Incidental Mutation 'R9278:Vmn2r108'
| ID |
703473 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R9278 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20692561 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 98
(N98K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: N98K
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: N98K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 93.4%
- 3x: 93.4%
- 10x: 93.2%
- 20x: 92.9%
|
| Validation Efficiency |
97% (77/79) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afdn |
T |
A |
17: 14,024,270 (GRCm39) |
C59S |
probably damaging |
Het |
| Aicda |
C |
T |
6: 122,538,854 (GRCm39) |
A161V |
possibly damaging |
Het |
| Ankrd12 |
C |
T |
17: 66,344,599 (GRCm39) |
E91K |
possibly damaging |
Het |
| Arpc2 |
C |
A |
1: 74,276,041 (GRCm39) |
F19L |
probably benign |
Het |
| Aspa |
T |
C |
11: 73,215,280 (GRCm39) |
K12E |
possibly damaging |
Het |
| Chd8 |
G |
A |
14: 52,472,627 (GRCm39) |
P392L |
probably benign |
Het |
| Cldn10 |
C |
T |
14: 119,111,647 (GRCm39) |
R206W |
probably damaging |
Het |
| Clec4b2 |
T |
A |
6: 123,181,224 (GRCm39) |
M203K |
probably damaging |
Het |
| Clec4d |
G |
T |
6: 123,251,651 (GRCm39) |
E178* |
probably null |
Het |
| Clec4d |
T |
C |
6: 123,251,649 (GRCm39) |
M177T |
probably benign |
Het |
| Cmpk2 |
A |
T |
12: 26,519,568 (GRCm39) |
Y73F |
probably benign |
Het |
| Col1a1 |
T |
A |
11: 94,838,103 (GRCm39) |
V845D |
unknown |
Het |
| Cyp2c67 |
C |
T |
19: 39,597,699 (GRCm39) |
R433Q |
probably damaging |
Het |
| Dda1 |
A |
T |
8: 71,927,130 (GRCm39) |
|
probably null |
Het |
| Ddx60 |
A |
T |
8: 62,431,012 (GRCm39) |
Y849F |
possibly damaging |
Het |
| Dnm2 |
C |
T |
9: 21,416,977 (GRCm39) |
R837W |
possibly damaging |
Het |
| Dtwd1 |
C |
T |
2: 126,006,728 (GRCm39) |
T250I |
probably damaging |
Het |
| Efcab6 |
A |
G |
15: 83,777,094 (GRCm39) |
V1114A |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,945,171 (GRCm39) |
T1355A |
probably benign |
Het |
| Fbxo40 |
T |
G |
16: 36,789,940 (GRCm39) |
D390A |
possibly damaging |
Het |
| Gnaz |
T |
A |
10: 74,827,437 (GRCm39) |
L63Q |
probably benign |
Het |
| H6pd |
T |
A |
4: 150,080,307 (GRCm39) |
K179N |
probably damaging |
Het |
| Hmgb2 |
A |
G |
8: 57,965,786 (GRCm39) |
|
probably benign |
Het |
| Hps5 |
A |
G |
7: 46,440,397 (GRCm39) |
F18L |
probably benign |
Het |
| Hyal5 |
A |
G |
6: 24,876,694 (GRCm39) |
E189G |
probably benign |
Het |
| Ifnar1 |
T |
A |
16: 91,302,013 (GRCm39) |
I496N |
probably damaging |
Het |
| Ift70a2 |
T |
C |
2: 75,807,375 (GRCm39) |
D379G |
probably damaging |
Het |
| Igf2r |
C |
A |
17: 12,914,240 (GRCm39) |
C1743F |
probably damaging |
Het |
| Igfn1 |
C |
A |
1: 135,901,185 (GRCm39) |
R431L |
probably damaging |
Het |
| Itch |
A |
G |
2: 155,045,217 (GRCm39) |
Q507R |
probably benign |
Het |
| Kbtbd2 |
C |
A |
6: 56,757,331 (GRCm39) |
R135L |
probably damaging |
Het |
| Kcnn2 |
T |
C |
18: 45,725,446 (GRCm39) |
I314T |
probably damaging |
Het |
| Lix1 |
A |
G |
17: 17,623,211 (GRCm39) |
D2G |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 40,487,076 (GRCm39) |
Y4557C |
|
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Mcam |
G |
T |
9: 44,046,473 (GRCm39) |
|
probably benign |
Het |
| Med19 |
G |
T |
2: 84,508,975 (GRCm39) |
G63C |
probably damaging |
Het |
| Mfsd4b1 |
C |
T |
10: 39,883,330 (GRCm39) |
R40H |
probably damaging |
Het |
| Neb |
C |
T |
2: 52,146,190 (GRCm39) |
R2929H |
probably damaging |
Het |
| Nlrc5 |
A |
G |
8: 95,237,908 (GRCm39) |
D1434G |
probably benign |
Het |
| Nlrp14 |
A |
T |
7: 106,797,049 (GRCm39) |
N972I |
probably damaging |
Het |
| Or13a18 |
T |
C |
7: 140,190,936 (GRCm39) |
Y278H |
probably damaging |
Het |
| Or14j7 |
A |
T |
17: 38,235,275 (GRCm39) |
M273L |
probably benign |
Het |
| Or2h15 |
A |
T |
17: 38,441,693 (GRCm39) |
L130Q |
probably damaging |
Het |
| Or4a74 |
A |
C |
2: 89,439,948 (GRCm39) |
F166C |
probably damaging |
Het |
| Or8g29-ps1 |
A |
G |
9: 39,200,781 (GRCm39) |
V135A |
probably benign |
Het |
| Otop1 |
T |
C |
5: 38,460,158 (GRCm39) |
V575A |
probably damaging |
Het |
| Pcdhb4 |
A |
G |
18: 37,441,925 (GRCm39) |
S412G |
possibly damaging |
Het |
| Pcsk4 |
T |
C |
10: 80,161,224 (GRCm39) |
D230G |
probably damaging |
Het |
| Phldb2 |
C |
A |
16: 45,646,308 (GRCm39) |
S46I |
probably damaging |
Het |
| Pik3ca |
A |
T |
3: 32,508,587 (GRCm39) |
N785I |
probably damaging |
Het |
| Polr2b |
A |
G |
5: 77,471,485 (GRCm39) |
R274G |
probably damaging |
Het |
| Prkdc |
G |
A |
16: 15,634,523 (GRCm39) |
|
probably null |
Het |
| Prune2 |
C |
T |
19: 17,101,144 (GRCm39) |
T2216I |
probably benign |
Het |
| Psma3 |
A |
T |
12: 71,041,156 (GRCm39) |
D252V |
probably benign |
Het |
| Rnf213 |
T |
C |
11: 119,326,768 (GRCm39) |
V1586A |
|
Het |
| Ryr2 |
T |
C |
13: 11,897,976 (GRCm39) |
T140A |
probably benign |
Het |
| Slc25a48 |
A |
G |
13: 56,611,552 (GRCm39) |
I220V |
probably benign |
Het |
| Slc2a1 |
A |
T |
4: 118,990,607 (GRCm39) |
E246D |
probably benign |
Het |
| Slc45a4 |
A |
G |
15: 73,458,206 (GRCm39) |
Y448H |
probably benign |
Het |
| Sorl1 |
C |
T |
9: 41,957,857 (GRCm39) |
V596I |
probably benign |
Het |
| Spag6 |
A |
C |
2: 18,703,985 (GRCm39) |
E11A |
probably benign |
Het |
| Spef2 |
A |
G |
15: 9,727,495 (GRCm39) |
|
probably null |
Het |
| Spon1 |
T |
C |
7: 113,628,188 (GRCm39) |
S315P |
probably damaging |
Het |
| Stard3 |
G |
A |
11: 98,262,931 (GRCm39) |
|
probably benign |
Het |
| Sv2c |
A |
G |
13: 96,112,589 (GRCm39) |
M636T |
probably damaging |
Het |
| Syt17 |
T |
A |
7: 118,033,480 (GRCm39) |
D172V |
probably damaging |
Het |
| Tcf4 |
A |
G |
18: 69,766,652 (GRCm39) |
Y206C |
probably damaging |
Het |
| Tead2 |
G |
T |
7: 44,880,776 (GRCm39) |
S318I |
probably benign |
Het |
| Tom1 |
A |
T |
8: 75,783,883 (GRCm39) |
D289V |
probably damaging |
Het |
| Tonsl |
A |
G |
15: 76,520,971 (GRCm39) |
|
probably benign |
Het |
| Tsen15 |
T |
C |
1: 152,259,098 (GRCm39) |
I87V |
probably damaging |
Het |
| Usp15 |
A |
G |
10: 123,007,112 (GRCm39) |
F123S |
probably damaging |
Het |
| Vmn1r220 |
A |
T |
13: 23,368,258 (GRCm39) |
I146N |
possibly damaging |
Het |
| Vmn2r71 |
T |
A |
7: 85,269,788 (GRCm39) |
M433K |
probably benign |
Het |
| Vmn2r97 |
A |
T |
17: 19,134,762 (GRCm39) |
H60L |
probably benign |
Het |
| Wbp4 |
A |
G |
14: 79,699,486 (GRCm39) |
V336A |
probably benign |
Het |
| Zfp663 |
T |
C |
2: 165,202,010 (GRCm39) |
|
probably null |
Het |
| Zpld2 |
A |
G |
4: 133,922,770 (GRCm39) |
L521P |
probably damaging |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAATTTGGGCAGACGTTG -3'
(R):5'- CCCAACCAAGTTCTACATATTCATG -3'
Sequencing Primer
(F):5'- GCAGACGTTGTCCATGCTG -3'
(R):5'- TGTACTCTATATGTGGTCCA -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation