Mutagenetix > Incidental Mutation

Incidental Mutation 'R5567:Tenm4'

436921

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

l7Rn3, Doc4, Ten-m4, ELM2, l(7)-3Rn, Odz4

MMRRC Submission

043124-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5567 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

95820453-96560300 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 96545416 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 2477 (Y2477*)

Ref Sequence

ENSEMBL: ENSMUSP00000102784 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000107162
AA Change: Y2506*

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: Y2506*

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000107165
AA Change: Y2514*

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: Y2514*

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000107166
AA Change: Y2477*

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: Y2477*

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	C	T	6: 86,932,150 (GRCm39)	Q374*	probably null	Het
Adam19	A	G	11: 46,027,077 (GRCm39)	D570G	probably damaging	Het
Aqr	G	A	2: 113,979,451 (GRCm39)	T328M	probably damaging	Het
Bltp3b	T	A	10: 89,644,383 (GRCm39)	M29K	probably benign	Het
Boc	G	A	16: 44,313,187 (GRCm39)	T559I	probably damaging	Het
Cadps	A	T	14: 12,473,497 (GRCm38)	I876N	possibly damaging	Het
Cdh9	A	G	15: 16,855,930 (GRCm39)	T657A	probably damaging	Het
Cep104	T	C	4: 154,086,734 (GRCm39)	S794P	possibly damaging	Het
Cep72	T	C	13: 74,188,260 (GRCm39)	Q211R	probably benign	Het
Coq6	T	A	12: 84,415,413 (GRCm39)	D145E	probably benign	Het
Crym	T	C	7: 119,801,116 (GRCm39)	E11G	probably benign	Het
Csmd3	A	T	15: 47,508,864 (GRCm39)	M2907K	possibly damaging	Het
Cspg4	A	C	9: 56,793,932 (GRCm39)	I556L	probably benign	Het
Cwf19l2	T	A	9: 3,456,831 (GRCm39)	D721E	probably damaging	Het
Defb36	T	A	2: 152,454,503 (GRCm39)	V54E	probably damaging	Het
Dlg5	C	A	14: 24,242,981 (GRCm39)	E55*	probably null	Het
Dna2	G	T	10: 62,802,452 (GRCm39)	A857S	possibly damaging	Het
E330034G19Rik	A	G	14: 24,346,892 (GRCm39)	K60E	possibly damaging	Het
Eps8l2	G	A	7: 140,934,920 (GRCm39)	R76Q	possibly damaging	Het
Fbxl18	A	G	5: 142,881,022 (GRCm39)		probably benign	Het
Flnc	T	A	6: 29,444,044 (GRCm39)	C619*	probably null	Het
Ftcd	A	G	10: 76,423,967 (GRCm39)	K503E	probably benign	Het
Gbp2b	C	T	3: 142,317,126 (GRCm39)	A494V	possibly damaging	Het
Gfral	C	T	9: 76,115,900 (GRCm39)	A25T	probably benign	Het
Gins2	T	A	8: 121,315,684 (GRCm39)	D24V	possibly damaging	Het
Gm10985	T	C	3: 53,752,683 (GRCm39)	I22T	probably damaging	Het
Golga4	T	A	9: 118,387,251 (GRCm39)	S1458T	probably damaging	Het
Gpatch1	T	C	7: 35,006,640 (GRCm39)	K176R	probably damaging	Het
Gsto1	T	C	19: 47,846,338 (GRCm39)	W62R	probably damaging	Het
Gtf2h3	C	T	5: 124,722,360 (GRCm39)	T121I	probably benign	Het
Gxylt1	A	G	15: 93,152,180 (GRCm39)		probably null	Het
Hs6st1	C	T	1: 36,142,719 (GRCm39)	P218L	probably benign	Het
Itpr3	C	T	17: 27,322,880 (GRCm39)	T1119M	possibly damaging	Het
Kif5c	A	G	2: 49,620,211 (GRCm39)	D226G	possibly damaging	Het
Klk1b1	T	A	7: 43,620,593 (GRCm39)	S228T	probably damaging	Het
Krt1	A	G	15: 101,755,340 (GRCm39)	F473S	probably benign	Het
Large1	A	G	8: 73,564,081 (GRCm39)	S562P	possibly damaging	Het
Lpxn	T	A	19: 12,810,023 (GRCm39)	M265K	possibly damaging	Het
Lrriq1	G	A	10: 103,006,457 (GRCm39)	P1223S	possibly damaging	Het
Map3k9	A	G	12: 81,778,798 (GRCm39)	L505P	possibly damaging	Het
Morn2	A	G	17: 80,604,709 (GRCm39)	D128G	probably damaging	Het
Msl2	A	G	9: 100,978,936 (GRCm39)	K437E	possibly damaging	Het
Msr1	T	C	8: 40,064,760 (GRCm39)	I305V	probably benign	Het
Muc4	A	G	16: 32,598,066 (GRCm39)	E3237G	possibly damaging	Het
Mxra8	T	C	4: 155,925,465 (GRCm39)	M58T	probably damaging	Het
Myo16	A	G	8: 10,372,676 (GRCm39)	D125G	probably damaging	Het
Myom2	A	G	8: 15,152,546 (GRCm39)	Q631R	probably benign	Het
Nlrp1b	T	A	11: 71,072,229 (GRCm39)	H538L	probably benign	Het
Nme3	T	A	17: 25,115,823 (GRCm39)		probably null	Het
Nop2	T	C	6: 125,110,726 (GRCm39)	S68P	probably benign	Het
Nploc4	C	T	11: 120,275,440 (GRCm39)	V499M	probably benign	Het
Nub1	A	G	5: 24,913,814 (GRCm39)	E565G	possibly damaging	Het
Or1e19	C	T	11: 73,316,272 (GRCm39)	C179Y	probably damaging	Het
Or6e1	A	G	14: 54,519,825 (GRCm39)	F176L	probably damaging	Het
Or7e168	A	G	9: 19,719,674 (GRCm39)	D20G	probably damaging	Het
Or9g3	G	A	2: 85,589,994 (GRCm39)	S242F	probably damaging	Het
Parl	A	G	16: 20,101,762 (GRCm39)	M90T	probably damaging	Het
Pelo	T	C	13: 115,226,152 (GRCm39)	I102V	probably benign	Het
Pigt	T	A	2: 164,343,482 (GRCm39)	Y319*	probably null	Het
Plb1	A	G	5: 32,521,543 (GRCm39)	T1465A	unknown	Het
Plxna4	T	C	6: 32,134,915 (GRCm39)	N1763D	possibly damaging	Het
Pmpca	A	G	2: 26,280,553 (GRCm39)	E133G	probably damaging	Het
Pus7l	G	A	15: 94,425,746 (GRCm39)	P552S	probably benign	Het
Qsox2	A	G	2: 26,115,230 (GRCm39)	M1T	probably null	Het
Ralb	C	T	1: 119,411,265 (GRCm39)	V25I	probably damaging	Het
Rbbp6	A	G	7: 122,601,057 (GRCm39)		probably benign	Het
Rnf43	A	G	11: 87,618,271 (GRCm39)	E187G	probably damaging	Het
Rpl31	C	T	1: 39,409,108 (GRCm39)	R41C	probably benign	Het
Scap	A	G	9: 110,206,712 (GRCm39)	S386G	probably damaging	Het
Skint10	T	C	4: 112,573,067 (GRCm39)	Y243C	probably damaging	Het
Stpg2	A	G	3: 139,125,547 (GRCm39)	T447A	probably benign	Het
Tas1r1	G	A	4: 152,122,782 (GRCm39)	A21V	probably damaging	Het
Tas2r122	C	T	6: 132,688,335 (GRCm39)	G186E	probably benign	Het
Them7	A	G	2: 105,209,153 (GRCm39)	T158A	probably benign	Het
Tmcc2	A	C	1: 132,285,543 (GRCm39)	S608A	probably benign	Het
Ttc41	T	C	10: 86,596,784 (GRCm39)		probably null	Het
Ttk	T	A	9: 83,744,588 (GRCm39)	N593K	possibly damaging	Het
Tulp1	A	G	17: 28,578,172 (GRCm39)	V289A	possibly damaging	Het
Unc93a2	T	C	17: 7,631,202 (GRCm39)	T456A	probably benign	Het
Usp34	A	C	11: 23,438,336 (GRCm39)	Q278P	probably damaging	Het
Vmn2r78	T	A	7: 86,570,737 (GRCm39)	D418E	probably benign	Het
Vmn2r90	C	T	17: 17,932,336 (GRCm39)	A81V	probably damaging	Het
Xpc	T	A	6: 91,475,117 (GRCm39)	N636I	probably damaging	Het
Zfp563	A	T	17: 33,308,431 (GRCm39)		probably benign	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,517,216 (GRCm39)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,523,679 (GRCm39)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,454,345 (GRCm39)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,378,598 (GRCm39)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,523,474 (GRCm39)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,378,592 (GRCm39)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,544,384 (GRCm39)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,523,510 (GRCm39)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,534,565 (GRCm39)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,202,931 (GRCm39)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,534,611 (GRCm39)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,545,271 (GRCm39)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,544,716 (GRCm39)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,544,419 (GRCm39)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,202,757 (GRCm39)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,544,869 (GRCm39)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,523,323 (GRCm39)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,473,029 (GRCm39)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,503,941 (GRCm39)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,353,344 (GRCm39)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,523,281 (GRCm39)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,423,383 (GRCm39)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,534,640 (GRCm39)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,545,426 (GRCm39)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,544,205 (GRCm39)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,522,913 (GRCm39)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,492,175 (GRCm39)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,522,969 (GRCm39)	missense	probably damaging	1.00
principium	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
toccata	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,523,734 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,545,259 (GRCm39)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,378,547 (GRCm39)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,421,242 (GRCm39)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,555,088 (GRCm39)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,522,973 (GRCm39)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,427,058 (GRCm39)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,544,830 (GRCm39)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,423,227 (GRCm39)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,545,482 (GRCm39)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,497,251 (GRCm39)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,199,258 (GRCm39)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,492,255 (GRCm39)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,552,096 (GRCm39)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,537,892 (GRCm39)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,522,987 (GRCm39)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,545,147 (GRCm39)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,544,533 (GRCm39)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,555,497 (GRCm39)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,552,054 (GRCm39)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,555,216 (GRCm39)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,545,069 (GRCm39)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,544,197 (GRCm39)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,542,332 (GRCm39)	splice site	probably null
R3409:Tenm4	UTSW	7	96,544,367 (GRCm39)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,512,770 (GRCm39)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,544,979 (GRCm39)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4511:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4543:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,544,949 (GRCm39)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,544,131 (GRCm39)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,446,691 (GRCm39)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,555,025 (GRCm39)	splice site	probably null
R5036:Tenm4	UTSW	7	96,501,768 (GRCm39)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,343,997 (GRCm39)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,544,995 (GRCm39)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,492,164 (GRCm39)	missense	probably damaging	1.00
R5106:Tenm4	UTSW	7	96,492,356 (GRCm39)	missense	probably damaging	0.99
R5118:Tenm4	UTSW	7	96,542,293 (GRCm39)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,523,410 (GRCm39)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,486,538 (GRCm39)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,538,034 (GRCm39)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,543,887 (GRCm39)	missense	probably damaging	1.00
R5590:Tenm4	UTSW	7	96,446,608 (GRCm39)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,446,607 (GRCm39)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,202,724 (GRCm39)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,542,246 (GRCm39)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,492,424 (GRCm39)	intron	probably benign
R5890:Tenm4	UTSW	7	96,552,067 (GRCm39)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,503,926 (GRCm39)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,495,102 (GRCm39)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,171,640 (GRCm39)	intron	probably benign
R6060:Tenm4	UTSW	7	96,522,918 (GRCm39)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,486,496 (GRCm39)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,523,701 (GRCm39)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,423,331 (GRCm39)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,492,251 (GRCm39)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,542,067 (GRCm39)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,494,919 (GRCm39)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,461,166 (GRCm39)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,544,478 (GRCm39)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,486,502 (GRCm39)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,446,599 (GRCm39)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,544,757 (GRCm39)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,545,342 (GRCm39)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,544,430 (GRCm39)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,385,020 (GRCm39)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,523,333 (GRCm39)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,344,010 (GRCm39)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,423,194 (GRCm39)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,523,420 (GRCm39)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,423,353 (GRCm39)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,495,015 (GRCm39)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,486,521 (GRCm39)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,497,224 (GRCm39)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,538,021 (GRCm39)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,495,133 (GRCm39)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,545,192 (GRCm39)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,542,221 (GRCm39)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,512,740 (GRCm39)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,544,610 (GRCm39)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,543,909 (GRCm39)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,544,899 (GRCm39)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,423,221 (GRCm39)	missense	possibly damaging	0.54
R7855:Tenm4	UTSW	7	96,523,081 (GRCm39)	missense	probably damaging	1.00
R7868:Tenm4	UTSW	7	96,555,587 (GRCm39)	missense	possibly damaging	0.79
R7878:Tenm4	UTSW	7	96,501,564 (GRCm39)	missense	probably damaging	1.00
R7997:Tenm4	UTSW	7	96,523,512 (GRCm39)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,378,553 (GRCm39)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,501,663 (GRCm39)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,503,935 (GRCm39)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,544,383 (GRCm39)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,544,614 (GRCm39)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,421,313 (GRCm39)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,461,139 (GRCm39)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8670:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8683:Tenm4	UTSW	7	96,552,064 (GRCm39)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8692:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8714:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8716:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8735:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8736:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8737:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,523,047 (GRCm39)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8776:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,523,335 (GRCm39)	missense	probably benign	0.01
R8851:Tenm4	UTSW	7	96,501,710 (GRCm39)	missense	probably damaging	1.00
R8913:Tenm4	UTSW	7	96,351,952 (GRCm39)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,461,177 (GRCm39)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,495,061 (GRCm39)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,473,125 (GRCm39)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,473,080 (GRCm39)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,421,234 (GRCm39)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,542,126 (GRCm39)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,534,646 (GRCm39)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,545,352 (GRCm39)	missense	probably damaging	1.00
R9414:Tenm4	UTSW	7	96,545,367 (GRCm39)	missense	probably benign
R9466:Tenm4	UTSW	7	96,199,252 (GRCm39)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,473,056 (GRCm39)	missense	probably benign
R9626:Tenm4	UTSW	7	96,545,345 (GRCm39)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,517,196 (GRCm39)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,544,638 (GRCm39)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,386,619 (GRCm39)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,555,761 (GRCm39)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,202,685 (GRCm39)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,523,116 (GRCm39)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,517,294 (GRCm39)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,544,001 (GRCm39)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,497,237 (GRCm39)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,555,121 (GRCm39)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,512,792 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TCAGTGGAACTGGCTTGATG -3'
(R):5'- TCATAGACTTTGGGAGATGATGTC -3'

Sequencing Primer
(F):5'- AGATCCTATACACGGCCTATGGG -3'
(R):5'- ATGTCTTTAGAGATAGCCAGTGTCCC -3'

Posted On

2016-10-24