Incidental Mutation 'R6990:Ppp2cb'
ID 543201
Institutional Source Beutler Lab
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
MMRRC Submission 045096-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6990 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34109161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 290 (D290G)
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774] [ENSMUST00000095349]
AlphaFold P62715
Predicted Effect probably benign
Transcript: ENSMUST00000009774
AA Change: D290G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630
AA Change: D290G

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000095349
SMART Domains Protein: ENSMUSP00000092992
Gene: ENSMUSG00000052906

DomainStartEndE-ValueType
transmembrane domain 5 22 N/A INTRINSIC
transmembrane domain 34 56 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
Pfam:UBX 192 271 3.8e-16 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T G 10: 78,902,925 (GRCm39) T464P probably damaging Het
Abca16 A G 7: 120,126,950 (GRCm39) I1214V probably benign Het
Arap2 A G 5: 62,833,860 (GRCm39) F869S probably damaging Het
Astn2 G T 4: 65,910,540 (GRCm39) H431N possibly damaging Het
Bap1 A G 14: 30,977,608 (GRCm39) T308A probably benign Het
Bcr G A 10: 74,966,868 (GRCm39) E492K possibly damaging Het
Bltp3b A G 10: 89,641,979 (GRCm39) D1050G probably benign Het
Camta1 A G 4: 151,229,501 (GRCm39) F444L probably damaging Het
Chd7 A T 4: 8,844,525 (GRCm39) T1545S probably benign Het
Dnmt1 A T 9: 20,827,110 (GRCm39) Y877* probably null Het
Fam13b A G 18: 34,630,500 (GRCm39) V86A possibly damaging Het
Gm11562 T A 11: 99,510,817 (GRCm39) R128W unknown Het
Krt86 A G 15: 101,371,714 (GRCm39) I95V probably benign Het
Mroh2b A G 15: 4,942,284 (GRCm39) T349A possibly damaging Het
Ms4a7 A T 19: 11,310,605 (GRCm39) L38Q probably damaging Het
Myo1h T C 5: 114,468,221 (GRCm39) S339P probably damaging Het
Nf2 T C 11: 4,749,944 (GRCm39) I46V probably benign Het
Nr1h4 T C 10: 89,290,792 (GRCm39) D416G probably benign Het
Oga G A 19: 45,755,915 (GRCm39) A576V probably benign Het
Or11l3 T C 11: 58,516,284 (GRCm39) E196G probably damaging Het
Or4p18 A G 2: 88,232,639 (GRCm39) M213T probably benign Het
Pde1c C G 6: 56,419,020 (GRCm39) E87Q possibly damaging Het
Peg10 T TCCA 6: 4,756,451 (GRCm39) probably benign Het
Pga5 A T 19: 10,646,779 (GRCm39) D317E probably benign Het
Pira2 T A 7: 3,844,067 (GRCm39) K568N probably damaging Het
Sall4 T C 2: 168,596,990 (GRCm39) K617E probably damaging Het
Slc7a14 G A 3: 31,277,728 (GRCm39) P626S possibly damaging Het
Speer4b A T 5: 27,702,076 (GRCm39) L228* probably null Het
Spns2 T C 11: 72,380,447 (GRCm39) T59A probably benign Het
Tbc1d5 A T 17: 51,275,260 (GRCm39) N78K probably benign Het
Tmem63a T C 1: 180,788,686 (GRCm39) V341A probably benign Het
Trpt1 A G 19: 6,975,683 (GRCm39) T146A probably benign Het
Tyrp1 T C 4: 80,753,674 (GRCm39) C122R probably damaging Het
Uchl1 A G 5: 66,839,818 (GRCm39) E120G possibly damaging Het
Ucn3 C T 13: 3,991,295 (GRCm39) R119Q possibly damaging Het
Vmn2r2 T G 3: 64,024,608 (GRCm39) I658L probably benign Het
Vmn2r96 T A 17: 18,804,082 (GRCm39) V444E probably benign Het
Wdr54 A C 6: 83,132,629 (GRCm39) probably null Het
Xcr1 A G 9: 123,685,300 (GRCm39) L154P probably benign Het
Zbtb26 T C 2: 37,326,557 (GRCm39) K160E probably benign Het
Zfp157 T G 5: 138,454,772 (GRCm39) Y323* probably null Het
Zfp850 A T 7: 27,689,801 (GRCm39) F136I probably benign Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 34,101,791 (GRCm39) missense probably benign 0.38
IGL02985:Ppp2cb APN 8 34,105,474 (GRCm39) unclassified probably benign
IGL03251:Ppp2cb APN 8 34,100,679 (GRCm39) splice site probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2187:Ppp2cb UTSW 8 34,100,705 (GRCm39) missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R4566:Ppp2cb UTSW 8 34,100,723 (GRCm39) missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- TTTCACCATAGCTGTGAAGTGC -3'
(R):5'- ATGGCACGTTTTGGTCCATG -3'

Sequencing Primer
(F):5'- CACCATAGCTGTGAAGTGCTAACTG -3'
(R):5'- GTCCATGATGTGTTTTAATGTCAAG -3'
Posted On 2018-11-28