Incidental Mutation 'R7135:Mink1'
| ID |
553015 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mink1
|
| Ensembl Gene |
ENSMUSG00000020827 |
| Gene Name |
misshapen-like kinase 1 (zebrafish) |
| Synonyms |
Misshapen/NIKs-related kinase, Map4k6, Ysk2, MINK |
| MMRRC Submission |
045247-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7135 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
70453707-70505309 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70494329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 243
(F243S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099619
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072237]
[ENSMUST00000072873]
[ENSMUST00000079244]
[ENSMUST00000102558]
[ENSMUST00000102559]
|
| AlphaFold |
Q9JM52 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072237
AA Change: F243S
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000072091
Gene: ENSMUSG00000020827
AA Change: F243S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
874 |
N/A |
INTRINSIC |
|
CNH
|
1026 |
1324 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072873
AA Change: F243S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000072649
Gene: ENSMUSG00000020827
AA Change: F243S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
853 |
N/A |
INTRINSIC |
|
CNH
|
1019 |
1317 |
1.58e-113 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000079244
AA Change: F243S
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000078234
Gene: ENSMUSG00000020827
AA Change: F243S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
314 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
348 |
493 |
N/A |
INTRINSIC |
|
low complexity region
|
554 |
566 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
656 |
N/A |
INTRINSIC |
|
low complexity region
|
716 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
826 |
850 |
N/A |
INTRINSIC |
|
CNH
|
1016 |
1314 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102558
AA Change: F243S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099618
Gene: ENSMUSG00000020827
AA Change: F243S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
816 |
N/A |
INTRINSIC |
|
CNH
|
982 |
1280 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102559
AA Change: F243S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000099619
Gene: ENSMUSG00000020827
AA Change: F243S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
800 |
824 |
N/A |
INTRINSIC |
|
CNH
|
990 |
1288 |
1.58e-113 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000117959
Gene: ENSMUSG00000020827
AA Change: F96S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
1 |
140 |
2.3e-22 |
PFAM |
|
Pfam:Pkinase
|
1 |
143 |
1.6e-30 |
PFAM |
|
low complexity region
|
161 |
192 |
N/A |
INTRINSIC |
|
coiled coil region
|
204 |
349 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
423 |
N/A |
INTRINSIC |
|
low complexity region
|
474 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
500 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
728 |
N/A |
INTRINSIC |
|
CNH
|
880 |
1178 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149845
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178764
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (83/83) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
T |
A |
17: 45,819,887 (GRCm39) |
Y221* |
probably null |
Het |
| AC166344.1 |
T |
A |
14: 43,158,245 (GRCm39) |
F97I |
|
Het |
| Ankmy2 |
T |
C |
12: 36,246,311 (GRCm39) |
S412P |
probably benign |
Het |
| Ap1s3 |
T |
C |
1: 79,586,919 (GRCm39) |
T144A |
probably benign |
Het |
| Armh2 |
T |
C |
13: 24,925,489 (GRCm39) |
S78P |
probably benign |
Het |
| Asb3 |
T |
A |
11: 30,948,501 (GRCm39) |
L59* |
probably null |
Het |
| Asxl3 |
G |
T |
18: 22,650,758 (GRCm39) |
G916* |
probably null |
Het |
| Asxl3 |
G |
C |
18: 22,650,759 (GRCm39) |
G916A |
probably damaging |
Het |
| Birc2 |
A |
C |
9: 7,818,762 (GRCm39) |
F610V |
probably damaging |
Het |
| Camk4 |
G |
A |
18: 33,240,996 (GRCm39) |
|
probably null |
Het |
| Ccdc162 |
A |
G |
10: 41,549,855 (GRCm39) |
S343P |
probably benign |
Het |
| Ccnk |
T |
A |
12: 108,152,734 (GRCm39) |
L17Q |
probably damaging |
Het |
| Cd59b |
G |
A |
2: 103,914,792 (GRCm39) |
W63* |
probably null |
Het |
| Chrm3 |
C |
T |
13: 9,927,837 (GRCm39) |
V400I |
probably benign |
Het |
| Crb1 |
C |
A |
1: 139,171,105 (GRCm39) |
V762F |
probably damaging |
Het |
| Cspp1 |
C |
T |
1: 10,159,161 (GRCm39) |
T529I |
possibly damaging |
Het |
| Cttnbp2 |
A |
G |
6: 18,448,446 (GRCm39) |
I71T |
possibly damaging |
Het |
| Cyb561 |
C |
A |
11: 105,826,393 (GRCm39) |
G90V |
probably damaging |
Het |
| Cyld |
T |
A |
8: 89,471,520 (GRCm39) |
D804E |
possibly damaging |
Het |
| Ddx31 |
G |
A |
2: 28,738,318 (GRCm39) |
V160I |
probably benign |
Het |
| Dgkg |
T |
C |
16: 22,319,132 (GRCm39) |
D643G |
probably damaging |
Het |
| Dnah12 |
G |
A |
14: 26,500,869 (GRCm39) |
|
probably null |
Het |
| Dnah12 |
T |
G |
14: 26,523,370 (GRCm39) |
I1953S |
probably damaging |
Het |
| Dnah7b |
T |
C |
1: 46,178,870 (GRCm39) |
W848R |
probably damaging |
Het |
| Dnah7c |
C |
T |
1: 46,572,368 (GRCm39) |
T947M |
probably damaging |
Het |
| Dnmt3c |
C |
A |
2: 153,556,872 (GRCm39) |
|
probably null |
Het |
| Dsp |
A |
T |
13: 38,363,049 (GRCm39) |
Y443F |
probably damaging |
Het |
| Espl1 |
T |
A |
15: 102,227,959 (GRCm39) |
C1603* |
probably null |
Het |
| Faiml |
G |
T |
9: 99,116,496 (GRCm39) |
R65S |
probably benign |
Het |
| Gfpt2 |
T |
C |
11: 49,695,782 (GRCm39) |
I4T |
probably damaging |
Het |
| Gm10376 |
T |
A |
14: 42,867,950 (GRCm39) |
M179L |
probably benign |
Het |
| Gm4302 |
T |
A |
10: 100,177,589 (GRCm39) |
M291K |
unknown |
Het |
| Gnb1l |
T |
A |
16: 18,363,918 (GRCm39) |
D154E |
probably benign |
Het |
| Igkv10-94 |
T |
C |
6: 68,681,727 (GRCm39) |
R38G |
possibly damaging |
Het |
| Inmt |
A |
T |
6: 55,148,013 (GRCm39) |
Y205* |
probably null |
Het |
| Krba1 |
A |
G |
6: 48,393,233 (GRCm39) |
Q1049R |
probably benign |
Het |
| Lpxn |
T |
A |
19: 12,810,683 (GRCm39) |
C376S |
probably damaging |
Het |
| Lrrc52 |
T |
A |
1: 167,294,019 (GRCm39) |
I89F |
probably damaging |
Het |
| Map9 |
A |
T |
3: 82,270,765 (GRCm39) |
T110S |
probably benign |
Het |
| Mccc1 |
T |
C |
3: 36,049,967 (GRCm39) |
Y75C |
probably damaging |
Het |
| Mff |
T |
A |
1: 82,724,812 (GRCm39) |
L203* |
probably null |
Het |
| Micall1 |
C |
A |
15: 78,993,624 (GRCm39) |
D47E |
unknown |
Het |
| Mlycd |
C |
T |
8: 120,129,216 (GRCm39) |
R228W |
probably damaging |
Het |
| Msr1 |
A |
T |
8: 40,042,465 (GRCm39) |
V370E |
possibly damaging |
Het |
| Naip6 |
T |
C |
13: 100,436,927 (GRCm39) |
E532G |
probably damaging |
Het |
| Nepn |
G |
A |
10: 52,267,815 (GRCm39) |
C27Y |
probably damaging |
Het |
| Ninl |
T |
C |
2: 150,797,524 (GRCm39) |
H592R |
probably benign |
Het |
| Nr4a2 |
A |
G |
2: 57,002,261 (GRCm39) |
M64T |
possibly damaging |
Het |
| Oprm1 |
A |
T |
10: 6,780,203 (GRCm39) |
I171F |
possibly damaging |
Het |
| Or4g16 |
T |
A |
2: 111,137,365 (GRCm39) |
F272I |
probably benign |
Het |
| Or5p60 |
T |
C |
7: 107,723,781 (GRCm39) |
K230E |
probably damaging |
Het |
| Pcbp1 |
A |
T |
6: 86,502,488 (GRCm39) |
M137K |
possibly damaging |
Het |
| Pcf11 |
A |
T |
7: 92,306,524 (GRCm39) |
S1215T |
probably benign |
Het |
| Pdlim5 |
A |
T |
3: 142,017,683 (GRCm39) |
|
probably null |
Het |
| Pecam1 |
T |
C |
11: 106,579,857 (GRCm39) |
I402V |
probably damaging |
Het |
| Pex12 |
T |
C |
11: 83,188,468 (GRCm39) |
T176A |
probably benign |
Het |
| Phf3 |
T |
C |
1: 30,870,190 (GRCm39) |
K286R |
possibly damaging |
Het |
| Pik3ap1 |
T |
A |
19: 41,320,760 (GRCm39) |
D153V |
probably damaging |
Het |
| Pkhd1l1 |
T |
A |
15: 44,448,374 (GRCm39) |
|
probably null |
Het |
| Plekhn1 |
A |
G |
4: 156,307,792 (GRCm39) |
V378A |
probably benign |
Het |
| Pramel26 |
A |
T |
4: 143,537,233 (GRCm39) |
L366Q |
probably damaging |
Het |
| Ptprm |
A |
T |
17: 67,251,283 (GRCm39) |
D531E |
possibly damaging |
Het |
| Pum2 |
A |
T |
12: 8,778,952 (GRCm39) |
Q508L |
possibly damaging |
Het |
| Rad54l |
A |
G |
4: 115,963,027 (GRCm39) |
S324P |
probably damaging |
Het |
| Recql5 |
C |
T |
11: 115,821,498 (GRCm39) |
|
probably null |
Het |
| Reln |
A |
T |
5: 22,181,594 (GRCm39) |
V1763D |
possibly damaging |
Het |
| Rp1 |
T |
C |
1: 4,418,391 (GRCm39) |
N907S |
possibly damaging |
Het |
| Scaf11 |
T |
A |
15: 96,318,209 (GRCm39) |
N452Y |
possibly damaging |
Het |
| Scgb2b3 |
T |
A |
7: 31,059,639 (GRCm39) |
H45L |
possibly damaging |
Het |
| Sim1 |
A |
G |
10: 50,772,023 (GRCm39) |
T11A |
probably damaging |
Het |
| Slc5a12 |
T |
A |
2: 110,447,059 (GRCm39) |
M189K |
possibly damaging |
Het |
| Slco2b1 |
C |
T |
7: 99,344,270 (GRCm39) |
G10S |
probably null |
Het |
| Speer1j |
C |
T |
5: 11,555,198 (GRCm39) |
P83S |
probably damaging |
Het |
| Stxbp3 |
A |
G |
3: 108,708,071 (GRCm39) |
L410P |
probably damaging |
Het |
| Sugct |
T |
C |
13: 17,476,594 (GRCm39) |
N297D |
probably benign |
Het |
| Syne1 |
A |
G |
10: 5,183,409 (GRCm39) |
I4132T |
probably benign |
Het |
| Teddm1b |
A |
T |
1: 153,750,912 (GRCm39) |
L240F |
probably damaging |
Het |
| Tlr5 |
C |
A |
1: 182,803,088 (GRCm39) |
D797E |
possibly damaging |
Het |
| Tmprss13 |
G |
T |
9: 45,249,643 (GRCm39) |
G327C |
probably damaging |
Het |
| Tnrc18 |
G |
T |
5: 142,773,572 (GRCm39) |
A419D |
|
Het |
| Ttc28 |
T |
C |
5: 111,427,873 (GRCm39) |
Y1790H |
probably damaging |
Het |
| Vmn1r125 |
T |
G |
7: 21,006,327 (GRCm39) |
M75R |
probably damaging |
Het |
| Vwa3a |
T |
A |
7: 120,372,253 (GRCm39) |
D276E |
possibly damaging |
Het |
| Wdfy3 |
C |
T |
5: 102,063,303 (GRCm39) |
V1322M |
probably damaging |
Het |
| Wdr11 |
T |
C |
7: 129,229,830 (GRCm39) |
S872P |
possibly damaging |
Het |
| Zc3h13 |
T |
C |
14: 75,559,161 (GRCm39) |
S357P |
unknown |
Het |
|
| Other mutations in Mink1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00501:Mink1
|
APN |
11 |
70,494,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00709:Mink1
|
APN |
11 |
70,503,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01064:Mink1
|
APN |
11 |
70,494,307 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02612:Mink1
|
APN |
11 |
70,488,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02797:Mink1
|
APN |
11 |
70,501,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03056:Mink1
|
APN |
11 |
70,503,409 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03066:Mink1
|
APN |
11 |
70,499,715 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03185:Mink1
|
APN |
11 |
70,494,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4498001:Mink1
|
UTSW |
11 |
70,489,714 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0488:Mink1
|
UTSW |
11 |
70,488,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0637:Mink1
|
UTSW |
11 |
70,492,502 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0828:Mink1
|
UTSW |
11 |
70,500,971 (GRCm39) |
nonsense |
probably null |
|
|
R1081:Mink1
|
UTSW |
11 |
70,497,861 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1175:Mink1
|
UTSW |
11 |
70,502,166 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1441:Mink1
|
UTSW |
11 |
70,497,940 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1532:Mink1
|
UTSW |
11 |
70,492,833 (GRCm39) |
missense |
probably null |
1.00 |
|
R1545:Mink1
|
UTSW |
11 |
70,489,717 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1634:Mink1
|
UTSW |
11 |
70,499,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1932:Mink1
|
UTSW |
11 |
70,499,254 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2033:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2184:Mink1
|
UTSW |
11 |
70,494,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2859:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3713:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3714:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3715:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3716:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3717:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4607:Mink1
|
UTSW |
11 |
70,496,893 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4735:Mink1
|
UTSW |
11 |
70,500,086 (GRCm39) |
splice site |
probably null |
|
|
R4790:Mink1
|
UTSW |
11 |
70,489,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4847:Mink1
|
UTSW |
11 |
70,492,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Mink1
|
UTSW |
11 |
70,502,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4860:Mink1
|
UTSW |
11 |
70,502,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5081:Mink1
|
UTSW |
11 |
70,495,970 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5310:Mink1
|
UTSW |
11 |
70,498,169 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5677:Mink1
|
UTSW |
11 |
70,495,991 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5767:Mink1
|
UTSW |
11 |
70,496,901 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5795:Mink1
|
UTSW |
11 |
70,498,616 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5888:Mink1
|
UTSW |
11 |
70,500,885 (GRCm39) |
unclassified |
probably benign |
|
|
R5950:Mink1
|
UTSW |
11 |
70,500,412 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6024:Mink1
|
UTSW |
11 |
70,489,915 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6058:Mink1
|
UTSW |
11 |
70,502,546 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6144:Mink1
|
UTSW |
11 |
70,501,478 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6154:Mink1
|
UTSW |
11 |
70,500,927 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6218:Mink1
|
UTSW |
11 |
70,489,720 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6262:Mink1
|
UTSW |
11 |
70,494,151 (GRCm39) |
splice site |
probably null |
|
|
R6269:Mink1
|
UTSW |
11 |
70,489,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Mink1
|
UTSW |
11 |
70,502,261 (GRCm39) |
nonsense |
probably null |
|
|
R6301:Mink1
|
UTSW |
11 |
70,503,120 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6603:Mink1
|
UTSW |
11 |
70,500,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6876:Mink1
|
UTSW |
11 |
70,498,261 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7030:Mink1
|
UTSW |
11 |
70,498,601 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7050:Mink1
|
UTSW |
11 |
70,503,158 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7094:Mink1
|
UTSW |
11 |
70,500,901 (GRCm39) |
splice site |
probably null |
|
|
R7238:Mink1
|
UTSW |
11 |
70,502,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7320:Mink1
|
UTSW |
11 |
70,489,899 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7396:Mink1
|
UTSW |
11 |
70,495,994 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7446:Mink1
|
UTSW |
11 |
70,500,455 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7723:Mink1
|
UTSW |
11 |
70,503,736 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7896:Mink1
|
UTSW |
11 |
70,503,108 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8058:Mink1
|
UTSW |
11 |
70,494,594 (GRCm39) |
nonsense |
probably null |
|
|
R8082:Mink1
|
UTSW |
11 |
70,504,103 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8160:Mink1
|
UTSW |
11 |
70,496,907 (GRCm39) |
nonsense |
probably null |
|
|
R8335:Mink1
|
UTSW |
11 |
70,500,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8353:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8453:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8732:Mink1
|
UTSW |
11 |
70,500,902 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9072:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9073:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9324:Mink1
|
UTSW |
11 |
70,502,477 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9596:Mink1
|
UTSW |
11 |
70,497,915 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCTAGGAATCACAGCCATTG -3'
(R):5'- ATCCCTGTAGTTGCTGCCTG -3'
Sequencing Primer
(F):5'- CTCTAGGAATCACAGCCATTGAAATG -3'
(R):5'- GCCTGCAGTTCCCACAC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation