Incidental Mutation 'R7202:Kmt2e'
| ID |
574639 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kmt2e
|
| Ensembl Gene |
ENSMUSG00000029004 |
| Gene Name |
lysine (K)-specific methyltransferase 2E |
| Synonyms |
9530077A04Rik, 1810033J14Rik, D230038D11Rik, Mll5 |
| MMRRC Submission |
045280-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7202 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
23639439-23709233 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to T
at 23697292 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141126
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094962]
[ENSMUST00000115128]
[ENSMUST00000126586]
[ENSMUST00000146375]
[ENSMUST00000196260]
|
| AlphaFold |
Q3UG20 |
| Predicted Effect |
silent
Transcript: ENSMUST00000094962
|
| SMART Domains |
Protein: ENSMUSP00000092569
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000115128
|
| SMART Domains |
Protein: ENSMUSP00000110781
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126586
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000146375
AA Change: Q135L
|
| SMART Domains |
Protein: ENSMUSP00000142547
Gene: ENSMUSG00000029004
AA Change: Q135L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
117 |
N/A |
INTRINSIC |
|
| Predicted Effect |
silent
Transcript: ENSMUST00000196260
|
| SMART Domains |
Protein: ENSMUSP00000143791
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
62 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
99% (74/75) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
T |
C |
7: 119,917,236 (GRCm39) |
I1467T |
probably damaging |
Het |
| Abtb3 |
A |
G |
10: 85,223,629 (GRCm39) |
E146G |
unknown |
Het |
| Adgrf3 |
T |
A |
5: 30,409,378 (GRCm39) |
K38* |
probably null |
Het |
| Ahdc1 |
T |
A |
4: 132,789,198 (GRCm39) |
C146* |
probably null |
Het |
| Ahnak |
A |
T |
19: 8,995,163 (GRCm39) |
K5482N |
probably damaging |
Het |
| Arhgap23 |
C |
T |
11: 97,342,819 (GRCm39) |
A367V |
possibly damaging |
Het |
| Arvcf |
T |
C |
16: 18,223,948 (GRCm39) |
S960P |
probably damaging |
Het |
| Asb14 |
C |
A |
14: 26,622,394 (GRCm39) |
P74Q |
probably benign |
Het |
| Atad5 |
T |
C |
11: 79,980,601 (GRCm39) |
V2A |
probably damaging |
Het |
| Baz2a |
A |
G |
10: 127,954,428 (GRCm39) |
I691M |
possibly damaging |
Het |
| Brca2 |
A |
G |
5: 150,455,819 (GRCm39) |
T187A |
probably benign |
Het |
| Calr4 |
T |
A |
4: 109,101,254 (GRCm39) |
N152K |
possibly damaging |
Het |
| Ccnb2 |
C |
T |
9: 70,318,128 (GRCm39) |
A215T |
probably damaging |
Het |
| Cdh16 |
C |
T |
8: 105,340,780 (GRCm39) |
D140N |
unknown |
Het |
| Ces1g |
T |
C |
8: 94,029,595 (GRCm39) |
T546A |
probably benign |
Het |
| Cfap74 |
G |
T |
4: 155,510,654 (GRCm39) |
|
probably null |
Het |
| Cfap91 |
T |
C |
16: 38,155,959 (GRCm39) |
Y88C |
probably benign |
Het |
| Col5a1 |
G |
T |
2: 27,842,390 (GRCm39) |
D422Y |
unknown |
Het |
| Cyp2c66 |
A |
T |
19: 39,130,348 (GRCm39) |
Y61F |
probably damaging |
Het |
| Dnah12 |
G |
A |
14: 26,500,869 (GRCm39) |
|
probably null |
Het |
| Dnah6 |
A |
G |
6: 73,158,688 (GRCm39) |
|
probably null |
Het |
| Dop1a |
T |
G |
9: 86,386,220 (GRCm39) |
|
probably null |
Het |
| Fam163a |
A |
G |
1: 155,954,834 (GRCm39) |
F106L |
probably damaging |
Het |
| Gfy |
T |
C |
7: 44,827,596 (GRCm39) |
T167A |
probably benign |
Het |
| Gm6525 |
A |
T |
3: 84,082,341 (GRCm39) |
R87S |
probably benign |
Het |
| Gramd1c |
C |
A |
16: 43,879,584 (GRCm39) |
A19S |
possibly damaging |
Het |
| Herc2 |
T |
C |
7: 55,781,034 (GRCm39) |
V1233A |
probably damaging |
Het |
| Hibch |
G |
A |
1: 52,892,874 (GRCm39) |
|
probably null |
Het |
| Ibsp |
A |
T |
5: 104,450,027 (GRCm39) |
S9C |
probably benign |
Het |
| Il17ra |
A |
G |
6: 120,452,572 (GRCm39) |
I252V |
probably benign |
Het |
| Ino80 |
A |
T |
2: 119,204,918 (GRCm39) |
M1536K |
probably benign |
Het |
| Ipo11 |
A |
T |
13: 107,012,078 (GRCm39) |
L568Q |
probably damaging |
Het |
| Kcnu1 |
T |
G |
8: 26,409,609 (GRCm39) |
|
probably null |
Het |
| Kdm5b |
T |
G |
1: 134,552,497 (GRCm39) |
S1158A |
probably benign |
Het |
| Kmt2a |
T |
C |
9: 44,759,012 (GRCm39) |
T946A |
probably benign |
Het |
| Krba1 |
G |
A |
6: 48,389,261 (GRCm39) |
V594M |
probably damaging |
Het |
| Lamb1 |
T |
C |
12: 31,374,314 (GRCm39) |
L1559P |
probably damaging |
Het |
| Lig1 |
C |
T |
7: 13,025,175 (GRCm39) |
P227S |
probably benign |
Het |
| Lims2 |
T |
A |
18: 32,090,017 (GRCm39) |
D255E |
probably benign |
Het |
| Marchf3 |
C |
T |
18: 56,909,161 (GRCm39) |
C208Y |
probably benign |
Het |
| Mei1 |
A |
G |
15: 81,976,843 (GRCm39) |
E142G |
|
Het |
| Melk |
G |
T |
4: 44,351,106 (GRCm39) |
R549L |
probably benign |
Het |
| Muc6 |
AGGCGCAGAAACCCTGGC |
AGGC |
7: 141,214,363 (GRCm39) |
|
probably null |
Het |
| Myorg |
T |
C |
4: 41,498,268 (GRCm39) |
Y454C |
probably damaging |
Het |
| Nae1 |
T |
C |
8: 105,250,215 (GRCm39) |
Y226C |
possibly damaging |
Het |
| Nap1l1 |
T |
C |
10: 111,326,964 (GRCm39) |
F175S |
probably damaging |
Het |
| Ndn |
T |
C |
7: 61,998,709 (GRCm39) |
L185P |
probably damaging |
Het |
| Ndst3 |
T |
A |
3: 123,465,388 (GRCm39) |
I195F |
possibly damaging |
Het |
| Ndufaf1 |
A |
T |
2: 119,488,907 (GRCm39) |
S206T |
probably benign |
Het |
| Nek10 |
C |
A |
14: 14,836,171 (GRCm38) |
H131N |
probably benign |
Het |
| Obsl1 |
T |
A |
1: 75,466,360 (GRCm39) |
D1456V |
possibly damaging |
Het |
| Or10a2 |
A |
G |
7: 106,673,448 (GRCm39) |
N138D |
probably benign |
Het |
| Or10ak7 |
C |
T |
4: 118,791,215 (GRCm39) |
V277I |
probably benign |
Het |
| Or52s6 |
T |
A |
7: 103,092,292 (GRCm39) |
T13S |
probably benign |
Het |
| Otog |
C |
T |
7: 45,937,474 (GRCm39) |
L1728F |
probably damaging |
Het |
| Pcx |
A |
T |
19: 4,652,361 (GRCm39) |
M150L |
possibly damaging |
Het |
| Pole |
A |
G |
5: 110,444,973 (GRCm39) |
D443G |
possibly damaging |
Het |
| Prr14 |
G |
T |
7: 127,075,648 (GRCm39) |
R552L |
probably damaging |
Het |
| Rasgrf1 |
T |
G |
9: 89,899,125 (GRCm39) |
S1156A |
possibly damaging |
Het |
| Rfc4 |
T |
A |
16: 22,946,359 (GRCm39) |
|
probably benign |
Het |
| Rfx5 |
G |
T |
3: 94,866,272 (GRCm39) |
A524S |
unknown |
Het |
| Ryr3 |
G |
A |
2: 112,596,664 (GRCm39) |
P2497S |
probably damaging |
Het |
| Scg3 |
T |
C |
9: 75,590,992 (GRCm39) |
T6A |
probably benign |
Het |
| Slc26a9 |
A |
T |
1: 131,690,526 (GRCm39) |
D510V |
possibly damaging |
Het |
| Stpg3 |
A |
G |
2: 25,104,586 (GRCm39) |
F10L |
probably damaging |
Het |
| Tmc5 |
T |
A |
7: 118,239,179 (GRCm39) |
H357Q |
possibly damaging |
Het |
| Tmem40 |
A |
T |
6: 115,707,420 (GRCm39) |
L253H |
probably damaging |
Het |
| Tmie |
A |
G |
9: 110,696,632 (GRCm39) |
V83A |
probably damaging |
Het |
| Uck2 |
A |
T |
1: 167,054,084 (GRCm39) |
I218N |
probably damaging |
Het |
| Vtn |
A |
G |
11: 78,391,626 (GRCm39) |
D310G |
possibly damaging |
Het |
| Wdr49 |
A |
T |
3: 75,240,580 (GRCm39) |
S430T |
probably benign |
Het |
| Wtip |
A |
G |
7: 33,832,087 (GRCm39) |
V133A |
probably benign |
Het |
| Zbtb9 |
T |
A |
17: 27,193,666 (GRCm39) |
V357E |
probably damaging |
Het |
| Zfp953 |
G |
A |
13: 67,491,706 (GRCm39) |
T82M |
probably benign |
Het |
|
| Other mutations in Kmt2e |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00783:Kmt2e
|
APN |
5 |
23,697,356 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01330:Kmt2e
|
APN |
5 |
23,702,946 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01457:Kmt2e
|
APN |
5 |
23,707,017 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01691:Kmt2e
|
APN |
5 |
23,702,089 (GRCm39) |
missense |
probably benign |
|
|
IGL02274:Kmt2e
|
APN |
5 |
23,705,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Kmt2e
|
APN |
5 |
23,702,882 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02964:Kmt2e
|
APN |
5 |
23,672,098 (GRCm39) |
splice site |
probably benign |
|
|
IGL03011:Kmt2e
|
APN |
5 |
23,702,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03291:Kmt2e
|
APN |
5 |
23,704,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Kmt2e
|
UTSW |
5 |
23,690,619 (GRCm39) |
splice site |
probably benign |
|
|
R0446:Kmt2e
|
UTSW |
5 |
23,702,532 (GRCm39) |
splice site |
probably null |
|
|
R0498:Kmt2e
|
UTSW |
5 |
23,683,970 (GRCm39) |
nonsense |
probably null |
|
|
R0699:Kmt2e
|
UTSW |
5 |
23,678,581 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0701:Kmt2e
|
UTSW |
5 |
23,678,581 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0761:Kmt2e
|
UTSW |
5 |
23,708,032 (GRCm39) |
nonsense |
probably null |
|
|
R1110:Kmt2e
|
UTSW |
5 |
23,707,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1295:Kmt2e
|
UTSW |
5 |
23,707,402 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1432:Kmt2e
|
UTSW |
5 |
23,655,319 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1495:Kmt2e
|
UTSW |
5 |
23,704,325 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1505:Kmt2e
|
UTSW |
5 |
23,705,533 (GRCm39) |
missense |
probably null |
0.01 |
|
R1623:Kmt2e
|
UTSW |
5 |
23,687,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1675:Kmt2e
|
UTSW |
5 |
23,687,451 (GRCm39) |
nonsense |
probably null |
|
|
R1691:Kmt2e
|
UTSW |
5 |
23,669,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1778:Kmt2e
|
UTSW |
5 |
23,697,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1820:Kmt2e
|
UTSW |
5 |
23,678,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Kmt2e
|
UTSW |
5 |
23,704,484 (GRCm39) |
intron |
probably benign |
|
|
R1912:Kmt2e
|
UTSW |
5 |
23,697,393 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2070:Kmt2e
|
UTSW |
5 |
23,706,993 (GRCm39) |
missense |
probably benign |
|
|
R2195:Kmt2e
|
UTSW |
5 |
23,707,194 (GRCm39) |
splice site |
probably null |
|
|
R2571:Kmt2e
|
UTSW |
5 |
23,706,885 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3901:Kmt2e
|
UTSW |
5 |
23,706,640 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3902:Kmt2e
|
UTSW |
5 |
23,706,640 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3905:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3906:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3909:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3956:Kmt2e
|
UTSW |
5 |
23,701,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4242:Kmt2e
|
UTSW |
5 |
23,707,820 (GRCm39) |
unclassified |
probably benign |
|
|
R4299:Kmt2e
|
UTSW |
5 |
23,669,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4448:Kmt2e
|
UTSW |
5 |
23,669,788 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4528:Kmt2e
|
UTSW |
5 |
23,678,556 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4574:Kmt2e
|
UTSW |
5 |
23,697,405 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R4719:Kmt2e
|
UTSW |
5 |
23,697,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Kmt2e
|
UTSW |
5 |
23,687,439 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4787:Kmt2e
|
UTSW |
5 |
23,668,081 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4812:Kmt2e
|
UTSW |
5 |
23,707,585 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4853:Kmt2e
|
UTSW |
5 |
23,707,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Kmt2e
|
UTSW |
5 |
23,707,693 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5306:Kmt2e
|
UTSW |
5 |
23,704,331 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5659:Kmt2e
|
UTSW |
5 |
23,702,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5907:Kmt2e
|
UTSW |
5 |
23,669,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5920:Kmt2e
|
UTSW |
5 |
23,704,440 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6280:Kmt2e
|
UTSW |
5 |
23,704,514 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6353:Kmt2e
|
UTSW |
5 |
23,698,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6375:Kmt2e
|
UTSW |
5 |
23,704,517 (GRCm39) |
missense |
probably benign |
|
|
R6553:Kmt2e
|
UTSW |
5 |
23,668,024 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6572:Kmt2e
|
UTSW |
5 |
23,702,579 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6678:Kmt2e
|
UTSW |
5 |
23,704,293 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6791:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6792:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6794:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6797:Kmt2e
|
UTSW |
5 |
23,687,505 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6947:Kmt2e
|
UTSW |
5 |
23,702,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Kmt2e
|
UTSW |
5 |
23,705,485 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7036:Kmt2e
|
UTSW |
5 |
23,683,741 (GRCm39) |
missense |
probably null |
1.00 |
|
R7173:Kmt2e
|
UTSW |
5 |
23,669,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7563:Kmt2e
|
UTSW |
5 |
23,705,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Kmt2e
|
UTSW |
5 |
23,683,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Kmt2e
|
UTSW |
5 |
23,706,763 (GRCm39) |
missense |
not run |
|
|
R7722:Kmt2e
|
UTSW |
5 |
23,702,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7758:Kmt2e
|
UTSW |
5 |
23,701,068 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7794:Kmt2e
|
UTSW |
5 |
23,669,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kmt2e
|
UTSW |
5 |
23,706,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8341:Kmt2e
|
UTSW |
5 |
23,704,451 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8383:Kmt2e
|
UTSW |
5 |
23,690,539 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8400:Kmt2e
|
UTSW |
5 |
23,702,090 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8546:Kmt2e
|
UTSW |
5 |
23,686,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8750:Kmt2e
|
UTSW |
5 |
23,698,215 (GRCm39) |
missense |
probably benign |
|
|
R8786:Kmt2e
|
UTSW |
5 |
23,669,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Kmt2e
|
UTSW |
5 |
23,669,770 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9660:Kmt2e
|
UTSW |
5 |
23,683,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9786:Kmt2e
|
UTSW |
5 |
23,702,982 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF026:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF028:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF040:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF042:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
Z1177:Kmt2e
|
UTSW |
5 |
23,686,206 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGATCGGCTCACTGAGATGAAG -3'
(R):5'- TAAGGCACTAAACTTGGACAGTC -3'
Sequencing Primer
(F):5'- CACACATGCTGAGTGGCTGTAATC -3'
(R):5'- CTAAACTTGGACAGTCAGGGTGATTC -3'
|
| Posted On |
2019-09-26 |
Incidental Mutation