Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03132:Vmn2r99'

410368

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r99

Ensembl Gene

ENSMUSG00000090304

Gene Name

vomeronasal 2, receptor 99

Synonyms

EG665376

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

IGL03132

Quality Score

Status

Chromosome

Chromosomal Location

19582397-19614852 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 19598485 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 170 (Q170*)

Ref Sequence

ENSEMBL: ENSMUSP00000156067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176107] [ENSMUST00000231989]

AlphaFold

H3BK37

Predicted Effect

probably null
Transcript: ENSMUST00000176107
AA Change: Q170*

SMART Domains

Protein: ENSMUSP00000135236
Gene: ENSMUSG00000090304
AA Change: Q170*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	81	448	5.7e-33	PFAM
Pfam:NCD3G	508	561	1.8e-21	PFAM
Pfam:7tm_3	593	829	4.6e-52	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000231989
AA Change: Q170*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb1	G	A	6: 88,815,941 (GRCm39)	R177C	probably benign	Het
Adam21	C	A	12: 81,607,148 (GRCm39)	G205*	probably null	Het
Baz2b	T	A	2: 59,738,097 (GRCm39)		probably benign	Het
Col6a3	C	T	1: 90,731,615 (GRCm39)	G939D	probably damaging	Het
Csf1r	A	G	18: 61,261,171 (GRCm39)	E749G	probably benign	Het
Dnm3	C	T	1: 161,838,674 (GRCm39)		probably null	Het
Dsg3	A	G	18: 20,657,653 (GRCm39)	D241G	probably damaging	Het
Dst	T	C	1: 34,295,722 (GRCm39)	S6015P	probably benign	Het
Dvl2	T	C	11: 69,896,514 (GRCm39)	S183P	probably benign	Het
Exoc6b	T	C	6: 84,768,246 (GRCm39)	N699S	possibly damaging	Het
Fat2	T	C	11: 55,144,746 (GRCm39)	R4043G	probably benign	Het
Gbp9	T	A	5: 105,232,819 (GRCm39)	T278S	possibly damaging	Het
Gm2a	T	A	11: 54,994,474 (GRCm39)	I48N	probably damaging	Het
Gorasp2	T	C	2: 70,514,379 (GRCm39)	V232A	probably benign	Het
Gpa33	G	A	1: 165,980,218 (GRCm39)	D94N	probably benign	Het
Il1rap	A	T	16: 26,498,869 (GRCm39)	S123C	probably damaging	Het
Kctd17	T	C	15: 78,319,887 (GRCm39)	S102P	probably damaging	Het
Lamb1	A	G	12: 31,350,333 (GRCm39)		probably null	Het
Mfsd1	T	A	3: 67,495,273 (GRCm39)	I131K	possibly damaging	Het
Pkhd1l1	G	A	15: 44,438,013 (GRCm39)	C3576Y	probably damaging	Het
Pla2g4a	A	T	1: 149,778,035 (GRCm39)		probably benign	Het
Ptpn11	T	A	5: 121,272,878 (GRCm39)	D575V	possibly damaging	Het
Reck	A	T	4: 43,938,898 (GRCm39)	R755*	probably null	Het
Scgb2b21	A	G	7: 33,219,299 (GRCm39)	V35A	possibly damaging	Het
Srpra	G	A	9: 35,125,574 (GRCm39)		probably null	Het
Stk11ip	T	C	1: 75,512,733 (GRCm39)	S1025P	probably benign	Het
Tmprss9	G	A	10: 80,730,699 (GRCm39)	V742M	probably damaging	Het
Trh	T	C	6: 92,220,755 (GRCm39)	T36A	probably benign	Het
Trim35	A	G	14: 66,546,595 (GRCm39)	E454G	probably damaging	Het

Other mutations in Vmn2r99

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Vmn2r99	APN	17	19,599,116 (GRCm39)	missense	probably benign	0.01
IGL01113:Vmn2r99	APN	17	19,614,518 (GRCm39)	missense	probably benign	0.20
IGL01138:Vmn2r99	APN	17	19,602,885 (GRCm39)	missense	probably damaging	0.97
IGL01646:Vmn2r99	APN	17	19,613,920 (GRCm39)	splice site	probably benign
IGL01769:Vmn2r99	APN	17	19,600,377 (GRCm39)	missense	probably damaging	1.00
IGL02112:Vmn2r99	APN	17	19,600,494 (GRCm39)	missense	probably null	0.99
IGL02891:Vmn2r99	APN	17	19,598,952 (GRCm39)	nonsense	probably null
FR4548:Vmn2r99	UTSW	17	19,614,547 (GRCm39)	missense	probably damaging	0.97
FR4976:Vmn2r99	UTSW	17	19,614,547 (GRCm39)	missense	probably damaging	0.97
PIT4382001:Vmn2r99	UTSW	17	19,614,605 (GRCm39)	missense	probably damaging	1.00
R0196:Vmn2r99	UTSW	17	19,614,835 (GRCm39)	missense	probably benign	0.00
R0720:Vmn2r99	UTSW	17	19,599,305 (GRCm39)	missense	probably benign	0.00
R1501:Vmn2r99	UTSW	17	19,582,521 (GRCm39)	missense	possibly damaging	0.93
R1519:Vmn2r99	UTSW	17	19,600,322 (GRCm39)	missense	probably benign	0.00
R1670:Vmn2r99	UTSW	17	19,582,514 (GRCm39)	missense	probably benign	0.37
R1682:Vmn2r99	UTSW	17	19,598,207 (GRCm39)	missense	probably damaging	0.97
R1873:Vmn2r99	UTSW	17	19,582,415 (GRCm39)	missense	probably benign	0.25
R1967:Vmn2r99	UTSW	17	19,599,077 (GRCm39)	missense	probably benign	0.01
R2101:Vmn2r99	UTSW	17	19,598,253 (GRCm39)	missense	probably damaging	1.00
R2474:Vmn2r99	UTSW	17	19,598,891 (GRCm39)	missense	probably benign	0.04
R2519:Vmn2r99	UTSW	17	19,598,970 (GRCm39)	missense	probably damaging	0.99
R3911:Vmn2r99	UTSW	17	19,614,635 (GRCm39)	missense	possibly damaging	0.92
R3947:Vmn2r99	UTSW	17	19,599,252 (GRCm39)	missense	probably benign	0.40
R3949:Vmn2r99	UTSW	17	19,599,252 (GRCm39)	missense	probably benign	0.40
R4016:Vmn2r99	UTSW	17	19,598,832 (GRCm39)	missense	possibly damaging	0.86
R4413:Vmn2r99	UTSW	17	19,599,522 (GRCm39)	missense	probably damaging	1.00
R4594:Vmn2r99	UTSW	17	19,613,924 (GRCm39)	missense	probably damaging	1.00
R4999:Vmn2r99	UTSW	17	19,582,397 (GRCm39)	start codon destroyed	probably null	0.96
R5206:Vmn2r99	UTSW	17	19,598,868 (GRCm39)	missense	probably benign	0.40
R5362:Vmn2r99	UTSW	17	19,599,601 (GRCm39)	missense	probably benign	0.00
R5377:Vmn2r99	UTSW	17	19,599,531 (GRCm39)	missense	probably damaging	1.00
R5455:Vmn2r99	UTSW	17	19,614,408 (GRCm39)	nonsense	probably null
R6021:Vmn2r99	UTSW	17	19,598,210 (GRCm39)	missense	probably damaging	1.00
R6059:Vmn2r99	UTSW	17	19,599,242 (GRCm39)	missense	probably benign	0.00
R6214:Vmn2r99	UTSW	17	19,602,820 (GRCm39)	missense	probably benign	0.19
R6215:Vmn2r99	UTSW	17	19,602,820 (GRCm39)	missense	probably benign	0.19
R6313:Vmn2r99	UTSW	17	19,602,867 (GRCm39)	missense	probably damaging	1.00
R6646:Vmn2r99	UTSW	17	19,600,293 (GRCm39)	missense	probably damaging	1.00
R6810:Vmn2r99	UTSW	17	19,600,296 (GRCm39)	missense	probably benign	0.20
R6885:Vmn2r99	UTSW	17	19,600,457 (GRCm39)	missense	possibly damaging	0.52
R6991:Vmn2r99	UTSW	17	19,598,372 (GRCm39)	missense	probably benign	0.03
R7060:Vmn2r99	UTSW	17	19,614,826 (GRCm39)	nonsense	probably null
R7090:Vmn2r99	UTSW	17	19,613,972 (GRCm39)	missense	possibly damaging	0.83
R7094:Vmn2r99	UTSW	17	19,599,573 (GRCm39)	missense	probably benign	0.00
R7449:Vmn2r99	UTSW	17	19,599,407 (GRCm39)	missense	probably benign	0.01
R7789:Vmn2r99	UTSW	17	19,614,079 (GRCm39)	missense	possibly damaging	0.91
R8039:Vmn2r99	UTSW	17	19,600,302 (GRCm39)	missense	probably benign	0.00
R8493:Vmn2r99	UTSW	17	19,614,020 (GRCm39)	missense	probably benign	0.15
R8511:Vmn2r99	UTSW	17	19,614,443 (GRCm39)	missense	probably damaging	1.00
R8715:Vmn2r99	UTSW	17	19,613,922 (GRCm39)	critical splice acceptor site	probably benign
R9462:Vmn2r99	UTSW	17	19,598,388 (GRCm39)	nonsense	probably null
R9681:Vmn2r99	UTSW	17	19,598,889 (GRCm39)	missense	probably damaging	1.00
R9737:Vmn2r99	UTSW	17	19,582,563 (GRCm39)	missense	probably benign
Z1088:Vmn2r99	UTSW	17	19,599,563 (GRCm39)	missense	probably benign	0.18

Posted On

2016-08-02