Incidental Mutation 'R4649:Lrrk1'
| ID |
350588 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
041910-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4649 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 65922801 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1366
(I1366V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015277
AA Change: I1366V
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: I1366V
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131239
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
AA Change: I281V
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
AA Change: I281V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Meta Mutation Damage Score |
0.1612 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 4933409G03Rik |
G |
A |
2: 68,436,559 (GRCm39) |
E168K |
unknown |
Het |
| Abca4 |
G |
T |
3: 121,963,542 (GRCm39) |
V841F |
probably damaging |
Het |
| Adcy10 |
G |
A |
1: 165,331,618 (GRCm39) |
E84K |
probably damaging |
Het |
| Adgrg6 |
C |
A |
10: 14,344,571 (GRCm39) |
M127I |
probably damaging |
Het |
| Agpat5 |
A |
G |
8: 18,929,668 (GRCm39) |
I266V |
possibly damaging |
Het |
| Agtpbp1 |
A |
T |
13: 59,676,213 (GRCm39) |
Y186N |
possibly damaging |
Het |
| Alx1 |
A |
T |
10: 102,845,193 (GRCm39) |
N279K |
probably damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Arsi |
A |
G |
18: 61,050,170 (GRCm39) |
Y351C |
probably damaging |
Het |
| B4galnt3 |
T |
A |
6: 120,201,581 (GRCm39) |
R155W |
probably damaging |
Het |
| BC028528 |
T |
C |
3: 95,795,577 (GRCm39) |
E75G |
probably damaging |
Het |
| Bmp2k |
C |
T |
5: 97,200,970 (GRCm39) |
P297S |
possibly damaging |
Het |
| Btnl4 |
A |
G |
17: 34,691,602 (GRCm39) |
S296P |
probably benign |
Het |
| Bzw2 |
A |
T |
12: 36,173,980 (GRCm39) |
V98E |
probably null |
Het |
| Cacna1d |
C |
T |
14: 29,817,365 (GRCm39) |
M1232I |
probably benign |
Het |
| Cast |
A |
G |
13: 74,894,133 (GRCm39) |
S171P |
probably benign |
Het |
| Catsperb |
G |
A |
12: 101,507,771 (GRCm39) |
A513T |
probably benign |
Het |
| Cd19 |
A |
G |
7: 126,013,664 (GRCm39) |
S42P |
probably benign |
Het |
| Chml |
A |
G |
1: 175,514,962 (GRCm39) |
S138P |
probably benign |
Het |
| Clic6 |
T |
G |
16: 92,327,827 (GRCm39) |
|
probably null |
Het |
| Col12a1 |
A |
T |
9: 79,547,076 (GRCm39) |
V2252E |
probably damaging |
Het |
| Cplx2 |
G |
A |
13: 54,527,361 (GRCm39) |
E82K |
probably benign |
Het |
| Csmd2 |
G |
A |
4: 128,439,866 (GRCm39) |
V3107M |
probably benign |
Het |
| Cspg4 |
T |
A |
9: 56,794,149 (GRCm39) |
V628D |
possibly damaging |
Het |
| Dcaf13 |
G |
A |
15: 39,001,637 (GRCm39) |
R315Q |
possibly damaging |
Het |
| Deaf1 |
A |
G |
7: 140,877,486 (GRCm39) |
V547A |
possibly damaging |
Het |
| Dmxl1 |
C |
T |
18: 50,011,698 (GRCm39) |
T1285I |
probably damaging |
Het |
| Dnah3 |
C |
A |
7: 119,646,921 (GRCm39) |
W1036L |
probably damaging |
Het |
| Dnai3 |
A |
G |
3: 145,753,922 (GRCm39) |
S713P |
probably damaging |
Het |
| Dpy19l1 |
A |
C |
9: 24,393,350 (GRCm39) |
S140A |
possibly damaging |
Het |
| Dsg2 |
T |
A |
18: 20,735,302 (GRCm39) |
D1093E |
possibly damaging |
Het |
| Edaradd |
T |
A |
13: 12,523,304 (GRCm39) |
H12L |
probably damaging |
Het |
| Enam |
T |
C |
5: 88,640,827 (GRCm39) |
M163T |
probably benign |
Het |
| Fbxo22 |
T |
A |
9: 55,128,333 (GRCm39) |
V218E |
probably damaging |
Het |
| Fbxo34 |
A |
T |
14: 47,767,085 (GRCm39) |
K148N |
probably damaging |
Het |
| Foxi3 |
A |
G |
6: 70,933,960 (GRCm39) |
D149G |
probably damaging |
Het |
| Gbp8 |
C |
T |
5: 105,189,807 (GRCm39) |
G75D |
probably damaging |
Het |
| Gm10784 |
C |
T |
13: 50,099,251 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7247 |
G |
A |
14: 51,807,051 (GRCm39) |
|
probably null |
Het |
| Grik3 |
T |
A |
4: 125,544,278 (GRCm39) |
V333E |
probably damaging |
Het |
| Gsap |
A |
T |
5: 21,431,309 (GRCm39) |
D211V |
probably damaging |
Het |
| H2-T15 |
T |
C |
17: 36,368,768 (GRCm39) |
Y104C |
possibly damaging |
Het |
| Ino80 |
T |
C |
2: 119,261,489 (GRCm39) |
N725S |
probably damaging |
Het |
| Itgad |
A |
G |
7: 127,788,703 (GRCm39) |
I443V |
probably benign |
Het |
| Itsn1 |
T |
A |
16: 91,638,476 (GRCm39) |
I52N |
probably damaging |
Het |
| Kmt2b |
TCTCCTCCTCCTCCTCCTCCTCCTCC |
TCTCCTCCTCCTCCTCCTCCTCC |
7: 30,285,783 (GRCm39) |
|
probably benign |
Het |
| Lamc1 |
T |
G |
1: 153,104,523 (GRCm39) |
S59R |
probably damaging |
Het |
| Lyn |
C |
A |
4: 3,738,850 (GRCm39) |
Q41K |
probably benign |
Het |
| Mapk13 |
C |
T |
17: 28,997,461 (GRCm39) |
R360* |
probably null |
Het |
| Mapk8ip3 |
T |
A |
17: 25,123,726 (GRCm39) |
I599F |
probably damaging |
Het |
| Me1 |
T |
C |
9: 86,561,905 (GRCm39) |
K60R |
probably benign |
Het |
| Mga |
T |
A |
2: 119,771,974 (GRCm39) |
D1532E |
possibly damaging |
Het |
| Miga1 |
G |
A |
3: 151,984,642 (GRCm39) |
S427L |
probably benign |
Het |
| Mknk2 |
A |
T |
10: 80,505,173 (GRCm39) |
V186E |
probably damaging |
Het |
| Myo1a |
C |
A |
10: 127,546,086 (GRCm39) |
N236K |
probably benign |
Het |
| Myt1 |
A |
G |
2: 181,439,207 (GRCm39) |
D243G |
probably benign |
Het |
| Ncf4 |
T |
C |
15: 78,140,189 (GRCm39) |
V196A |
possibly damaging |
Het |
| Nlrp5 |
G |
T |
7: 23,117,603 (GRCm39) |
L442F |
probably damaging |
Het |
| Olfm4 |
G |
A |
14: 80,258,747 (GRCm39) |
D332N |
probably benign |
Het |
| Or4a81 |
C |
A |
2: 89,619,637 (GRCm39) |
V20F |
probably benign |
Het |
| Or4b1d |
T |
A |
2: 89,969,432 (GRCm39) |
D17V |
probably damaging |
Het |
| Osbpl11 |
T |
A |
16: 33,016,452 (GRCm39) |
M69K |
probably benign |
Het |
| Oxnad1 |
T |
A |
14: 31,824,366 (GRCm39) |
*312K |
probably null |
Het |
| Plekhg1 |
A |
G |
10: 3,906,985 (GRCm39) |
Q634R |
probably benign |
Het |
| Plekhh2 |
T |
C |
17: 84,882,691 (GRCm39) |
Y733H |
probably damaging |
Het |
| Ppp1r21 |
A |
G |
17: 88,856,941 (GRCm39) |
H132R |
probably benign |
Het |
| Prkcq |
T |
C |
2: 11,284,333 (GRCm39) |
V501A |
possibly damaging |
Het |
| Prpf38b |
G |
A |
3: 108,811,408 (GRCm39) |
|
probably benign |
Het |
| Prpf4b |
A |
T |
13: 35,083,954 (GRCm39) |
M908L |
probably benign |
Het |
| Prps2 |
T |
C |
X: 166,135,288 (GRCm39) |
D183G |
probably damaging |
Het |
| Pudp |
T |
C |
18: 50,701,259 (GRCm39) |
D158G |
probably damaging |
Het |
| R3hdm1 |
T |
C |
1: 128,112,181 (GRCm39) |
S422P |
probably damaging |
Het |
| Ranbp3 |
T |
A |
17: 57,003,640 (GRCm39) |
|
probably null |
Het |
| Ranbp6 |
A |
G |
19: 29,787,721 (GRCm39) |
V877A |
probably benign |
Het |
| Rgsl1 |
A |
T |
1: 153,693,328 (GRCm39) |
S618T |
probably benign |
Het |
| Rhox2a |
A |
T |
X: 36,509,015 (GRCm39) |
I61L |
probably benign |
Het |
| Rhox2a |
G |
C |
X: 36,508,962 (GRCm39) |
R43P |
probably benign |
Het |
| Rnf207 |
A |
C |
4: 152,396,612 (GRCm39) |
D466E |
probably benign |
Het |
| Rnf7 |
A |
G |
9: 96,353,883 (GRCm39) |
I80T |
probably benign |
Het |
| Ros1 |
T |
A |
10: 52,005,764 (GRCm39) |
I878F |
possibly damaging |
Het |
| Rsbn1 |
T |
A |
3: 103,861,096 (GRCm39) |
|
probably null |
Het |
| Sbk1 |
T |
C |
7: 125,890,301 (GRCm39) |
S105P |
probably damaging |
Het |
| Sdk1 |
T |
C |
5: 141,992,380 (GRCm39) |
Y790H |
probably damaging |
Het |
| Sec62 |
T |
A |
3: 30,864,683 (GRCm39) |
N182K |
unknown |
Het |
| Slc15a1 |
T |
C |
14: 121,715,504 (GRCm39) |
Y345C |
probably damaging |
Het |
| Slc27a1 |
G |
A |
8: 72,023,408 (GRCm39) |
A15T |
probably benign |
Het |
| Slc35d1 |
A |
G |
4: 103,070,426 (GRCm39) |
F110L |
probably damaging |
Het |
| Slc39a5 |
T |
A |
10: 128,233,136 (GRCm39) |
S333C |
probably benign |
Het |
| Tarbp1 |
A |
G |
8: 127,173,934 (GRCm39) |
S927P |
probably damaging |
Het |
| Tns1 |
A |
G |
1: 73,992,930 (GRCm39) |
S583P |
probably damaging |
Het |
| Trim38 |
A |
T |
13: 23,966,952 (GRCm39) |
D133V |
probably damaging |
Het |
| Trim40 |
T |
C |
17: 37,193,531 (GRCm39) |
|
probably null |
Het |
| Trim42 |
C |
A |
9: 97,244,998 (GRCm39) |
V601L |
probably benign |
Het |
| Trpc7 |
G |
A |
13: 57,035,367 (GRCm39) |
R189C |
probably damaging |
Het |
| Ttc29 |
A |
T |
8: 79,060,208 (GRCm39) |
Y376F |
probably benign |
Het |
| Vmn2r63 |
A |
G |
7: 42,553,114 (GRCm39) |
I714T |
possibly damaging |
Het |
| Vmn2r68 |
C |
A |
7: 84,870,743 (GRCm39) |
A847S |
probably benign |
Het |
| Zbp1 |
G |
A |
2: 173,049,608 (GRCm39) |
P385S |
possibly damaging |
Het |
| Zfat |
A |
G |
15: 68,056,325 (GRCm39) |
Y237H |
probably damaging |
Het |
| Zfp236 |
A |
T |
18: 82,615,784 (GRCm39) |
W1840R |
probably damaging |
Het |
| Zfp426 |
G |
T |
9: 20,381,923 (GRCm39) |
Q341K |
possibly damaging |
Het |
| Zfp462 |
T |
A |
4: 55,009,349 (GRCm39) |
N438K |
probably benign |
Het |
| Zfp952 |
T |
A |
17: 33,221,899 (GRCm39) |
V88E |
probably damaging |
Het |
| Znfx1 |
G |
T |
2: 166,898,276 (GRCm39) |
A216D |
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGATACCTTCTCGTCATACAC -3'
(R):5'- CTCCTCCCAATAGTGCTATACAAG -3'
Sequencing Primer
(F):5'- ATACACGATGCGAGGCCTGATC -3'
(R):5'- GCTATACAAGCCAACCCTGAAAC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation