Mutagenetix > Incidental Mutation

Incidental Mutation 'R7692:Zfand6'

593448

Institutional Source

Beutler Lab

Gene Symbol

Zfand6

Ensembl Gene

ENSMUSG00000030629

Gene Name

zinc finger, AN1-type domain 6

Synonyms

Za20d3, 3110005P07Rik, Awp1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.182) question?

Stock #

R7692 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84613766-84689959 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 84633933 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 72 (P72L)

Ref Sequence

ENSEMBL: ENSMUSP00000069228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069537]

AlphaFold

Q9DCH6

Predicted Effect

not run
Transcript: ENSMUST00000069537
AA Change: P72L

SMART Domains

Protein: ENSMUSP00000069228
Gene: ENSMUSG00000030629
AA Change: P72L

Domain	Start	End	E-Value	Type
ZnF_A20	11	35	1.91e-10	SMART
ZnF_AN1	164	201	1.46e-15	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26b	G	A	8: 43,520,795	T390I	probably benign	Het
Adgb	A	G	10: 10,411,712		probably null	Het
Ado	G	T	10: 67,548,435	Y113*	probably null	Het
Angptl1	A	G	1: 156,845,315	E237G	probably damaging	Het
Arid2	T	A	15: 96,356,697	Y141*	probably null	Het
Clvs1	T	C	4: 9,350,739	I183T	probably benign	Het
Dnah1	T	C	14: 31,292,338	K1817E	probably benign	Het
Eif3e	C	A	15: 43,263,246	R271L	probably damaging	Het
Eml6	A	G	11: 29,753,085	V1611A	probably damaging	Het
Enpp3	G	T	10: 24,784,841	Y634*	probably null	Het
Evi5l	C	T	8: 4,200,886	R394W	probably damaging	Het
Fcgr3	A	C	1: 171,054,092	F156V	probably damaging	Het
Fmo1	T	A	1: 162,833,833	T294S	probably benign	Het
Gabrb3	A	G	7: 57,816,455	Q339R	probably damaging	Het
Gen1	T	A	12: 11,242,166	T606S	probably benign	Het
Gfod1	T	C	13: 43,201,052	Q149R	probably benign	Het
Golm1	A	G	13: 59,640,257	V276A	probably benign	Het
Hc	C	A	2: 35,024,149	V849F	probably damaging	Het
Hectd4	T	C	5: 121,321,564	I832T	possibly damaging	Het
Hspa14	T	C	2: 3,496,606	D283G	probably damaging	Het
Lztfl1	C	T	9: 123,712,471	W94*	probably null	Het
Lzts3	T	C	2: 130,635,386	S381G	probably benign	Het
Mgat2	A	G	12: 69,184,670	Y6C	probably damaging	Het
Mrpl30	T	C	1: 37,895,358	I27T	probably benign	Het
Muc5b	A	T	7: 141,853,229	T1045S	unknown	Het
Nlrp4a	G	A	7: 26,449,265	R99Q	probably benign	Het
Olfr1450	A	G	19: 12,953,642	T18A	possibly damaging	Het
Olfr1510	T	C	14: 52,410,488	Y128C	probably damaging	Het
Phlpp1	T	C	1: 106,281,402	L495P	probably damaging	Het
Pla2g4d	T	C	2: 120,279,295	D178G	possibly damaging	Het
Prl5a1	C	G	13: 28,150,014	L167V	probably damaging	Het
Sardh	A	G	2: 27,197,639	V740A	probably benign	Het
Sbno1	T	G	5: 124,405,646	T277P	probably benign	Het
Slc2a1	T	C	4: 119,136,265	V433A	probably damaging	Het
Slc4a10	T	C	2: 62,303,964	V1008A	possibly damaging	Het
Smarcal1	T	G	1: 72,586,020	S109A	probably benign	Het
Speg	A	G	1: 75,401,190	D864G	probably benign	Het
Steap4	T	C	5: 7,976,976	I313T	probably benign	Het
Tab2	A	T	10: 7,911,105	D614E	probably damaging	Het
Tenm4	A	G	7: 96,895,403	K2246E	probably damaging	Het
Timm23	A	G	14: 32,180,563	S208P	probably damaging	Het
Tmem229a	C	A	6: 24,955,212	C181F	probably benign	Het
Ugdh	T	C	5: 65,417,615	Y356C	probably damaging	Het
Ugt2a1	A	G	5: 87,486,727	L7P	probably damaging	Het
Uhrf1	A	G	17: 56,312,905	D272G	possibly damaging	Het
Vmn1r206	T	A	13: 22,620,657	I127F	probably damaging	Het
Vmn2r106	T	C	17: 20,285,228	Y68C	possibly damaging	Het

Other mutations in Zfand6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02396:Zfand6	APN	7	84617903	missense	probably damaging	0.99
IGL03162:Zfand6	APN	7	84633977	missense	probably benign	0.01
R0780:Zfand6	UTSW	7	84615834	missense	probably damaging	1.00
R1055:Zfand6	UTSW	7	84615973	splice site	probably benign
R2427:Zfand6	UTSW	7	84634290	nonsense	probably null
R3683:Zfand6	UTSW	7	84634362	missense	probably damaging	1.00
R3685:Zfand6	UTSW	7	84634362	missense	probably damaging	1.00
R4663:Zfand6	UTSW	7	84617885	missense	probably benign	0.27
R4939:Zfand6	UTSW	7	84615822	makesense	probably null
R6013:Zfand6	UTSW	7	84632692	missense	probably benign	0.00
R6867:Zfand6	UTSW	7	84615914	missense	probably damaging	1.00
R7113:Zfand6	UTSW	7	84615869	missense	probably damaging	1.00
R8140:Zfand6	UTSW	7	84632749	missense	possibly damaging	0.71
R8755:Zfand6	UTSW	7	84632691	missense	probably benign
R9185:Zfand6	UTSW	7	84634350	missense	probably damaging	1.00

Predicted Primers

Posted On

2019-11-12