|Institutional Source||Beutler Lab|
|Gene Name||G two S phase expressed protein 1|
|Is this an essential gene?||Probably non essential (E-score: 0.086)|
|Stock #||R5170 (G1)|
|Chromosomal Location||85859745-85876573 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 85864264 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000155552 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000170629] [ENSMUST00000231074]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gtse1||
(F):5'- GACCAGGTAGTCTTCACCTCTC -3'
(R):5'- AGTTCACTGCACATGGCCAG -3'
(F):5'- AGGTAGTCTTCACCTCTCAAATCGAC -3'
(R):5'- TCACCAAGTTGGCTAAGCTG -3'