Mutagenetix > Incidental Mutation

Incidental Mutation 'R1921:Vmn2r95'

213103

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r95

Ensembl Gene

ENSMUSG00000091631

Gene Name

vomeronasal 2, receptor 95

Synonyms

MMRRC Submission

039939-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R1921 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18644366-18672586 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18644575 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 70 (N70K)

Ref Sequence

ENSEMBL: ENSMUSP00000156117 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166327] [ENSMUST00000232090] [ENSMUST00000232464]

AlphaFold

A0A338P6T0

Predicted Effect

probably benign
Transcript: ENSMUST00000166327
AA Change: N70K

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000126106
Gene: ENSMUSG00000091631
AA Change: N70K

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	462	1.8e-35	PFAM
Pfam:NCD3G	509	562	3.2e-20	PFAM
Pfam:7tm_3	594	830	3.2e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232090
AA Change: N70K

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably benign
Transcript: ENSMUST00000232464
AA Change: N70K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	C	A	6: 121,631,571 (GRCm39)	L623M	probably benign	Het
Abhd2	T	C	7: 78,998,104 (GRCm39)	I212T	possibly damaging	Het
Adam7	A	C	14: 68,750,074 (GRCm39)	S449A	possibly damaging	Het
Alkbh2	C	T	5: 114,262,287 (GRCm39)	E148K	probably damaging	Het
Aox3	T	C	1: 58,219,810 (GRCm39)	Y1137H	probably damaging	Het
Atp11b	T	C	3: 35,888,474 (GRCm39)	Y715H	probably damaging	Het
Atrn	A	G	2: 130,836,971 (GRCm39)	Y1145C	probably damaging	Het
Btbd7	A	G	12: 102,760,055 (GRCm39)	I631T	probably benign	Het
Cadps	T	C	14: 12,465,859 (GRCm38)	K1017R	possibly damaging	Het
Cfap45	A	G	1: 172,372,679 (GRCm39)	E458G	probably damaging	Het
Cptp	C	T	4: 155,950,995 (GRCm39)	R157H	probably damaging	Het
Dcbld1	A	C	10: 52,195,747 (GRCm39)	E318D	possibly damaging	Het
Ddr2	G	T	1: 169,831,814 (GRCm39)	P197Q	probably damaging	Het
Dlg5	T	C	14: 24,226,639 (GRCm39)	Y421C	probably damaging	Het
Dlgap2	A	G	8: 14,893,624 (GRCm39)	K980E	probably benign	Het
Drc7	T	C	8: 95,782,644 (GRCm39)	V3A	unknown	Het
Dst	T	C	1: 34,200,110 (GRCm39)	V96A	probably damaging	Het
Ect2l	T	C	10: 18,018,752 (GRCm39)	D548G	possibly damaging	Het
Efcab10	A	T	12: 33,448,434 (GRCm39)	Y89F	probably benign	Het
Eif1ad	CGAGGAGGAGGAGGAGGAGG	CGAGGAGGAGGAGGAGG	19: 5,420,086 (GRCm39)		probably benign	Het
Entpd6	A	G	2: 150,600,732 (GRCm39)	T147A	probably damaging	Het
Fbxl5	T	A	5: 43,922,832 (GRCm39)	E189D	probably benign	Het
Fer1l6	T	A	15: 58,497,080 (GRCm39)	S1217T	probably damaging	Het
Frem2	A	T	3: 53,560,916 (GRCm39)	V1197D	possibly damaging	Het
Fsip2	T	A	2: 82,811,127 (GRCm39)	L2482*	probably null	Het
Fsip2	A	T	2: 82,817,164 (GRCm39)	D4299V	probably benign	Het
Gipc3	T	A	10: 81,174,049 (GRCm39)	I242F	probably damaging	Het
Hoxb1	T	A	11: 96,256,938 (GRCm39)	Y96N	probably damaging	Het
Ibsp	A	G	5: 104,458,078 (GRCm39)	E205G	probably damaging	Het
Ibtk	A	G	9: 85,585,135 (GRCm39)	S1170P	probably benign	Het
Igfn1	A	G	1: 135,893,801 (GRCm39)		probably null	Het
Iqsec1	A	G	6: 90,639,877 (GRCm39)	S954P	probably benign	Het
Kalrn	A	T	16: 34,212,463 (GRCm39)	D28E	probably benign	Het
Lrmda	T	C	14: 22,627,938 (GRCm39)	F52L	probably damaging	Het
Lrp2	T	C	2: 69,353,631 (GRCm39)	D543G	probably damaging	Het
Lrrtm3	T	C	10: 63,924,157 (GRCm39)	T337A	probably benign	Het
Marf1	C	T	16: 13,946,465 (GRCm39)	D1219N	possibly damaging	Het
Mkln1	A	G	6: 31,405,113 (GRCm39)	K118R	probably benign	Het
Nedd4l	T	C	18: 65,300,646 (GRCm39)		probably null	Het
Neu2	A	G	1: 87,525,023 (GRCm39)	E336G	probably benign	Het
Nfasc	A	G	1: 132,538,543 (GRCm39)	F448S	probably damaging	Het
Nlrx1	C	A	9: 44,165,431 (GRCm39)	E822*	probably null	Het
Nr5a1	T	C	2: 38,584,108 (GRCm39)	Y437C	probably damaging	Het
Or4c119	A	G	2: 88,986,925 (GRCm39)	V198A	probably benign	Het
Or7a37	T	A	10: 78,805,975 (GRCm39)	L164*	probably null	Het
Or8b38	T	C	9: 37,972,981 (GRCm39)	Y122H	probably damaging	Het
Phtf1	C	T	3: 103,876,438 (GRCm39)	Q13*	probably null	Het
Pnldc1	A	G	17: 13,107,815 (GRCm39)	L525P	possibly damaging	Het
Ppl	T	A	16: 4,923,988 (GRCm39)	D162V	possibly damaging	Het
Prkdc	T	A	16: 15,532,079 (GRCm39)	S1448T	possibly damaging	Het
Ptgdr	A	G	14: 45,090,738 (GRCm39)	I340T	probably benign	Het
Recql	T	C	6: 142,311,315 (GRCm39)	I458M	probably benign	Het
Rrbp1	A	T	2: 143,830,211 (GRCm39)	V652E	probably benign	Het
Rtp1	T	A	16: 23,250,160 (GRCm39)	I175N	probably damaging	Het
Ryr1	A	G	7: 28,754,369 (GRCm39)	M3523T	probably damaging	Het
S100a16	T	C	3: 90,449,703 (GRCm39)	L62P	probably damaging	Het
Samd11	T	C	4: 156,333,166 (GRCm39)	E364G	probably damaging	Het
Satb1	C	A	17: 52,049,143 (GRCm39)	G603*	probably null	Het
Shroom3	T	A	5: 93,110,224 (GRCm39)		probably null	Het
Slc25a15	A	G	8: 22,885,777 (GRCm39)	S3P	probably benign	Het
Socs2	A	T	10: 95,248,900 (GRCm39)	L71*	probably null	Het
Sptbn1	T	C	11: 30,054,469 (GRCm39)	E2208G	probably damaging	Het
St14	A	G	9: 31,001,166 (GRCm39)	V855A	possibly damaging	Het
Susd1	T	A	4: 59,412,191 (GRCm39)	T121S	probably benign	Het
Svs3b	A	T	2: 164,097,848 (GRCm39)	S158T	probably benign	Het
Synpo	C	T	18: 60,736,661 (GRCm39)	M428I	probably benign	Het
Syt10	C	T	15: 89,674,979 (GRCm39)	D456N	probably damaging	Het
Taar4	A	G	10: 23,837,239 (GRCm39)	D283G	probably damaging	Het
Tango6	T	A	8: 107,415,426 (GRCm39)	D82E	probably benign	Het
Tcof1	T	C	18: 60,971,927 (GRCm39)	T127A	possibly damaging	Het
Tle3	G	A	9: 61,318,622 (GRCm39)		probably null	Het
Tmem45a	A	G	16: 56,642,665 (GRCm39)	F169L	probably benign	Het
Trp53rkb	T	A	2: 166,637,743 (GRCm39)	V233E	probably damaging	Het
Ttc7b	C	T	12: 100,381,389 (GRCm39)		probably null	Het
Tubgcp3	A	T	8: 12,671,932 (GRCm39)	L770*	probably null	Het
Tut1	G	A	19: 8,943,466 (GRCm39)	G851D	probably benign	Het
Ubr1	G	A	2: 120,761,449 (GRCm39)	T576I	probably benign	Het
Vmn1r125	T	A	7: 21,006,530 (GRCm39)	Y143N	probably damaging	Het
Vmn2r120	T	A	17: 57,831,839 (GRCm39)	I317F	probably benign	Het
Vps35l	A	G	7: 118,432,971 (GRCm39)	N568S	probably damaging	Het
Wdr59	A	T	8: 112,213,582 (GRCm39)	L311*	probably null	Het
Wnt2	A	G	6: 18,030,252 (GRCm39)	L12P	unknown	Het
Xrn1	T	C	9: 95,881,550 (GRCm39)	I700T	probably benign	Het
Ypel1	A	G	16: 16,900,443 (GRCm39)	H98R	probably benign	Het
Zfp219	T	C	14: 52,245,691 (GRCm39)	T434A	probably benign	Het
Zik1	A	C	7: 10,223,943 (GRCm39)	C385G	probably damaging	Het

Other mutations in Vmn2r95

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01024:Vmn2r95	APN	17	18,672,590 (GRCm39)	utr 3 prime	probably benign
IGL01479:Vmn2r95	APN	17	18,664,124 (GRCm39)	missense	probably damaging	1.00
IGL01890:Vmn2r95	APN	17	18,671,737 (GRCm39)	missense	probably damaging	1.00
IGL01986:Vmn2r95	APN	17	18,660,473 (GRCm39)	missense	probably benign	0.06
IGL02113:Vmn2r95	APN	17	18,660,169 (GRCm39)	missense	possibly damaging	0.47
IGL02154:Vmn2r95	APN	17	18,672,248 (GRCm39)	missense	probably benign	0.16
IGL02190:Vmn2r95	APN	17	18,672,038 (GRCm39)	missense	probably benign	0.00
IGL02412:Vmn2r95	APN	17	18,660,218 (GRCm39)	missense	probably damaging	1.00
IGL02550:Vmn2r95	APN	17	18,671,994 (GRCm39)	missense	probably damaging	1.00
IGL02679:Vmn2r95	APN	17	18,664,116 (GRCm39)	missense	probably damaging	1.00
IGL02691:Vmn2r95	APN	17	18,672,120 (GRCm39)	missense	probably benign	0.07
IGL02990:Vmn2r95	APN	17	18,672,298 (GRCm39)	nonsense	probably null
IGL03032:Vmn2r95	APN	17	18,672,575 (GRCm39)	missense	probably benign	0.00
R0416:Vmn2r95	UTSW	17	18,661,664 (GRCm39)	missense	probably damaging	1.00
R0448:Vmn2r95	UTSW	17	18,672,005 (GRCm39)	missense	possibly damaging	0.92
R0514:Vmn2r95	UTSW	17	18,671,844 (GRCm39)	missense	probably benign
R0519:Vmn2r95	UTSW	17	18,659,765 (GRCm39)	missense	probably damaging	1.00
R0539:Vmn2r95	UTSW	17	18,672,362 (GRCm39)	missense	probably damaging	1.00
R1501:Vmn2r95	UTSW	17	18,660,118 (GRCm39)	missense	probably damaging	0.99
R1598:Vmn2r95	UTSW	17	18,672,575 (GRCm39)	missense	probably benign	0.03
R1613:Vmn2r95	UTSW	17	18,660,901 (GRCm39)	splice site	probably benign
R1861:Vmn2r95	UTSW	17	18,672,530 (GRCm39)	missense	probably damaging	1.00
R1986:Vmn2r95	UTSW	17	18,671,805 (GRCm39)	missense	probably benign
R2031:Vmn2r95	UTSW	17	18,659,717 (GRCm39)	missense	possibly damaging	0.94
R2040:Vmn2r95	UTSW	17	18,661,561 (GRCm39)	missense	probably damaging	1.00
R3608:Vmn2r95	UTSW	17	18,660,235 (GRCm39)	missense	possibly damaging	0.47
R3727:Vmn2r95	UTSW	17	18,661,744 (GRCm39)	nonsense	probably null
R3953:Vmn2r95	UTSW	17	18,660,358 (GRCm39)	missense	possibly damaging	0.79
R3955:Vmn2r95	UTSW	17	18,660,358 (GRCm39)	missense	possibly damaging	0.79
R3957:Vmn2r95	UTSW	17	18,660,358 (GRCm39)	missense	possibly damaging	0.79
R4474:Vmn2r95	UTSW	17	18,672,507 (GRCm39)	missense	probably damaging	1.00
R4672:Vmn2r95	UTSW	17	18,672,413 (GRCm39)	missense	probably damaging	1.00
R4850:Vmn2r95	UTSW	17	18,671,915 (GRCm39)	missense	probably damaging	1.00
R5054:Vmn2r95	UTSW	17	18,671,708 (GRCm39)	missense	possibly damaging	0.63
R5178:Vmn2r95	UTSW	17	18,660,337 (GRCm39)	missense	probably benign	0.01
R5980:Vmn2r95	UTSW	17	18,661,624 (GRCm39)	missense	probably benign
R6183:Vmn2r95	UTSW	17	18,664,192 (GRCm39)	missense	probably damaging	0.99
R6276:Vmn2r95	UTSW	17	18,671,732 (GRCm39)	missense	possibly damaging	0.96
R6651:Vmn2r95	UTSW	17	18,660,622 (GRCm39)	missense	probably damaging	1.00
R6682:Vmn2r95	UTSW	17	18,660,489 (GRCm39)	missense	probably damaging	1.00
R6797:Vmn2r95	UTSW	17	18,672,551 (GRCm39)	utr 3 prime	probably benign
R6799:Vmn2r95	UTSW	17	18,659,555 (GRCm39)	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18,664,182 (GRCm39)	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18,664,181 (GRCm39)	missense	probably damaging	1.00
R6982:Vmn2r95	UTSW	17	18,672,323 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r95	UTSW	17	18,661,577 (GRCm39)	missense	probably benign	0.01
R7226:Vmn2r95	UTSW	17	18,672,245 (GRCm39)	missense	possibly damaging	0.90
R7240:Vmn2r95	UTSW	17	18,672,225 (GRCm39)	missense	probably benign	0.15
R7383:Vmn2r95	UTSW	17	18,660,734 (GRCm39)	missense	probably benign	0.06
R7614:Vmn2r95	UTSW	17	18,660,352 (GRCm39)	missense	probably benign
R7755:Vmn2r95	UTSW	17	18,644,367 (GRCm39)	start codon destroyed	probably null	0.99
R7942:Vmn2r95	UTSW	17	18,660,529 (GRCm39)	missense	possibly damaging	0.74
R8355:Vmn2r95	UTSW	17	18,660,352 (GRCm39)	missense	probably benign
R8455:Vmn2r95	UTSW	17	18,660,352 (GRCm39)	missense	probably benign
R8478:Vmn2r95	UTSW	17	18,672,544 (GRCm39)	missense	probably damaging	1.00
R8547:Vmn2r95	UTSW	17	18,664,161 (GRCm39)	missense	probably damaging	1.00
R8752:Vmn2r95	UTSW	17	18,661,738 (GRCm39)	missense	probably damaging	0.98
R8788:Vmn2r95	UTSW	17	18,671,790 (GRCm39)	missense	probably benign	0.09
R8852:Vmn2r95	UTSW	17	18,664,113 (GRCm39)	missense	possibly damaging	0.95
R9098:Vmn2r95	UTSW	17	18,660,167 (GRCm39)	missense	possibly damaging	0.88
R9202:Vmn2r95	UTSW	17	18,644,394 (GRCm39)	missense	probably benign	0.00
R9244:Vmn2r95	UTSW	17	18,672,189 (GRCm39)	missense	possibly damaging	0.91
R9546:Vmn2r95	UTSW	17	18,661,721 (GRCm39)	missense	probably benign	0.01
R9665:Vmn2r95	UTSW	17	18,660,607 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r95	UTSW	17	18,660,663 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CTCCATGAAGCAGACCCATG -3'
(R):5'- TTTCCGATCCCACTGAGTAAG -3'

Sequencing Primer
(F):5'- GACCCATGAACTAAGAGGATGTTCTC -3'
(R):5'- CCCACTGAGTAAGGAAAATAATCTG -3'

Posted On

2014-07-14