Incidental Mutation 'R6238:Vmn2r74'
| ID |
505050 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| MMRRC Submission |
044401-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
R6238 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 85601280 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 786
(C786Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166355
AA Change: C786Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: C786Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.8%
|
| Validation Efficiency |
100% (62/62) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610028H24Rik |
A |
C |
10: 76,285,096 (GRCm39) |
T2P |
possibly damaging |
Het |
| 2610042L04Rik |
A |
G |
14: 4,348,962 (GRCm38) |
N41S |
probably damaging |
Het |
| 4933402N03Rik |
T |
C |
7: 130,747,863 (GRCm39) |
D43G |
probably benign |
Het |
| Adcy10 |
C |
A |
1: 165,403,297 (GRCm39) |
Y1598* |
probably null |
Het |
| Adgrv1 |
G |
A |
13: 81,614,402 (GRCm39) |
T3997M |
probably benign |
Het |
| Amfr |
A |
C |
8: 94,726,992 (GRCm39) |
F74V |
probably damaging |
Het |
| Ankrd13a |
T |
C |
5: 114,924,787 (GRCm39) |
Y91H |
probably benign |
Het |
| Baiap3 |
A |
G |
17: 25,464,732 (GRCm39) |
S767P |
probably benign |
Het |
| Car12 |
C |
T |
9: 66,661,008 (GRCm39) |
T124I |
probably damaging |
Het |
| Casp9 |
G |
T |
4: 141,534,448 (GRCm39) |
G286V |
probably damaging |
Het |
| Cc2d2a |
T |
A |
5: 43,828,577 (GRCm39) |
D18E |
probably benign |
Het |
| Cdc27 |
T |
C |
11: 104,419,270 (GRCm39) |
N221D |
probably damaging |
Het |
| Cebpz |
A |
G |
17: 79,244,339 (GRCm39) |
S41P |
possibly damaging |
Het |
| Cenpo |
T |
A |
12: 4,281,968 (GRCm39) |
S10C |
possibly damaging |
Het |
| Chid1 |
A |
G |
7: 141,076,049 (GRCm39) |
V368A |
probably benign |
Het |
| Clca3a1 |
C |
A |
3: 144,714,716 (GRCm39) |
V634L |
probably benign |
Het |
| Cmtr1 |
A |
G |
17: 29,901,122 (GRCm39) |
D683G |
probably damaging |
Het |
| Cpsf3 |
G |
T |
12: 21,350,163 (GRCm39) |
R294L |
probably damaging |
Het |
| Ddrgk1 |
G |
A |
2: 130,496,599 (GRCm39) |
T255M |
possibly damaging |
Het |
| Dennd6a |
T |
A |
14: 26,337,813 (GRCm39) |
|
probably null |
Het |
| Dnah10 |
A |
G |
5: 124,820,743 (GRCm39) |
R526G |
probably damaging |
Het |
| Dock3 |
G |
A |
9: 106,790,147 (GRCm39) |
T1484I |
probably benign |
Het |
| Efcab10 |
T |
C |
12: 33,448,433 (GRCm39) |
Y89H |
probably damaging |
Het |
| Etl4 |
T |
A |
2: 20,806,379 (GRCm39) |
D1200E |
probably damaging |
Het |
| Fbn1 |
T |
A |
2: 125,166,865 (GRCm39) |
D2017V |
probably damaging |
Het |
| Ftmt |
G |
A |
18: 52,465,307 (GRCm39) |
V208M |
probably damaging |
Het |
| Fzd10 |
T |
C |
5: 128,679,995 (GRCm39) |
Y572H |
probably damaging |
Het |
| Gcc1 |
T |
C |
6: 28,420,742 (GRCm39) |
K39E |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,118,743 (GRCm39) |
|
probably null |
Het |
| Lif |
A |
G |
11: 4,218,940 (GRCm39) |
E73G |
possibly damaging |
Het |
| Lrtm1 |
C |
A |
14: 28,749,628 (GRCm39) |
Q357K |
probably benign |
Het |
| Mef2d |
T |
A |
3: 88,066,852 (GRCm39) |
L205Q |
probably damaging |
Het |
| Naalad2 |
T |
A |
9: 18,296,361 (GRCm39) |
E96D |
probably damaging |
Het |
| Nbas |
T |
C |
12: 13,532,596 (GRCm39) |
I1768T |
probably benign |
Het |
| Nodal |
T |
C |
10: 61,259,258 (GRCm39) |
S232P |
probably damaging |
Het |
| Or52ab7 |
A |
T |
7: 102,978,115 (GRCm39) |
I141F |
possibly damaging |
Het |
| Or8b12c |
A |
G |
9: 37,715,317 (GRCm39) |
T37A |
probably benign |
Het |
| Parl |
G |
A |
16: 20,120,963 (GRCm39) |
R39C |
possibly damaging |
Het |
| Pcdha9 |
G |
A |
18: 37,132,028 (GRCm39) |
V366I |
probably benign |
Het |
| Pdzd8 |
A |
G |
19: 59,288,994 (GRCm39) |
V802A |
probably benign |
Het |
| Plcl2 |
T |
C |
17: 50,913,873 (GRCm39) |
V294A |
probably damaging |
Het |
| Plxna2 |
T |
A |
1: 194,472,504 (GRCm39) |
S1083T |
probably benign |
Het |
| Polr2a |
G |
T |
11: 69,638,047 (GRCm39) |
L141I |
possibly damaging |
Het |
| Ptpre |
C |
A |
7: 135,272,909 (GRCm39) |
R468S |
probably damaging |
Het |
| Raet1e |
T |
A |
10: 22,056,770 (GRCm39) |
N115K |
probably benign |
Het |
| Rfx8 |
C |
A |
1: 39,709,554 (GRCm39) |
S491I |
probably damaging |
Het |
| Rpe |
T |
A |
1: 66,740,807 (GRCm39) |
L48* |
probably null |
Het |
| Skint5 |
A |
T |
4: 113,800,064 (GRCm39) |
|
probably null |
Het |
| Spata24 |
C |
A |
18: 35,793,389 (GRCm39) |
S111I |
possibly damaging |
Het |
| Suz12 |
G |
C |
11: 79,893,006 (GRCm39) |
|
probably benign |
Het |
| Taf4 |
T |
A |
2: 179,573,832 (GRCm39) |
I679F |
probably damaging |
Het |
| Tlr1 |
G |
T |
5: 65,084,472 (GRCm39) |
P35Q |
possibly damaging |
Het |
| Tonsl |
T |
C |
15: 76,520,418 (GRCm39) |
|
probably null |
Het |
| Tsen54 |
G |
A |
11: 115,711,513 (GRCm39) |
R310H |
probably benign |
Het |
| Ttc7b |
A |
G |
12: 100,461,681 (GRCm39) |
S99P |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Uhmk1 |
T |
A |
1: 170,027,563 (GRCm39) |
N378I |
probably damaging |
Het |
| Vmn2r107 |
A |
G |
17: 20,565,849 (GRCm39) |
T55A |
probably benign |
Het |
| Wdr20rt |
C |
T |
12: 65,272,964 (GRCm39) |
|
probably benign |
Het |
| Zfand2a |
T |
A |
5: 139,467,746 (GRCm39) |
H42L |
probably damaging |
Het |
| Zfp990 |
T |
A |
4: 145,264,483 (GRCm39) |
C494S |
probably damaging |
Het |
| Zkscan4 |
A |
T |
13: 21,668,757 (GRCm39) |
R403W |
possibly damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACGTCGTTTCCTGAACTTG -3'
(R):5'- ATTTGGCTGGGAACTTCTCC -3'
Sequencing Primer
(F):5'- CTGCACTTGAAGCCAAGAT -3'
(R):5'- GTTGATGCTGATCTACATATGGTAC -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation