Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03132:Vmn2r99'

410368

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r99

Ensembl Gene

ENSMUSG00000090304

Gene Name

vomeronasal 2, receptor 99

Synonyms

EG665376

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL03132

Quality Score

Status

Chromosome

Chromosomal Location

19361949-19401098 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 19378223 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 170 (Q170*)

Ref Sequence

ENSEMBL: ENSMUSP00000156067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176107] [ENSMUST00000231989]

Predicted Effect

probably null
Transcript: ENSMUST00000176107
AA Change: Q170*

SMART Domains

Protein: ENSMUSP00000135236
Gene: ENSMUSG00000090304
AA Change: Q170*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	81	448	5.7e-33	PFAM
Pfam:NCD3G	508	561	1.8e-21	PFAM
Pfam:7tm_3	593	829	4.6e-52	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000231989
AA Change: Q170*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb1	G	A	6: 88,838,959	R177C	probably benign	Het
Adam21	C	A	12: 81,560,374	G205*	probably null	Het
Baz2b	T	A	2: 59,907,753		probably benign	Het
Col6a3	C	T	1: 90,803,893	G939D	probably damaging	Het
Csf1r	A	G	18: 61,128,099	E749G	probably benign	Het
Dnm3	C	T	1: 162,011,105		probably null	Het
Dsg3	A	G	18: 20,524,596	D241G	probably damaging	Het
Dst	T	C	1: 34,256,641	S6015P	probably benign	Het
Dvl2	T	C	11: 70,005,688	S183P	probably benign	Het
Exoc6b	T	C	6: 84,791,264	N699S	possibly damaging	Het
Fat2	T	C	11: 55,253,920	R4043G	probably benign	Het
Gbp9	T	A	5: 105,084,953	T278S	possibly damaging	Het
Gm2a	T	A	11: 55,103,648	I48N	probably damaging	Het
Gorasp2	T	C	2: 70,684,035	V232A	probably benign	Het
Gpa33	G	A	1: 166,152,649	D94N	probably benign	Het
Il1rap	A	T	16: 26,680,119	S123C	probably damaging	Het
Kctd17	T	C	15: 78,435,687	S102P	probably damaging	Het
Lamb1	A	G	12: 31,300,334		probably null	Het
Mfsd1	T	A	3: 67,587,940	I131K	possibly damaging	Het
Pkhd1l1	G	A	15: 44,574,617	C3576Y	probably damaging	Het
Pla2g4a	A	T	1: 149,902,284		probably benign	Het
Ptpn11	T	A	5: 121,134,815	D575V	possibly damaging	Het
Reck	A	T	4: 43,938,898	R755*	probably null	Het
Scgb2b21	A	G	7: 33,519,874	V35A	possibly damaging	Het
Srpr	G	A	9: 35,214,278		probably null	Het
Stk11ip	T	C	1: 75,536,089	S1025P	probably benign	Het
Tmprss9	G	A	10: 80,894,865	V742M	probably damaging	Het
Trh	T	C	6: 92,243,774	T36A	probably benign	Het
Trim35	A	G	14: 66,309,146	E454G	probably damaging	Het

Other mutations in Vmn2r99

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Vmn2r99	APN	17	19378854	missense	probably benign	0.01
IGL01113:Vmn2r99	APN	17	19394256	missense	probably benign	0.20
IGL01138:Vmn2r99	APN	17	19382623	missense	probably damaging	0.97
IGL01646:Vmn2r99	APN	17	19393658	splice site	probably benign
IGL01769:Vmn2r99	APN	17	19380115	missense	probably damaging	1.00
IGL02112:Vmn2r99	APN	17	19380232	missense	probably null	0.99
IGL02891:Vmn2r99	APN	17	19378690	nonsense	probably null
FR4548:Vmn2r99	UTSW	17	19394285	missense	probably damaging	0.97
FR4976:Vmn2r99	UTSW	17	19394285	missense	probably damaging	0.97
PIT4382001:Vmn2r99	UTSW	17	19394343	missense	probably damaging	1.00
R0196:Vmn2r99	UTSW	17	19394573	missense	probably benign	0.00
R0720:Vmn2r99	UTSW	17	19379043	missense	probably benign	0.00
R1501:Vmn2r99	UTSW	17	19362259	missense	possibly damaging	0.93
R1519:Vmn2r99	UTSW	17	19380060	missense	probably benign	0.00
R1670:Vmn2r99	UTSW	17	19362252	missense	probably benign	0.37
R1682:Vmn2r99	UTSW	17	19377945	missense	probably damaging	0.97
R1873:Vmn2r99	UTSW	17	19362153	missense	probably benign	0.25
R1967:Vmn2r99	UTSW	17	19378815	missense	probably benign	0.01
R2101:Vmn2r99	UTSW	17	19377991	missense	probably damaging	1.00
R2474:Vmn2r99	UTSW	17	19378629	missense	probably benign	0.04
R2519:Vmn2r99	UTSW	17	19378708	missense	probably damaging	0.99
R3911:Vmn2r99	UTSW	17	19394373	missense	possibly damaging	0.92
R3947:Vmn2r99	UTSW	17	19378990	missense	probably benign	0.40
R3949:Vmn2r99	UTSW	17	19378990	missense	probably benign	0.40
R4016:Vmn2r99	UTSW	17	19378570	missense	possibly damaging	0.86
R4413:Vmn2r99	UTSW	17	19379260	missense	probably damaging	1.00
R4594:Vmn2r99	UTSW	17	19393662	missense	probably damaging	1.00
R4999:Vmn2r99	UTSW	17	19362135	start codon destroyed	probably null	0.96
R5206:Vmn2r99	UTSW	17	19378606	missense	probably benign	0.40
R5362:Vmn2r99	UTSW	17	19379339	missense	probably benign	0.00
R5377:Vmn2r99	UTSW	17	19379269	missense	probably damaging	1.00
R5455:Vmn2r99	UTSW	17	19394146	nonsense	probably null
R6021:Vmn2r99	UTSW	17	19377948	missense	probably damaging	1.00
R6059:Vmn2r99	UTSW	17	19378980	missense	probably benign	0.00
R6214:Vmn2r99	UTSW	17	19382558	missense	probably benign	0.19
R6215:Vmn2r99	UTSW	17	19382558	missense	probably benign	0.19
R6313:Vmn2r99	UTSW	17	19382605	missense	probably damaging	1.00
R6646:Vmn2r99	UTSW	17	19380031	missense	probably damaging	1.00
R6810:Vmn2r99	UTSW	17	19380034	missense	probably benign	0.20
R6885:Vmn2r99	UTSW	17	19380195	missense	possibly damaging	0.52
R6991:Vmn2r99	UTSW	17	19378110	missense	probably benign	0.03
R7060:Vmn2r99	UTSW	17	19394564	nonsense	probably null
R7090:Vmn2r99	UTSW	17	19393710	missense	possibly damaging	0.83
R7094:Vmn2r99	UTSW	17	19379311	missense	probably benign	0.00
R7449:Vmn2r99	UTSW	17	19379145	missense	probably benign	0.01
R7789:Vmn2r99	UTSW	17	19393817	missense	possibly damaging	0.91
R8039:Vmn2r99	UTSW	17	19380040	missense	probably benign	0.00
R8493:Vmn2r99	UTSW	17	19393758	missense	probably benign	0.15
R8511:Vmn2r99	UTSW	17	19394181	missense	probably damaging	1.00
R8715:Vmn2r99	UTSW	17	19393660	critical splice acceptor site	probably benign
Z1088:Vmn2r99	UTSW	17	19379301	missense	probably benign	0.18

Posted On

2016-08-02