Incidental Mutation 'R5399:Vmn2r63'
| ID |
429864 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r63
|
| Ensembl Gene |
ENSMUSG00000090751 |
| Gene Name |
vomeronasal 2, receptor 63 |
| Synonyms |
EG435975 |
| MMRRC Submission |
042970-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R5399 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
42552675-42583213 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 42577701 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 279
(V279D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163803]
|
| AlphaFold |
E9Q0K5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163803
AA Change: V279D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: V279D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
3.5e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
3.5e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6820408C15Rik |
G |
T |
2: 152,282,788 (GRCm39) |
L214F |
probably damaging |
Het |
| Abcb1b |
T |
C |
5: 8,877,410 (GRCm39) |
S657P |
probably benign |
Het |
| Abcb5 |
T |
A |
12: 118,875,234 (GRCm39) |
Y646F |
probably benign |
Het |
| Agl |
A |
T |
3: 116,575,277 (GRCm39) |
L620Q |
probably damaging |
Het |
| Anapc15 |
C |
T |
7: 101,547,810 (GRCm39) |
P68L |
probably damaging |
Het |
| Arhgap23 |
A |
G |
11: 97,391,743 (GRCm39) |
N1420S |
probably damaging |
Het |
| Barx2 |
A |
G |
9: 31,765,407 (GRCm39) |
|
probably null |
Het |
| Birc6 |
C |
A |
17: 74,911,573 (GRCm39) |
S28R |
possibly damaging |
Het |
| Bmal2 |
T |
G |
6: 146,724,159 (GRCm39) |
D350E |
probably damaging |
Het |
| Btbd19 |
G |
A |
4: 116,980,957 (GRCm39) |
A104V |
probably damaging |
Het |
| Casp4 |
A |
T |
9: 5,324,928 (GRCm39) |
K247* |
probably null |
Het |
| Ccdc196 |
A |
C |
12: 78,244,227 (GRCm39) |
N60T |
probably damaging |
Het |
| Clk4 |
T |
C |
11: 51,166,084 (GRCm39) |
Y17H |
probably damaging |
Het |
| Cntnap1 |
A |
G |
11: 101,074,142 (GRCm39) |
Q722R |
probably benign |
Het |
| Col6a6 |
A |
G |
9: 105,586,306 (GRCm39) |
V1905A |
possibly damaging |
Het |
| Csmd1 |
C |
A |
8: 16,760,613 (GRCm39) |
G174V |
probably damaging |
Het |
| Cul1 |
T |
A |
6: 47,462,018 (GRCm39) |
|
probably null |
Het |
| Cux1 |
T |
C |
5: 136,281,458 (GRCm39) |
E568G |
possibly damaging |
Het |
| Dnaaf2 |
A |
G |
12: 69,243,516 (GRCm39) |
I515T |
probably damaging |
Het |
| Fbn1 |
T |
C |
2: 125,174,253 (GRCm39) |
I1868V |
possibly damaging |
Het |
| Fcgbp |
G |
T |
7: 27,804,480 (GRCm39) |
V1863L |
probably benign |
Het |
| G2e3 |
T |
C |
12: 51,403,977 (GRCm39) |
|
probably null |
Het |
| Gabrr2 |
T |
C |
4: 33,071,458 (GRCm39) |
|
probably null |
Het |
| Gad1-ps |
G |
A |
10: 99,281,009 (GRCm39) |
|
noncoding transcript |
Het |
| Gbgt1 |
C |
T |
2: 28,393,230 (GRCm39) |
P106L |
probably damaging |
Het |
| Golga3 |
A |
G |
5: 110,352,890 (GRCm39) |
E927G |
probably damaging |
Het |
| Hfm1 |
T |
A |
5: 107,065,428 (GRCm39) |
I84F |
possibly damaging |
Het |
| Htt |
G |
T |
5: 35,034,495 (GRCm39) |
D1989Y |
probably damaging |
Het |
| Ihh |
C |
T |
1: 74,985,436 (GRCm39) |
A350T |
probably benign |
Het |
| Irx4 |
G |
C |
13: 73,413,658 (GRCm39) |
A43P |
probably benign |
Het |
| Itk |
A |
G |
11: 46,228,938 (GRCm39) |
V414A |
probably benign |
Het |
| Itsn2 |
A |
T |
12: 4,703,535 (GRCm39) |
I744L |
probably benign |
Het |
| Kdm5b |
G |
A |
1: 134,549,836 (GRCm39) |
|
probably null |
Het |
| Kif14 |
A |
G |
1: 136,431,062 (GRCm39) |
D1153G |
probably benign |
Het |
| Morc3 |
A |
G |
16: 93,659,427 (GRCm39) |
|
probably null |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Msc |
A |
T |
1: 14,825,780 (GRCm39) |
C65S |
probably benign |
Het |
| Mybpc1 |
A |
G |
10: 88,358,876 (GRCm39) |
V343A |
probably damaging |
Het |
| Myo5c |
T |
C |
9: 75,195,356 (GRCm39) |
I1218T |
possibly damaging |
Het |
| Mypn |
C |
T |
10: 62,955,965 (GRCm39) |
V1163I |
probably benign |
Het |
| Obox3 |
A |
T |
7: 15,360,213 (GRCm39) |
M152K |
probably benign |
Het |
| Or1e16 |
AGCGGTCGTAGGC |
AGC |
11: 73,286,480 (GRCm39) |
|
probably null |
Het |
| Or2t47 |
A |
G |
11: 58,442,969 (GRCm39) |
V32A |
probably benign |
Het |
| Or4c106 |
T |
A |
2: 88,682,999 (GRCm39) |
L235H |
probably damaging |
Het |
| Or4c3 |
T |
A |
2: 89,852,267 (GRCm39) |
T48S |
probably benign |
Het |
| Pcdhb21 |
G |
T |
18: 37,648,772 (GRCm39) |
V634L |
probably benign |
Het |
| Ppp1r9b |
G |
A |
11: 94,882,974 (GRCm39) |
A201T |
probably benign |
Het |
| Pramel25 |
T |
C |
4: 143,521,602 (GRCm39) |
F406S |
probably benign |
Het |
| Prss23 |
A |
T |
7: 89,159,174 (GRCm39) |
D298E |
probably benign |
Het |
| Rab4b |
A |
T |
7: 26,875,587 (GRCm39) |
N31K |
probably benign |
Het |
| Ros1 |
A |
G |
10: 51,967,040 (GRCm39) |
|
probably null |
Het |
| Rragb |
G |
A |
X: 151,923,550 (GRCm39) |
G24E |
probably damaging |
Het |
| Rtl1 |
A |
T |
12: 109,556,736 (GRCm39) |
L1701Q |
probably damaging |
Het |
| Sbno1 |
T |
A |
5: 124,530,804 (GRCm39) |
N831Y |
probably benign |
Het |
| Selp |
A |
G |
1: 163,954,155 (GRCm39) |
K152E |
possibly damaging |
Het |
| Sema4b |
A |
G |
7: 79,874,634 (GRCm39) |
T675A |
probably benign |
Het |
| Slc36a3 |
T |
C |
11: 55,037,006 (GRCm39) |
I100V |
possibly damaging |
Het |
| Slco1a4 |
T |
A |
6: 141,776,433 (GRCm39) |
I196F |
probably damaging |
Het |
| Spata13 |
G |
A |
14: 60,984,990 (GRCm39) |
S828N |
probably benign |
Het |
| Stard13 |
A |
T |
5: 150,971,266 (GRCm39) |
Y643* |
probably null |
Het |
| Tll1 |
T |
C |
8: 64,538,522 (GRCm39) |
H374R |
probably damaging |
Het |
| Trmt10a |
T |
A |
3: 137,853,265 (GRCm39) |
I42K |
probably damaging |
Het |
| Trmu |
A |
T |
15: 85,780,609 (GRCm39) |
|
probably null |
Het |
| Trp53 |
T |
A |
11: 69,479,372 (GRCm39) |
D183E |
probably benign |
Het |
| Ttc22 |
T |
G |
4: 106,493,954 (GRCm39) |
F305V |
probably damaging |
Het |
| Unc13c |
A |
G |
9: 73,656,970 (GRCm39) |
F1077S |
possibly damaging |
Het |
| Utrn |
T |
A |
10: 12,516,727 (GRCm39) |
Q2289L |
probably damaging |
Het |
| Vmn1r65 |
C |
A |
7: 6,011,809 (GRCm39) |
E142* |
probably null |
Het |
| Zfp810 |
G |
A |
9: 22,190,125 (GRCm39) |
T261I |
possibly damaging |
Het |
| Zkscan17 |
A |
G |
11: 59,393,744 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01399:Vmn2r63
|
APN |
7 |
42,553,543 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01765:Vmn2r63
|
APN |
7 |
42,552,788 (GRCm39) |
missense |
probably benign |
|
|
IGL02203:Vmn2r63
|
APN |
7 |
42,553,432 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02825:Vmn2r63
|
APN |
7 |
42,576,274 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03155:Vmn2r63
|
APN |
7 |
42,552,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03260:Vmn2r63
|
APN |
7 |
42,578,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03411:Vmn2r63
|
APN |
7 |
42,577,368 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4280001:Vmn2r63
|
UTSW |
7 |
42,553,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Vmn2r63
|
UTSW |
7 |
42,576,514 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r63
|
UTSW |
7 |
42,552,699 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0344:Vmn2r63
|
UTSW |
7 |
42,553,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0554:Vmn2r63
|
UTSW |
7 |
42,583,129 (GRCm39) |
nonsense |
probably null |
|
|
R0555:Vmn2r63
|
UTSW |
7 |
42,577,952 (GRCm39) |
nonsense |
probably null |
|
|
R0685:Vmn2r63
|
UTSW |
7 |
42,577,434 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0751:Vmn2r63
|
UTSW |
7 |
42,577,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1372:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1416:Vmn2r63
|
UTSW |
7 |
42,577,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Vmn2r63
|
UTSW |
7 |
42,578,015 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1563:Vmn2r63
|
UTSW |
7 |
42,553,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1652:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1693:Vmn2r63
|
UTSW |
7 |
42,577,743 (GRCm39) |
missense |
probably benign |
|
|
R1698:Vmn2r63
|
UTSW |
7 |
42,583,038 (GRCm39) |
missense |
probably benign |
|
|
R1753:Vmn2r63
|
UTSW |
7 |
42,577,669 (GRCm39) |
nonsense |
probably null |
|
|
R2136:Vmn2r63
|
UTSW |
7 |
42,576,297 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2175:Vmn2r63
|
UTSW |
7 |
42,583,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2261:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2262:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2263:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3413:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3426:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3427:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3802:Vmn2r63
|
UTSW |
7 |
42,552,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4319:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4321:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4323:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4346:Vmn2r63
|
UTSW |
7 |
42,577,537 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4568:Vmn2r63
|
UTSW |
7 |
42,583,250 (GRCm39) |
splice site |
probably null |
|
|
R4649:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4653:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4679:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4741:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4748:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4806:Vmn2r63
|
UTSW |
7 |
42,576,314 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4933:Vmn2r63
|
UTSW |
7 |
42,553,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5198:Vmn2r63
|
UTSW |
7 |
42,553,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5400:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6158:Vmn2r63
|
UTSW |
7 |
42,583,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6185:Vmn2r63
|
UTSW |
7 |
42,578,435 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6267:Vmn2r63
|
UTSW |
7 |
42,578,059 (GRCm39) |
splice site |
probably null |
|
|
R6362:Vmn2r63
|
UTSW |
7 |
42,552,721 (GRCm39) |
missense |
probably benign |
|
|
R6706:Vmn2r63
|
UTSW |
7 |
42,578,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6764:Vmn2r63
|
UTSW |
7 |
42,552,695 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7104:Vmn2r63
|
UTSW |
7 |
42,577,959 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7503:Vmn2r63
|
UTSW |
7 |
42,583,014 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7506:Vmn2r63
|
UTSW |
7 |
42,576,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7658:Vmn2r63
|
UTSW |
7 |
42,574,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Vmn2r63
|
UTSW |
7 |
42,576,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7702:Vmn2r63
|
UTSW |
7 |
42,577,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7918:Vmn2r63
|
UTSW |
7 |
42,552,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8826:Vmn2r63
|
UTSW |
7 |
42,576,441 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8973:Vmn2r63
|
UTSW |
7 |
42,577,919 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9024:Vmn2r63
|
UTSW |
7 |
42,577,874 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9154:Vmn2r63
|
UTSW |
7 |
42,576,413 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9731:Vmn2r63
|
UTSW |
7 |
42,553,361 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1088:Vmn2r63
|
UTSW |
7 |
42,577,983 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGATAAGCATCTTCTGGGTATGTG -3'
(R):5'- TGTCCCAAATGACCCCAGAG -3'
Sequencing Primer
(F):5'- CTTCTGGGTATGTGTAGGGATTCAC -3'
(R):5'- ATTCCTGGCACCTGGAAT -3'
|
| Posted On |
2016-09-06 |
Incidental Mutation