Incidental Mutation 'R5879:Ipo13'
ID 455703
Institutional Source Beutler Lab
Gene Symbol Ipo13
Ensembl Gene ENSMUSG00000033365
Gene Name importin 13
Synonyms Imp13, Kap13
Accession Numbers
Essential gene? Probably essential (E-score: 0.959) question?
Stock # R5879 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 117751683-117772196 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 117760400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 649 (T649I)
Ref Sequence ENSEMBL: ENSMUSP00000035989 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036156]
AlphaFold Q8K0C1
Predicted Effect possibly damaging
Transcript: ENSMUST00000036156
AA Change: T649I

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000035989
Gene: ENSMUSG00000033365
AA Change: T649I

DomainStartEndE-ValueType
low complexity region 9 18 N/A INTRINSIC
IBN_N 45 111 2.05e-7 SMART
Pfam:Xpo1 116 263 4.8e-29 PFAM
low complexity region 668 692 N/A INTRINSIC
low complexity region 767 779 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153918
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a gene trap insertion die prior to genotyping age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh16a1 C T 7: 44,796,930 (GRCm39) W66* probably null Het
Arhgap39 T C 15: 76,636,007 (GRCm39) D76G probably damaging Het
Arhgef2 G A 3: 88,550,924 (GRCm39) probably null Het
C1qtnf2 T C 11: 43,376,835 (GRCm39) M99T probably damaging Het
Cyren A G 6: 34,851,593 (GRCm39) L87P probably damaging Het
Eml3 G A 19: 8,912,379 (GRCm39) C392Y possibly damaging Het
Ephb4 C A 5: 137,358,678 (GRCm39) P287Q probably benign Het
Fat4 G T 3: 38,941,485 (GRCm39) R126L probably benign Het
Flt3 T C 5: 147,271,719 (GRCm39) M858V probably damaging Het
Gprin3 A C 6: 59,331,698 (GRCm39) I203R probably benign Het
Insr G T 8: 3,248,173 (GRCm39) Y457* probably null Het
Krba1 A G 6: 48,392,678 (GRCm39) D818G possibly damaging Het
Llgl1 G A 11: 60,603,806 (GRCm39) G1016R probably benign Het
Loxl4 A G 19: 42,596,066 (GRCm39) V142A probably benign Het
Mthfd1 A G 12: 76,340,992 (GRCm39) I464V probably benign Het
Mycs C A X: 5,380,131 (GRCm39) K316N probably damaging Het
Ncor2 A G 5: 125,103,839 (GRCm39) probably benign Het
Nlrc3 A G 16: 3,781,909 (GRCm39) F516S probably damaging Het
Oacyl A G 18: 65,882,743 (GRCm39) S540G probably damaging Het
Olfml2a A T 2: 38,850,242 (GRCm39) T653S probably damaging Het
Or8s16 C T 15: 98,211,369 (GRCm39) V21I probably benign Het
Pcnx2 A T 8: 126,500,685 (GRCm39) N1468K probably damaging Het
Plbd1 A G 6: 136,611,503 (GRCm39) I258T probably damaging Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Pramel21 A T 4: 143,344,161 (GRCm39) Y487F possibly damaging Het
Prop1 C T 11: 50,844,153 (GRCm39) V27M probably damaging Het
Rfx4 T G 10: 84,650,625 (GRCm39) probably null Het
Rgs11 C T 17: 26,422,437 (GRCm39) probably benign Het
Slc6a5 T A 7: 49,595,260 (GRCm39) F541I probably damaging Het
Srgap3 A T 6: 112,699,807 (GRCm39) V1057E possibly damaging Het
Synpo2 A T 3: 122,907,946 (GRCm39) W457R probably damaging Het
Tet2 T A 3: 133,193,721 (GRCm39) N238Y possibly damaging Het
Tiam2 T A 17: 3,487,540 (GRCm39) M687K probably damaging Het
Ticrr A G 7: 79,346,438 (GRCm39) E1866G probably benign Het
Tspan8 T C 10: 115,669,156 (GRCm39) S64P possibly damaging Het
Ugt2b37 C T 5: 87,402,265 (GRCm39) G122D probably benign Het
