Incidental Mutation 'R7692:Zfand6'
ID593448
Institutional Source Beutler Lab
Gene Symbol Zfand6
Ensembl Gene ENSMUSG00000030629
Gene Namezinc finger, AN1-type domain 6
SynonymsZa20d3, 3110005P07Rik, Awp1
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.162) question?
Stock #R7692 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location84613766-84689959 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 84633933 bp
ZygosityHeterozygous
Amino Acid Change Proline to Leucine at position 72 (P72L)
Ref Sequence ENSEMBL: ENSMUSP00000069228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069537]
Predicted Effect not run
Transcript: ENSMUST00000069537
AA Change: P72L
SMART Domains Protein: ENSMUSP00000069228
Gene: ENSMUSG00000030629
AA Change: P72L

DomainStartEndE-ValueType
ZnF_A20 11 35 1.91e-10 SMART
ZnF_AN1 164 201 1.46e-15 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b G A 8: 43,520,795 T390I probably benign Het
Adgb A G 10: 10,411,712 probably null Het
Ado G T 10: 67,548,435 Y113* probably null Het
Angptl1 A G 1: 156,845,315 E237G probably damaging Het
Arid2 T A 15: 96,356,697 Y141* probably null Het
Clvs1 T C 4: 9,350,739 I183T probably benign Het
Dnah1 T C 14: 31,292,338 K1817E probably benign Het
Eif3e C A 15: 43,263,246 R271L probably damaging Het
Eml6 A G 11: 29,753,085 V1611A probably damaging Het
Enpp3 G T 10: 24,784,841 Y634* probably null Het
Evi5l C T 8: 4,200,886 R394W probably damaging Het
Fcgr3 A C 1: 171,054,092 F156V probably damaging Het
Fmo1 T A 1: 162,833,833 T294S probably benign Het
Gabrb3 A G 7: 57,816,455 Q339R probably damaging Het
Gen1 T A 12: 11,242,166 T606S probably benign Het
Gfod1 T C 13: 43,201,052 Q149R probably benign Het
Golm1 A G 13: 59,640,257 V276A probably benign Het
Hc C A 2: 35,024,149 V849F probably damaging Het
Hectd4 T C 5: 121,321,564 I832T possibly damaging Het
Hspa14 T C 2: 3,496,606 D283G probably damaging Het
Lztfl1 C T 9: 123,712,471 W94* probably null Het
Lzts3 T C 2: 130,635,386 S381G probably benign Het
Mgat2 A G 12: 69,184,670 Y6C probably damaging Het
Mrpl30 T C 1: 37,895,358 I27T probably benign Het
Muc5b A T 7: 141,853,229 T1045S unknown Het
Nlrp4a G A 7: 26,449,265 R99Q probably benign Het
Olfr1450 A G 19: 12,953,642 T18A possibly damaging Het
Olfr1510 T C 14: 52,410,488 Y128C probably damaging Het
Phlpp1 T C 1: 106,281,402 L495P probably damaging Het
Pla2g4d T C 2: 120,279,295 D178G possibly damaging Het
Prl5a1 C G 13: 28,150,014 L167V probably damaging Het
Sardh A G 2: 27,197,639 V740A probably benign Het
Sbno1 T G 5: 124,405,646 T277P probably benign Het
Slc2a1 T C 4: 119,136,265 V433A probably damaging Het
Slc4a10 T C 2: 62,303,964 V1008A possibly damaging Het
Smarcal1 T G 1: 72,586,020 S109A probably benign Het
Speg A G 1: 75,401,190 D864G probably benign Het
Steap4 T C 5: 7,976,976 I313T probably benign Het
Tab2 A T 10: 7,911,105 D614E probably damaging Het
Tenm4 A G 7: 96,895,403 K2246E probably damaging Het
Timm23 A G 14: 32,180,563 S208P probably damaging Het
Tmem229a C A 6: 24,955,212 C181F probably benign Het
Ugdh T C 5: 65,417,615 Y356C probably damaging Het
Ugt2a1 A G 5: 87,486,727 L7P probably damaging Het
Uhrf1 A G 17: 56,312,905 D272G possibly damaging Het
Vmn1r206 T A 13: 22,620,657 I127F probably damaging Het
Vmn2r106 T C 17: 20,285,228 Y68C possibly damaging Het
Other mutations in Zfand6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02396:Zfand6 APN 7 84617903 missense probably damaging 0.99
IGL03162:Zfand6 APN 7 84633977 missense probably benign 0.01
R0780:Zfand6 UTSW 7 84615834 missense probably damaging 1.00
R1055:Zfand6 UTSW 7 84615973 splice site probably benign
R2427:Zfand6 UTSW 7 84634290 nonsense probably null
R3683:Zfand6 UTSW 7 84634362 missense probably damaging 1.00
R3685:Zfand6 UTSW 7 84634362 missense probably damaging 1.00
R4663:Zfand6 UTSW 7 84617885 missense probably benign 0.27
R4939:Zfand6 UTSW 7 84615822 makesense probably null
R6013:Zfand6 UTSW 7 84632692 missense probably benign 0.00
R6867:Zfand6 UTSW 7 84615914 missense probably damaging 1.00
R7113:Zfand6 UTSW 7 84615869 missense probably damaging 1.00
R8140:Zfand6 UTSW 7 84632749 missense possibly damaging 0.71
R8755:Zfand6 UTSW 7 84632691 missense probably benign
Predicted Primers
Posted On2019-11-12