S800R |
possibly damaging |
Het |
| Nfix |
G |
A |
8: 85,453,155 (GRCm39) |
R300C |
probably damaging |
Het |
| Nr2e3 |
A |
T |
9: 59,856,488 (GRCm39) |
S67R |
probably damaging |
Het |
| Odf2l |
T |
C |
3: 144,854,797 (GRCm39) |
S545P |
possibly damaging |
Het |
| Or10d3 |
A |
T |
9: 39,462,080 (GRCm39) |
V29E |
possibly damaging |
Het |
| Or4a47 |
G |
A |
2: 89,665,516 (GRCm39) |
R258* |
probably null |
Het |
| Or52s1b |
T |
A |
7: 102,822,658 (GRCm39) |
Y62F |
probably benign |
Het |
| Or5k1b |
C |
T |
16: 58,581,216 (GRCm39) |
E108K |
probably damaging |
Het |
| Or7e176 |
A |
C |
9: 20,171,728 (GRCm39) |
Q197H |
possibly damaging |
Het |
| Or7g27 |
C |
T |
9: 19,249,948 (GRCm39) |
S64F |
probably benign |
Het |
| Or8b51 |
T |
G |
9: 38,569,014 (GRCm39) |
I225L |
probably damaging |
Het |
| Otog |
A |
T |
7: 45,908,688 (GRCm39) |
H562L |
possibly damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,430,023 (GRCm39) |
V1250A |
probably damaging |
Het |
| Pde1c |
A |
G |
6: 56,150,592 (GRCm39) |
V309A |
possibly damaging |
Het |
| Pfkfb4 |
A |
C |
9: 108,836,373 (GRCm39) |
T134P |
probably damaging |
Het |
| Phc3 |
G |
T |
3: 30,990,724 (GRCm39) |
Q498K |
possibly damaging |
Het |
| Phlpp1 |
T |
C |
1: 106,320,049 (GRCm39) |
V1348A |
probably damaging |
Het |
| Pik3ap1 |
T |
C |
19: 41,309,997 (GRCm39) |
D441G |
probably damaging |
Het |
| Pkd1l2 |
T |
C |
8: 117,792,239 (GRCm39) |
|
probably null |
Het |
| Pla2g4a |
T |
C |
1: 149,733,437 (GRCm39) |
|
probably null |
Het |
| Pola2 |
A |
T |
19: 5,998,434 (GRCm39) |
I376N |
probably damaging |
Het |
| Pold2 |
T |
A |
11: 5,826,833 (GRCm39) |
N34Y |
probably damaging |
Het |
| Ppp2r5c |
T |
C |
12: 110,521,320 (GRCm39) |
L281P |
probably damaging |
Het |
| Prss46 |
A |
G |
9: 110,678,703 (GRCm39) |
I29V |
probably benign |
Het |
| Ranbp6 |
A |
T |
19: 29,788,846 (GRCm39) |
V502E |
probably benign |
Het |
| Rdh14 |
T |
C |
12: 10,444,613 (GRCm39) |
F155L |
probably damaging |
Het |
| Rnaseh2a |
A |
T |
8: 85,692,487 (GRCm39) |
|
probably null |
Het |
| Rpp30 |
A |
G |
19: 36,071,785 (GRCm39) |
T118A |
possibly damaging |
Het |
| Rragd |
T |
C |
4: 32,996,005 (GRCm39) |
F117L |
probably damaging |
Het |
| Rxylt1 |
A |
G |
10: 121,926,384 (GRCm39) |
W243R |
probably damaging |
Het |
| S100a2 |
T |
A |
3: 90,498,599 (GRCm39) |
|
probably null |
Het |
| Septin12 |
T |
C |
16: 4,814,340 (GRCm39) |
K43R |
probably damaging |
Het |
| Sh3tc2 |
A |
G |
18: 62,141,559 (GRCm39) |
E1080G |
probably damaging |
Het |
| Slc26a9 |
A |
G |
1: 131,678,415 (GRCm39) |
K27R |
probably damaging |
Het |
| Spata17 |
T |
A |
1: 186,926,191 (GRCm39) |
K46N |
probably damaging |
Het |
| St14 |
A |
C |
9: 31,019,511 (GRCm39) |
D103E |
probably benign |
Het |
| St6galnac2 |
T |
A |
11: 116,575,173 (GRCm39) |
Q222L |
possibly damaging |
Het |
| Tdrd9 |
T |
C |
12: 112,002,844 (GRCm39) |
V831A |
probably damaging |
Het |
| Tert |
A |
G |
13: 73,790,175 (GRCm39) |
E843G |
probably damaging |
Het |
| Tex21 |
A |
G |
12: 76,251,044 (GRCm39) |
V464A |
probably benign |
Het |
| Tmem232 |
T |
A |
17: 65,791,496 (GRCm39) |
H124L |
probably damaging |
Het |
| Tnfrsf19 |
T |
G |
14: 61,242,555 (GRCm39) |
S110R |
probably damaging |
Het |
| Tnnt3 |
A |
T |
7: 142,069,562 (GRCm39) |
K272* |
probably null |
Het |
| Tnxb |
T |
C |
17: 34,930,477 (GRCm39) |
L2054P |
probably damaging |
Het |
| Trcg1 |
A |
C |
9: 57,149,748 (GRCm39) |
D440A |
probably benign |
Het |
| Trpm5 |
C |
T |
7: 142,636,626 (GRCm39) |
R437H |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,571,511 (GRCm39) |
R18134G |
probably damaging |
Het |
| Uchl5 |
A |
C |
1: 143,674,160 (GRCm39) |
M64L |
possibly damaging |
Het |
| Urb1 |
G |
A |
16: 90,550,751 (GRCm39) |
R2034W |
probably damaging |
Het |
| Usp44 |
T |
A |
10: 93,683,048 (GRCm39) |
C452* |
probably null |
Het |
| Uvssa |
G |
A |
5: 33,571,278 (GRCm39) |
A641T |
probably damaging |
Het |
| Vmn1r204 |
T |
A |
13: 22,741,248 (GRCm39) |
I293N |
probably benign |
Het |
| Vmn2r84 |
A |
T |
10: 130,225,137 (GRCm39) |
C458S |
probably benign |
Het |
| Vmn2r85 |
T |
G |
10: 130,261,788 (GRCm39) |
H183P |
probably damaging |
Het |
| Vps13d |
G |
T |
4: 144,832,431 (GRCm39) |
T2825K |
probably benign |
Het |
| Zc3hc1 |
T |
A |
6: 30,376,024 (GRCm39) |
I179F |
probably benign |
Het |
| Zfp112 |
A |
G |
7: 23,825,210 (GRCm39) |
N393D |
probably damaging |
Het |
| Zfp558 |
A |
G |
9: 18,367,859 (GRCm39) |
S310P |
possibly damaging |
Het |
| Zfp560 |
A |
C |
9: 20,260,071 (GRCm39) |
|
probably null |
Het |
| Zfp668 |
C |
T |
7: 127,466,252 (GRCm39) |
E311K |
probably benign |
Het |
| Zfp763 |
T |
A |
17: 33,252,276 (GRCm39) |
M1L |
probably benign |
Het |
| Zfp947 |
A |
T |
17: 22,364,813 (GRCm39) |
M287K |
probably benign |
Het |
|
| Other mutations in Trpm3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00514:Trpm3
|
APN |
19 |
22,965,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00773:Trpm3
|
APN |
19 |
22,877,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00852:Trpm3
|
APN |
19 |
22,964,435 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01597:Trpm3
|
APN |
19 |
22,692,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01607:Trpm3
|
APN |
19 |
22,964,491 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01818:Trpm3
|
APN |
19 |
22,891,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01890:Trpm3
|
APN |
19 |
22,689,083 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02016:Trpm3
|
APN |
19 |
22,879,433 (GRCm39) |
nonsense |
probably null |
|
|
IGL02324:Trpm3
|
APN |
19 |
22,676,143 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02947:Trpm3
|
APN |
19 |
22,878,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03037:Trpm3
|
APN |
19 |
22,866,776 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03128:Trpm3
|
APN |
19 |
22,891,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03335:Trpm3
|
APN |
19 |
22,903,435 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03354:Trpm3
|
APN |
19 |
22,834,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bit
|
UTSW |
19 |
22,965,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
G1patch:Trpm3
|
UTSW |
19 |
22,903,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0041:Trpm3
|
UTSW |
19 |
22,875,050 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0001:Trpm3
|
UTSW |
19 |
22,692,695 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0007:Trpm3
|
UTSW |
19 |
22,964,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0007:Trpm3
|
UTSW |
19 |
22,964,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0009:Trpm3
|
UTSW |
19 |
22,891,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0009:Trpm3
|
UTSW |
19 |
22,891,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0142:Trpm3
|
UTSW |
19 |
22,965,280 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0194:Trpm3
|
UTSW |
19 |
22,692,720 (GRCm39) |
splice site |
probably null |
|
|
R0268:Trpm3
|
UTSW |
19 |
22,874,885 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0299:Trpm3
|
UTSW |
19 |
22,964,237 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0449:Trpm3
|
UTSW |
19 |
22,965,418 (GRCm39) |
missense |
probably benign |
|
|
R0481:Trpm3
|
UTSW |
19 |
22,878,435 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0496:Trpm3
|
UTSW |
19 |
22,676,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0499:Trpm3
|
UTSW |
19 |
22,964,237 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0550:Trpm3
|
UTSW |
19 |
22,965,176 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0729:Trpm3
|
UTSW |
19 |
22,965,153 (GRCm39) |
missense |
probably benign |
|
|
R0883:Trpm3
|
UTSW |
19 |
22,956,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0926:Trpm3
|
UTSW |
19 |
22,965,407 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1185:Trpm3
|
UTSW |
19 |
22,891,781 (GRCm39) |
splice site |
probably benign |
|
|
R1185:Trpm3
|
UTSW |
19 |
22,891,781 (GRCm39) |
splice site |
probably benign |
|
|
R1513:Trpm3
|
UTSW |
19 |
22,964,236 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1522:Trpm3
|
UTSW |
19 |
22,955,698 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1569:Trpm3
|
UTSW |
19 |
22,866,809 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1598:Trpm3
|
UTSW |
19 |
22,710,388 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1600:Trpm3
|
UTSW |
19 |
22,116,519 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1616:Trpm3
|
UTSW |
19 |
22,960,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Trpm3
|
UTSW |
19 |
22,689,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1923:Trpm3
|
UTSW |
19 |
22,862,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Trpm3
|
UTSW |
19 |
22,903,446 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2002:Trpm3
|
UTSW |
19 |
22,959,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Trpm3
|
UTSW |
19 |
22,710,398 (GRCm39) |
missense |
probably benign |
0.15 |
|
R3719:Trpm3
|
UTSW |
19 |
22,964,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3766:Trpm3
|
UTSW |
19 |
22,425,741 (GRCm39) |
missense |
probably benign |
|
|
R3774:Trpm3
|
UTSW |
19 |
22,965,339 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3774:Trpm3
|
UTSW |
19 |
22,955,966 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3776:Trpm3
|
UTSW |
19 |
22,955,966 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3820:Trpm3
|
UTSW |
19 |
22,964,813 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3899:Trpm3
|
UTSW |
19 |
22,878,524 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4204:Trpm3
|
UTSW |
19 |
22,964,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4238:Trpm3
|
UTSW |
19 |
22,956,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4301:Trpm3
|
UTSW |
19 |
22,964,656 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4344:Trpm3
|
UTSW |
19 |
22,875,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4345:Trpm3
|
UTSW |
19 |
22,875,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4365:Trpm3
|
UTSW |
19 |
22,955,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4510:Trpm3
|
UTSW |
19 |
22,965,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4511:Trpm3
|
UTSW |
19 |
22,965,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4565:Trpm3
|
UTSW |
19 |
22,965,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4573:Trpm3
|
UTSW |
19 |
22,879,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4606:Trpm3
|
UTSW |
19 |
22,955,988 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4677:Trpm3
|
UTSW |
19 |
22,964,752 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4684:Trpm3
|
UTSW |
19 |
22,965,145 (GRCm39) |
missense |
probably benign |
|
|
R4713:Trpm3
|
UTSW |
19 |
22,866,799 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4745:Trpm3
|
UTSW |
19 |
22,692,659 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5015:Trpm3
|
UTSW |
19 |
22,689,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5030:Trpm3
|
UTSW |
19 |
22,676,130 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5074:Trpm3
|
UTSW |
19 |
22,862,713 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5089:Trpm3
|
UTSW |
19 |
22,744,120 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5100:Trpm3
|
UTSW |
19 |
22,896,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5108:Trpm3
|
UTSW |
19 |
22,882,078 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5204:Trpm3
|
UTSW |
19 |
22,425,705 (GRCm39) |
nonsense |
probably null |
|
|
R5213:Trpm3
|
UTSW |
19 |
22,674,818 (GRCm39) |
nonsense |
probably null |
|
|
R5358:Trpm3
|
UTSW |
19 |
22,903,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Trpm3
|
UTSW |
19 |
22,903,548 (GRCm39) |
nonsense |
probably null |
|
|
R5382:Trpm3
|
UTSW |
19 |
22,862,705 (GRCm39) |
splice site |
probably null |
|
|
R5509:Trpm3
|
UTSW |
19 |
22,964,622 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5558:Trpm3
|
UTSW |
19 |
22,955,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6154:Trpm3
|
UTSW |
19 |
22,965,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6250:Trpm3
|
UTSW |
19 |
22,887,418 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6433:Trpm3
|
UTSW |
19 |
22,878,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6542:Trpm3
|
UTSW |
19 |
22,903,477 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6630:Trpm3
|
UTSW |
19 |
22,965,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6640:Trpm3
|
UTSW |
19 |
22,955,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6725:Trpm3
|
UTSW |
19 |
22,903,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7275:Trpm3
|
UTSW |
19 |
22,956,048 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7371:Trpm3
|
UTSW |
19 |
22,879,557 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7467:Trpm3
|
UTSW |
19 |
22,955,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7488:Trpm3
|
UTSW |
19 |
22,955,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7495:Trpm3
|
UTSW |
19 |
22,875,160 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7600:Trpm3
|
UTSW |
19 |
22,903,458 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7710:Trpm3
|
UTSW |
19 |
22,896,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7877:Trpm3
|
UTSW |
19 |
22,882,148 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8184:Trpm3
|
UTSW |
19 |
22,896,060 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8234:Trpm3
|
UTSW |
19 |
22,692,640 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8236:Trpm3
|
UTSW |
19 |
22,964,772 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8443:Trpm3
|
UTSW |
19 |
22,676,226 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8470:Trpm3
|
UTSW |
19 |
22,887,501 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8784:Trpm3
|
UTSW |
19 |
22,896,040 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8816:Trpm3
|
UTSW |
19 |
22,965,580 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8818:Trpm3
|
UTSW |
19 |
22,955,952 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8875:Trpm3
|
UTSW |
19 |
22,887,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8931:Trpm3
|
UTSW |
19 |
22,744,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8969:Trpm3
|
UTSW |
19 |
22,903,308 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8987:Trpm3
|
UTSW |
19 |
22,896,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Trpm3
|
UTSW |
19 |
22,955,745 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9327:Trpm3
|
UTSW |
19 |
22,896,004 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9354:Trpm3
|
UTSW |
19 |
22,425,696 (GRCm39) |
missense |
probably benign |
|
|
R9514:Trpm3
|
UTSW |
19 |
22,960,040 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9545:Trpm3
|
UTSW |
19 |
22,878,458 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9712:Trpm3
|
UTSW |
19 |
22,692,716 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9721:Trpm3
|
UTSW |
19 |
22,866,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9750:Trpm3
|
UTSW |
19 |
22,903,495 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Trpm3
|
UTSW |
19 |
22,964,854 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCTTTAGGATCAGAGCTGGGCTG -3'
(R):5'- GGGATGAACTGCATGGTGATGTGAC -3'
Sequencing Primer
(F):5'- CATAGCGTGGGTCATCCATTAG -3'
(R):5'- TATGAAGCCCAGAGCTTCTCG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation