Incidental Mutation 'R5170:Gtse1'
ID 397523
Institutional Source Beutler Lab
Gene Symbol Gtse1
Ensembl Gene ENSMUSG00000022385
Gene Name G two S phase expressed protein 1
Synonyms B99, Gtse-1
MMRRC Submission 042750-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5170 (G1)
Quality Score 131
Status Not validated
Chromosome 15
Chromosomal Location 85743946-85760774 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 85748465 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170629] [ENSMUST00000231074]
AlphaFold Q8R080
Predicted Effect probably null
Transcript: ENSMUST00000170629
SMART Domains Protein: ENSMUSP00000128759
Gene: ENSMUSG00000022385

DomainStartEndE-ValueType
Pfam:GTSE1_N 10 153 3e-62 PFAM
low complexity region 284 301 N/A INTRINSIC
low complexity region 310 321 N/A INTRINSIC
low complexity region 360 372 N/A INTRINSIC
low complexity region 478 497 N/A INTRINSIC
low complexity region 568 593 N/A INTRINSIC
low complexity region 644 653 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000231074
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,745,969 (GRCm39) I51V probably benign Het
Agbl2 A G 2: 90,633,541 (GRCm39) K559R probably benign Het
Arhgap30 A G 1: 171,235,618 (GRCm39) D664G probably benign Het
BC034090 A G 1: 155,089,396 (GRCm39) V798A probably damaging Het
Bdp1 A T 13: 100,167,302 (GRCm39) C2237* probably null Het
C3 C T 17: 57,530,938 (GRCm39) V388M probably damaging Het
Ccdc170 G A 10: 4,464,200 (GRCm39) E60K probably damaging Het
Cdh8 G A 8: 100,006,182 (GRCm39) T135M probably damaging Het
Cep131 G T 11: 119,961,435 (GRCm39) A572E probably damaging Het
Clec16a A G 16: 10,559,655 (GRCm39) Y976C probably benign Het
Cplx3 G A 9: 57,522,902 (GRCm39) R153* probably null Het
Defa41 A T 8: 21,691,696 (GRCm39) D26V probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Eno3 A G 11: 70,553,040 (GRCm39) I393V probably benign Het
Fbxo47 A G 11: 97,748,520 (GRCm39) V305A probably benign Het
Fry G A 5: 150,353,319 (GRCm39) V1779M probably benign Het
Gucy2e A T 11: 69,126,396 (GRCm39) L328Q probably damaging Het
Ifi207 T C 1: 173,558,064 (GRCm39) T225A unknown Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Lamc3 A T 2: 31,777,356 (GRCm39) M1L probably benign Het
Myo16 A G 8: 10,619,745 (GRCm39) D1432G probably benign Het
Nwd2 A T 5: 63,963,380 (GRCm39) N988I probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp14 T C 16: 35,677,649 (GRCm39) E773G probably benign Het
Psen1 T A 12: 83,761,636 (GRCm39) M146K probably damaging Het
Ptx4 G A 17: 25,342,152 (GRCm39) R209Q probably benign Het
Slc13a2 T C 11: 78,291,634 (GRCm39) T340A probably damaging Het
St8sia1 T C 6: 142,909,434 (GRCm39) K21E probably damaging Het
Stxbp1 T C 2: 32,684,686 (GRCm39) D581G probably benign Het
Sumo2 G A 11: 115,425,486 (GRCm39) probably benign Het
Supt5 G A 7: 28,015,508 (GRCm39) P910S probably benign Het
Tbc1d30 T C 10: 121,142,743 (GRCm39) Q158R possibly damaging Het
Tenm2 T A 11: 35,915,633 (GRCm39) H1968L probably damaging Het
Trmt1 T C 8: 85,421,861 (GRCm39) Y220H probably damaging Het
Trp73 C T 4: 154,189,295 (GRCm39) E60K possibly damaging Het
Ttn A G 2: 76,617,413 (GRCm39) Y8026H probably damaging Het
Zar1l A G 5: 150,441,050 (GRCm39) probably null Het
Zfp740 T C 15: 102,117,640 (GRCm39) Y117H probably damaging Het
Zfp941 G A 7: 140,392,870 (GRCm39) probably benign Het
Zp1 C A 19: 10,897,918 (GRCm39) V8F possibly damaging Het
Other mutations in Gtse1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gtse1 APN 15 85,753,018 (GRCm39) missense possibly damaging 0.54
IGL01344:Gtse1 APN 15 85,746,267 (GRCm39) critical splice acceptor site probably null
IGL01541:Gtse1 APN 15 85,759,855 (GRCm39) nonsense probably null
IGL01621:Gtse1 APN 15 85,759,283 (GRCm39) missense probably benign 0.01
IGL01945:Gtse1 APN 15 85,755,748 (GRCm39) missense probably benign 0.00
IGL02193:Gtse1 APN 15 85,746,531 (GRCm39) missense probably benign 0.27
IGL02215:Gtse1 APN 15 85,746,799 (GRCm39) missense possibly damaging 0.92
IGL02494:Gtse1 APN 15 85,751,704 (GRCm39) missense probably damaging 1.00
IGL02879:Gtse1 APN 15 85,753,264 (GRCm39) splice site probably benign
R0009:Gtse1 UTSW 15 85,746,636 (GRCm39) missense probably benign 0.06
R0047:Gtse1 UTSW 15 85,746,579 (GRCm39) missense probably damaging 1.00
R0047:Gtse1 UTSW 15 85,746,579 (GRCm39) missense probably damaging 1.00
R0576:Gtse1 UTSW 15 85,753,252 (GRCm39) missense probably damaging 1.00
R1078:Gtse1 UTSW 15 85,746,508 (GRCm39) missense probably damaging 0.98
R1442:Gtse1 UTSW 15 85,744,303 (GRCm39) splice site probably benign
R1623:Gtse1 UTSW 15 85,751,779 (GRCm39) missense probably benign
R1925:Gtse1 UTSW 15 85,757,939 (GRCm39) missense probably benign 0.00
R1928:Gtse1 UTSW 15 85,746,264 (GRCm39) splice site probably benign
R4565:Gtse1 UTSW 15 85,759,385 (GRCm39) missense probably damaging 0.99
R5310:Gtse1 UTSW 15 85,757,993 (GRCm39) missense probably benign 0.04
R5428:Gtse1 UTSW 15 85,746,340 (GRCm39) missense probably benign 0.12
R5748:Gtse1 UTSW 15 85,751,778 (GRCm39) missense probably benign
R5996:Gtse1 UTSW 15 85,748,381 (GRCm39) missense probably benign 0.00
R6179:Gtse1 UTSW 15 85,753,158 (GRCm39) missense possibly damaging 0.95
R6379:Gtse1 UTSW 15 85,748,425 (GRCm39) missense probably benign 0.01
R6381:Gtse1 UTSW 15 85,746,349 (GRCm39) missense probably benign 0.00
R6434:Gtse1 UTSW 15 85,759,370 (GRCm39) missense probably benign 0.21
R7086:Gtse1 UTSW 15 85,759,750 (GRCm39) missense probably damaging 1.00
R7304:Gtse1 UTSW 15 85,755,748 (GRCm39) missense probably benign 0.00
R7485:Gtse1 UTSW 15 85,752,901 (GRCm39) missense probably benign 0.04
R7580:Gtse1 UTSW 15 85,746,432 (GRCm39) missense probably damaging 1.00
R7856:Gtse1 UTSW 15 85,748,342 (GRCm39) missense probably benign 0.09
R8496:Gtse1 UTSW 15 85,746,283 (GRCm39) missense probably damaging 1.00
R8674:Gtse1 UTSW 15 85,746,376 (GRCm39) missense probably damaging 1.00
R8987:Gtse1 UTSW 15 85,753,109 (GRCm39) missense probably benign 0.00
R9491:Gtse1 UTSW 15 85,755,734 (GRCm39) missense probably damaging 1.00
R9642:Gtse1 UTSW 15 85,751,697 (GRCm39) missense probably damaging 0.98
Z1176:Gtse1 UTSW 15 85,752,947 (GRCm39) missense possibly damaging 0.85
Z1177:Gtse1 UTSW 15 85,759,938 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GACCAGGTAGTCTTCACCTCTC -3'
(R):5'- AGTTCACTGCACATGGCCAG -3'

Sequencing Primer
(F):5'- AGGTAGTCTTCACCTCTCAAATCGAC -3'
(R):5'- TCACCAAGTTGGCTAAGCTG -3'
Posted On 2016-07-06