Incidental Mutation 'R8845:Vmn2r108'
| ID |
674683 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
068734-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R8845 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20691361 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 387
(H387Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: H387Q
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: H387Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
C |
T |
7: 119,846,428 (GRCm39) |
P627S |
probably benign |
Het |
| Abca4 |
G |
A |
3: 121,930,651 (GRCm39) |
V1383M |
probably damaging |
Het |
| Acer3 |
A |
G |
7: 97,910,832 (GRCm39) |
S77P |
probably damaging |
Het |
| Adgrv1 |
G |
T |
13: 81,629,478 (GRCm39) |
T3640N |
possibly damaging |
Het |
| Agmo |
T |
C |
12: 37,294,364 (GRCm39) |
L104P |
probably benign |
Het |
| Alox12 |
C |
A |
11: 70,137,877 (GRCm39) |
G421V |
probably damaging |
Het |
| Atad2 |
A |
G |
15: 57,989,532 (GRCm39) |
V182A |
probably damaging |
Het |
| Bnc2 |
C |
T |
4: 84,194,338 (GRCm39) |
A929T |
possibly damaging |
Het |
| Bola3 |
T |
C |
6: 83,335,154 (GRCm39) |
M83T |
probably damaging |
Het |
| Brca2 |
T |
C |
5: 150,466,847 (GRCm39) |
F2204L |
possibly damaging |
Het |
| Cachd1 |
T |
C |
4: 100,810,343 (GRCm39) |
V315A |
probably benign |
Het |
| Ccdc154 |
C |
A |
17: 25,390,138 (GRCm39) |
N547K |
probably damaging |
Het |
| Ccdc62 |
C |
A |
5: 124,092,470 (GRCm39) |
T485K |
probably benign |
Het |
| Cdc40 |
G |
A |
10: 40,717,790 (GRCm39) |
T371I |
possibly damaging |
Het |
| Cep112 |
T |
C |
11: 108,461,193 (GRCm39) |
F657L |
probably damaging |
Het |
| Cirbp |
A |
G |
10: 80,005,931 (GRCm39) |
D62G |
probably damaging |
Het |
| Cntf |
A |
C |
19: 12,741,664 (GRCm39) |
S65R |
probably benign |
Het |
| Cxxc4 |
CGGC |
CGGCGGGGGC |
3: 133,945,912 (GRCm39) |
|
probably benign |
Het |
| Cyfip1 |
G |
T |
7: 55,579,834 (GRCm39) |
G1229V |
probably benign |
Het |
| Cyp4a30b |
A |
C |
4: 115,315,493 (GRCm39) |
N238T |
probably benign |
Het |
| Dbx2 |
G |
A |
15: 95,552,517 (GRCm39) |
R43C |
probably benign |
Het |
| Efcab3 |
A |
T |
11: 104,899,787 (GRCm39) |
I4350F |
possibly damaging |
Het |
| Fbxw13 |
G |
T |
9: 109,023,833 (GRCm39) |
F70L |
possibly damaging |
Het |
| Fhod3 |
A |
G |
18: 25,265,976 (GRCm39) |
T1555A |
probably damaging |
Het |
| Fnbp4 |
A |
G |
2: 90,606,368 (GRCm39) |
M763V |
probably benign |
Het |
| Gdf7 |
A |
G |
12: 8,348,905 (GRCm39) |
S131P |
unknown |
Het |
| Gm9938 |
A |
T |
19: 23,701,941 (GRCm39) |
E93V |
unknown |
Het |
| Golim4 |
A |
T |
3: 75,802,272 (GRCm39) |
M340K |
probably damaging |
Het |
| Gphn |
A |
G |
12: 78,538,953 (GRCm39) |
S200G |
probably benign |
Het |
| Hpse |
T |
C |
5: 100,859,248 (GRCm39) |
D99G |
probably benign |
Het |
| Iqgap2 |
A |
T |
13: 95,794,392 (GRCm39) |
N1193K |
possibly damaging |
Het |
| Jag2 |
A |
T |
12: 112,883,714 (GRCm39) |
C256S |
probably damaging |
Het |
| Ldb3 |
T |
C |
14: 34,258,634 (GRCm39) |
Y657C |
probably damaging |
Het |
| Lmtk2 |
T |
A |
5: 144,110,704 (GRCm39) |
Y475N |
probably damaging |
Het |
| Mep1b |
A |
T |
18: 21,230,379 (GRCm39) |
K644* |
probably null |
Het |
| Muc4 |
A |
C |
16: 32,576,889 (GRCm39) |
T60P |
possibly damaging |
Het |
| Nckap5 |
G |
T |
1: 125,909,423 (GRCm39) |
Q1603K |
possibly damaging |
Het |
| Npy6r |
C |
T |
18: 44,408,606 (GRCm39) |
T9I |
probably benign |
Het |
| Nsd2 |
T |
C |
5: 34,039,885 (GRCm39) |
C846R |
probably damaging |
Het |
| Oard1 |
A |
C |
17: 48,721,259 (GRCm39) |
K64Q |
probably benign |
Het |
| Or4c103 |
T |
A |
2: 88,513,735 (GRCm39) |
I114F |
possibly damaging |
Het |
| Or52e19b |
A |
T |
7: 103,032,357 (GRCm39) |
V284D |
probably damaging |
Het |
| Or5w8 |
G |
T |
2: 87,687,545 (GRCm39) |
V9L |
probably benign |
Het |
| Or6c208 |
A |
G |
10: 129,224,065 (GRCm39) |
T188A |
probably damaging |
Het |
| Pkhd1l1 |
T |
G |
15: 44,368,650 (GRCm39) |
S823A |
probably benign |
Het |
| Pla2r1 |
A |
G |
2: 60,259,053 (GRCm39) |
S1112P |
possibly damaging |
Het |
| Plekho2 |
T |
C |
9: 65,465,963 (GRCm39) |
T142A |
probably damaging |
Het |
| Prr35 |
A |
T |
17: 26,165,823 (GRCm39) |
V488E |
probably benign |
Het |
| Prrc2b |
T |
A |
2: 32,102,105 (GRCm39) |
M726K |
possibly damaging |
Het |
| Prrc2b |
A |
T |
2: 32,106,162 (GRCm39) |
K1514I |
possibly damaging |
Het |
| Rin1 |
A |
T |
19: 5,104,947 (GRCm39) |
D669V |
probably damaging |
Het |
| Setd1b |
C |
T |
5: 123,282,310 (GRCm39) |
A146V |
unknown |
Het |
| Sigmar1 |
G |
A |
4: 41,741,234 (GRCm39) |
R7W |
probably damaging |
Het |
| Slain1 |
C |
T |
14: 103,925,747 (GRCm39) |
T365I |
possibly damaging |
Het |
| Slc38a2 |
G |
A |
15: 96,592,900 (GRCm39) |
T186I |
probably benign |
Het |
| Tas2r130 |
A |
T |
6: 131,607,642 (GRCm39) |
V51E |
probably benign |
Het |
| Tgfb1i1 |
A |
T |
7: 127,851,690 (GRCm39) |
H332L |
possibly damaging |
Het |
| Trav7n-4 |
T |
C |
14: 53,328,846 (GRCm39) |
L15S |
probably damaging |
Het |
| Ttc28 |
T |
C |
5: 111,372,041 (GRCm39) |
V861A |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,632,658 (GRCm39) |
I14132T |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,606,380 (GRCm39) |
E18143G |
probably damaging |
Het |
| Vmn1r203 |
C |
T |
13: 22,708,720 (GRCm39) |
S167L |
possibly damaging |
Het |
| Vps33a |
A |
T |
5: 123,709,538 (GRCm39) |
|
probably null |
Het |
| Vps50 |
G |
A |
6: 3,504,926 (GRCm39) |
V31I |
probably benign |
Het |
| Wdcp |
A |
G |
12: 4,901,439 (GRCm39) |
T432A |
probably benign |
Het |
| Wdr36 |
T |
A |
18: 32,994,098 (GRCm39) |
Y645* |
probably null |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGTGATGGTGATACAATGTAGTAG -3'
(R):5'- TGCTTGACTCATTCCATGGTAG -3'
Sequencing Primer
(F):5'- AGAGTGGTTATTACCTGCCAG -3'
(R):5'- TCCATGGTAGCTTAATTTTTACACAC -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation