Incidental Mutation 'R6018:Vmn2r108'
| ID |
478748 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
044192-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R6018 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20683268 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 645
(N645K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167314
AA Change: N645K
PolyPhen 2
Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: N645K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.3%
- 20x: 91.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
T |
3: 124,210,448 (GRCm39) |
Y155N |
probably damaging |
Het |
| 1700019A02Rik |
C |
T |
1: 53,202,405 (GRCm39) |
|
probably null |
Het |
| 2310022B05Rik |
A |
G |
8: 125,365,853 (GRCm39) |
F297L |
probably benign |
Het |
| Acbd3 |
T |
C |
1: 180,579,903 (GRCm39) |
S516P |
possibly damaging |
Het |
| Agbl3 |
A |
G |
6: 34,776,190 (GRCm39) |
N227S |
probably damaging |
Het |
| Ak6 |
C |
T |
13: 100,802,459 (GRCm39) |
Q151* |
probably null |
Het |
| Ano4 |
A |
G |
10: 88,865,128 (GRCm39) |
L297P |
probably benign |
Het |
| Anxa5 |
T |
C |
3: 36,504,807 (GRCm39) |
T252A |
probably benign |
Het |
| Ap5s1 |
G |
A |
2: 131,054,915 (GRCm39) |
W212* |
probably null |
Het |
| Arl9 |
A |
G |
5: 77,155,253 (GRCm39) |
Q113R |
probably damaging |
Het |
| Atg2b |
T |
C |
12: 105,627,430 (GRCm39) |
H519R |
probably damaging |
Het |
| Atp1a2 |
A |
G |
1: 172,125,579 (GRCm39) |
|
probably benign |
Het |
| Atp2b1 |
G |
A |
10: 98,846,622 (GRCm39) |
A808T |
probably damaging |
Het |
| Bckdhb |
C |
A |
9: 83,951,237 (GRCm39) |
T342K |
probably benign |
Het |
| Bdp1 |
T |
C |
13: 100,174,732 (GRCm39) |
H1996R |
probably benign |
Het |
| Brix1 |
C |
T |
15: 10,476,675 (GRCm39) |
R267H |
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,926,235 (GRCm39) |
I1148M |
probably damaging |
Het |
| Csf3r |
T |
A |
4: 125,937,414 (GRCm39) |
M766K |
probably benign |
Het |
| Ctnnd1 |
T |
A |
2: 84,480,812 (GRCm39) |
|
probably benign |
Het |
| Cyp2c39 |
A |
T |
19: 39,499,436 (GRCm39) |
N41I |
probably damaging |
Het |
| D2hgdh |
G |
T |
1: 93,754,182 (GRCm39) |
V52L |
probably benign |
Het |
| Dppa4 |
T |
A |
16: 48,109,490 (GRCm39) |
Y77* |
probably null |
Het |
| Eif4enif1 |
T |
C |
11: 3,192,481 (GRCm39) |
S770P |
probably damaging |
Het |
| Fbxl16 |
A |
T |
17: 26,036,709 (GRCm39) |
D230V |
probably damaging |
Het |
| Gm4847 |
G |
A |
1: 166,471,017 (GRCm39) |
A11V |
probably damaging |
Het |
| Gm9978 |
C |
T |
10: 78,322,915 (GRCm39) |
|
noncoding transcript |
Het |
| Gpatch8 |
A |
G |
11: 102,371,741 (GRCm39) |
L599P |
unknown |
Het |
| Hdac4 |
A |
G |
1: 91,886,120 (GRCm39) |
L254P |
probably damaging |
Het |
| Heatr1 |
A |
G |
13: 12,419,828 (GRCm39) |
I384V |
probably benign |
Het |
| Heatr1 |
A |
T |
13: 12,420,939 (GRCm39) |
Q410L |
probably benign |
Het |
| Hmcn2 |
A |
G |
2: 31,260,804 (GRCm39) |
I1065V |
probably benign |
Het |
| Igkv6-14 |
A |
G |
6: 70,412,024 (GRCm39) |
S87P |
probably damaging |
Het |
| Il2rb |
G |
T |
15: 78,366,266 (GRCm39) |
Q344K |
possibly damaging |
Het |
| Ipo4 |
A |
G |
14: 55,863,609 (GRCm39) |
|
probably null |
Het |
| Ipo9 |
A |
G |
1: 135,318,274 (GRCm39) |
|
probably null |
Het |
| Khdrbs1 |
T |
C |
4: 129,613,887 (GRCm39) |
T374A |
probably benign |
Het |
| Lamc3 |
G |
T |
2: 31,795,724 (GRCm39) |
G370W |
probably damaging |
Het |
| Lipn |
T |
A |
19: 34,054,335 (GRCm39) |
L191Q |
probably damaging |
Het |
| Lpl |
T |
C |
8: 69,353,940 (GRCm39) |
V427A |
probably benign |
Het |
| Magi3 |
T |
C |
3: 104,013,128 (GRCm39) |
S120G |
probably damaging |
Het |
| Mgl2 |
T |
C |
11: 70,027,937 (GRCm39) |
*382Q |
probably null |
Het |
| Nab2 |
G |
A |
10: 127,500,793 (GRCm39) |
Q100* |
probably null |
Het |
| Nfat5 |
T |
A |
8: 108,082,283 (GRCm39) |
|
probably null |
Het |
| Nqo1 |
T |
C |
8: 108,115,500 (GRCm39) |
H259R |
probably damaging |
Het |
| Nrdc |
T |
A |
4: 108,870,944 (GRCm39) |
D190E |
probably benign |
Het |
| Or5m5 |
T |
A |
2: 85,815,148 (GRCm39) |
|
probably benign |
Het |
| Osmr |
G |
A |
15: 6,845,276 (GRCm39) |
P830L |
probably damaging |
Het |
| Parp14 |
G |
A |
16: 35,661,827 (GRCm39) |
P1403S |
probably benign |
Het |
| Pde11a |
T |
A |
2: 75,848,194 (GRCm39) |
M878L |
probably benign |
Het |
| Pik3ap1 |
T |
C |
19: 41,373,455 (GRCm39) |
|
probably benign |
Het |
| Pla2g3 |
T |
C |
11: 3,441,916 (GRCm39) |
L360P |
probably damaging |
Het |
| Plxnc1 |
A |
G |
10: 94,779,710 (GRCm39) |
V244A |
probably benign |
Het |
| Pramel16 |
C |
T |
4: 143,677,469 (GRCm39) |
A37T |
possibly damaging |
Het |
| Ptpra |
T |
C |
2: 130,345,422 (GRCm39) |
V8A |
probably benign |
Het |
| Rbbp5 |
T |
C |
1: 132,422,078 (GRCm39) |
V199A |
probably damaging |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Rp1 |
A |
G |
1: 4,423,059 (GRCm39) |
V7A |
possibly damaging |
Het |
| Sdk2 |
T |
C |
11: 113,720,889 (GRCm39) |
T1347A |
probably benign |
Het |
| Sgo2a |
T |
A |
1: 58,056,118 (GRCm39) |
H767Q |
probably benign |
Het |
| Sis |
G |
A |
3: 72,820,525 (GRCm39) |
P1413L |
possibly damaging |
Het |
| Slc22a5 |
G |
T |
11: 53,766,846 (GRCm39) |
A214E |
probably damaging |
Het |
| Snx13 |
G |
T |
12: 35,097,318 (GRCm39) |
|
probably benign |
Het |
| Sun5 |
T |
A |
2: 153,700,363 (GRCm39) |
I295F |
probably damaging |
Het |
| Themis3 |
C |
T |
17: 66,900,204 (GRCm39) |
A55T |
probably damaging |
Het |
| Tmem255b |
T |
C |
8: 13,505,138 (GRCm39) |
Y148H |
probably benign |
Het |
| Tmem74b |
A |
G |
2: 151,548,639 (GRCm39) |
E122G |
probably damaging |
Het |
| Top3b |
T |
C |
16: 16,710,756 (GRCm39) |
V862A |
probably damaging |
Het |
| Trim35 |
A |
T |
14: 66,546,199 (GRCm39) |
D322V |
probably damaging |
Het |
| Trpm2 |
A |
G |
10: 77,753,547 (GRCm39) |
F1319S |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,785,020 (GRCm39) |
R756S |
probably benign |
Het |
| Vmn2r73 |
A |
G |
7: 85,521,875 (GRCm39) |
S155P |
possibly damaging |
Het |
| Vstm4 |
G |
A |
14: 32,585,627 (GRCm39) |
A65T |
probably benign |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCGACATTGTCATCCATATTC -3'
(R):5'- ATGACACTGGCCTGTATAGC -3'
Sequencing Primer
(F):5'- TCCACAAATAAAAAGTTGGATCAGCG -3'
(R):5'- ACACTGGCCTGTATAGCTTTGTG -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation