Incidental Mutation 'R8158:Vmn2r82'
| ID |
633381 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r82
|
| Ensembl Gene |
ENSMUSG00000091468 |
| Gene Name |
vomeronasal 2, receptor 82 |
| Synonyms |
EG624845 |
| MMRRC Submission |
067584-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R8158 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
79192425-79232600 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 79213636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Threonine
at position 74
(N74T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130114
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170596]
|
| AlphaFold |
G3UWA2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170596
AA Change: N74T
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000130114
Gene: ENSMUSG00000091468
AA Change: N74T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
474 |
6e-35 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
9.3e-22 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
6.5e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abl2 |
T |
A |
1: 156,469,639 (GRCm39) |
S968T |
probably benign |
Het |
| Adcy8 |
T |
C |
15: 64,655,655 (GRCm39) |
D608G |
probably benign |
Het |
| Adgb |
C |
T |
10: 10,254,478 (GRCm39) |
V1162M |
probably benign |
Het |
| Agrn |
A |
G |
4: 156,258,346 (GRCm39) |
V1040A |
probably benign |
Het |
| Amer3 |
A |
T |
1: 34,626,741 (GRCm39) |
T327S |
possibly damaging |
Het |
| Apaf1 |
C |
T |
10: 90,895,520 (GRCm39) |
C426Y |
probably benign |
Het |
| Bsn |
T |
C |
9: 107,987,232 (GRCm39) |
D2840G |
unknown |
Het |
| Camsap1 |
A |
T |
2: 25,834,440 (GRCm39) |
C406* |
probably null |
Het |
| Cbr2 |
A |
T |
11: 120,621,123 (GRCm39) |
M158K |
probably damaging |
Het |
| Cgrrf1 |
T |
C |
14: 47,091,192 (GRCm39) |
S239P |
probably benign |
Het |
| Clnk |
C |
A |
5: 38,952,254 (GRCm39) |
|
probably null |
Het |
| Csad |
T |
C |
15: 102,086,197 (GRCm39) |
M445V |
probably damaging |
Het |
| Dnajb7 |
T |
A |
15: 81,291,600 (GRCm39) |
N246Y |
probably damaging |
Het |
| Dok6 |
T |
C |
18: 89,492,071 (GRCm39) |
I169V |
probably benign |
Het |
| H2bc14 |
T |
C |
13: 21,906,631 (GRCm39) |
Y122H |
probably benign |
Het |
| Il1f10 |
T |
G |
2: 24,181,267 (GRCm39) |
I11R |
possibly damaging |
Het |
| Irs1 |
C |
T |
1: 82,267,254 (GRCm39) |
V321M |
probably damaging |
Het |
| Itga9 |
T |
C |
9: 118,706,211 (GRCm39) |
F938L |
probably damaging |
Het |
| Kif7 |
T |
C |
7: 79,354,442 (GRCm39) |
D781G |
probably damaging |
Het |
| Klhl41 |
A |
T |
2: 69,501,505 (GRCm39) |
N322I |
probably damaging |
Het |
| Krtap31-1 |
T |
G |
11: 99,798,901 (GRCm39) |
C35G |
possibly damaging |
Het |
| Lsm11 |
A |
T |
11: 45,824,824 (GRCm39) |
D234E |
probably benign |
Het |
| Med6 |
T |
C |
12: 81,620,677 (GRCm39) |
K223R |
probably benign |
Het |
| Mfsd4b2 |
G |
A |
10: 39,798,064 (GRCm39) |
T97I |
probably benign |
Het |
| Mrgpra1 |
A |
T |
7: 46,985,204 (GRCm39) |
C158* |
probably null |
Het |
| Nr2e1 |
T |
C |
10: 42,458,881 (GRCm39) |
T8A |
probably benign |
Het |
| Oas2 |
T |
C |
5: 120,887,838 (GRCm39) |
M1V |
probably null |
Het |
| Or13a27 |
T |
C |
7: 139,925,162 (GRCm39) |
I247V |
probably benign |
Het |
| Or14a260 |
T |
A |
7: 85,984,885 (GRCm39) |
I240F |
probably benign |
Het |
| Or1e33 |
T |
A |
11: 73,738,697 (GRCm39) |
M85L |
probably benign |
Het |
| Or8k17 |
T |
C |
2: 86,066,504 (GRCm39) |
Y218C |
probably damaging |
Het |
| Or8w1 |
T |
A |
2: 87,465,233 (GRCm39) |
N286I |
probably damaging |
Het |
| Otof |
C |
T |
5: 30,537,538 (GRCm39) |
G1257D |
probably benign |
Het |
| Phf2 |
T |
C |
13: 48,971,236 (GRCm39) |
T479A |
probably benign |
Het |
| Pik3c2a |
T |
C |
7: 115,942,232 (GRCm39) |
N1516S |
probably benign |
Het |
| Qrich1 |
C |
A |
9: 108,433,236 (GRCm39) |
T622K |
probably damaging |
Het |
| Rasip1 |
A |
G |
7: 45,281,943 (GRCm39) |
K482R |
probably damaging |
Het |
| Rgl2 |
T |
C |
17: 34,155,918 (GRCm39) |
F698L |
probably benign |
Het |
| Scarb1 |
T |
C |
5: 125,380,201 (GRCm39) |
D124G |
probably benign |
Het |
| Sclt1 |
A |
G |
3: 41,625,917 (GRCm39) |
I350T |
probably benign |
Het |
| Sec23ip |
T |
G |
7: 128,369,364 (GRCm39) |
V696G |
probably damaging |
Het |
| Serpina1e |
G |
T |
12: 103,917,354 (GRCm39) |
T105K |
probably benign |
Het |
| Sin3a |
A |
G |
9: 57,020,828 (GRCm39) |
|
probably null |
Het |
| Slc34a2 |
A |
G |
5: 53,218,182 (GRCm39) |
T154A |
probably damaging |
Het |
| Slc9a3 |
T |
C |
13: 74,303,241 (GRCm39) |
L178P |
probably damaging |
Het |
| Smarca2 |
A |
C |
19: 26,659,448 (GRCm39) |
I913L |
probably benign |
Het |
| Spaca7b |
T |
A |
8: 11,715,056 (GRCm39) |
D46V |
probably damaging |
Het |
| Tcea3 |
G |
A |
4: 136,001,027 (GRCm39) |
|
probably null |
Het |
| Tektl1 |
G |
C |
10: 78,584,509 (GRCm39) |
Q338E |
probably benign |
Het |
| Tmcc1 |
T |
A |
6: 116,020,435 (GRCm39) |
H339L |
|
Het |
| Trpm2 |
G |
T |
10: 77,783,731 (GRCm39) |
H247Q |
probably damaging |
Het |
| Tyr |
T |
A |
7: 87,121,724 (GRCm39) |
D356V |
probably damaging |
Het |
| Vmn2r54 |
A |
T |
7: 12,349,888 (GRCm39) |
C565S |
probably damaging |
Het |
| Zcchc4 |
T |
C |
5: 52,973,260 (GRCm39) |
Y375H |
probably damaging |
Het |
| Zfhx3 |
T |
A |
8: 109,675,353 (GRCm39) |
D2134E |
possibly damaging |
Het |
| Zfhx4 |
T |
A |
3: 5,464,010 (GRCm39) |
Y1414* |
probably null |
Het |
| Zfp282 |
A |
T |
6: 47,867,626 (GRCm39) |
E267D |
possibly damaging |
Het |
| Zfp442 |
A |
T |
2: 150,251,096 (GRCm39) |
C269S |
possibly damaging |
Het |
| Zp3 |
T |
A |
5: 136,014,418 (GRCm39) |
S246T |
probably benign |
Het |
|
| Other mutations in Vmn2r82 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01800:Vmn2r82
|
APN |
10 |
79,192,581 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01860:Vmn2r82
|
APN |
10 |
79,214,691 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01927:Vmn2r82
|
APN |
10 |
79,213,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01929:Vmn2r82
|
APN |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02028:Vmn2r82
|
APN |
10 |
79,215,057 (GRCm39) |
missense |
probably benign |
|
|
IGL02112:Vmn2r82
|
APN |
10 |
79,231,833 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02632:Vmn2r82
|
APN |
10 |
79,192,542 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02665:Vmn2r82
|
APN |
10 |
79,215,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02716:Vmn2r82
|
APN |
10 |
79,213,678 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL03030:Vmn2r82
|
APN |
10 |
79,217,149 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03190:Vmn2r82
|
APN |
10 |
79,192,643 (GRCm39) |
splice site |
probably null |
|
|
IGL03349:Vmn2r82
|
APN |
10 |
79,213,703 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL03048:Vmn2r82
|
UTSW |
10 |
79,232,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0080:Vmn2r82
|
UTSW |
10 |
79,232,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0193:Vmn2r82
|
UTSW |
10 |
79,217,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0217:Vmn2r82
|
UTSW |
10 |
79,214,634 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0285:Vmn2r82
|
UTSW |
10 |
79,232,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r82
|
UTSW |
10 |
79,213,739 (GRCm39) |
nonsense |
probably null |
|
|
R1385:Vmn2r82
|
UTSW |
10 |
79,232,325 (GRCm39) |
nonsense |
probably null |
|
|
R1386:Vmn2r82
|
UTSW |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Vmn2r82
|
UTSW |
10 |
79,215,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Vmn2r82
|
UTSW |
10 |
79,214,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1538:Vmn2r82
|
UTSW |
10 |
79,192,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1607:Vmn2r82
|
UTSW |
10 |
79,215,253 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1812:Vmn2r82
|
UTSW |
10 |
79,215,046 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1906:Vmn2r82
|
UTSW |
10 |
79,232,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Vmn2r82
|
UTSW |
10 |
79,231,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1972:Vmn2r82
|
UTSW |
10 |
79,214,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2093:Vmn2r82
|
UTSW |
10 |
79,231,813 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2156:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Vmn2r82
|
UTSW |
10 |
79,192,519 (GRCm39) |
missense |
probably benign |
|
|
R2442:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2444:Vmn2r82
|
UTSW |
10 |
79,213,702 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2857:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2858:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2884:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2886:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4369:Vmn2r82
|
UTSW |
10 |
79,231,914 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4445:Vmn2r82
|
UTSW |
10 |
79,214,874 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn2r82
|
UTSW |
10 |
79,192,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4703:Vmn2r82
|
UTSW |
10 |
79,214,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r82
|
UTSW |
10 |
79,214,589 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Vmn2r82
|
UTSW |
10 |
79,215,010 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5199:Vmn2r82
|
UTSW |
10 |
79,231,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5391:Vmn2r82
|
UTSW |
10 |
79,192,491 (GRCm39) |
missense |
probably null |
0.01 |
|
R5601:Vmn2r82
|
UTSW |
10 |
79,232,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5635:Vmn2r82
|
UTSW |
10 |
79,214,652 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6065:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Vmn2r82
|
UTSW |
10 |
79,231,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6474:Vmn2r82
|
UTSW |
10 |
79,214,871 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6995:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Vmn2r82
|
UTSW |
10 |
79,214,605 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7212:Vmn2r82
|
UTSW |
10 |
79,215,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7335:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7353:Vmn2r82
|
UTSW |
10 |
79,232,452 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7354:Vmn2r82
|
UTSW |
10 |
79,192,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7362:Vmn2r82
|
UTSW |
10 |
79,232,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Vmn2r82
|
UTSW |
10 |
79,232,276 (GRCm39) |
nonsense |
probably null |
|
|
R7430:Vmn2r82
|
UTSW |
10 |
79,217,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7509:Vmn2r82
|
UTSW |
10 |
79,231,842 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7874:Vmn2r82
|
UTSW |
10 |
79,232,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7943:Vmn2r82
|
UTSW |
10 |
79,232,079 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8324:Vmn2r82
|
UTSW |
10 |
79,214,727 (GRCm39) |
nonsense |
probably null |
|
|
R8340:Vmn2r82
|
UTSW |
10 |
79,217,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8787:Vmn2r82
|
UTSW |
10 |
79,213,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8929:Vmn2r82
|
UTSW |
10 |
79,232,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Vmn2r82
|
UTSW |
10 |
79,232,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9399:Vmn2r82
|
UTSW |
10 |
79,214,768 (GRCm39) |
nonsense |
probably null |
|
|
R9517:Vmn2r82
|
UTSW |
10 |
79,213,641 (GRCm39) |
nonsense |
probably null |
|
|
R9587:Vmn2r82
|
UTSW |
10 |
79,214,936 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9602:Vmn2r82
|
UTSW |
10 |
79,214,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1088:Vmn2r82
|
UTSW |
10 |
79,192,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,232,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,192,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTCTATAATTAACAAGGTCCCC -3'
(R):5'- GTAAGTGTAGCAGCTGATTTGC -3'
Sequencing Primer
(F):5'- AGGTCCCCCTTTCAGGATC -3'
(R):5'- TAATTAGGGATCACACTACTCAAACC -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation