Incidental Mutation 'R7560:Cic'
| ID |
585021 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cic
|
| Ensembl Gene |
ENSMUSG00000005442 |
| Gene Name |
capicua transcriptional repressor |
| Synonyms |
1200010B10Rik |
| MMRRC Submission |
045626-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.949)
|
| Stock # |
R7560 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 24972278 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 670
(V670M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132351
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169266]
[ENSMUST00000169392]
|
| AlphaFold |
Q924A2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169266
AA Change: V670M
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132351
Gene: ENSMUSG00000005442
AA Change: V670M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
|
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
|
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
|
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
|
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
|
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
|
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
|
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
|
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
|
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
|
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
|
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
|
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
|
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
|
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
|
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
|
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
|
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169392
|
| SMART Domains |
Protein: ENSMUSP00000131680
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
100% (100/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot12 |
A |
G |
13: 91,932,510 (GRCm39) |
D502G |
probably benign |
Het |
| Adrb1 |
T |
C |
19: 56,711,120 (GRCm39) |
V106A |
probably damaging |
Het |
| Ahcyl2 |
G |
T |
6: 29,886,139 (GRCm39) |
G352W |
probably damaging |
Het |
| Ahnak2 |
T |
G |
12: 112,745,851 (GRCm39) |
D446A |
|
Het |
| Arhgap42 |
T |
C |
9: 9,035,532 (GRCm39) |
D270G |
probably benign |
Het |
| Atp2a1 |
A |
G |
7: 126,058,828 (GRCm39) |
V129A |
possibly damaging |
Het |
| B9d2 |
G |
A |
7: 25,380,784 (GRCm39) |
|
probably benign |
Het |
| Bace1 |
A |
T |
9: 45,767,437 (GRCm39) |
I207F |
possibly damaging |
Het |
| Blnk |
T |
A |
19: 40,940,834 (GRCm39) |
I190F |
possibly damaging |
Het |
| Bmp7 |
C |
T |
2: 172,781,757 (GRCm39) |
E36K |
possibly damaging |
Het |
| Brsk2 |
A |
G |
7: 141,554,597 (GRCm39) |
E654G |
probably benign |
Het |
| Cacna2d3 |
T |
C |
14: 28,780,378 (GRCm39) |
H661R |
probably benign |
Het |
| Cdh4 |
T |
C |
2: 179,532,695 (GRCm39) |
V719A |
probably benign |
Het |
| Cdkn2d |
G |
T |
9: 21,200,540 (GRCm39) |
P77H |
probably damaging |
Het |
| Chd3 |
A |
G |
11: 69,247,096 (GRCm39) |
V1024A |
probably damaging |
Het |
| Chsy1 |
T |
A |
7: 65,820,992 (GRCm39) |
M409K |
possibly damaging |
Het |
| Chsy1 |
T |
C |
7: 65,821,319 (GRCm39) |
L518P |
probably damaging |
Het |
| Clock |
A |
T |
5: 76,390,738 (GRCm39) |
|
probably null |
Het |
| Coro1a |
C |
A |
7: 126,302,306 (GRCm39) |
V14L |
probably damaging |
Het |
| Ctcfl |
C |
A |
2: 172,960,199 (GRCm39) |
C128F |
probably damaging |
Het |
| Cyb5b |
A |
G |
8: 107,896,491 (GRCm39) |
T71A |
probably damaging |
Het |
| Cyp2c40 |
C |
G |
19: 39,795,658 (GRCm39) |
V174L |
possibly damaging |
Het |
| D630045J12Rik |
T |
A |
6: 38,173,562 (GRCm39) |
Q202L |
possibly damaging |
Het |
| Dgkz |
T |
C |
2: 91,773,160 (GRCm39) |
|
probably benign |
Het |
| Dlgap2 |
T |
C |
8: 14,872,697 (GRCm39) |
|
probably null |
Het |
| Dnah1 |
T |
C |
14: 31,026,940 (GRCm39) |
I695V |
probably benign |
Het |
| Dst |
T |
A |
1: 34,221,532 (GRCm39) |
S2445R |
possibly damaging |
Het |
| Elob |
T |
C |
17: 24,043,950 (GRCm39) |
D83G |
probably benign |
Het |
| Elp4 |
T |
A |
2: 105,624,933 (GRCm39) |
D320V |
probably damaging |
Het |
| Enpp5 |
G |
A |
17: 44,396,155 (GRCm39) |
G356S |
probably damaging |
Het |
| Etfdh |
T |
C |
3: 79,530,886 (GRCm39) |
Y45C |
probably damaging |
Het |
| Exph5 |
A |
G |
9: 53,287,073 (GRCm39) |
I1385V |
probably benign |
Het |
| Fat3 |
A |
T |
9: 15,908,138 (GRCm39) |
D2621E |
probably damaging |
Het |
| Fbxl6 |
G |
T |
15: 76,422,669 (GRCm39) |
A83D |
probably benign |
Het |
| Fmo2 |
A |
G |
1: 162,716,318 (GRCm39) |
Y90H |
probably damaging |
Het |
| Fzd4 |
T |
A |
7: 89,056,761 (GRCm39) |
Y269* |
probably null |
Het |
| Grik5 |
T |
A |
7: 24,757,951 (GRCm39) |
I377F |
probably damaging |
Het |
| Havcr2 |
C |
A |
11: 46,349,889 (GRCm39) |
P137Q |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,392,405 (GRCm39) |
N223S |
possibly damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,347,185 (GRCm39) |
S4792G |
probably benign |
Het |
| Hps3 |
T |
G |
3: 20,084,616 (GRCm39) |
I191L |
probably benign |
Het |
| Ica1l |
T |
A |
1: 60,049,369 (GRCm39) |
K195* |
probably null |
Het |
| Idh2 |
TCCCAGGGCC |
TCC |
7: 79,748,079 (GRCm39) |
|
probably null |
Het |
| Ift140 |
A |
G |
17: 25,311,315 (GRCm39) |
D1170G |
probably benign |
Het |
| Igflr1 |
T |
C |
7: 30,266,776 (GRCm39) |
F208S |
possibly damaging |
Het |
| Kcnma1 |
T |
C |
14: 23,580,310 (GRCm39) |
T313A |
probably benign |
Het |
| Krt6a |
T |
A |
15: 101,598,994 (GRCm39) |
I524F |
unknown |
Het |
| Lce1d |
G |
T |
3: 92,593,148 (GRCm39) |
H88Q |
unknown |
Het |
| Lrmda |
A |
G |
14: 22,878,770 (GRCm39) |
E177G |
probably benign |
Het |
| Lrrn3 |
T |
A |
12: 41,502,712 (GRCm39) |
N535I |
possibly damaging |
Het |
| Map2k4 |
T |
A |
11: 65,666,583 (GRCm39) |
I40L |
unknown |
Het |
| Map7d1 |
A |
G |
4: 126,130,429 (GRCm39) |
L459P |
probably damaging |
Het |
| Mipol1 |
A |
T |
12: 57,352,859 (GRCm39) |
N66I |
possibly damaging |
Het |
| Mycn |
A |
C |
12: 12,990,292 (GRCm39) |
F35V |
probably benign |
Het |
| Mzt2 |
A |
C |
16: 15,680,669 (GRCm39) |
M40R |
possibly damaging |
Het |
| N4bp2 |
T |
G |
5: 65,948,458 (GRCm39) |
L363V |
probably damaging |
Het |
| Nfat5 |
T |
A |
8: 108,097,221 (GRCm39) |
M1532K |
probably benign |
Het |
| Notch1 |
G |
A |
2: 26,350,177 (GRCm39) |
T2321M |
probably benign |
Het |
| Nr1h4 |
T |
C |
10: 89,334,123 (GRCm39) |
D89G |
probably benign |
Het |
| Nsun4 |
G |
A |
4: 115,908,691 (GRCm39) |
T623I |
possibly damaging |
Het |
| Nup155 |
T |
C |
15: 8,184,531 (GRCm39) |
S1309P |
probably benign |
Het |
| Or4e1 |
T |
C |
14: 52,700,851 (GRCm39) |
N205S |
probably damaging |
Het |
| Or51f5 |
T |
C |
7: 102,430,889 (GRCm39) |
S69P |
probably damaging |
Het |
| Or8h10 |
T |
C |
2: 86,809,122 (GRCm39) |
Y6C |
probably benign |
Het |
| Pcsk5 |
A |
G |
19: 17,814,336 (GRCm39) |
F61L |
probably benign |
Het |
| Phrf1 |
A |
T |
7: 140,811,138 (GRCm39) |
|
probably null |
Het |
| Pkd1 |
G |
A |
17: 24,792,605 (GRCm39) |
E1431K |
probably benign |
Het |
| Pkd2 |
T |
A |
5: 104,628,219 (GRCm39) |
I431N |
probably damaging |
Het |
| Plcb2 |
A |
G |
2: 118,546,124 (GRCm39) |
L557P |
probably damaging |
Het |
| Poteg |
A |
G |
8: 27,984,988 (GRCm39) |
N449S |
probably benign |
Het |
| Ppargc1b |
C |
A |
18: 61,445,281 (GRCm39) |
G192W |
probably damaging |
Het |
| Rab13 |
T |
C |
3: 90,132,206 (GRCm39) |
S178P |
probably benign |
Het |
| Ralgds |
A |
G |
2: 28,437,607 (GRCm39) |
D571G |
probably damaging |
Het |
| Ror2 |
A |
G |
13: 53,264,849 (GRCm39) |
S748P |
probably benign |
Het |
| Sart1 |
A |
T |
19: 5,434,905 (GRCm39) |
L167Q |
probably damaging |
Het |
| Septin12 |
A |
G |
16: 4,810,055 (GRCm39) |
V160A |
possibly damaging |
Het |
| Sgo1 |
T |
C |
17: 53,986,295 (GRCm39) |
S299G |
probably benign |
Het |
| Shoc1 |
T |
C |
4: 59,076,140 (GRCm39) |
N601S |
possibly damaging |
Het |
| Slc35b4 |
T |
A |
6: 34,140,296 (GRCm39) |
D152V |
probably benign |
Het |
| Spata31h1 |
T |
C |
10: 82,120,449 (GRCm39) |
Y4187C |
probably damaging |
Het |
| Specc1 |
T |
A |
11: 62,019,235 (GRCm39) |
|
probably null |
Het |
| Synj1 |
G |
A |
16: 90,737,371 (GRCm39) |
T1308I |
probably benign |
Het |
| Thap12 |
T |
G |
7: 98,359,438 (GRCm39) |
L106V |
probably damaging |
Het |
| Togaram1 |
T |
C |
12: 65,057,916 (GRCm39) |
M1501T |
possibly damaging |
Het |
| Top2a |
G |
T |
11: 98,891,663 (GRCm39) |
N1153K |
probably benign |
Het |
| Trpm5 |
A |
G |
7: 142,634,723 (GRCm39) |
L658P |
probably damaging |
Het |
| Ttc21b |
G |
A |
2: 66,047,548 (GRCm39) |
A849V |
possibly damaging |
Het |
| Vcf1 |
C |
T |
11: 113,554,215 (GRCm39) |
G160D |
probably damaging |
Het |
| Vmn1r80 |
A |
T |
7: 11,927,750 (GRCm39) |
I287F |
probably damaging |
Het |
| Vmn1r87 |
T |
C |
7: 12,865,745 (GRCm39) |
S181G |
probably damaging |
Het |
| Vmn2r71 |
A |
T |
7: 85,273,115 (GRCm39) |
H643L |
probably benign |
Het |
| Washc5 |
G |
A |
15: 59,238,041 (GRCm39) |
R228C |
probably damaging |
Het |
| Wdr72 |
T |
C |
9: 74,117,408 (GRCm39) |
S719P |
probably damaging |
Het |
| Xrcc3 |
G |
T |
12: 111,774,336 (GRCm39) |
D164E |
probably benign |
Het |
| Zc2hc1b |
G |
A |
10: 13,044,529 (GRCm39) |
R45C |
probably damaging |
Het |
| Zfp335 |
A |
G |
2: 164,737,912 (GRCm39) |
Y900H |
probably damaging |
Het |
| Zfp512b |
G |
A |
2: 181,228,875 (GRCm39) |
R697C |
probably damaging |
Het |
| Zfp60 |
T |
C |
7: 27,448,561 (GRCm39) |
Y410H |
probably damaging |
Het |
| Zfp60 |
T |
A |
7: 27,448,696 (GRCm39) |
C455S |
probably damaging |
Het |
| Zfp605 |
C |
T |
5: 110,275,157 (GRCm39) |
Q92* |
probably null |
Het |
| Zfp64 |
C |
T |
2: 168,767,585 (GRCm39) |
D676N |
probably damaging |
Het |
|
| Other mutations in Cic |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Cic
|
UTSW |
7 |
24,979,162 (GRCm39) |
intron |
probably benign |
|
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4776:Cic
|
UTSW |
7 |
24,982,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4820:Cic
|
UTSW |
7 |
24,971,157 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6995:Cic
|
UTSW |
7 |
24,970,736 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9301:Cic
|
UTSW |
7 |
24,991,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCACGCTTCGAGTTTGATG -3'
(R):5'- TCACTCTTGGGGAAGTCTGG -3'
Sequencing Primer
(F):5'- GTGTCACTTGGCAGCTCC -3'
(R):5'- GAAGTCTGGGGCGGCTC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation