Mutagenetix > Incidental Mutation

Incidental Mutation 'R6805:Olfr1129'

543630

Institutional Source

Beutler Lab

Gene Symbol

Olfr1129

Ensembl Gene

ENSMUSG00000062272

Gene Name

olfactory receptor 1129

Synonyms

GA_x6K02T2Q125-49078087-49079031, MOR264-9P, MOR264-23

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R6805 (G1)

Quality Score

101.008

Status

Validated

Chromosome

Chromosomal Location

87573902-87577259 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 87574918 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150986 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081034] [ENSMUST00000213315] [ENSMUST00000214773] [ENSMUST00000214773]

AlphaFold

A2AV41

Predicted Effect

probably benign
Transcript: ENSMUST00000081034

SMART Domains

Protein: ENSMUSP00000079823
Gene: ENSMUSG00000062272

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	6e-53	PFAM
Pfam:7tm_1	47	296	2.1e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213315

Predicted Effect

probably null
Transcript: ENSMUST00000214773

Predicted Effect

probably null
Transcript: ENSMUST00000214773

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.8%
20x: 97.1%

Validation Efficiency

98% (62/63)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	C	15: 8,244,306	V2591A	probably benign	Het
4930407I10Rik	A	G	15: 82,062,543	T214A	possibly damaging	Het
A930009A15Rik	G	T	10: 115,579,905		probably benign	Het
Aadac	A	C	3: 60,037,336	D143A	probably benign	Het
Acot10	T	G	15: 20,665,366	T430P	probably benign	Het
Adgrb3	T	C	1: 25,826,172	T197A	possibly damaging	Het
B230118H07Rik	T	C	2: 101,566,459	K192E	probably benign	Het
Bbs1	A	G	19: 4,900,615	I200T	probably damaging	Het
C1ra	G	A	6: 124,517,725	E316K	probably benign	Het
Cadps	G	A	14: 12,467,103	A943V	probably damaging	Het
Cc2d2a	A	G	5: 43,681,331	E48G	probably damaging	Het
Clca1	A	T	3: 145,018,667	C211S	probably damaging	Het
Col18a1	A	G	10: 77,054,239	L1429P	probably damaging	Het
Cul2	T	G	18: 3,421,263	Y196D	probably damaging	Het
D630023F18Rik	T	C	1: 65,117,206	S43G	probably benign	Het
Ddx39	G	A	8: 83,723,137	R427Q	probably damaging	Het
Def6	A	G	17: 28,223,717	T285A	probably damaging	Het
Defb21	T	A	2: 152,574,869	D88E	probably benign	Het
Defb6	A	G	8: 19,228,101	K63R	probably benign	Het
Dnph1	T	C	17: 46,498,744	S112P	probably damaging	Het
Dock10	T	A	1: 80,586,690	I467L	probably benign	Het
Dspp	C	A	5: 104,175,850	H286Q	probably benign	Het
Eya1	T	A	1: 14,183,277	T459S	probably benign	Het
Faf1	T	C	4: 109,861,852	L385P	probably damaging	Het
Fbxw21	C	A	9: 109,157,565	R82L	probably damaging	Het
Fryl	A	G	5: 73,065,094	V2048A	probably benign	Het
Galnt5	A	T	2: 58,035,299	D864V	possibly damaging	Het
Gata6	T	G	18: 11,054,460	S130A	possibly damaging	Het
Gbf1	G	T	19: 46,262,507	R434L	probably damaging	Het
Gga3	A	G	11: 115,585,762	F709L	probably damaging	Het
Hcar1	A	G	5: 123,879,130	V166A	probably benign	Het
Hexa	T	A	9: 59,563,937	N491K	possibly damaging	Het
Hpse2	A	T	19: 43,294,321	C164*	probably null	Het
Ifi202b	T	C	1: 173,974,989	Y93C	probably damaging	Het
Iscu	T	A	5: 113,775,243	I79N	probably damaging	Het
Jmjd7	T	A	2: 120,031,323	Y182*	probably null	Het
Jup	A	T	11: 100,383,458	D135E	probably benign	Het
Kit	T	A	5: 75,652,808	I881N	probably damaging	Het
Llgl1	T	A	11: 60,702,865	S55T	probably benign	Het
Lonp2	G	A	8: 86,709,096	M653I	probably benign	Het
Lrp8	T	C	4: 107,854,320	Y307H	probably damaging	Het
Med13	A	T	11: 86,278,796	M1914K	possibly damaging	Het
Ms4a1	A	G	19: 11,253,173		probably null	Het
Naip1	A	G	13: 100,427,341	S439P	probably benign	Het
Nrg1	T	C	8: 31,821,264	R476G	probably damaging	Het
Olfr835	G	T	9: 19,035,301	M59I	probably damaging	Het
Pds5b	T	A	5: 150,805,561		probably null	Het
Phf12	G	A	11: 78,027,373	G804R	probably damaging	Het
Pou6f2	T	C	13: 18,239,489	T234A		Het
Prune2	A	T	19: 17,120,590	I1153L	probably benign	Het
Ptprc	C	T	1: 138,067,885		probably null	Het
Qpctl	T	C	7: 19,149,154	Q11R	probably benign	Het
Rfx4	A	G	10: 84,840,228	K103E	possibly damaging	Het
Srcin1	T	A	11: 97,551,980		probably null	Het
St6galnac1	G	T	11: 116,768,944	A181D	probably damaging	Het
Stk36	T	C	1: 74,622,239	V475A	probably benign	Het
Tbc1d21	T	C	9: 58,361,288	T263A	possibly damaging	Het
Tex24	A	T	8: 27,345,000	K185N	probably damaging	Het
Tnxb	T	A	17: 34,698,153	V2174E	possibly damaging	Het
Tollip	A	G	7: 141,890,845	S57P	probably benign	Het
Zbtb49	A	G	5: 38,213,241		probably benign	Het
Zfp758	A	G	17: 22,361,669	T30A	probably benign	Het

Other mutations in Olfr1129

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01312:Olfr1129	APN	2	87575174	missense	probably damaging	1.00
IGL01731:Olfr1129	APN	2	87575938	missense	probably benign	0.26
IGL01819:Olfr1129	APN	2	87575479	missense	probably damaging	1.00
IGL01995:Olfr1129	APN	2	87575462	missense	probably damaging	1.00
IGL02280:Olfr1129	APN	2	87575345	missense	probably damaging	0.98
IGL02451:Olfr1129	APN	2	87575232	missense	probably benign	0.02
IGL02514:Olfr1129	APN	2	87575193	missense	probably benign
IGL03039:Olfr1129	APN	2	87575192	missense	probably benign	0.01
IGL03074:Olfr1129	APN	2	87575336	missense	possibly damaging	0.66
R0396:Olfr1129	UTSW	2	87575567	missense	possibly damaging	0.95
R0960:Olfr1129	UTSW	2	87575935	missense	probably benign	0.44
R1955:Olfr1129	UTSW	2	87576005	missense	probably damaging	1.00
R2006:Olfr1129	UTSW	2	87575192	missense	probably benign	0.01
R3752:Olfr1129	UTSW	2	87575713	missense	probably benign
R4546:Olfr1129	UTSW	2	87575186	missense	probably benign	0.03
R4812:Olfr1129	UTSW	2	87575743	missense	probably benign	0.11
R5327:Olfr1129	UTSW	2	87575699	missense	probably damaging	1.00
R5845:Olfr1129	UTSW	2	87576023	missense	probably benign	0.06
R6057:Olfr1129	UTSW	2	87576019	missense	probably benign
R6087:Olfr1129	UTSW	2	87575915	missense	probably benign	0.43
R6125:Olfr1129	UTSW	2	87575246	missense	probably benign	0.01
R6496:Olfr1129	UTSW	2	87575116	missense	probably damaging	1.00
R6967:Olfr1129	UTSW	2	87575513	missense	possibly damaging	0.50
R7286:Olfr1129	UTSW	2	87575519	missense	probably benign	0.00
R7296:Olfr1129	UTSW	2	87575708	missense	probably damaging	1.00
R7496:Olfr1129	UTSW	2	87575371	missense	probably damaging	1.00
R7753:Olfr1129	UTSW	2	87575797	missense	probably benign	0.16
R8444:Olfr1129	UTSW	2	87575739	missense	probably benign
Z1088:Olfr1129	UTSW	2	87575680	missense	possibly damaging	0.88

Predicted Primers

PCR Primer
(F):5'- GCCTGTATTTTAGAAAATCCTAGTGGC -3'
(R):5'- AAGCATTGTCCTCTGCCCTG -3'

Sequencing Primer
(F):5'- AAATCCTAGTGGCTTTCTTAGTTTG -3'
(R):5'- GCCCTGATTTCTGTGAATTTCATCTG -3'

Posted On

2019-04-08