|Institutional Source||Beutler Lab|
|Gene Name||CUB domain containing protein 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7674 (G1)|
|Chromosomal Location||123170824-123216038 bp(-) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||C to A at 123216006 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000042057 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000039229]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||100% (58/58)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdcp1||
(F):5'- TCGTGTAACCCCTGAACAC -3'
(R):5'- CTTTGAGAAAGGAACTGAAGCCC -3'
(F):5'- GGCCACAGGTTGCTCTTAC -3'
(R):5'- ACTGAAGCCCGGGAAGG -3'