Uqcrc2 A G 7: 120,237,111 (GRCm39) E53G probably damaging Het
Vcan T C 13: 89,852,071 (GRCm39) D963G probably damaging Het
Vmn2r24 T A 6: 123,764,226 (GRCm39) Y368N possibly damaging Het
Wdr5 A G 2: 27,418,323 (GRCm39) T208A probably benign Het
Zbtb18 A G 1: 177,275,936 (GRCm39) Y423C probably damaging Het
Zc3h6 A G 2: 128,839,696 (GRCm39) probably null Het
Other mutations in Ipo13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Ipo13 APN 4 117,760,602 (GRCm39) missense probably benign 0.10
IGL00800:Ipo13 APN 4 117,769,505 (GRCm39) missense probably benign 0.31
IGL00971:Ipo13 APN 4 117,771,564 (GRCm39) missense possibly damaging 0.83
IGL01552:Ipo13 APN 4 117,758,161 (GRCm39) missense probably benign 0.16
IGL01957:Ipo13 APN 4 117,761,078 (GRCm39) missense probably damaging 0.99
IGL02262:Ipo13 APN 4 117,761,010 (GRCm39) missense probably damaging 1.00
R0109:Ipo13 UTSW 4 117,762,213 (GRCm39) missense possibly damaging 0.92
R0142:Ipo13 UTSW 4 117,762,766 (GRCm39) missense probably damaging 1.00
R0771:Ipo13 UTSW 4 117,751,843 (GRCm39) missense possibly damaging 0.78
R1248:Ipo13 UTSW 4 117,758,228 (GRCm39) missense probably damaging 1.00
R1381:Ipo13 UTSW 4 117,761,592 (GRCm39) missense probably damaging 1.00
R1497:Ipo13 UTSW 4 117,761,856 (GRCm39) missense probably benign 0.04
R1614:Ipo13 UTSW 4 117,761,815 (GRCm39) missense probably benign 0.00
R1711:Ipo13 UTSW 4 117,761,719 (GRCm39) missense probably benign 0.38
R2037:Ipo13 UTSW 4 117,761,858 (GRCm39) nonsense probably null
R2200:Ipo13 UTSW 4 117,762,100 (GRCm39) critical splice donor site probably null
R3698:Ipo13 UTSW 4 117,757,890 (GRCm39) missense probably damaging 1.00
R3949:Ipo13 UTSW 4 117,758,239 (GRCm39) missense probably benign 0.10
R4687:Ipo13 UTSW 4 117,758,773 (GRCm39) missense probably benign 0.06
R4894:Ipo13 UTSW 4 117,761,687 (GRCm39) missense possibly damaging 0.84
R4894:Ipo13 UTSW 4 117,760,638 (GRCm39) missense probably damaging 0.99
R4956:Ipo13 UTSW 4 117,758,768 (GRCm39) missense probably benign 0.00
R5679:Ipo13 UTSW 4 117,752,029 (GRCm39) missense probably damaging 1.00
R5921:Ipo13 UTSW 4 117,769,286 (GRCm39) missense probably benign 0.14
R6250:Ipo13 UTSW 4 117,769,351 (GRCm39) missense possibly damaging 0.93
R6875:Ipo13 UTSW 4 117,762,108 (GRCm39) missense possibly damaging 0.90
R7178:Ipo13 UTSW 4 117,761,081 (GRCm39) missense possibly damaging 0.83
R7412:Ipo13 UTSW 4 117,752,068 (GRCm39) missense probably benign
R7687:Ipo13 UTSW 4 117,769,088 (GRCm39) missense probably benign 0.01
R7774:Ipo13 UTSW 4 117,771,494 (GRCm39) missense probably benign 0.11
R8390:Ipo13 UTSW 4 117,769,534 (GRCm39) missense probably damaging 0.99
R8489:Ipo13 UTSW 4 117,758,219 (GRCm39) missense probably damaging 0.98
R8525:Ipo13 UTSW 4 117,762,126 (GRCm39) missense probably damaging 0.99
R9039:Ipo13 UTSW 4 117,758,185 (GRCm39) missense probably damaging 0.98
R9229:Ipo13 UTSW 4 117,758,801 (GRCm39) missense probably damaging 0.96
R9319:Ipo13 UTSW 4 117,769,585 (GRCm39) missense probably benign 0.00
R9760:Ipo13 UTSW 4 117,762,778 (GRCm39) missense probably benign 0.05
Z1088:Ipo13 UTSW 4 117,761,877 (GRCm39) missense probably benign 0.14
Z1176:Ipo13 UTSW 4 117,761,827 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGTCAGGGAGCAATGCTAAC -3'
(R):5'- AGATCCTGAAGAACCTGCACTC -3'

Sequencing Primer
(F):5'- GTCAGGGAGCAATGCTAACATTACC -3'
(R):5'- TGAGTGAGCTCGGGGAC -3'
Posted On 2017-02-10