Mutagenetix > Incidental Mutation

Incidental Mutation 'R1953:Celsr3'

217490

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo, Adgrc3

MMRRC Submission

039967-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1953 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108703519-108730168 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108720381 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 2551 (V2551A)

Ref Sequence

ENSEMBL: ENSMUSP00000024238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000194079] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000024238
AA Change: V2551A

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: V2551A

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175326

Predicted Effect

probably benign
Transcript: ENSMUST00000194079

SMART Domains

Protein: ENSMUSP00000141789
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
Pfam:7tm_2	1	185	6.9e-45	PFAM
low complexity region	240	256	N/A	INTRINSIC
low complexity region	309	333	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195255

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195857

Predicted Effect

probably benign
Transcript: ENSMUST00000213524
AA Change: V2558A

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730455P16Rik	A	T	11: 80,268,772 (GRCm39)	D12E	probably damaging	Het
Abca15	C	T	7: 119,960,655 (GRCm39)	R706C	probably damaging	Het
Actr1a	G	A	19: 46,369,387 (GRCm39)	S209F	probably benign	Het
Adcy1	A	G	11: 7,028,991 (GRCm39)	N247S	probably benign	Het
Anapc4	T	C	5: 52,997,030 (GRCm39)	L101S	probably damaging	Het
Asap3	C	T	4: 135,954,767 (GRCm39)	R60*	probably null	Het
Ascc3	T	C	10: 50,721,726 (GRCm39)	S2060P	probably benign	Het
Atp9b	G	A	18: 80,797,522 (GRCm39)	T851I	possibly damaging	Het
Borcs5	A	G	6: 134,687,230 (GRCm39)	H196R	unknown	Het
Bpifb9b	A	C	2: 154,153,234 (GRCm39)	D100A	probably damaging	Het
Cant1	G	C	11: 118,299,609 (GRCm39)	P247A	probably damaging	Het
Capza3	A	T	6: 139,988,294 (GRCm39)	I298L	possibly damaging	Het
Cdh10	T	C	15: 18,966,997 (GRCm39)		probably null	Het
Ces4a	G	A	8: 105,864,729 (GRCm39)	G69S	probably damaging	Het
Cmtr2	T	C	8: 110,948,551 (GRCm39)	L287P	probably damaging	Het
Crebbp	G	A	16: 3,997,313 (GRCm39)	T257I	probably benign	Het
Crispld2	G	A	8: 120,742,035 (GRCm39)	V128M	probably damaging	Het
Crnkl1	G	A	2: 145,770,120 (GRCm39)	A241V	probably damaging	Het
Dmd	T	A	X: 82,874,123 (GRCm39)	I1342N	probably damaging	Het
Dnah10	A	G	5: 124,859,332 (GRCm39)	T2043A	probably benign	Het
Dscaml1	C	T	9: 45,581,522 (GRCm39)	T447I	probably benign	Het
Eif2ak3	A	G	6: 70,869,538 (GRCm39)	T742A	probably benign	Het
Farp1	A	G	14: 121,492,894 (GRCm39)	T499A	probably benign	Het
Fcgr1	G	A	3: 96,194,386 (GRCm39)	T167I	probably damaging	Het
Fgd5	C	A	6: 92,001,611 (GRCm39)	H935Q	probably benign	Het
Fhl4	A	T	10: 84,934,171 (GRCm39)	D203E	probably benign	Het
Gapt	T	G	13: 110,490,340 (GRCm39)	T108P	probably damaging	Het
Gpt2	A	G	8: 86,248,013 (GRCm39)	T419A	probably benign	Het
Gucy2c	A	G	6: 136,681,291 (GRCm39)	V907A	probably damaging	Het
Hmbs	T	C	9: 44,248,741 (GRCm39)	D211G	probably damaging	Het
Irx5	A	G	8: 93,086,438 (GRCm39)	N174D	probably damaging	Het
Itfg1	A	G	8: 86,557,860 (GRCm39)	V170A	probably benign	Het
Itga2b	T	A	11: 102,349,009 (GRCm39)	T732S	probably benign	Het
Klhl3	A	G	13: 58,159,022 (GRCm39)	Y546H	probably damaging	Het
Lama5	G	A	2: 179,832,540 (GRCm39)	H1670Y	possibly damaging	Het
Mlst8	AT	ATT	17: 24,696,987 (GRCm39)		probably null	Het
Nbeal1	T	C	1: 60,273,999 (GRCm39)	V409A	probably damaging	Het
Nlgn1	T	A	3: 25,490,464 (GRCm39)	D421V	probably damaging	Het
Nlrp10	T	C	7: 108,524,325 (GRCm39)	D385G	probably benign	Het
Nr2e3	T	A	9: 59,857,079 (GRCm39)	D30V	probably benign	Het
Nyap1	A	G	5: 137,733,294 (GRCm39)	S580P	probably benign	Het
Or4c108	G	A	2: 88,804,224 (GRCm39)	Q4*	probably null	Het
Or4c12	A	G	2: 89,774,267 (GRCm39)	L64P	probably damaging	Het
Or4e2	T	A	14: 52,688,344 (GRCm39)	V158E	probably benign	Het
Pex1	A	G	5: 3,680,038 (GRCm39)	H952R	probably damaging	Het
Plin4	T	A	17: 56,410,849 (GRCm39)	I1061F	possibly damaging	Het
Pnkp	C	A	7: 44,512,026 (GRCm39)	R517S	probably benign	Het
Polr2e	T	A	10: 79,874,388 (GRCm39)	E39D	probably benign	Het
Pramel18	T	C	4: 101,767,312 (GRCm39)	I187T	probably benign	Het
Prokr1	T	C	6: 87,565,575 (GRCm39)	Y90C	probably benign	Het
Ptprm	A	T	17: 67,247,575 (GRCm39)	S587T	probably benign	Het
Rere	G	A	4: 150,701,294 (GRCm39)	E1225K	probably damaging	Het
Rsl24d1	G	T	9: 73,021,896 (GRCm39)		probably benign	Het
Selp	A	G	1: 163,954,081 (GRCm39)	N127S	probably benign	Het
Slc22a18	C	T	7: 143,029,984 (GRCm39)	T17I	probably damaging	Het
Smad2	A	G	18: 76,395,776 (GRCm39)	T72A	possibly damaging	Het
Snx29	G	A	16: 11,217,647 (GRCm39)	W149*	probably null	Het
Stk31	G	T	6: 49,423,412 (GRCm39)		probably null	Het
Sult1e1	T	G	5: 87,735,530 (GRCm39)		probably null	Het
Syngap1	G	A	17: 27,163,661 (GRCm39)	R41H	possibly damaging	Het
Tbc1d17	T	A	7: 44,490,822 (GRCm39)		probably null	Het
Tex55	G	T	16: 38,648,275 (GRCm39)	T278K	possibly damaging	Het
Tie1	A	T	4: 118,329,987 (GRCm39)		probably null	Het
Ttn	A	T	2: 76,641,587 (GRCm39)	L5176Q	possibly damaging	Het
Usp47	T	A	7: 111,692,083 (GRCm39)	D848E	probably benign	Het
Vmn1r72	A	G	7: 11,403,731 (GRCm39)	L239P	probably damaging	Het
Vmn2r124	T	C	17: 18,283,122 (GRCm39)	I272T	probably benign	Het
Vwa1	C	T	4: 155,857,571 (GRCm39)	V76M	probably damaging	Het
Xrn1	G	T	9: 95,906,274 (GRCm39)		probably null	Het
Zfp667	G	T	7: 6,308,087 (GRCm39)	V252F	probably benign	Het
Zranb3	A	T	1: 127,927,136 (GRCm39)	V343D	probably damaging	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,726,124 (GRCm39)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,706,391 (GRCm39)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,718,462 (GRCm39)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,719,775 (GRCm39)	missense	probably benign
IGL01420:Celsr3	APN	9	108,718,389 (GRCm39)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,708,907 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,711,756 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,713,141 (GRCm39)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,705,614 (GRCm39)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,704,755 (GRCm39)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,719,709 (GRCm39)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,707,159 (GRCm39)	missense	probably benign
IGL02392:Celsr3	APN	9	108,711,920 (GRCm39)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,709,318 (GRCm39)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,717,662 (GRCm39)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,720,092 (GRCm39)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,720,774 (GRCm39)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,726,652 (GRCm39)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,723,134 (GRCm39)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,718,454 (GRCm39)	splice site	probably null
IGL03089:Celsr3	APN	9	108,703,806 (GRCm39)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,719,757 (GRCm39)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,713,724 (GRCm39)	splice site	probably benign
Diminishment	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
little_d	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
nogal	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
F6893:Celsr3	UTSW	9	108,712,266 (GRCm39)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,709,507 (GRCm39)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,722,932 (GRCm39)	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108,720,923 (GRCm39)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,706,417 (GRCm39)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,706,272 (GRCm39)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,711,854 (GRCm39)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,705,017 (GRCm39)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,719,832 (GRCm39)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,723,224 (GRCm39)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,710,375 (GRCm39)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,713,069 (GRCm39)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,704,104 (GRCm39)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,726,064 (GRCm39)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,725,857 (GRCm39)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,726,083 (GRCm39)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,706,267 (GRCm39)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,720,151 (GRCm39)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,709,056 (GRCm39)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,706,157 (GRCm39)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,711,825 (GRCm39)	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1839:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1874:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1875:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1960:Celsr3	UTSW	9	108,723,016 (GRCm39)	missense	probably benign
R2113:Celsr3	UTSW	9	108,715,669 (GRCm39)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,720,423 (GRCm39)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2373:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2374:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2375:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2844:Celsr3	UTSW	9	108,706,507 (GRCm39)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,709,390 (GRCm39)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,714,338 (GRCm39)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,704,909 (GRCm39)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R4194:Celsr3	UTSW	9	108,720,501 (GRCm39)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,723,248 (GRCm39)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,707,046 (GRCm39)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,720,443 (GRCm39)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,723,262 (GRCm39)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,722,922 (GRCm39)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,704,953 (GRCm39)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,724,851 (GRCm39)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,721,140 (GRCm39)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,726,620 (GRCm39)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,714,759 (GRCm39)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,709,958 (GRCm39)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,720,357 (GRCm39)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
R5345:Celsr3	UTSW	9	108,709,323 (GRCm39)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,709,224 (GRCm39)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,705,781 (GRCm39)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,717,241 (GRCm39)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,721,233 (GRCm39)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,705,836 (GRCm39)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,721,743 (GRCm39)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,726,266 (GRCm39)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,714,332 (GRCm39)	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108,715,671 (GRCm39)	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108,704,357 (GRCm39)	missense	probably benign
R5785:Celsr3	UTSW	9	108,704,996 (GRCm39)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,722,926 (GRCm39)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,708,993 (GRCm39)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,714,350 (GRCm39)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,705,554 (GRCm39)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,706,041 (GRCm39)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,712,989 (GRCm39)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,714,283 (GRCm39)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,706,327 (GRCm39)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,704,549 (GRCm39)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,706,390 (GRCm39)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,704,914 (GRCm39)	missense	probably benign
R7061:Celsr3	UTSW	9	108,724,793 (GRCm39)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,705,766 (GRCm39)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,715,203 (GRCm39)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,720,150 (GRCm39)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,722,961 (GRCm39)	missense	probably benign
R7213:Celsr3	UTSW	9	108,726,239 (GRCm39)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,706,343 (GRCm39)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,720,777 (GRCm39)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,713,821 (GRCm39)	missense	probably benign
R7554:Celsr3	UTSW	9	108,718,408 (GRCm39)	missense	probably benign
R7615:Celsr3	UTSW	9	108,714,851 (GRCm39)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,712,269 (GRCm39)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,707,177 (GRCm39)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,705,271 (GRCm39)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,706,840 (GRCm39)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,722,282 (GRCm39)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,706,306 (GRCm39)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,705,530 (GRCm39)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,723,612 (GRCm39)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,715,169 (GRCm39)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,725,993 (GRCm39)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,704,539 (GRCm39)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,703,734 (GRCm39)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,706,256 (GRCm39)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,708,988 (GRCm39)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,706,829 (GRCm39)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,715,319 (GRCm39)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,707,062 (GRCm39)	missense	probably benign
R8728:Celsr3	UTSW	9	108,723,940 (GRCm39)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,717,582 (GRCm39)	missense	probably benign
R8877:Celsr3	UTSW	9	108,706,877 (GRCm39)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,718,501 (GRCm39)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,706,151 (GRCm39)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,704,293 (GRCm39)	missense	probably benign
R9157:Celsr3	UTSW	9	108,707,185 (GRCm39)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,706,595 (GRCm39)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,715,689 (GRCm39)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,706,961 (GRCm39)	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108,723,596 (GRCm39)	missense	probably damaging	1.00
R9432:Celsr3	UTSW	9	108,726,032 (GRCm39)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,717,701 (GRCm39)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,703,559 (GRCm39)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,704,296 (GRCm39)	missense	probably benign
R9645:Celsr3	UTSW	9	108,704,691 (GRCm39)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,704,522 (GRCm39)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,728,502 (GRCm39)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,705,794 (GRCm39)	missense	probably damaging	1.00
RF020:Celsr3	UTSW	9	108,726,256 (GRCm39)	missense	probably benign
X0018:Celsr3	UTSW	9	108,717,611 (GRCm39)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,704,977 (GRCm39)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,706,129 (GRCm39)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,703,676 (GRCm39)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- TGGAGTCCTTATGGATGCCTC -3'
(R):5'- AACTTGGACCCCAGGCTTTC -3'

Sequencing Primer
(F):5'- TATGGATGCCTCTCCCCGG -3'
(R):5'- CTTTCCAGAAAAAGGCGGAGTCAC -3'

Posted On

2014-08-01