Incidental Mutation 'R5495:Galnt15'
ID432306
Institutional Source Beutler Lab
Gene Symbol Galnt15
Ensembl Gene ENSMUSG00000021903
Gene Namepolypeptide N-acetylgalactosaminyltransferase 15
Synonyms
MMRRC Submission 043056-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #R5495 (G1)
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location32028989-32062197 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 32029817 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 109 (S109G)
Ref Sequence ENSEMBL: ENSMUSP00000022460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022460] [ENSMUST00000164208]
Predicted Effect probably damaging
Transcript: ENSMUST00000022460
AA Change: S109G

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000022460
Gene: ENSMUSG00000021903
AA Change: S109G

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 105 116 N/A INTRINSIC
low complexity region 166 180 N/A INTRINSIC
Pfam:Glyco_tranf_2_3 191 436 2e-8 PFAM
Pfam:Glycos_transf_2 194 362 9e-32 PFAM
RICIN 505 630 1.19e-6 SMART
Predicted Effect unknown
Transcript: ENSMUST00000164208
AA Change: S109G
SMART Domains Protein: ENSMUSP00000131978
Gene: ENSMUSG00000021903
AA Change: S109G

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 105 116 N/A INTRINSIC
low complexity region 166 180 N/A INTRINSIC
low complexity region 228 248 N/A INTRINSIC
RICIN 381 506 1.19e-6 SMART
Coding Region Coverage
  • 1x: 98.4%
  • 3x: 97.3%
  • 10x: 95.3%
  • 20x: 91.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130204L05Rik A T 3: 91,090,295 L38M possibly damaging Het
Akt2 T C 7: 27,636,169 probably null Het
Arhgap29 T G 3: 122,014,929 M844R probably damaging Het
Atp1a1 T G 3: 101,591,425 D184A probably benign Het
Bcl11a T A 11: 24,165,042 V795E possibly damaging Het
Casp12 T A 9: 5,353,797 I277N possibly damaging Het
Ccdc59 A G 10: 105,845,378 K164E probably damaging Het
D630003M21Rik C T 2: 158,220,511 G30S possibly damaging Het
Dgkd A G 1: 87,926,872 D632G probably damaging Het
Efr3a A G 15: 65,815,409 K56E possibly damaging Het
Egflam T A 15: 7,251,241 R434S probably damaging Het
Fancl C G 11: 26,397,801 A51G probably damaging Het
Fkbp7 T C 2: 76,663,294 Y185C probably damaging Het
Galc A G 12: 98,231,414 probably null Het
Gm13757 T C 2: 88,446,057 T294A probably benign Het
Gramd3 T C 18: 56,482,622 I163T probably damaging Het
Impa1 A G 3: 10,326,170 V80A probably benign Het
Itga10 T C 3: 96,647,371 M56T possibly damaging Het
Larp1b G T 3: 41,035,822 R135I probably damaging Het
Lgals12 C T 19: 7,604,130 A71T probably damaging Het
Lmbr1 A T 5: 29,346,853 L78* probably null Het
Lrat C A 3: 82,896,982 M229I probably benign Het
Mug2 A T 6: 122,079,650 M1185L probably damaging Het
Naprt T C 15: 75,893,847 probably null Het
Nfat5 A G 8: 107,368,447 I1107V probably benign Het
Nr4a2 T C 2: 57,112,375 Y22C probably damaging Het
Ogfod1 C A 8: 94,064,278 Q526K probably benign Het
Olfr139 G A 11: 74,044,785 T163I probably damaging Het
Olfr710 C A 7: 106,944,492 G170* probably null Het
Olfr957 T C 9: 39,511,145 T192A probably benign Het
Parp10 T G 15: 76,243,166 I24L probably benign Het
Pcdha11 A G 18: 37,011,026 T57A probably benign Het
Prdm8 A G 5: 98,185,306 E244G possibly damaging Het
Prl6a1 T C 13: 27,312,671 S3P possibly damaging Het
Rab11fip3 T A 17: 26,016,143 T18S probably damaging Het
Rfc4 T C 16: 23,122,254 probably benign Het
Rubcnl G T 14: 75,042,337 V387F possibly damaging Het
Serpinb12 T C 1: 106,956,421 L299P probably damaging Het
Sptbn5 G A 2: 120,046,484 probably benign Het
Taar4 A T 10: 23,961,283 I264F possibly damaging Het
Tdpoz4 A T 3: 93,797,499 T368S probably benign Het
Thsd7b T A 1: 129,595,833 H124Q probably damaging Het
Ugt1a6a A T 1: 88,139,024 Q184L probably benign Het
Vnn1 T A 10: 23,898,564 F168L probably damaging Het
Zan A G 5: 137,470,408 L267P probably damaging Het
Zswim8 A G 14: 20,722,286 S1621G probably damaging Het
Other mutations in Galnt15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Galnt15 APN 14 32052356 missense possibly damaging 0.47
IGL02491:Galnt15 APN 14 32056316 missense probably damaging 1.00
R0323:Galnt15 UTSW 14 32048085 missense probably damaging 0.99
R1900:Galnt15 UTSW 14 32049865 missense probably damaging 1.00
R4369:Galnt15 UTSW 14 32029539 missense possibly damaging 0.90
R4423:Galnt15 UTSW 14 32058269 missense possibly damaging 0.95
R4979:Galnt15 UTSW 14 32043290 missense probably damaging 0.99
R5093:Galnt15 UTSW 14 32049829 missense probably damaging 1.00
R5201:Galnt15 UTSW 14 32049865 missense probably damaging 1.00
R5254:Galnt15 UTSW 14 32058287 nonsense probably null
R5434:Galnt15 UTSW 14 32049843 missense possibly damaging 0.88
R5451:Galnt15 UTSW 14 32029911 missense probably benign 0.25
R5874:Galnt15 UTSW 14 32052367 missense probably damaging 1.00
R6374:Galnt15 UTSW 14 32058159 missense probably damaging 0.96
R6444:Galnt15 UTSW 14 32040411 missense probably damaging 1.00
R7798:Galnt15 UTSW 14 32029905 missense possibly damaging 0.52
Z1177:Galnt15 UTSW 14 32052365 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGGTGATCCTGCTGCATC -3'
(R):5'- TACTTACAGTGGGTGTCGCAC -3'

Sequencing Primer
(F):5'- TGCACCAGGCTGTCACAG -3'
(R):5'- ACTCTCCTCAGGGGCAG -3'
Posted On2016-10-05