Incidental Mutation 'R6374:Sipa1l2'
| ID |
513697 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l2
|
| Ensembl Gene |
ENSMUSG00000001995 |
| Gene Name |
signal-induced proliferation-associated 1 like 2 |
| Synonyms |
|
| MMRRC Submission |
044524-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.312)
|
| Stock # |
R6374 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
126144802-126296547 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 126171369 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 1371
(V1371D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148536
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108775]
[ENSMUST00000212168]
[ENSMUST00000212987]
|
| AlphaFold |
Q80TE4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108775
AA Change: V1371D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000104405
Gene: ENSMUSG00000001995
AA Change: V1371D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
53 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
163 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
261 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
625 |
807 |
2.6e-67 |
PFAM |
|
PDZ
|
960 |
1026 |
6.47e-9 |
SMART |
|
low complexity region
|
1091 |
1103 |
N/A |
INTRINSIC |
|
low complexity region
|
1120 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1238 |
N/A |
INTRINSIC |
|
low complexity region
|
1299 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1321 |
1329 |
N/A |
INTRINSIC |
|
low complexity region
|
1334 |
1355 |
N/A |
INTRINSIC |
|
low complexity region
|
1404 |
1418 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1421 |
1666 |
2.5e-76 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212168
AA Change: V1371D
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212987
AA Change: V1371D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.5%
- 20x: 92.4%
|
| Validation Efficiency |
99% (75/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921509C19Rik |
A |
C |
2: 151,314,800 (GRCm39) |
S293A |
possibly damaging |
Het |
| 5430401F13Rik |
A |
T |
6: 131,529,892 (GRCm39) |
Q162L |
unknown |
Het |
| Abca8a |
A |
T |
11: 109,974,216 (GRCm39) |
Y239* |
probably null |
Het |
| Aox3 |
T |
C |
1: 58,211,320 (GRCm39) |
I959T |
probably benign |
Het |
| Atad2b |
T |
C |
12: 5,068,002 (GRCm39) |
V1000A |
probably damaging |
Het |
| Atic |
C |
T |
1: 71,604,100 (GRCm39) |
T221M |
probably damaging |
Het |
| Atp1a2 |
C |
T |
1: 172,116,942 (GRCm39) |
R225H |
probably damaging |
Het |
| BC024139 |
A |
G |
15: 76,004,657 (GRCm39) |
|
probably null |
Het |
| Bpi |
A |
T |
2: 158,113,974 (GRCm39) |
T291S |
probably damaging |
Het |
| Ccdc170 |
C |
T |
10: 4,499,746 (GRCm39) |
Q556* |
probably null |
Het |
| Cd3e |
G |
A |
9: 44,920,661 (GRCm39) |
L12F |
probably benign |
Het |
| Cdc42ep1 |
A |
T |
15: 78,731,649 (GRCm39) |
R31S |
probably damaging |
Het |
| Cyp21a1 |
G |
T |
17: 35,023,110 (GRCm39) |
|
probably null |
Het |
| Dnase1l3 |
A |
G |
14: 7,974,115 (GRCm38) |
M192T |
probably damaging |
Het |
| Dnmt1 |
A |
T |
9: 20,835,341 (GRCm39) |
H330Q |
possibly damaging |
Het |
| Enah |
T |
C |
1: 181,751,145 (GRCm39) |
E232G |
unknown |
Het |
| Etnppl |
C |
T |
3: 130,414,342 (GRCm39) |
T73I |
probably damaging |
Het |
| Fam83b |
T |
A |
9: 76,400,189 (GRCm39) |
I305F |
probably benign |
Het |
| Galnt15 |
T |
A |
14: 31,780,116 (GRCm39) |
I471N |
probably damaging |
Het |
| Gm19965 |
T |
A |
1: 116,750,021 (GRCm39) |
N567K |
probably benign |
Het |
| Golga1 |
T |
C |
2: 38,924,080 (GRCm39) |
Q435R |
probably benign |
Het |
| Gpat2 |
G |
C |
2: 127,273,838 (GRCm39) |
G294R |
possibly damaging |
Het |
| Hao1 |
T |
G |
2: 134,365,024 (GRCm39) |
D201A |
probably benign |
Het |
| Heg1 |
T |
C |
16: 33,547,499 (GRCm39) |
L786P |
possibly damaging |
Het |
| Hnrnpll |
A |
T |
17: 80,357,303 (GRCm39) |
C238S |
possibly damaging |
Het |
| Hrg |
A |
G |
16: 22,779,742 (GRCm39) |
Y340C |
probably damaging |
Het |
| Kyat3 |
A |
T |
3: 142,443,998 (GRCm39) |
I411F |
probably damaging |
Het |
| Myo1a |
T |
C |
10: 127,543,549 (GRCm39) |
Y202H |
probably damaging |
Het |
| Nags |
T |
C |
11: 102,037,337 (GRCm39) |
C143R |
possibly damaging |
Het |
| Ncoa6 |
T |
C |
2: 155,263,076 (GRCm39) |
N453D |
probably damaging |
Het |
| Nup35 |
G |
T |
2: 80,488,730 (GRCm39) |
M322I |
probably benign |
Het |
| Oprl1 |
T |
C |
2: 181,357,721 (GRCm39) |
V69A |
probably damaging |
Het |
| Or51v14 |
A |
G |
7: 103,261,128 (GRCm39) |
L144P |
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,784,215 (GRCm39) |
Y265F |
probably damaging |
Het |
| Pcsk6 |
C |
T |
7: 65,629,903 (GRCm39) |
P343L |
possibly damaging |
Het |
| Peak1 |
C |
A |
9: 56,164,950 (GRCm39) |
D993Y |
probably damaging |
Het |
| Polr2a |
T |
C |
11: 69,627,758 (GRCm39) |
Y1383C |
probably damaging |
Het |
| Ppme1 |
A |
G |
7: 99,990,272 (GRCm39) |
S226P |
probably damaging |
Het |
| Prom1 |
C |
T |
5: 44,213,325 (GRCm39) |
C127Y |
probably damaging |
Het |
| Ptpn6 |
A |
T |
6: 124,709,532 (GRCm39) |
|
probably null |
Het |
| Reln |
T |
C |
5: 22,285,712 (GRCm39) |
E419G |
probably benign |
Het |
| Rnf32 |
C |
T |
5: 29,430,266 (GRCm39) |
Q362* |
probably null |
Het |
| Sbspon |
T |
C |
1: 15,953,887 (GRCm39) |
D131G |
probably benign |
Het |
| Scyl3 |
T |
C |
1: 163,776,783 (GRCm39) |
S392P |
probably benign |
Het |
| Shtn1 |
T |
A |
19: 59,026,728 (GRCm39) |
D121V |
possibly damaging |
Het |
| Sin3a |
A |
G |
9: 57,024,765 (GRCm39) |
T1042A |
probably benign |
Het |
| Slc20a2 |
T |
C |
8: 23,055,668 (GRCm39) |
V584A |
possibly damaging |
Het |
| Smc6 |
T |
A |
12: 11,355,874 (GRCm39) |
|
probably null |
Het |
| Spata31h1 |
T |
A |
10: 82,124,731 (GRCm39) |
|
probably benign |
Het |
| Specc1 |
C |
T |
11: 62,047,418 (GRCm39) |
T849I |
possibly damaging |
Het |
| Spta1 |
T |
A |
1: 174,041,734 (GRCm39) |
L1368H |
probably damaging |
Het |
| Sqle |
A |
G |
15: 59,187,959 (GRCm39) |
E89G |
possibly damaging |
Het |
| Strbp |
A |
G |
2: 37,493,020 (GRCm39) |
V422A |
probably damaging |
Het |
| Sult6b1 |
G |
T |
17: 79,214,360 (GRCm39) |
T21K |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,065,940 (GRCm39) |
E1790G |
probably damaging |
Het |
| Tmem88b |
T |
A |
4: 155,870,221 (GRCm39) |
|
probably benign |
Het |
| Traf3ip3 |
T |
C |
1: 192,864,318 (GRCm39) |
D355G |
possibly damaging |
Het |
| Trim24 |
T |
A |
6: 37,930,484 (GRCm39) |
V576E |
probably benign |
Het |
| Trim30c |
C |
T |
7: 104,039,609 (GRCm39) |
G62D |
probably benign |
Het |
| Trim66 |
T |
G |
7: 109,085,269 (GRCm39) |
K100N |
probably benign |
Het |
| Tsnaxip1 |
A |
T |
8: 106,568,172 (GRCm39) |
T313S |
possibly damaging |
Het |
| Ugt2b37 |
A |
T |
5: 87,390,279 (GRCm39) |
I389N |
probably damaging |
Het |
| Unc13a |
C |
T |
8: 72,094,097 (GRCm39) |
V1335M |
possibly damaging |
Het |
| Urah |
A |
G |
7: 140,415,124 (GRCm39) |
T5A |
probably benign |
Het |
| Usp34 |
T |
C |
11: 23,388,914 (GRCm39) |
Y2185H |
probably damaging |
Het |
| Usp44 |
T |
C |
10: 93,692,172 (GRCm39) |
S643P |
probably benign |
Het |
| Vars2 |
A |
G |
17: 35,970,937 (GRCm39) |
V631A |
probably damaging |
Het |
| Vmn2r11 |
G |
A |
5: 109,201,679 (GRCm39) |
T275I |
possibly damaging |
Het |
| Vmn2r54 |
C |
A |
7: 12,349,420 (GRCm39) |
V721F |
probably damaging |
Het |
| Vmn2r79 |
T |
C |
7: 86,651,498 (GRCm39) |
I299T |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,849,251 (GRCm39) |
T2387A |
probably damaging |
Het |
| Washc5 |
A |
T |
15: 59,209,044 (GRCm39) |
L610Q |
probably benign |
Het |
| Zbtb21 |
T |
C |
16: 97,751,568 (GRCm39) |
E905G |
probably damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,309,095 (GRCm39) |
T774A |
probably damaging |
Het |
| Zfp534 |
T |
C |
4: 147,759,299 (GRCm39) |
I457V |
probably benign |
Het |
| Zfp964 |
T |
C |
8: 70,111,994 (GRCm39) |
Y29H |
possibly damaging |
Het |
| Znrf4 |
A |
G |
17: 56,818,702 (GRCm39) |
F202L |
probably damaging |
Het |
|
| Other mutations in Sipa1l2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00534:Sipa1l2
|
APN |
8 |
126,218,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00939:Sipa1l2
|
APN |
8 |
126,191,174 (GRCm39) |
splice site |
probably benign |
|
|
IGL00965:Sipa1l2
|
APN |
8 |
126,174,613 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01321:Sipa1l2
|
APN |
8 |
126,218,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01450:Sipa1l2
|
APN |
8 |
126,149,316 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01753:Sipa1l2
|
APN |
8 |
126,180,031 (GRCm39) |
splice site |
probably benign |
|
|
IGL01930:Sipa1l2
|
APN |
8 |
126,145,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02041:Sipa1l2
|
APN |
8 |
126,218,558 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02215:Sipa1l2
|
APN |
8 |
126,174,576 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02272:Sipa1l2
|
APN |
8 |
126,218,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02370:Sipa1l2
|
APN |
8 |
126,207,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02538:Sipa1l2
|
APN |
8 |
126,178,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02633:Sipa1l2
|
APN |
8 |
126,174,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03394:Sipa1l2
|
APN |
8 |
126,218,398 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Rebellious
|
UTSW |
8 |
126,195,078 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0144:Sipa1l2
|
UTSW |
8 |
126,176,615 (GRCm39) |
splice site |
probably null |
|
|
R0153:Sipa1l2
|
UTSW |
8 |
126,148,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0276:Sipa1l2
|
UTSW |
8 |
126,148,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0318:Sipa1l2
|
UTSW |
8 |
126,174,436 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0373:Sipa1l2
|
UTSW |
8 |
126,191,149 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0427:Sipa1l2
|
UTSW |
8 |
126,207,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0634:Sipa1l2
|
UTSW |
8 |
126,149,363 (GRCm39) |
nonsense |
probably null |
|
|
R1377:Sipa1l2
|
UTSW |
8 |
126,218,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
126,176,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
126,176,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1435:Sipa1l2
|
UTSW |
8 |
126,195,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1523:Sipa1l2
|
UTSW |
8 |
126,174,352 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1577:Sipa1l2
|
UTSW |
8 |
126,219,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1581:Sipa1l2
|
UTSW |
8 |
126,218,356 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1583:Sipa1l2
|
UTSW |
8 |
126,148,634 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1719:Sipa1l2
|
UTSW |
8 |
126,171,274 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1730:Sipa1l2
|
UTSW |
8 |
126,206,880 (GRCm39) |
splice site |
probably null |
|
|
R1940:Sipa1l2
|
UTSW |
8 |
126,206,887 (GRCm39) |
splice site |
probably benign |
|
|
R2007:Sipa1l2
|
UTSW |
8 |
126,166,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2141:Sipa1l2
|
UTSW |
8 |
126,218,230 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2203:Sipa1l2
|
UTSW |
8 |
126,218,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2764:Sipa1l2
|
UTSW |
8 |
126,219,113 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3722:Sipa1l2
|
UTSW |
8 |
126,200,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Sipa1l2
|
UTSW |
8 |
126,177,122 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R3787:Sipa1l2
|
UTSW |
8 |
126,149,944 (GRCm39) |
missense |
probably benign |
|
|
R4106:Sipa1l2
|
UTSW |
8 |
126,219,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4117:Sipa1l2
|
UTSW |
8 |
126,195,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4194:Sipa1l2
|
UTSW |
8 |
126,218,411 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4237:Sipa1l2
|
UTSW |
8 |
126,218,395 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4240:Sipa1l2
|
UTSW |
8 |
126,218,395 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4448:Sipa1l2
|
UTSW |
8 |
126,219,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4515:Sipa1l2
|
UTSW |
8 |
126,218,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4519:Sipa1l2
|
UTSW |
8 |
126,218,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Sipa1l2
|
UTSW |
8 |
126,219,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Sipa1l2
|
UTSW |
8 |
126,191,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4667:Sipa1l2
|
UTSW |
8 |
126,180,209 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4687:Sipa1l2
|
UTSW |
8 |
126,217,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4854:Sipa1l2
|
UTSW |
8 |
126,200,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4890:Sipa1l2
|
UTSW |
8 |
126,218,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Sipa1l2
|
UTSW |
8 |
126,218,324 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5194:Sipa1l2
|
UTSW |
8 |
126,166,012 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5266:Sipa1l2
|
UTSW |
8 |
126,218,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5475:Sipa1l2
|
UTSW |
8 |
126,218,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Sipa1l2
|
UTSW |
8 |
126,217,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5910:Sipa1l2
|
UTSW |
8 |
126,218,423 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5916:Sipa1l2
|
UTSW |
8 |
126,195,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Sipa1l2
|
UTSW |
8 |
126,200,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6083:Sipa1l2
|
UTSW |
8 |
126,195,212 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6185:Sipa1l2
|
UTSW |
8 |
126,194,992 (GRCm39) |
nonsense |
probably null |
|
|
R6235:Sipa1l2
|
UTSW |
8 |
126,201,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Sipa1l2
|
UTSW |
8 |
126,196,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Sipa1l2
|
UTSW |
8 |
126,180,203 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6459:Sipa1l2
|
UTSW |
8 |
126,171,223 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6462:Sipa1l2
|
UTSW |
8 |
126,217,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6496:Sipa1l2
|
UTSW |
8 |
126,176,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6543:Sipa1l2
|
UTSW |
8 |
126,177,101 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7154:Sipa1l2
|
UTSW |
8 |
126,195,078 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7192:Sipa1l2
|
UTSW |
8 |
126,149,348 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7240:Sipa1l2
|
UTSW |
8 |
126,196,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Sipa1l2
|
UTSW |
8 |
126,180,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7383:Sipa1l2
|
UTSW |
8 |
126,174,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7417:Sipa1l2
|
UTSW |
8 |
126,208,845 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7604:Sipa1l2
|
UTSW |
8 |
126,146,011 (GRCm39) |
missense |
probably benign |
0.45 |
|
R7658:Sipa1l2
|
UTSW |
8 |
126,219,029 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7743:Sipa1l2
|
UTSW |
8 |
126,190,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Sipa1l2
|
UTSW |
8 |
126,218,566 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7812:Sipa1l2
|
UTSW |
8 |
126,218,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7829:Sipa1l2
|
UTSW |
8 |
126,178,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7880:Sipa1l2
|
UTSW |
8 |
126,191,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7884:Sipa1l2
|
UTSW |
8 |
126,174,337 (GRCm39) |
missense |
probably benign |
|
|
R8057:Sipa1l2
|
UTSW |
8 |
126,195,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Sipa1l2
|
UTSW |
8 |
126,218,548 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8092:Sipa1l2
|
UTSW |
8 |
126,145,907 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8247:Sipa1l2
|
UTSW |
8 |
126,149,372 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8252:Sipa1l2
|
UTSW |
8 |
126,195,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8386:Sipa1l2
|
UTSW |
8 |
126,218,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8466:Sipa1l2
|
UTSW |
8 |
126,218,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8697:Sipa1l2
|
UTSW |
8 |
126,208,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8725:Sipa1l2
|
UTSW |
8 |
126,177,125 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8727:Sipa1l2
|
UTSW |
8 |
126,177,125 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9048:Sipa1l2
|
UTSW |
8 |
126,174,465 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9224:Sipa1l2
|
UTSW |
8 |
126,218,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Sipa1l2
|
UTSW |
8 |
126,208,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9392:Sipa1l2
|
UTSW |
8 |
126,194,960 (GRCm39) |
missense |
probably benign |
|
|
R9574:Sipa1l2
|
UTSW |
8 |
126,169,453 (GRCm39) |
missense |
probably benign |
|
|
R9591:Sipa1l2
|
UTSW |
8 |
126,219,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9614:Sipa1l2
|
UTSW |
8 |
126,196,565 (GRCm39) |
missense |
probably null |
0.01 |
|
R9690:Sipa1l2
|
UTSW |
8 |
126,218,996 (GRCm39) |
missense |
probably benign |
|
|
X0027:Sipa1l2
|
UTSW |
8 |
126,218,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Sipa1l2
|
UTSW |
8 |
126,174,295 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGGTGTACAATGACTATGGTTATAG -3'
(R):5'- ACTGAGTGGCCTACAGCTTG -3'
Sequencing Primer
(F):5'- ATAGATTTACCTGGGGCATTCC -3'
(R):5'- CGTCCAGCAAGCTATGTGGTAG -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation