Incidental Mutation 'R4911:Dock10'
| ID |
379468 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock10
|
| Ensembl Gene |
ENSMUSG00000038608 |
| Gene Name |
dedicator of cytokinesis 10 |
| Synonyms |
Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik |
| MMRRC Submission |
042513-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.487)
|
| Stock # |
R4911 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
80478790-80736244 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 80583953 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Cysteine
at position 163
(G163C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140513
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077946]
[ENSMUST00000186087]
[ENSMUST00000187774]
[ENSMUST00000190983]
[ENSMUST00000191449]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077946
AA Change: G181C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: G181C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
25 |
42 |
N/A |
INTRINSIC |
|
Pfam:DUF3398
|
61 |
153 |
1.7e-36 |
PFAM |
|
PH
|
182 |
292 |
8.5e-17 |
SMART |
|
Blast:PH
|
350 |
458 |
7e-18 |
BLAST |
|
Pfam:DOCK-C2
|
668 |
859 |
1e-50 |
PFAM |
|
low complexity region
|
1269 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1284 |
1295 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1592 |
2143 |
1.3e-216 |
PFAM |
|
low complexity region
|
2174 |
2187 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186087
AA Change: G194C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140102
Gene: ENSMUSG00000038608
AA Change: G194C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
71 |
166 |
1.5e-29 |
PFAM |
|
PH
|
195 |
305 |
3.9e-19 |
SMART |
|
Blast:PH
|
363 |
475 |
3e-18 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000187774
AA Change: G169C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: G169C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
46 |
141 |
9e-29 |
PFAM |
|
PH
|
170 |
280 |
3.9e-19 |
SMART |
|
Blast:PH
|
338 |
446 |
7e-18 |
BLAST |
|
Pfam:DOCK-C2
|
655 |
848 |
1.5e-54 |
PFAM |
|
low complexity region
|
1257 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1272 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1870 |
1890 |
N/A |
INTRINSIC |
|
Pfam:Ded_cyto
|
1954 |
2131 |
3.4e-65 |
PFAM |
|
low complexity region
|
2162 |
2175 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190983
AA Change: G168C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: G168C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
45 |
140 |
8.9e-29 |
PFAM |
|
PH
|
169 |
279 |
3.9e-19 |
SMART |
|
Blast:PH
|
337 |
445 |
7e-18 |
BLAST |
|
Pfam:DOCK-C2
|
654 |
847 |
1.5e-54 |
PFAM |
|
low complexity region
|
1256 |
1266 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1282 |
N/A |
INTRINSIC |
|
low complexity region
|
1869 |
1889 |
N/A |
INTRINSIC |
|
Pfam:Ded_cyto
|
1953 |
2130 |
3.4e-65 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000191449
AA Change: G163C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140513
Gene: ENSMUSG00000038608
AA Change: G163C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
40 |
135 |
1.1e-32 |
PFAM |
|
PH
|
164 |
274 |
8.5e-17 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191505
|
| Meta Mutation Damage Score |
0.2408 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 89.7%
|
| Validation Efficiency |
97% (149/153) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 132 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aacs |
A |
G |
5: 125,583,224 (GRCm39) |
D260G |
possibly damaging |
Het |
| Aadacl4 |
T |
A |
4: 144,340,362 (GRCm39) |
L29H |
probably damaging |
Het |
| Abca7 |
T |
C |
10: 79,848,022 (GRCm39) |
|
probably null |
Het |
| Adgre1 |
G |
A |
17: 57,754,832 (GRCm39) |
M643I |
possibly damaging |
Het |
| Adgrl2 |
A |
T |
3: 148,596,099 (GRCm39) |
M79K |
probably damaging |
Het |
| Ankrd55 |
T |
A |
13: 112,459,573 (GRCm39) |
|
probably null |
Het |
| Aopep |
A |
T |
13: 63,318,753 (GRCm39) |
|
probably null |
Het |
| Arhgap21 |
A |
G |
2: 20,863,800 (GRCm39) |
I1257T |
probably damaging |
Het |
| Arhgap26 |
T |
A |
18: 39,126,690 (GRCm39) |
|
probably benign |
Het |
| Arhgap39 |
A |
G |
15: 76,622,005 (GRCm39) |
S199P |
probably damaging |
Het |
| Arhgef5 |
A |
G |
6: 43,249,762 (GRCm39) |
D171G |
probably benign |
Het |
| Atp7a |
T |
C |
X: 105,163,980 (GRCm39) |
V1305A |
probably damaging |
Het |
| B3gnt3 |
T |
A |
8: 72,145,578 (GRCm39) |
R263S |
probably benign |
Het |
| B9d1 |
A |
C |
11: 61,398,497 (GRCm39) |
D59A |
probably benign |
Het |
| Bag2 |
A |
T |
1: 33,787,357 (GRCm39) |
I55N |
probably benign |
Het |
| Bank1 |
T |
C |
3: 135,990,004 (GRCm39) |
I29V |
probably benign |
Het |
| Bbs2 |
A |
T |
8: 94,815,743 (GRCm39) |
D174E |
probably damaging |
Het |
| Bmp8b |
T |
C |
4: 123,009,030 (GRCm39) |
W203R |
probably damaging |
Het |
| Cacnb2 |
A |
T |
2: 14,986,151 (GRCm39) |
E359D |
possibly damaging |
Het |
| Camp |
T |
A |
9: 109,676,651 (GRCm39) |
|
probably null |
Het |
| Casp4 |
C |
T |
9: 5,328,580 (GRCm39) |
|
probably benign |
Het |
| Ccdc110 |
A |
T |
8: 46,395,944 (GRCm39) |
T612S |
probably benign |
Het |
| Cd209b |
T |
A |
8: 3,976,640 (GRCm39) |
|
probably null |
Het |
| Cemip |
T |
C |
7: 83,632,461 (GRCm39) |
D367G |
probably damaging |
Het |
| Cers5 |
T |
A |
15: 99,644,960 (GRCm39) |
N131I |
probably damaging |
Het |
| Cfhr4 |
T |
G |
1: 139,702,301 (GRCm39) |
D61A |
probably damaging |
Het |
| Chd5 |
T |
G |
4: 152,445,129 (GRCm39) |
V370G |
probably damaging |
Het |
| Cipc |
C |
A |
12: 86,999,531 (GRCm39) |
Q20K |
probably benign |
Het |
| Cnr2 |
T |
A |
4: 135,644,512 (GRCm39) |
F197I |
possibly damaging |
Het |
| Col7a1 |
G |
A |
9: 108,804,287 (GRCm39) |
G2233S |
unknown |
Het |
| Dcdc2b |
T |
A |
4: 129,505,060 (GRCm39) |
I125F |
possibly damaging |
Het |
| Ddi2 |
A |
G |
4: 141,411,713 (GRCm39) |
S400P |
probably benign |
Het |
| Ddx31 |
C |
A |
2: 28,794,696 (GRCm39) |
T664K |
probably benign |
Het |
| Dhx30 |
C |
A |
9: 109,929,992 (GRCm39) |
G35C |
probably damaging |
Het |
| Dmxl2 |
G |
A |
9: 54,318,937 (GRCm39) |
T1576I |
probably damaging |
Het |
| Dnah1 |
T |
C |
14: 31,017,280 (GRCm39) |
Y1510C |
probably damaging |
Het |
| Dnah2 |
C |
T |
11: 69,389,930 (GRCm39) |
|
probably null |
Het |
| Edar |
T |
C |
10: 58,457,146 (GRCm39) |
N144S |
probably benign |
Het |
| Elavl2 |
T |
A |
4: 91,196,915 (GRCm39) |
E54D |
possibly damaging |
Het |
| Enam |
T |
G |
5: 88,650,173 (GRCm39) |
S561A |
probably benign |
Het |
| Ercc5 |
C |
A |
1: 44,206,031 (GRCm39) |
H315N |
possibly damaging |
Het |
| Esp31 |
A |
G |
17: 38,955,552 (GRCm39) |
E65G |
possibly damaging |
Het |
| Faap100 |
T |
C |
11: 120,262,939 (GRCm39) |
I806M |
probably benign |
Het |
| Fbxw21 |
T |
C |
9: 108,974,731 (GRCm39) |
Y263C |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,811,837 (GRCm39) |
S2719T |
possibly damaging |
Het |
| Fv1 |
T |
C |
4: 147,953,875 (GRCm39) |
V147A |
probably benign |
Het |
| Gal |
T |
C |
19: 3,461,590 (GRCm39) |
E65G |
probably benign |
Het |
| Galnt2l |
A |
G |
8: 123,807,343 (GRCm39) |
|
probably benign |
Het |
| Galnt6 |
T |
C |
15: 100,614,059 (GRCm39) |
T81A |
probably benign |
Het |
| Gcc2 |
A |
G |
10: 58,106,261 (GRCm39) |
E399G |
probably damaging |
Het |
| Gfi1b |
A |
T |
2: 28,500,114 (GRCm39) |
C306S |
probably damaging |
Het |
| Gm10654 |
T |
A |
8: 71,384,496 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4953 |
T |
A |
1: 158,995,929 (GRCm39) |
|
noncoding transcript |
Het |
| Gorasp2 |
T |
C |
2: 70,518,683 (GRCm39) |
|
probably benign |
Het |
| Gse1 |
T |
C |
8: 121,295,205 (GRCm39) |
|
probably benign |
Het |
| H2-D1 |
A |
G |
17: 35,484,973 (GRCm39) |
E278G |
probably damaging |
Het |
| Herc2 |
T |
C |
7: 55,877,640 (GRCm39) |
L4569P |
probably damaging |
Het |
| Hgs |
T |
A |
11: 120,368,028 (GRCm39) |
S246T |
probably damaging |
Het |
| Hs2st1 |
T |
C |
3: 144,170,843 (GRCm39) |
T110A |
probably benign |
Het |
| Hydin |
A |
G |
8: 111,322,070 (GRCm39) |
Y4574C |
probably benign |
Het |
| Ighv1-23 |
C |
A |
12: 114,728,372 (GRCm39) |
V17F |
possibly damaging |
Het |
| Ighv8-14 |
A |
T |
12: 115,772,185 (GRCm39) |
|
noncoding transcript |
Het |
| Igsf21 |
C |
T |
4: 139,761,934 (GRCm39) |
R248H |
probably benign |
Het |
| Il22b |
T |
C |
10: 118,130,894 (GRCm39) |
M1V |
probably null |
Het |
| Il23r |
T |
C |
6: 67,400,545 (GRCm39) |
N595S |
probably benign |
Het |
| Il5ra |
G |
T |
6: 106,692,629 (GRCm39) |
P372Q |
probably damaging |
Het |
| Inppl1 |
A |
G |
7: 101,481,516 (GRCm39) |
V222A |
possibly damaging |
Het |
| Ints10 |
T |
C |
8: 69,279,964 (GRCm39) |
V697A |
probably damaging |
Het |
| Isg15 |
T |
A |
4: 156,284,217 (GRCm39) |
T104S |
probably benign |
Het |
| Kif11 |
A |
G |
19: 37,406,385 (GRCm39) |
T983A |
probably benign |
Het |
| Kif3b |
A |
T |
2: 153,159,212 (GRCm39) |
K338* |
probably null |
Het |
| Kpna2 |
T |
A |
11: 106,881,545 (GRCm39) |
I362F |
probably damaging |
Het |
| Lama2 |
G |
A |
10: 27,014,923 (GRCm39) |
T1595M |
probably damaging |
Het |
| Lrrc36 |
A |
G |
8: 106,153,567 (GRCm39) |
T126A |
probably benign |
Het |
| Lrrk1 |
T |
A |
7: 65,945,202 (GRCm39) |
D604V |
probably damaging |
Het |
| Map7d1 |
T |
C |
4: 126,130,484 (GRCm39) |
K409E |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,210,254 (GRCm39) |
T110A |
probably benign |
Het |
| Micall2 |
G |
A |
5: 139,702,580 (GRCm39) |
T221M |
probably damaging |
Het |
| Morc2b |
T |
A |
17: 33,356,351 (GRCm39) |
N474Y |
probably damaging |
Het |
| Myo1e |
T |
A |
9: 70,250,378 (GRCm39) |
M528K |
probably benign |
Het |
| Nlrp1c-ps |
G |
T |
11: 71,151,195 (GRCm39) |
|
noncoding transcript |
Het |
| Nostrin |
T |
C |
2: 68,991,486 (GRCm39) |
S160P |
possibly damaging |
Het |
| Nup133 |
T |
C |
8: 124,653,870 (GRCm39) |
R530G |
possibly damaging |
Het |
| Or2f2 |
T |
A |
6: 42,767,138 (GRCm39) |
L55H |
probably damaging |
Het |
| Or5p64 |
T |
C |
7: 107,855,244 (GRCm39) |
I34V |
possibly damaging |
Het |
| Or8c16 |
A |
G |
9: 38,130,392 (GRCm39) |
E91G |
probably damaging |
Het |
| Pabpc4l |
A |
T |
3: 46,400,597 (GRCm39) |
M349K |
possibly damaging |
Het |
| Pah |
G |
A |
10: 87,406,129 (GRCm39) |
G256S |
probably benign |
Het |
| Pigk |
T |
C |
3: 152,445,841 (GRCm39) |
S151P |
probably damaging |
Het |
| Plcd4 |
A |
C |
1: 74,603,572 (GRCm39) |
T658P |
possibly damaging |
Het |
| Pld4 |
A |
T |
12: 112,730,951 (GRCm39) |
S178C |
probably benign |
Het |
| Polr1a |
G |
A |
6: 71,886,213 (GRCm39) |
E23K |
possibly damaging |
Het |
| Pomt1 |
T |
C |
2: 32,131,691 (GRCm39) |
S127P |
probably damaging |
Het |
| Pon2 |
A |
G |
6: 5,269,029 (GRCm39) |
V215A |
possibly damaging |
Het |
| Ppp3cb |
A |
T |
14: 20,559,508 (GRCm39) |
M416K |
probably damaging |
Het |
| Prdm1 |
A |
T |
10: 44,318,048 (GRCm39) |
N273K |
possibly damaging |
Het |
| Prg4 |
T |
A |
1: 150,331,574 (GRCm39) |
|
probably benign |
Het |
| Prkn |
G |
T |
17: 11,059,359 (GRCm39) |
|
probably benign |
Het |
| Ptch1 |
G |
A |
13: 63,670,866 (GRCm39) |
T888M |
probably damaging |
Het |
| Pusl1 |
T |
G |
4: 155,975,899 (GRCm39) |
|
probably benign |
Het |
| Rapgef6 |
A |
T |
11: 54,513,143 (GRCm39) |
E122D |
probably damaging |
Het |
| Rif1 |
C |
T |
2: 52,000,530 (GRCm39) |
T1328I |
probably damaging |
Het |
| Rngtt |
T |
G |
4: 33,500,292 (GRCm39) |
|
probably null |
Het |
| Runx2 |
G |
A |
17: 45,125,079 (GRCm39) |
P80L |
probably damaging |
Het |
| Samd1 |
A |
G |
8: 84,725,618 (GRCm39) |
|
probably benign |
Het |
| Scamp5 |
A |
T |
9: 57,358,735 (GRCm39) |
F14I |
probably damaging |
Het |
| Shank3 |
C |
T |
15: 89,388,547 (GRCm39) |
R380C |
probably damaging |
Het |
| Shisal2a |
T |
C |
4: 108,234,658 (GRCm39) |
T70A |
probably benign |
Het |
| Slc1a4 |
C |
A |
11: 20,282,166 (GRCm39) |
A103S |
probably damaging |
Het |
| Slc39a14 |
A |
G |
14: 70,547,371 (GRCm39) |
V325A |
probably benign |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Spata6l |
G |
A |
19: 28,874,903 (GRCm39) |
|
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,013,213 (GRCm39) |
S375T |
probably damaging |
Het |
| Sval1 |
A |
G |
6: 41,932,378 (GRCm39) |
N76S |
probably benign |
Het |
| Synpo |
C |
T |
18: 60,762,936 (GRCm39) |
|
probably benign |
Het |
| Sytl5 |
C |
T |
X: 9,781,841 (GRCm39) |
P181L |
possibly damaging |
Het |
| Tacc1 |
A |
G |
8: 25,672,622 (GRCm39) |
M111T |
possibly damaging |
Het |
| Tec |
T |
C |
5: 72,913,694 (GRCm39) |
D613G |
probably benign |
Het |
| Tecpr2 |
C |
T |
12: 110,897,921 (GRCm39) |
T391I |
possibly damaging |
Het |
| Thop1 |
G |
A |
10: 80,909,125 (GRCm39) |
G52D |
probably damaging |
Het |
| Tmco5 |
T |
A |
2: 116,722,689 (GRCm39) |
V270D |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,556,973 (GRCm39) |
E28265K |
possibly damaging |
Het |
| Tuft1 |
T |
C |
3: 94,542,750 (GRCm39) |
D72G |
probably damaging |
Het |
| Tyrp1 |
C |
T |
4: 80,769,144 (GRCm39) |
|
probably benign |
Het |
| Usp9y |
T |
C |
Y: 1,308,041 (GRCm39) |
D2265G |
probably damaging |
Het |
| Vmn2r104 |
G |
A |
17: 20,250,288 (GRCm39) |
A661V |
probably benign |
Het |
| Vwa5a |
A |
T |
9: 38,649,268 (GRCm39) |
N672I |
probably benign |
Het |
| Wdr95 |
A |
T |
5: 149,535,157 (GRCm39) |
K772* |
probably null |
Het |
| Ybx1 |
T |
C |
4: 119,140,010 (GRCm39) |
T106A |
probably benign |
Het |
| Ypel3 |
T |
C |
7: 126,376,961 (GRCm39) |
S14P |
probably benign |
Het |
| Zfp518a |
T |
A |
19: 40,903,972 (GRCm39) |
S1300R |
probably benign |
Het |
| Zscan5b |
A |
T |
7: 6,242,189 (GRCm39) |
*469Y |
probably null |
Het |
|
| Other mutations in Dock10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00569:Dock10
|
APN |
1 |
80,562,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00783:Dock10
|
APN |
1 |
80,550,166 (GRCm39) |
splice site |
probably benign |
|
|
IGL00784:Dock10
|
APN |
1 |
80,550,166 (GRCm39) |
splice site |
probably benign |
|
|
IGL00858:Dock10
|
APN |
1 |
80,545,720 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01298:Dock10
|
APN |
1 |
80,508,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Dock10
|
APN |
1 |
80,570,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01356:Dock10
|
APN |
1 |
80,501,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01584:Dock10
|
APN |
1 |
80,511,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01619:Dock10
|
APN |
1 |
80,612,015 (GRCm39) |
splice site |
probably benign |
|
|
IGL01678:Dock10
|
APN |
1 |
80,521,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01759:Dock10
|
APN |
1 |
80,503,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02238:Dock10
|
APN |
1 |
80,511,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02352:Dock10
|
APN |
1 |
80,483,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02359:Dock10
|
APN |
1 |
80,483,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02377:Dock10
|
APN |
1 |
80,562,711 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02433:Dock10
|
APN |
1 |
80,507,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02471:Dock10
|
APN |
1 |
80,493,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02645:Dock10
|
APN |
1 |
80,551,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02646:Dock10
|
APN |
1 |
80,551,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02648:Dock10
|
APN |
1 |
80,551,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02649:Dock10
|
APN |
1 |
80,551,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02650:Dock10
|
APN |
1 |
80,551,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02652:Dock10
|
APN |
1 |
80,570,561 (GRCm39) |
splice site |
probably null |
|
|
IGL02718:Dock10
|
APN |
1 |
80,501,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02998:Dock10
|
APN |
1 |
80,551,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03057:Dock10
|
APN |
1 |
80,545,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03066:Dock10
|
APN |
1 |
80,562,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03106:Dock10
|
APN |
1 |
80,546,551 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03148:Dock10
|
APN |
1 |
80,518,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03271:Dock10
|
APN |
1 |
80,483,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03352:Dock10
|
APN |
1 |
80,584,013 (GRCm39) |
splice site |
probably benign |
|
|
LCD18:Dock10
|
UTSW |
1 |
80,716,623 (GRCm38) |
intron |
probably benign |
|
|
PIT4366001:Dock10
|
UTSW |
1 |
80,573,438 (GRCm39) |
missense |
probably benign |
0.30 |
|
PIT4581001:Dock10
|
UTSW |
1 |
80,483,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Dock10
|
UTSW |
1 |
80,583,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0081:Dock10
|
UTSW |
1 |
80,584,295 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0095:Dock10
|
UTSW |
1 |
80,501,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0241:Dock10
|
UTSW |
1 |
80,556,340 (GRCm39) |
missense |
probably benign |
|
|
R0241:Dock10
|
UTSW |
1 |
80,556,340 (GRCm39) |
missense |
probably benign |
|
|
R0255:Dock10
|
UTSW |
1 |
80,583,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0267:Dock10
|
UTSW |
1 |
80,490,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0299:Dock10
|
UTSW |
1 |
80,514,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0365:Dock10
|
UTSW |
1 |
80,573,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Dock10
|
UTSW |
1 |
80,517,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0403:Dock10
|
UTSW |
1 |
80,501,787 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0408:Dock10
|
UTSW |
1 |
80,518,193 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0414:Dock10
|
UTSW |
1 |
80,513,650 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0591:Dock10
|
UTSW |
1 |
80,518,936 (GRCm39) |
splice site |
probably benign |
|
|
R0698:Dock10
|
UTSW |
1 |
80,507,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0711:Dock10
|
UTSW |
1 |
80,501,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0925:Dock10
|
UTSW |
1 |
80,514,657 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1162:Dock10
|
UTSW |
1 |
80,546,559 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1370:Dock10
|
UTSW |
1 |
80,518,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1440:Dock10
|
UTSW |
1 |
80,526,853 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1469:Dock10
|
UTSW |
1 |
80,490,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1469:Dock10
|
UTSW |
1 |
80,490,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1525:Dock10
|
UTSW |
1 |
80,583,881 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1544:Dock10
|
UTSW |
1 |
80,570,352 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1601:Dock10
|
UTSW |
1 |
80,527,519 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1757:Dock10
|
UTSW |
1 |
80,511,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1765:Dock10
|
UTSW |
1 |
80,583,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Dock10
|
UTSW |
1 |
80,551,897 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1823:Dock10
|
UTSW |
1 |
80,520,814 (GRCm39) |
splice site |
probably null |
|
|
R1827:Dock10
|
UTSW |
1 |
80,508,009 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1844:Dock10
|
UTSW |
1 |
80,520,918 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1856:Dock10
|
UTSW |
1 |
80,584,285 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1974:Dock10
|
UTSW |
1 |
80,488,143 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2006:Dock10
|
UTSW |
1 |
80,527,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2112:Dock10
|
UTSW |
1 |
80,483,360 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2112:Dock10
|
UTSW |
1 |
80,483,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2113:Dock10
|
UTSW |
1 |
80,584,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2439:Dock10
|
UTSW |
1 |
80,510,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2566:Dock10
|
UTSW |
1 |
80,517,970 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3086:Dock10
|
UTSW |
1 |
80,510,074 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3766:Dock10
|
UTSW |
1 |
80,514,643 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3768:Dock10
|
UTSW |
1 |
80,510,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Dock10
|
UTSW |
1 |
80,510,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4016:Dock10
|
UTSW |
1 |
80,584,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4179:Dock10
|
UTSW |
1 |
80,488,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4243:Dock10
|
UTSW |
1 |
80,544,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4244:Dock10
|
UTSW |
1 |
80,544,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4245:Dock10
|
UTSW |
1 |
80,544,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4674:Dock10
|
UTSW |
1 |
80,584,337 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4696:Dock10
|
UTSW |
1 |
80,493,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4789:Dock10
|
UTSW |
1 |
80,518,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Dock10
|
UTSW |
1 |
80,526,874 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4976:Dock10
|
UTSW |
1 |
80,545,711 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5086:Dock10
|
UTSW |
1 |
80,529,189 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5119:Dock10
|
UTSW |
1 |
80,545,711 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5301:Dock10
|
UTSW |
1 |
80,625,973 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5404:Dock10
|
UTSW |
1 |
80,481,630 (GRCm39) |
intron |
probably benign |
|
|
R5457:Dock10
|
UTSW |
1 |
80,501,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5790:Dock10
|
UTSW |
1 |
80,482,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5845:Dock10
|
UTSW |
1 |
80,483,459 (GRCm39) |
intron |
probably benign |
|
|
R5871:Dock10
|
UTSW |
1 |
80,519,057 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5873:Dock10
|
UTSW |
1 |
80,551,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5881:Dock10
|
UTSW |
1 |
80,538,640 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5895:Dock10
|
UTSW |
1 |
80,514,676 (GRCm39) |
missense |
probably benign |
|
|
R5935:Dock10
|
UTSW |
1 |
80,483,304 (GRCm39) |
intron |
probably benign |
|
|
R5965:Dock10
|
UTSW |
1 |
80,546,461 (GRCm39) |
splice site |
probably null |
|
|
R5966:Dock10
|
UTSW |
1 |
80,546,225 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6008:Dock10
|
UTSW |
1 |
80,583,890 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6029:Dock10
|
UTSW |
1 |
80,514,663 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6083:Dock10
|
UTSW |
1 |
80,510,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6145:Dock10
|
UTSW |
1 |
80,553,621 (GRCm39) |
nonsense |
probably null |
|
|
R6257:Dock10
|
UTSW |
1 |
80,481,413 (GRCm39) |
intron |
probably benign |
|
|
R6274:Dock10
|
UTSW |
1 |
80,516,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6324:Dock10
|
UTSW |
1 |
80,482,893 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6346:Dock10
|
UTSW |
1 |
80,553,573 (GRCm39) |
splice site |
probably null |
|
|
R6476:Dock10
|
UTSW |
1 |
80,518,959 (GRCm39) |
nonsense |
probably null |
|
|
R6516:Dock10
|
UTSW |
1 |
80,518,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6526:Dock10
|
UTSW |
1 |
80,564,068 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6534:Dock10
|
UTSW |
1 |
80,481,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6620:Dock10
|
UTSW |
1 |
80,570,355 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6640:Dock10
|
UTSW |
1 |
80,511,555 (GRCm39) |
nonsense |
probably null |
|
|
R6669:Dock10
|
UTSW |
1 |
80,570,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6672:Dock10
|
UTSW |
1 |
80,490,248 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6679:Dock10
|
UTSW |
1 |
80,544,514 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6682:Dock10
|
UTSW |
1 |
80,490,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6712:Dock10
|
UTSW |
1 |
80,514,583 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock10
|
UTSW |
1 |
80,490,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6788:Dock10
|
UTSW |
1 |
80,508,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6805:Dock10
|
UTSW |
1 |
80,564,407 (GRCm39) |
missense |
probably benign |
|
|
R6815:Dock10
|
UTSW |
1 |
80,516,576 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6818:Dock10
|
UTSW |
1 |
80,593,082 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6867:Dock10
|
UTSW |
1 |
80,508,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Dock10
|
UTSW |
1 |
80,481,365 (GRCm39) |
intron |
probably benign |
|
|
R7026:Dock10
|
UTSW |
1 |
80,479,504 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7084:Dock10
|
UTSW |
1 |
80,481,573 (GRCm39) |
missense |
|
|
|
R7087:Dock10
|
UTSW |
1 |
80,570,543 (GRCm39) |
missense |
probably benign |
|
|
R7158:Dock10
|
UTSW |
1 |
80,564,589 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7191:Dock10
|
UTSW |
1 |
80,518,048 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7214:Dock10
|
UTSW |
1 |
80,546,246 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7255:Dock10
|
UTSW |
1 |
80,520,816 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7320:Dock10
|
UTSW |
1 |
80,527,421 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7359:Dock10
|
UTSW |
1 |
80,687,065 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7423:Dock10
|
UTSW |
1 |
80,501,497 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7464:Dock10
|
UTSW |
1 |
80,518,032 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7483:Dock10
|
UTSW |
1 |
80,493,283 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7487:Dock10
|
UTSW |
1 |
80,562,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7789:Dock10
|
UTSW |
1 |
80,536,930 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7943:Dock10
|
UTSW |
1 |
80,626,006 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Dock10
|
UTSW |
1 |
80,564,085 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8079:Dock10
|
UTSW |
1 |
80,556,421 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8086:Dock10
|
UTSW |
1 |
80,481,707 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8184:Dock10
|
UTSW |
1 |
80,530,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8220:Dock10
|
UTSW |
1 |
80,506,366 (GRCm39) |
missense |
probably null |
1.00 |
|
R8225:Dock10
|
UTSW |
1 |
80,481,447 (GRCm39) |
nonsense |
probably null |
|
|
R8267:Dock10
|
UTSW |
1 |
80,518,045 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8276:Dock10
|
UTSW |
1 |
80,505,998 (GRCm39) |
missense |
probably benign |
|
|
R8294:Dock10
|
UTSW |
1 |
80,488,079 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8298:Dock10
|
UTSW |
1 |
80,514,654 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8326:Dock10
|
UTSW |
1 |
80,583,892 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8724:Dock10
|
UTSW |
1 |
80,570,344 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8828:Dock10
|
UTSW |
1 |
80,521,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8846:Dock10
|
UTSW |
1 |
80,545,786 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8919:Dock10
|
UTSW |
1 |
80,483,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8950:Dock10
|
UTSW |
1 |
80,519,016 (GRCm39) |
missense |
probably benign |
|
|
R8993:Dock10
|
UTSW |
1 |
80,551,888 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9028:Dock10
|
UTSW |
1 |
80,584,012 (GRCm39) |
splice site |
probably benign |
|
|
R9115:Dock10
|
UTSW |
1 |
80,490,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9327:Dock10
|
UTSW |
1 |
80,510,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9342:Dock10
|
UTSW |
1 |
80,570,360 (GRCm39) |
missense |
probably benign |
|
|
R9421:Dock10
|
UTSW |
1 |
80,501,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9431:Dock10
|
UTSW |
1 |
80,583,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9486:Dock10
|
UTSW |
1 |
80,479,452 (GRCm39) |
missense |
unknown |
|
|
R9521:Dock10
|
UTSW |
1 |
80,501,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Dock10
|
UTSW |
1 |
80,625,939 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9629:Dock10
|
UTSW |
1 |
80,481,389 (GRCm39) |
missense |
|
|
|
R9703:Dock10
|
UTSW |
1 |
80,517,540 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF021:Dock10
|
UTSW |
1 |
80,542,290 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
X0025:Dock10
|
UTSW |
1 |
80,514,637 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0065:Dock10
|
UTSW |
1 |
80,518,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Dock10
|
UTSW |
1 |
80,510,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Dock10
|
UTSW |
1 |
80,538,671 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Dock10
|
UTSW |
1 |
80,536,917 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATTGCATTTAGAGCAGAGG -3'
(R):5'- TTGACAGGGAACACGATTATTACG -3'
Sequencing Primer
(F):5'- GAAGATCCGGGATTGGTT -3'
(R):5'- GAACACGATTATTACGGATGAGTC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation