Mutagenetix > Incidental Mutation

Incidental Mutation 'R2048:Fpr-rs4'

222287

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

MMRRC Submission

040055-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R2048 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

18241995-18242966 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

CAGGAA to CA at 18242596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably null
Transcript: ENSMUST00000095651

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

98% (52/53)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam10	A	G	9: 70,647,357 (GRCm39)	D19G	possibly damaging	Het
Adhfe1	A	G	1: 9,633,778 (GRCm39)	K342R	probably benign	Het
Adk	A	G	14: 21,368,244 (GRCm39)	N223S	probably damaging	Het
Aff4	A	G	11: 53,289,212 (GRCm39)	S454G	probably benign	Het
Ahnak	T	A	19: 8,984,420 (GRCm39)	N1901K	probably damaging	Het
Camsap1	T	C	2: 25,819,755 (GRCm39)	T1578A	probably benign	Het
Ccdc63	A	C	5: 122,268,350 (GRCm39)		probably null	Het
Ceacam1	G	T	7: 25,176,113 (GRCm39)	S27Y	probably benign	Het
Cit	T	C	5: 116,024,872 (GRCm39)		probably null	Het
Cntn4	A	G	6: 106,414,825 (GRCm39)		probably benign	Het
Cyp2d26	A	G	15: 82,676,928 (GRCm39)		probably benign	Het
Cyp3a13	A	T	5: 137,908,237 (GRCm39)	V204E	probably damaging	Het
Cyp51	G	A	5: 4,136,636 (GRCm39)		probably benign	Het
Dipk1a	T	C	5: 108,057,886 (GRCm39)	D179G	probably damaging	Het
Epb41l4b	T	G	4: 57,142,866 (GRCm39)	E96D	probably benign	Het
Epg5	A	G	18: 78,067,202 (GRCm39)	E2221G	probably damaging	Het
Fbxo21	T	A	5: 118,146,169 (GRCm39)	N597K	probably damaging	Het
Fsip1	C	A	2: 118,072,197 (GRCm39)	E195D	probably damaging	Het
Gm10152	T	C	7: 144,317,049 (GRCm39)	F35L	unknown	Het
Gtpbp6	A	C	5: 110,254,931 (GRCm39)	V87G	probably damaging	Het
Hal	A	G	10: 93,327,002 (GRCm39)	T176A	probably damaging	Het
Il12rb2	G	T	6: 67,337,529 (GRCm39)	N117K	probably benign	Het
Kalrn	A	G	16: 34,072,680 (GRCm39)	V734A	probably benign	Het
Klf7	A	G	1: 64,117,913 (GRCm39)	V228A	possibly damaging	Het
Kng1	A	G	16: 22,877,354 (GRCm39)	Y54C	probably damaging	Het
Lpcat2	T	G	8: 93,596,471 (GRCm39)	N169K	possibly damaging	Het
Magohb	A	T	6: 131,266,385 (GRCm39)	S40R	probably damaging	Het
Mgam	A	G	6: 40,633,363 (GRCm39)	D186G	possibly damaging	Het
Mycbp2	A	G	14: 103,469,960 (GRCm39)		probably null	Het
Myh15	A	G	16: 48,975,928 (GRCm39)	D1332G	probably damaging	Het
Myh9	G	A	15: 77,655,332 (GRCm39)	T1208M	possibly damaging	Het
Ncor2	C	T	5: 125,161,996 (GRCm39)	R426H	unknown	Het
Nradd	T	C	9: 110,450,697 (GRCm39)	E160G	probably benign	Het
Or10u4	G	A	10: 129,801,861 (GRCm39)	S230L	probably damaging	Het
Or2a54	T	A	6: 43,093,312 (GRCm39)	M212K	probably benign	Het
Otog	A	T	7: 45,937,063 (GRCm39)	T1591S	probably damaging	Het
Oxsr1	A	G	9: 119,076,140 (GRCm39)	S389P	probably benign	Het
Pde3a	A	G	6: 141,434,732 (GRCm39)		probably benign	Het
Pi4k2b	A	T	5: 52,905,773 (GRCm39)	I105L	probably benign	Het
Pilrb1	T	C	5: 137,853,153 (GRCm39)	R217G	possibly damaging	Het
Poteg	A	T	8: 27,946,774 (GRCm39)	I159L	probably benign	Het
Ppargc1a	A	G	5: 51,705,858 (GRCm39)	F75S	probably damaging	Het
Ptk2b	T	G	14: 66,409,954 (GRCm39)	D466A	probably benign	Het
Ptpn21	A	G	12: 98,655,785 (GRCm39)	V394A	possibly damaging	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,229,114 (GRCm39)		probably benign	Het
Shisa3	G	A	5: 67,768,651 (GRCm39)	E184K	possibly damaging	Het
Slc4a2	A	G	5: 24,636,557 (GRCm39)	H283R	probably damaging	Het
Slc9a3	A	G	13: 74,311,860 (GRCm39)	S603G	probably damaging	Het
Tas2r124	A	G	6: 132,731,858 (GRCm39)	I56V	possibly damaging	Het
Tbcd	G	T	11: 121,431,762 (GRCm39)	C470F	probably damaging	Het
Thsd1	A	G	8: 22,749,333 (GRCm39)	R674G	probably benign	Het
Zbtb11	T	A	16: 55,818,372 (GRCm39)	C599S	probably damaging	Het
Zfp541	A	G	7: 15,812,252 (GRCm39)	R302G	possibly damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18,242,188 (GRCm39)	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18,242,779 (GRCm39)	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18,242,493 (GRCm39)	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18,242,473 (GRCm39)	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18,242,513 (GRCm39)	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18,242,289 (GRCm39)	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18,242,359 (GRCm39)	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18,242,613 (GRCm39)	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18,242,589 (GRCm39)	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18,242,518 (GRCm39)	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18,242,446 (GRCm39)	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18,242,317 (GRCm39)	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18,242,748 (GRCm39)	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R8703:Fpr-rs4	UTSW	17	18,242,332 (GRCm39)	missense	probably damaging	0.99
R9007:Fpr-rs4	UTSW	17	18,242,416 (GRCm39)	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18,242,217 (GRCm39)	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18,242,211 (GRCm39)	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18,242,391 (GRCm39)	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18,242,956 (GRCm39)	missense	probably benign	0.16
Z1088:Fpr-rs4	UTSW	17	18,242,181 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- CCAGAAAAGTGGTTCTTGGAGC -3'
(R):5'- AGCCAAGGTATTTGCTGGG -3'

Sequencing Primer
(F):5'- AGCTTGGATATTTGCTCTGCTGC -3'
(R):5'- CCAAGGTATTTGCTGGGTTAACCAAC -3'

Posted On

2014-08-25