Incidental Mutation 'R4713:Vipr2'
ID 500019
Institutional Source Beutler Lab
Gene Symbol Vipr2
Ensembl Gene ENSMUSG00000011171
Gene Name vasoactive intestinal peptide receptor 2
Synonyms VPAC2R, VPAC2, VIP receptor subtype 2, Vip2
MMRRC Submission 041601-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R4713 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 116041346-116109881 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 116043751 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 49 (R49S)
Ref Sequence ENSEMBL: ENSMUSP00000011315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011315]
AlphaFold P41588
Predicted Effect probably benign
Transcript: ENSMUST00000011315
AA Change: R49S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000011315
Gene: ENSMUSG00000011171
AA Change: R49S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
HormR 47 117 8.35e-25 SMART
Pfam:7tm_2 122 370 1.5e-81 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000100988
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175785
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176078
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177199
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I). [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 G T 1: 25,586,613 (GRCm39) T360K probably damaging Het
AW551984 T C 9: 39,508,449 (GRCm39) K356E probably benign Het
Bpifb2 T A 2: 153,723,113 (GRCm39) V123E probably damaging Het
Cacna1a T G 8: 85,276,143 (GRCm39) F532V probably damaging Het
Cct8 C A 16: 87,284,576 (GRCm39) E204* probably null Het
Cd163 T A 6: 124,294,577 (GRCm39) probably null Het
Cep152 C A 2: 125,429,868 (GRCm39) A685S possibly damaging Het
Chdh A G 14: 29,758,798 (GRCm39) D581G probably benign Het
Cnpy3 A C 17: 47,058,391 (GRCm39) Y77* probably null Het
Col5a3 T C 9: 20,704,870 (GRCm39) E762G unknown Het
Creb3 A G 4: 43,563,247 (GRCm39) T115A probably benign Het
Dlat G T 9: 50,555,781 (GRCm39) A412E probably benign Het
Dnah2 T C 11: 69,367,514 (GRCm39) N1789S probably damaging Het
Dzank1 C T 2: 144,333,724 (GRCm39) E370K probably benign Het
Eif3m A T 2: 104,837,184 (GRCm39) probably null Het
Gimap8 A T 6: 48,635,920 (GRCm39) M562L probably benign Het
Gprc6a T A 10: 51,507,553 (GRCm39) probably benign Het
Gsr T G 8: 34,170,347 (GRCm39) probably null Het
Gstcd A G 3: 132,688,860 (GRCm39) V630A probably damaging Het
Hip1r T C 5: 124,128,043 (GRCm39) I116T probably benign Het
Hivep3 A G 4: 119,989,000 (GRCm39) E1817G probably damaging Het
Inpp5f A C 7: 128,265,449 (GRCm39) T135P probably damaging Het
Ism2 A G 12: 87,331,801 (GRCm39) silent Het
Itga11 A G 9: 62,673,070 (GRCm39) D784G probably damaging Het
Itpr2 A G 6: 146,274,671 (GRCm39) F837S probably damaging Het
Itpr2 T C 6: 146,298,456 (GRCm39) E10G probably damaging Het
Knl1 A T 2: 118,899,618 (GRCm39) K440* probably null Het
Lonp2 T C 8: 87,439,943 (GRCm39) S648P probably damaging Het
Lrba T C 3: 86,267,175 (GRCm39) S1622P probably benign Het
Lrp2 G T 2: 69,318,310 (GRCm39) A2047D probably damaging Het
Mcm3 G A 1: 20,873,801 (GRCm39) T773I probably benign Het
Mki67 A G 7: 135,297,198 (GRCm39) V2612A probably benign Het
Mnx1 C A 5: 29,683,129 (GRCm39) G49W probably damaging Het
Muc5b T A 7: 141,402,816 (GRCm39) Y673* probably null Het
Myo15a A G 11: 60,370,756 (GRCm39) H1172R probably benign Het
Myo1g T C 11: 6,466,080 (GRCm39) K363R probably null Het
Ncoa4 T A 14: 31,898,598 (GRCm39) C473S probably benign Het
Nefh T C 11: 4,889,656 (GRCm39) T988A unknown Het
Nwd2 T A 5: 63,961,803 (GRCm39) D462E probably benign Het
Or2av9 T C 11: 58,380,913 (GRCm39) T223A probably benign Het
Pira13 G T 7: 3,825,680 (GRCm39) Y396* probably null Het
Plec T C 15: 76,065,267 (GRCm39) E1466G unknown Het
Prl3d2 G T 13: 27,306,379 (GRCm39) M35I probably benign Het
Reln T A 5: 22,357,461 (GRCm39) I202F probably benign Het
Rhot1 T A 11: 80,116,428 (GRCm39) D78E probably benign Het
Rsph3b T C 17: 7,172,528 (GRCm39) probably null Het
Scn10a C T 9: 119,438,717 (GRCm39) M1717I probably damaging Het
Sema6a T A 18: 47,382,363 (GRCm39) H728L possibly damaging Het
Slc26a3 G T 12: 31,507,079 (GRCm39) A345S possibly damaging Het
Slc35d2 A G 13: 64,247,097 (GRCm39) V261A possibly damaging Het
Slc49a3 T C 5: 108,589,945 (GRCm39) T486A probably damaging Het
Ssmem1 A G 6: 30,519,513 (GRCm39) D66G probably damaging Het
Sult2a8 A T 7: 14,159,402 (GRCm39) N72K probably benign Het
Tbx10 T C 19: 4,046,921 (GRCm39) L108P probably damaging Het
Tex14 T C 11: 87,427,691 (GRCm39) S48P probably damaging Het
Tmie A G 9: 110,696,596 (GRCm39) L95P probably damaging Het
Tom1l2 C G 11: 60,161,259 (GRCm39) R84P probably damaging Het
Trpm3 T A 19: 22,866,799 (GRCm39) D543E possibly damaging Het
Vps8 A T 16: 21,261,189 (GRCm39) S110C probably damaging Het
Zfp791 T A 8: 85,837,597 (GRCm39) N89I probably damaging Het
Other mutations in Vipr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00691:Vipr2 APN 12 116,102,368 (GRCm39) splice site probably null
IGL02233:Vipr2 APN 12 116,058,356 (GRCm39) missense probably damaging 0.99
IGL02691:Vipr2 APN 12 116,099,849 (GRCm39) missense probably benign 0.11
PIT4377001:Vipr2 UTSW 12 116,058,418 (GRCm39) missense probably benign 0.01
R0135:Vipr2 UTSW 12 116,106,447 (GRCm39) missense probably benign 0.00
R0207:Vipr2 UTSW 12 116,106,502 (GRCm39) missense probably damaging 1.00
R1389:Vipr2 UTSW 12 116,100,950 (GRCm39) missense probably benign 0.01
R1560:Vipr2 UTSW 12 116,058,401 (GRCm39) missense probably benign 0.18
R1575:Vipr2 UTSW 12 116,107,892 (GRCm39) missense probably benign
R1696:Vipr2 UTSW 12 116,102,777 (GRCm39) missense probably benign 0.13
R1970:Vipr2 UTSW 12 116,099,826 (GRCm39) missense probably benign 0.01
R2010:Vipr2 UTSW 12 116,086,430 (GRCm39) critical splice donor site probably null
R3873:Vipr2 UTSW 12 116,099,724 (GRCm39) unclassified probably benign
R4953:Vipr2 UTSW 12 116,107,876 (GRCm39) missense probably benign 0.07
R6041:Vipr2 UTSW 12 116,106,604 (GRCm39) missense probably damaging 1.00
R6337:Vipr2 UTSW 12 116,086,363 (GRCm39) nonsense probably null
R6902:Vipr2 UTSW 12 116,102,819 (GRCm39) missense possibly damaging 0.46
R6946:Vipr2 UTSW 12 116,102,819 (GRCm39) missense possibly damaging 0.46
R7763:Vipr2 UTSW 12 116,086,338 (GRCm39) missense probably damaging 1.00
R9339:Vipr2 UTSW 12 116,058,344 (GRCm39) missense probably damaging 0.96
R9523:Vipr2 UTSW 12 116,093,788 (GRCm39) missense probably damaging 1.00
X0066:Vipr2 UTSW 12 116,106,565 (GRCm39) splice site probably null
X0067:Vipr2 UTSW 12 116,102,792 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCGTTGGATCTTCCTGTAG -3'
(R):5'- AGCCATGGAAACTGTTGGTG -3'

Sequencing Primer
(F):5'- AGATTTTTGCTTAACCCTCTCTTGTG -3'
(R):5'- CCATGGAAACTGTTGGTGTAAAGC -3'
Posted On 2017-11-30