Incidental Mutation 'R4378:Vmn2r86'
| ID |
325204 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r86
|
| Ensembl Gene |
ENSMUSG00000092162 |
| Gene Name |
vomeronasal 2, receptor 86 |
| Synonyms |
EG625109 |
| MMRRC Submission |
041121-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.094)
|
| Stock # |
R4378 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130445707-130455894 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130452600 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 344
(I344T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
| AlphaFold |
G5E8Y4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170257
AA Change: I344T
PolyPhen 2
Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: I344T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
96% (47/49) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
G |
11: 9,293,644 (GRCm38) |
K1836E |
probably benign |
Het |
| Adora1 |
A |
G |
1: 134,203,210 (GRCm38) |
F241S |
probably damaging |
Het |
| Akt1s1 |
C |
T |
7: 44,853,960 (GRCm38) |
T168M |
probably damaging |
Het |
| Amigo1 |
C |
T |
3: 108,191,753 (GRCm38) |
|
probably benign |
Het |
| Amigo2 |
A |
G |
15: 97,245,978 (GRCm38) |
F188L |
possibly damaging |
Het |
| Armc2 |
T |
C |
10: 41,993,082 (GRCm38) |
T29A |
possibly damaging |
Het |
| Axl |
G |
A |
7: 25,758,837 (GRCm38) |
A822V |
probably benign |
Het |
| Borcs5 |
T |
C |
6: 134,644,329 (GRCm38) |
V21A |
probably benign |
Het |
| Cdc42ep3 |
A |
G |
17: 79,334,979 (GRCm38) |
S171P |
probably benign |
Het |
| Cmas |
T |
C |
6: 142,772,285 (GRCm38) |
|
probably benign |
Het |
| Cyp4f40 |
A |
G |
17: 32,668,029 (GRCm38) |
N158S |
probably null |
Het |
| Dnah6 |
G |
T |
6: 73,118,026 (GRCm38) |
N2139K |
probably benign |
Het |
| Elmo1 |
A |
T |
13: 20,373,116 (GRCm38) |
H409L |
possibly damaging |
Het |
| Exoc4 |
T |
A |
6: 33,815,687 (GRCm38) |
V584E |
probably damaging |
Het |
| Gm7271 |
A |
G |
5: 76,500,533 (GRCm38) |
K62R |
probably damaging |
Het |
| Gm9116 |
A |
G |
3: 93,910,479 (GRCm38) |
|
noncoding transcript |
Het |
| Gxylt2 |
A |
G |
6: 100,733,200 (GRCm38) |
S101G |
probably benign |
Het |
| Hsph1 |
C |
A |
5: 149,636,007 (GRCm38) |
E24* |
probably null |
Het |
| Ighv1-56 |
C |
T |
12: 115,242,948 (GRCm38) |
E50K |
probably benign |
Het |
| Kirrel |
C |
T |
3: 87,089,151 (GRCm38) |
M380I |
probably null |
Het |
| Lrriq1 |
A |
T |
10: 103,202,364 (GRCm38) |
D859E |
probably damaging |
Het |
| Mapk7 |
G |
A |
11: 61,493,667 (GRCm38) |
S71L |
probably damaging |
Het |
| Nars |
A |
G |
18: 64,501,353 (GRCm38) |
Y500H |
probably damaging |
Het |
| Olfr1165-ps |
G |
T |
2: 88,101,485 (GRCm38) |
N167K |
unknown |
Het |
| Olfr3 |
T |
C |
2: 36,812,469 (GRCm38) |
M208V |
probably benign |
Het |
| Phc1 |
T |
C |
6: 122,335,007 (GRCm38) |
N64S |
possibly damaging |
Het |
| Ppp4r3b |
T |
A |
11: 29,209,450 (GRCm38) |
N180K |
possibly damaging |
Het |
| Primpol |
G |
A |
8: 46,576,183 (GRCm38) |
|
probably benign |
Het |
| Prtg |
T |
C |
9: 72,842,760 (GRCm38) |
S149P |
possibly damaging |
Het |
| Qrich2 |
T |
C |
11: 116,446,915 (GRCm38) |
S1916G |
probably damaging |
Het |
| Rps6ka5 |
A |
T |
12: 100,597,937 (GRCm38) |
Y218N |
probably damaging |
Het |
| Setbp1 |
T |
C |
18: 78,856,618 (GRCm38) |
D1278G |
possibly damaging |
Het |
| Sirt1 |
C |
T |
10: 63,338,949 (GRCm38) |
A8T |
probably benign |
Het |
| Sobp |
C |
T |
10: 43,021,304 (GRCm38) |
V762I |
probably damaging |
Het |
| Sptan1 |
T |
C |
2: 30,025,569 (GRCm38) |
S1994P |
probably damaging |
Het |
| Taok3 |
T |
C |
5: 117,209,571 (GRCm38) |
I87T |
probably damaging |
Het |
| Tecta |
T |
C |
9: 42,366,708 (GRCm38) |
Y1168C |
probably damaging |
Het |
| Trhr |
A |
G |
15: 44,197,627 (GRCm38) |
Y181C |
probably damaging |
Het |
| Ube4b |
C |
T |
4: 149,383,798 (GRCm38) |
D174N |
probably damaging |
Het |
| Ubr4 |
C |
T |
4: 139,410,440 (GRCm38) |
H1067Y |
possibly damaging |
Het |
| Vmn2r88 |
T |
A |
14: 51,413,289 (GRCm38) |
L153* |
probably null |
Het |
| Zfp516 |
T |
A |
18: 82,987,180 (GRCm38) |
D736E |
probably benign |
Het |
| Zfp612 |
G |
T |
8: 110,089,051 (GRCm38) |
V258F |
possibly damaging |
Het |
|
| Other mutations in Vmn2r86 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Vmn2r86
|
APN |
10 |
130,453,026 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01328:Vmn2r86
|
APN |
10 |
130,452,496 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL01377:Vmn2r86
|
APN |
10 |
130,452,986 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01548:Vmn2r86
|
APN |
10 |
130,446,282 (GRCm38) |
missense |
probably benign |
0.22 |
|
IGL01804:Vmn2r86
|
APN |
10 |
130,452,989 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01921:Vmn2r86
|
APN |
10 |
130,455,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02406:Vmn2r86
|
APN |
10 |
130,448,639 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL02625:Vmn2r86
|
APN |
10 |
130,452,912 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02960:Vmn2r86
|
APN |
10 |
130,453,767 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL03104:Vmn2r86
|
APN |
10 |
130,446,632 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0408:Vmn2r86
|
UTSW |
10 |
130,446,854 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0437:Vmn2r86
|
UTSW |
10 |
130,446,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0577:Vmn2r86
|
UTSW |
10 |
130,452,575 (GRCm38) |
missense |
probably benign |
0.04 |
|
R0726:Vmn2r86
|
UTSW |
10 |
130,446,396 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0811:Vmn2r86
|
UTSW |
10 |
130,453,628 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0812:Vmn2r86
|
UTSW |
10 |
130,453,628 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1055:Vmn2r86
|
UTSW |
10 |
130,446,357 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1066:Vmn2r86
|
UTSW |
10 |
130,446,276 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1199:Vmn2r86
|
UTSW |
10 |
130,448,574 (GRCm38) |
splice site |
probably benign |
|
|
R1332:Vmn2r86
|
UTSW |
10 |
130,446,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1568:Vmn2r86
|
UTSW |
10 |
130,453,141 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1866:Vmn2r86
|
UTSW |
10 |
130,446,386 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r86
|
UTSW |
10 |
130,452,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn2r86
|
UTSW |
10 |
130,446,713 (GRCm38) |
missense |
probably benign |
0.39 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,455,804 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,455,804 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3858:Vmn2r86
|
UTSW |
10 |
130,455,725 (GRCm38) |
missense |
probably benign |
|
|
R4049:Vmn2r86
|
UTSW |
10 |
130,447,097 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4411:Vmn2r86
|
UTSW |
10 |
130,452,600 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4413:Vmn2r86
|
UTSW |
10 |
130,452,600 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4422:Vmn2r86
|
UTSW |
10 |
130,452,976 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4738:Vmn2r86
|
UTSW |
10 |
130,447,070 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4767:Vmn2r86
|
UTSW |
10 |
130,455,737 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4872:Vmn2r86
|
UTSW |
10 |
130,453,591 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4880:Vmn2r86
|
UTSW |
10 |
130,453,615 (GRCm38) |
missense |
probably benign |
0.33 |
|
R5092:Vmn2r86
|
UTSW |
10 |
130,446,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5421:Vmn2r86
|
UTSW |
10 |
130,446,936 (GRCm38) |
missense |
probably benign |
0.41 |
|
R6007:Vmn2r86
|
UTSW |
10 |
130,453,666 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6330:Vmn2r86
|
UTSW |
10 |
130,446,527 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6355:Vmn2r86
|
UTSW |
10 |
130,455,894 (GRCm38) |
start codon destroyed |
probably damaging |
0.98 |
|
R6397:Vmn2r86
|
UTSW |
10 |
130,446,262 (GRCm38) |
nonsense |
probably null |
|
|
R6419:Vmn2r86
|
UTSW |
10 |
130,446,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6933:Vmn2r86
|
UTSW |
10 |
130,446,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6937:Vmn2r86
|
UTSW |
10 |
130,448,654 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6959:Vmn2r86
|
UTSW |
10 |
130,446,531 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7010:Vmn2r86
|
UTSW |
10 |
130,455,857 (GRCm38) |
missense |
probably benign |
|
|
R7549:Vmn2r86
|
UTSW |
10 |
130,446,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8179:Vmn2r86
|
UTSW |
10 |
130,453,084 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8257:Vmn2r86
|
UTSW |
10 |
130,452,410 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8286:Vmn2r86
|
UTSW |
10 |
130,449,986 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8479:Vmn2r86
|
UTSW |
10 |
130,446,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8805:Vmn2r86
|
UTSW |
10 |
130,446,527 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8960:Vmn2r86
|
UTSW |
10 |
130,453,803 (GRCm38) |
missense |
probably benign |
0.27 |
|
R9021:Vmn2r86
|
UTSW |
10 |
130,447,065 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9120:Vmn2r86
|
UTSW |
10 |
130,453,808 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9137:Vmn2r86
|
UTSW |
10 |
130,446,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9311:Vmn2r86
|
UTSW |
10 |
130,452,571 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9312:Vmn2r86
|
UTSW |
10 |
130,452,537 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9433:Vmn2r86
|
UTSW |
10 |
130,446,698 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R9696:Vmn2r86
|
UTSW |
10 |
130,449,833 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGGCCACAGCATAAACAG -3'
(R):5'- GACATCTTCAGCAAAGGTTGTTATC -3'
Sequencing Primer
(F):5'- GGGCCACAGCATAAACAGCATTATAC -3'
(R):5'- AGAAGATGGGTATATTTAGGTGCTC -3'
|
| Posted On |
2015-07-06 |
Incidental Mutation