Mutagenetix > Incidental Mutation

Incidental Mutation 'R5266:Vmn1r128'

401696

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r128

Ensembl Gene

ENSMUSG00000095758

Gene Name

vomeronasal 1 receptor 128

Synonyms

Gm8509

MMRRC Submission

042858-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R5266 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

21083298-21084221 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 21083328 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 11 (T11S)

Ref Sequence

ENSEMBL: ENSMUSP00000129433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169165]

AlphaFold

L7N2B4

Predicted Effect

probably benign
Transcript: ENSMUST00000169165
AA Change: T11S

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000129433
Gene: ENSMUSG00000095758
AA Change: T11S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	299	3.6e-16	PFAM
Pfam:7tm_1	31	288	3.8e-6	PFAM
Pfam:V1R	41	296	8.4e-15	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.6%

Validation Efficiency

97% (56/58)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503L19Rik	T	C	18: 70,591,455 (GRCm39)	N457S	probably damaging	Het
Asic4	G	A	1: 75,427,567 (GRCm39)	G31E	probably benign	Het
Atp2a3	A	G	11: 72,866,223 (GRCm39)	D281G	probably damaging	Het
Azin1	T	C	15: 38,491,795 (GRCm39)	D387G	probably benign	Het
Bdp1	T	C	13: 100,204,043 (GRCm39)	M660V	probably benign	Het
Catsperg2	G	A	7: 29,416,491 (GRCm39)	T307M	probably damaging	Het
Cfap54	T	G	10: 92,651,764 (GRCm39)	K3095N	probably benign	Het
Chl1	A	G	6: 103,677,504 (GRCm39)	N706S	probably damaging	Het
Crym	A	G	7: 119,798,517 (GRCm39)	V113A	probably benign	Het
Cux1	A	G	5: 136,341,548 (GRCm39)	S607P	probably damaging	Het
Cyp3a44	T	C	5: 145,731,207 (GRCm39)	N198D	possibly damaging	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Het
Elac1	A	G	18: 73,875,740 (GRCm39)	V97A	probably benign	Het
Erbb3	G	A	10: 128,405,505 (GRCm39)	T1251M	probably damaging	Het
Gask1b	T	A	3: 79,843,910 (GRCm39)	N12K	probably damaging	Het
Gprc5c	G	T	11: 114,755,093 (GRCm39)	V257L	possibly damaging	Het
Hydin	A	G	8: 111,061,416 (GRCm39)	H316R	possibly damaging	Het
Ikzf3	A	T	11: 98,381,406 (GRCm39)	M58K	probably benign	Het
Lyst	T	C	13: 13,835,555 (GRCm39)	Y1746H	probably damaging	Het
Map3k11	T	A	19: 5,750,622 (GRCm39)	N613K	probably benign	Het
Mfng	C	T	15: 78,648,588 (GRCm39)	R163H	probably benign	Het
Mrm1	A	T	11: 84,710,086 (GRCm39)	L38Q	possibly damaging	Het
Myo7b	A	G	18: 32,131,787 (GRCm39)	F470L	probably damaging	Het
Ndst2	G	A	14: 20,774,555 (GRCm39)	R834W	probably damaging	Het
Opa1	T	A	16: 29,436,948 (GRCm39)	I637N	probably benign	Het
Or52h9	A	T	7: 104,203,026 (GRCm39)	Q300L	probably benign	Het
Or5d43	T	C	2: 88,104,565 (GRCm39)	Y276C	possibly damaging	Het
Padi4	A	G	4: 140,473,442 (GRCm39)	V665A	possibly damaging	Het
Pcdh1	A	G	18: 38,325,252 (GRCm39)	Y897H	probably damaging	Het
Pkp3	A	G	7: 140,663,190 (GRCm39)	D345G	probably damaging	Het
Pla2g4a	T	C	1: 149,740,918 (GRCm39)	M366V	possibly damaging	Het
Pnkp	C	T	7: 44,511,827 (GRCm39)	S113L	probably damaging	Het
Pon3	T	C	6: 5,240,860 (GRCm39)	D34G	possibly damaging	Het
Ppargc1b	A	T	18: 61,448,876 (GRCm39)	S133T	probably damaging	Het
Ppp4r3b	T	C	11: 29,123,309 (GRCm39)	S2P	possibly damaging	Het
Rbm20	A	G	19: 53,801,818 (GRCm39)	T109A	probably damaging	Het
Rexo5	C	A	7: 119,443,660 (GRCm39)	H690Q	probably benign	Het
Scube2	C	T	7: 109,408,437 (GRCm39)	G670D	probably damaging	Het
Sipa1l2	T	C	8: 126,218,865 (GRCm39)	I157M	probably damaging	Het
Slbp	A	T	5: 33,801,210 (GRCm39)	I167N	probably damaging	Het
Sry	C	G	Y: 2,662,975 (GRCm39)	Q228H	unknown	Het
Stk36	T	C	1: 74,650,317 (GRCm39)	V283A	probably benign	Het
Tead1	A	G	7: 112,358,673 (GRCm39)		probably benign	Het
Tecpr2	G	C	12: 110,881,836 (GRCm39)	W135S	probably damaging	Het
Tha1	A	C	11: 117,760,502 (GRCm39)	S241A	probably damaging	Het
Ttc39a	A	T	4: 109,279,701 (GRCm39)	I112F	probably benign	Het
Vnn1	G	A	10: 23,779,303 (GRCm39)	C404Y	probably damaging	Het
Wdr41	T	C	13: 95,131,759 (GRCm39)	F57L	probably damaging	Het
Zfp975	T	G	7: 42,311,654 (GRCm39)	T320P	probably damaging	Het
Zfp985	A	T	4: 147,667,289 (GRCm39)		probably null	Het
Zfpm2	T	C	15: 40,962,865 (GRCm39)	S176P	probably benign	Het

Other mutations in Vmn1r128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00972:Vmn1r128	APN	7	21,084,001 (GRCm39)	missense	probably benign	0.01
IGL02169:Vmn1r128	APN	7	21,084,163 (GRCm39)	missense	probably damaging	0.99
IGL02883:Vmn1r128	APN	7	21,083,440 (GRCm39)	missense	probably benign	0.00
R1740:Vmn1r128	UTSW	7	21,083,869 (GRCm39)	missense	probably benign	0.00
R2969:Vmn1r128	UTSW	7	21,084,046 (GRCm39)	missense	probably damaging	1.00
R4583:Vmn1r128	UTSW	7	21,083,644 (GRCm39)	missense	possibly damaging	0.79
R4867:Vmn1r128	UTSW	7	21,083,939 (GRCm39)	missense	possibly damaging	0.53
R5631:Vmn1r128	UTSW	7	21,083,300 (GRCm39)	start codon destroyed	probably null	1.00
R6267:Vmn1r128	UTSW	7	21,084,221 (GRCm39)	makesense	probably null
R7376:Vmn1r128	UTSW	7	21,083,668 (GRCm39)	missense	probably damaging	1.00
R8351:Vmn1r128	UTSW	7	21,083,597 (GRCm39)	missense	probably damaging	1.00
R8440:Vmn1r128	UTSW	7	21,083,745 (GRCm39)	missense	probably benign	0.22
R8773:Vmn1r128	UTSW	7	21,083,922 (GRCm39)	missense	probably benign	0.41
R8889:Vmn1r128	UTSW	7	21,083,740 (GRCm39)	missense	possibly damaging	0.61
R9182:Vmn1r128	UTSW	7	21,083,683 (GRCm39)	missense	possibly damaging	0.72
R9200:Vmn1r128	UTSW	7	21,083,316 (GRCm39)	missense	possibly damaging	0.89
R9665:Vmn1r128	UTSW	7	21,083,362 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTGTAGTGTGATAGAATAGTGTCTC -3'
(R):5'- CTTGCCACCATGTGACTGAAG -3'

Sequencing Primer
(F):5'- AGGAGAGTAGTGTCCTACCT -3'
(R):5'- CTTGCCACCATGTGACTGAAGAATTC -3'

Posted On

2016-07-06